Abstract:
:Cocaine was injected intravenously to non-anesthetized, freely moving adult male rats and caused dose-dependent elevations in plasma adrenocorticotropin (ACTH) levels. The observation that this stimulatory effect was completely abolished by pretreatment with a corticotropin-releasing factor (CRF) antiserum, coupled with the lack of effect of cocaine on ACTH secretion by cultured pituitary cells, suggests that cocaine acts within the brain to release endogenous CRF.
journal_name
Brain Resjournal_title
Brain researchauthors
Rivier C,Vale Wdoi
10.1016/0006-8993(87)90953-xsubject
Has Abstractpub_date
1987-10-06 00:00:00pages
403-6issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(87)90953-Xjournal_volume
422pub_type
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