Immunoreactive interleukin-1 beta localization in the rat forebrain.


:To determine whether the cytokine, interleukin-1 beta, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1 beta. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1 beta is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.


Brain Res


Brain research


Lechan RM,Toni R,Clark BD,Cannon JG,Shaw AR,Dinarello CA,Reichlin S




Has Abstract


1990-04-23 00:00:00














  • Atrophy of medium spiny I striatal dendrites in advanced Parkinson's disease.

    abstract::Loss of dopaminergic neurons from the pars compacta of the substantia nigra is the pathological hallmark of Parkinson's disease (PD) and results in a partial deafferentation to the striatum. Since deafferentation is known to induce transynaptic atrophy of postsynaptic cells, we examined by Golgi impregnation the morph...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: McNeill TH,Brown SA,Rafols JA,Shoulson I

    更新日期:1988-07-05 00:00:00

  • Reversible blockade of PGO waves and concomitant modifications of thalamic unit activity in chronic cats.

    abstract::The reversible blockade of geniculate PGO waves was carried out by localized cooling of the ponto-geniculate pathways during paradoxical sleep in chronic cats. In parallel, long-term recordings of unit activity were performed in non-specific visuooculomotor thalamic structures where no PGO waves occurred. Blockade of ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Laurent JP,Rondouin G,Benita M,Jouvet M

    更新日期:1977-12-02 00:00:00

  • Neuronal pathways linking substance P to drug addiction and stress.

    abstract::Accumulating evidence suggests that the neuropeptide substance P (SP) and its principal receptor neurokinin 1 (NK1) play a specific role in the behavioral response to opioids and stress that may help to initiate and maintain addictive behavior. In animal models, the NK1 receptor is required for opioids to produce thei...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Commons KG

    更新日期:2010-02-16 00:00:00

  • Sites in the male primate brain at which testosterone acts as an androgen.

    abstract::Quantitative autoradiographic analysis was used to identify regions in the brain of the male primate where androgen binding sites may be involved in the actions of testosterone. Three days after castration, adult male rhesus monkeys received a subcutaneous injection of either dihydrotestosterone propionate (DHTP, 20 m...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Michael RP,Rees HD,Bonsall RW

    更新日期:1989-11-13 00:00:00

  • Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice.

    abstract::Cerebral cortical blood flow (CBF) was measured autoradiographically in conscious mice without the monoamine oxidase B (MAOB) gene (KO, n=11) and the corresponding wild-type animals (WILD, n=11). Subgroups of animals of each genotype received a continuous intravenous infusion over 30 min of phenylethylamine (PEA), an ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Scremin OU,Holschneider DP,Chen K,Li MG,Shih JC

    更新日期:1999-04-03 00:00:00

  • Plasticity of [14C]2-deoxy-D-glucose incorporation into neostriatum and related structures in response to dopamine neuron damage and apomorphine replacement.

    abstract::Unilateral injections of 6-hydroxydopamine into the lateral hypothalamus or ventral tegmental area that damage extensively the mesotelencephalic dopaminergic projection result in significant hemispheric asymmetries in autoradiographic labeling after [14C]2-deoxy-D-glucose (2DG) administration. The incorporation of thi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kozlowski MR,Marshall JF

    更新日期:1980-09-15 00:00:00

  • The relation of hippocampal theta activity to arousal, attentive behaviour and somato-motor movements in unrestrained cats.

    abstract::EEG recordings of hippocampal theta activity and neocortical activity were correlated with direct observations and photographic recordings of the behaviour of unrestrained cats. The behaviour studied included (1) both spontaneous and induced changes in level of arousal (sleep-wakefulness), (2) different types of orien...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kemp IR,Kaada BR

    更新日期:1975-09-23 00:00:00

  • Adhesion properties of a neuronal epitope recognized by the monoclonal antibody HNK-1.

    abstract::A carbohydrate epitope on adhesion proteins of the developing nervous system, and on myelin-associated glycoprotein, is recognized by the monoclonal antibody HNK-1. The HNK-1 epitope bearing proteins and the monoclonal antibody alter, in a dose-dependent manner, the interaction between neurons and neurite-promoting su...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Riopelle RJ,McGarry RC,Roder JC

    更新日期:1986-03-05 00:00:00

  • Visual recognition memory and auditory brainstem response in infant rhesus monkeys exposed perinatally to environmental tobacco smoke.

    abstract::The impact of perinatal exposure to environmental tobacco smoke (ETS) on cognitive development is controversial. We exposed rhesus monkeys to ETS or filtered air (5 animals per group) beginning in utero on day 50 of pregnancy and continuing throughout postnatal testing. In infancy, we evaluated both groups for visual ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Golub MS,Slotkin TA,Tarantal AF,Pinkerton KE

    更新日期:2007-06-02 00:00:00

  • Social attraction between rats in open field: long-term consequences of kindled seizures.

