Abstract：
:To determine whether the cytokine, interleukin-1 beta, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1 beta. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1 beta is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.
journal_name
Brain Resjournal_title
Brain researchauthors
Lechan RM,Toni R,Clark BD,Cannon JG,Shaw AR,Dinarello CA,Reichlin Sdoi
10.1016/0006-8993(90)90445-hsubject
Has Abstractpub_date
1990-04-23 00:00:00pages
135-40issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(90)90445-Hjournal_volume
514pub_type
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