Abstract：
:Because brainstem auditory evoked potentials (BAEPs) are frequently recorded in anesthetized animals and humans, it is important to become familiar with the effects on the BAEP of drugs used during anesthesia, including pre-anesthetics. The dose-dependent and stimulus intensity-dependent effects on the BAEP of a pre-anesthetic, atropine sulfate, were studied in the unanesthetized rat. The animal subjects were 11 adult female Long-Evans rats. BAEPs in response to 0.1 ms clicks (12.5/s) were recorded from skull screw electrodes during a baseline period, as well as after saline and atropine treatments. Atropine sulfate was given i.p. in doses ranging from 0.250 to 40 mg/kg. Contrary to a prior report, doses in the standard pre-anesthetic range (i.e. 0.250-1.000 mg/kg) did not convincingly influence the BAEP. Only the highest dose (40 mg/kg) produced a significant and noteworthy change in the BAEP. This effect was characterized by significant amplitude increases in the P1, P2 and P3 components, but not in the P4, P5 and P6 components. This selective effect occurred at the highest stimulus intensity of 110 dB peak equivalent sound pressure level, but not at lower intensities. There were no convincing atropine-induced changes in BAEP latencies. Atropine-induced changes in the cortical auditory evoked potential (CAEP) were characterized by amplitude decrements. Thus, atropine seemed to have an excitatory effect on the BAEP and an inhibitory or depressive effect on the CAEP.
journal_name
Brain Resjournal_title
Brain researchauthors
Church MW,Gritzke Rdoi
10.1016/0006-8993(88)90221-1subject
Has Abstractpub_date
1988-07-26 00:00:00pages
224-34issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(88)90221-1journal_volume
456pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:beta-Amyloid is the primary protein component of neuritic plaques, which are degenerative foci in brains of patients with Alzheimer's disease (AD). The effects of this naturally occurring beta-amyloid on the cells of the central nervous system have not been completely understood. beta-Amyloid increases the vulnerabili...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00043-7
更新日期：1997-04-18 00:00:00
abstract：:Synaptic potentials evoked in the medial amygdala (m-AMG) neurons were studied in in vitro slice preparations obtained from normal and olfactory bulbectomized rats. Local stimulation induced a sequence of responses: a fast EPSP, a fast IPSP and a slow EPSP. The fast EPSP was suppressed by kynurenic acid (KYN) at a con...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91743-z
更新日期：1990-11-05 00:00:00
abstract：:The optic tecta of 55 Rutilus rutilus were examined at intervals varying from 2 days to 4 years after unilateral retinal ablation. Qualitative ultrastructural examination of the retinal target lamina of the optic tectum (stratum fibrosum et griseum superficiale, SFGS) revealed that an initial period of degeneration an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91133-x
更新日期：1988-05-03 00:00:00
abstract：:Hydroxyindole-O-methyltransferase (HIOMT) catalyses the last step of all the 5-methoxyindoles synthesized in the pineal gland. The synthetic activity of this neuroendocrine structure is driven not only by noradrenaline but also by various neuropeptides. Recently we have established (1) that one of these neuropeptides,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00556-3
更新日期：1998-08-10 00:00:00
abstract：:Inflammation and immune response have been implicated in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Recently, increased TLR4 expression has been associated with the development of cerebral vasospasm in a rabbit model of SAH. Peroxisome proliferator-activated receptor gamma (PPARgamma) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.073
更新日期：2010-03-31 00:00:00
abstract：:The activities of 5'-nucleotidase (EC 3.1.3.5) and of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNP) (EC 3.1.4.37) were measured in crude membrane preparations from 6 brain regions of hypothyroid rats 31 days and 42 days after conception (8-9 days and 19-20 days after birth respectively) and from normal rats 31, 36...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90185-2
更新日期：1983-04-01 00:00:00
abstract：:Axoaxonic synapses are common features of hair-follicle afferent boutons. We have attempted to discover the identity of the neurotransmitter in the associated axon terminals by combining intra-axonal labelling of hair-follicle afferent axons with immunocytochemistry in a correlated light and electron microscopical stu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90394-5