    abstract::Kindling of the amygdaloid complex in rats results in an enhanced emotionality frequently expressed by an elevated anxiety and defensive attitude toward other animals. Defensive attitude may have important consequences in social context and if tested in a large space it may eventually lead to social withdrawal. To tes...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Haimovici A,Wang Y,Cohen E,Mintz M

    更新日期:2001-12-13 00:00:00

  • The locus coeruleus of the Japanese monkey (Macaca fuscata) does not express mu-opioid receptor-like immunoreactivity.

    abstract::It is well known that locus coeruleus (LC) of the rat shows intense mu-opioid receptor-like immunoreactivity (MOR-LI). In the course of our study on the distribution of MOR-LI in the brain of the Japanese monkey (Macaca fuscata), however, no MOR-LI was found in the LC although the distribution pattern of MOR-LI in oth...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chen J,Koyama N,Kaneko T,Mizuno N

    更新日期:1997-05-02 00:00:00

  • Human neural stem cells express extra-neural markers.

    abstract::Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Parati EA,Bez A,Ponti D,de Grazia U,Corsini E,Cova L,Sala S,Colombo A,Alessandri G,Pagano SF

    更新日期:2002-01-25 00:00:00

  • Immunocytochemical localization of corticotropin releasing factor (CRF) in the rat spinal cord.

    abstract::The presence of corticotropin releasing factor (CRF)-immunoreactive nerve fibers and cell bodies in the spinal cord is demonstrated. Immunopositive fibers were found in the lateral column of the white matter, in laminae I, V-VII, X, and in the intermediolateral column of the spinal cord. Complete transection of the sp...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Merchenthaler I,Hynes MA,Vigh S,Shally AV,Petrusz P

    更新日期:1983-09-26 00:00:00

  • Role of central nervous system neurotransmitters in mediating the effects of morphine on growth hormone- and prolactin-secretion in the rat.

    abstract::Unanesthetized adult male rats with indwelling right atrial cannulae were used in the majority of experiments. Morphine (MOR, 3.0 mg/kg) caused a large but transient increase in both GH and PRL levels, which could be prevented with naloxone. Disruption of central noradrenergic function with diethyldithiocarbamate (400...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Koenig J,Mayfield MA,Coppings RJ,McCann SM,Krulich L

    更新日期:1980-09-22 00:00:00

  • Olfactory bulbectomy prevents short photoperiod-induced anestrus in female golden hamsters.

    abstract::When female golden hamsters are maintained on a photoperiod of less than 12.5 h of light per day, they go into a pineal gland-induced anestrus in 6-10 weeks. This acyclicity is similar in certain respects to the testicular regression which occurs in male golden hamsters maintained on a short photoperiod. A recent stud...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pieper DR,Samyn MM,Heverly RN

    更新日期:1986-08-13 00:00:00

  • Early social isolation disrupts latent inhibition and increases dopamine D2 receptor expression in the medial prefrontal cortex and nucleus accumbens of adult rats.

    abstract::Adolescence is a critical period for neurodevelopment. In the present study, we investigated the effects of peri-adolescent social isolation on latent inhibition (LI) and dopamine D2 receptor expression in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) of young adult rats. Male Sprague-Dawley rats wer...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Han X,Li N,Xue X,Shao F,Wang W

    更新日期:2012-04-04 00:00:00

  • Characterization of wild-type (R100R) and mutated (Q100Q) GABAA alpha 6 subunit in Sardinian alcohol non-preferring rats (sNP).

    abstract::Sardinian alcohol non-preferring (sNP) rats, selected for their low ethanol preference and consumption, carry a point mutation (R100Q) in the gene coding for GABA(A) receptor alpha(6) subunit, which becomes more sensitive to diazepam-evoked GABA currents. We performed binding studies in the cerebellum of normal (RR) a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sanna A,Congeddu E,Porcella A,Saba L,Pistis M,Peis M,Marchese G,Ruiu S,Lobina C,Grayson DR,Gessa GL,Pani L

    更新日期:2003-03-28 00:00:00

  • Similar 1H magnetic resonance spectroscopic metabolic pattern in the medial temporal lobes of patients with mild cognitive impairment and Alzheimer disease.

    abstract::Structures of the medial temporal lobes are recognized to play a central role in memory processing and to be the primary sites of deterioration in Alzheimer disease (AD). Mild cognitive impairment (MCI) represents potentially an intermediate state between normal aging and AD. Proton magnetic resonance spectroscopy (MR...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chantal S,Braun CM,Bouchard RW,Labelle M,Boulanger Y

    更新日期:2004-04-02 00:00:00

  • Differential effects of olfactory bulbectomy on beta-adrenoceptors in rat amygdala, hippocampus and cerebral cortex.

