Cocaine stimulates adrenocorticotropin (ACTH) secretion through a corticotropin-releasing factor (CRF)-mediated mechanism.

Abstract:

:Cocaine was injected intravenously to non-anesthetized, freely moving adult male rats and caused dose-dependent elevations in plasma adrenocorticotropin (ACTH) levels. The observation that this stimulatory effect was completely abolished by pretreatment with a corticotropin-releasing factor (CRF) antiserum, coupled with the lack of effect of cocaine on ACTH secretion by cultured pituitary cells, suggests that cocaine acts within the brain to release endogenous CRF.

journal_name

Brain Res

journal_title

Brain research

authors

Rivier C,Vale W

doi

10.1016/0006-8993(87)90953-x

subject

Has Abstract

pub_date

1987-10-06 00:00:00

pages

403-6

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(87)90953-X

journal_volume

422

pub_type

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