Abstract：
:Brain serotonin (5-HT) uptake sites were quantitated, by saturation binding of [3H]paroxetine, in 10 brain regions from 22 suicide victims and 20 control subjects. Suicide victims were restricted to those subjects in whom a firm retrospective diagnosis of depression was established and who had not recently been prescribed antidepressant drugs. The Kd and Bmax of [3H]paroxetine did not differ significantly between controls and depressed suicides in any of the brain regions. In putamen, Bmax values of suicides who died non-violently were lower than controls, whereas those who died by violent methods did not differ from controls. No significant differences between violent or non-violent suicides and their matched controls were found in other brain areas. These results offer little support for the view that suicide/depression is associated with an abnormality in 5-HT uptake.
journal_name
Brain Resjournal_title
Brain researchauthors
Lawrence KM,De Paermentier F,Cheetham SC,Crompton MR,Katona CL,Horton RWdoi
10.1016/0006-8993(90)90244-6subject
Has Abstractpub_date
1990-08-27 00:00:00pages
17-22issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)90244-6journal_volume
526pub_type
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