更新日期：1987-04-07 00:00:00
abstract：:Dural afferent neurons are implicated in primary headaches including migraine. Although a significant portion of primary afferent neurons innervating the dura are myelinated A-type neurons, previous electrophysiological studies have primarily characterized the functional properties of small-sized C-type sensory neuron...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.06.007
更新日期：2018-10-01 00:00:00
abstract：:The effects of 0.1 to 500 mM ethanol on NMDA-activated currents were studied in primary cultures of mouse cortical and hippocampal neurons. In whole-cell recordings the IC50S for inhibition of NMDA-activated currents by ethanol were 129 mM +/- 20 mM in hippocampal neurons and 126 +/- 18 mM in cortical neurons. In sing...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00780-9
更新日期：1996-11-04 00:00:00
abstract：:Neuronal cells in primary culture have been demonstrated to possess specific insulin receptors (Boyd et al., J. Biol. Chem., 260 (1985) 15880-15884). Incubation of these cultures with insulin causes a dose-dependent inhibition of maprotiline-sensitive [3H]norepinephrine uptake. Maximum inhibition of 95% of maprotiline...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91242-4
更新日期：1986-11-19 00:00:00
abstract：:Light-microscopical measurements have been made on teased pulpal nerve fibers from young adult cat canine teeth. In the root canal portion (apical to first branching point) the mean internodal length was approximately 250 micron. In the pulpal chamber portion (coronal to the first branching point) the pulpal nerve fib...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90221-x
更新日期：1984-06-11 00:00:00
abstract：:Molecular mechanism underlying ischemic stroke remains poorly understood. We previously reported glucose 6-phosphate dehydrogenase (G6PD) activity in pentose phosphate pathway (PPP) is activated via heat shock protein 27 (HSP27) phosphorylation at serine 85 (S85) by ataxia telangiectasia mutated (ATM) kinase during ce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.03.001
更新日期：2018-05-15 00:00:00
abstract：:The effects of target and non-target cells on the growth and function of intrastriatal grafts of mesencephalic dopamine neurons have been studied in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal dopamine pathway. Cell suspensions of ventral mesencephalon from 14-15-day-old rat fetuses (ri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90174-4
更新日期：1986-01-01 00:00:00
abstract：:The sexually dimorphic nucleus of the preoptic area (SDN-POA) is the most striking structure displaying a morphological sex difference in the rat brain. A potentially homologous nucleus has been identified in the human hypothalamus. The objective of the present study was to pursue the putative homology of the rat and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01005-0
更新日期：1996-12-02 00:00:00
abstract：:The two primary categories of stroke, ischemic and hemorrhagic, both have fundamentally different mechanisms and thus different treatment options. These two stroke categories were applied to rat models to identify potential biomarkers that can distinguish between them. Ischemic stroke was induced by middle cerebral ar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.09.051
更新日期：2013-12-02 00:00:00
abstract：:Glucocorticoids exacerbate aging-induced cell death, but relatively little is known about other CNS effects in senescence. We examined noradrenergic/adenylyl cyclase signaling in the cerebellum, which is a brain region that is susceptible to deterioration of synaptic function in aging. Aged control rats had increased ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00518-6
更新日期：1998-08-03 00:00:00
abstract：:Morphological and physiological effects of kainic acid (KA) lesions in rat ventral lateral geniculate nucleus (LGV) were studied 1.5 and 6 h after KA injection. Morphological changes were examined mainly by electron micrographs. At 1.5 h after KA injection dendrites were dilated and some vacuolations occurred in both ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90033-4
更新日期：1989-03-27 00:00:00
abstract：:To determine whether the cytokine, interleukin-1 beta, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1 beta. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90445-h
更新日期：1990-04-23 00:00:00
abstract：:Fronto-limbic circuits in the primate brain are responsible for executive function, learning and memory, and emotions, including fear. Consequently, changes in gene expression in cortical and subcortical brain regions housing these circuits are associated with many important psychiatric and neurological disorders. Whi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.12.031
更新日期：2015-03-10 00:00:00
abstract：:The effects of spinal cord hemisection on protein labeling in the medulla, pons, midbrain, and cortex in the Cebus monkey were studied by measuring the uptake of [3H]lysine into the trichloroacetic acid (TCA) precipitable and non-precipitable fractions of brain. Animals were sacrificed 3, 6 or 13 days after hemisectio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90458-9
更新日期：1977-02-25 00:00:00
abstract：:The medial amygdala plays a key role in regulating adult social behavior and undergoes structural changes during puberty that may be driven by gonadal hormone secretion during this developmental period. The current study sought to investigate potential organizational effects of testosterone during puberty, activationa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.035
更新日期：2012-06-15 00:00:00
abstract：:Regeneration of severed hypothalamic peptidergic neurosecretory axons into the ventral pia-arachnoid was observed in rats at the light microscopic and fine-structural levels. A temporal increase occurred in the number of neurophysin-positive axons regenerating into the leptomeninges for distances up to 3.3 mm by 40 da...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91557-0
更新日期：1988-05-31 00:00:00
abstract：:The release of adipokinetic hormones from the neurosecretory cells within the glandular lobe of the corpus cardiacum (CC) of locusts is under the synaptic control of axons within the nervi corporis cardiaca II (NCC II). This synapse has been shown to be aminergic with the transmitter tentatively identified as octopami...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91242-8
更新日期：1983-01-03 00:00:00
abstract：:The effects of substantia nigra (SN) stimulation on the activity of the nucleus ventralis lateralis of the thalamus (VL) have been studied. The VL cells were identified as relay or non-relay cells among the cerebellothalamocortical pathway on the basis of orthodromical activation from the cerebellum and antidromical a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90793-x
更新日期：1978-04-21 00:00:00
abstract：:Medial basal hypothalamic (MBH) 5 alpha-reductase activity was significantly blocked with a known inhibitor, Proscar (Finasteride), in pregnant rats while their open-field behavior was quantified during the last week of pregnancy. In control animals, open-field behavior significantly decreased (in a stair-step fashion...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01068-2
更新日期：1996-11-11 00:00:00
abstract：:This study has assessed the neuroprotective efficacy of five AP-1 inhibitory peptides in an in vitro excitotoxicity model. The five AP-1 inhibitory peptides and controls of the JNK inhibitor peptide (JNKI-1D-TAT) and TAT cell-penetrating-peptide were administered to primary cortical neuronal cultures prior to kainic a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.007
更新日期：2010-11-11 00:00:00
abstract：:This study investigated the effects of morphine microinjection into the nucleus raphe magnus (RMg) on electrically evoked C-fiber activities of convergent neurons in the spinal trigeminal nucleus oralis (Sp5O), in halothane-anesthetized rats. Although the neurons could be depressed by systemic morphine (6 mg/kg, i.v.)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00659-3
更新日期：1998-08-24 00:00:00
abstract：:Drebrins are developmentally regulated proteins found in chicken brain and are classified into two forms of the embryonic type (E1 and E2) and one form of the adult type (A). Although the time courses of their appearance are different from each other, the structures of the 3 forms are closely related. Two kinds of dre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(88)90027-7
更新日期：1988-11-01 00:00:00
abstract：:Previous studies have shown that long-term 5-hydroxytryptamine (5-HT) depletion induced by combined dorsal and median raphe injections of 5,7-dihydroxytryptamine (5,7-DHT) leads to impairments in the acquisition and performance of behaviour maintained under a differential-reinforcement-of-low-rate (DRL) schedule of re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00037-q
更新日期：1995-03-27 00:00:00
abstract：:More than 50% of the Xenopus pectoralis twitch muscle fibers with two distant endplates are innervated at both sites by the same neuron. This study indicates that there are three separable twitch motor unit types in this muscle which show very little overlap in innervation. This study also shows that each motor unit i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90697-3
更新日期：1985-03-25 00:00:00