    abstract::Rats were bilaterally olfactory bulbectomized. At 15 days post-lesion, olfactory bulbectomized (OB) rats exhibited significant deficits in the acquisition of passive avoidance learning compared to sham lesioned rats. beta-Adrenoceptor binding in the amygdala, hippocampus and cerebral cortex was assayed with (-)-[125I]...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tiong AH,Richardson JS

    更新日期:1990-10-29 00:00:00

  • Electrophysiological correlates of the efficient detection of emotional facial expressions.

    abstract::Behavioral studies have shown that emotional facial expressions are detected more rapidly and accurately than are neutral expressions. However, the neural mechanism underlying this efficient detection has remained unclear. To investigate this mechanism, we measured event-related potentials (ERPs) during a visual searc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sawada R,Sato W,Uono S,Kochiyama T,Toichi M

    更新日期:2014-04-29 00:00:00

  • Involvement of the glutamate transporter and the sodium-calcium exchanger in the hypoxia-induced increase in intracellular Ca2+ in rat hippocampal slices.

    abstract::Hippocampal slices prepared from adult rats were loaded with fura-2 and the intracellular free Ca2+ concentration ([Ca2+]i) in the CA1 pyramidal cell layer was measured. Hypoxia (oxygen-glucose deprivation) elicited a gradual increase in [Ca2+]i in normal Krebs solution. At high extracellular sodium concentrations ([N...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yamaguchi S,Endo K,Kitajima T,Ogata H,Hori Y

    更新日期:1998-12-07 00:00:00

  • Characterization and partial purification of a 5,700 dalton form of substance P-like immunoreactivity from the rat hypothalamus.

    abstract::Analysis of rat hypothalamic extracts by gel filtration and HPLC revealed the presence of a form of substance P-like immunoreactivity with a molecular weight of approximately 5,700 (6k-SP). 6k-SP is probably an N-terminally extended form of substance P; the peptide may be an intermediate in SP biosynthesis, or may fun...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Harmar AJ,Armstrong A,Lee CM,Emson PC

    更新日期:1984-12-10 00:00:00

  • Neonatal testosterone treatment increases neuron and synapse numbers in male rat superior cervical ganglion.

    abstract::Neonatal treatment with gonadal steroids has been reported to alter morphological as well as functional development in various regions of the brain and spinal cord. Among the observed alterations are changes in numbers of neurons and in the organization and numbers of synapses. These regions have been found to be sexu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wright LL,Smolen AJ

    更新日期:1983-06-01 00:00:00

  • The selective effects of somatostatin- and GABA-mediated transmissions on voltage gated Ca2+ channel immunoreactivity in the gerbil hippocampus.

    abstract::To identify whether altered expressions of voltage gated Ca(2+) channel (VGCC) are linked to inhibitory transmission abnormalities in the gerbil hippocampus, we investigated the effects of GABA receptor or somatostatin receptor (SST) antagonists/agonists on VGCC immunoreactivity in vivo. VGCC immunoreactivities in the...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kim DS,Kwak SE,Kim JE,Kim JS,Won MH,Kang TC

    更新日期:2006-10-18 00:00:00

  • Transitional properties of the mechanically evoked perioral reflex from infancy through adulthood.

    abstract::The organization of motor responses in the orbicularis oris muscle following the delivery of punctate mechanical inputs to vermilion skin of the lips was studied in a group of young infants, school-age children, and adults during periods of voluntary lip muscle activation. A specially designed multi-point array skin c...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Barlow SM,Finan DS,Bradford PT,Andreatta RD

    更新日期:1993-10-01 00:00:00

  • 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6-hydroxydopamine-lesioned rats.

    abstract::The subthalamic nucleus receives serotonergic projections from the dorsal raphe nucleus. However, the role of serotonergic innervation in the activity of subthalamic neurons in vivo is unknown. The aim of the present work is to study the changes in the firing of subthalamic neurons in rats with 5,7-dihydroxytryptamine...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Liu J,Chu YX,Zhang QJ,Wang S,Feng J,Li Q

    更新日期:2007-05-29 00:00:00

  • Response to an itch-producing substance in cat. I. Cutaneous receptor populations with myelinated axons.

    abstract::The purpose of this study was to determine which myelinated cutaneous receptor populations in cat are responsive to a stimulus (cowhage) that produces unambiguous pruritus in human subjects. Initial experiments using electrocutaneous stimuli demonstrated that fibers conducting as slowly as 1.5 m/s could be recorded fr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tuckett RP,Wei JY

    更新日期:1987-06-09 00:00:00

  • Maturational changes of amino acid concentration in cerebrospinal fluid of the rat.

    abstract::The cisternal spinal fluid (CF), plasma, and brain stem concentrations of 6 amino acids were measured in suckling rats between birth and one months of age. Each of the amino acids studied had its distinctive maturational pattern of CF concentration. Presumably these amino acids have separate mechanisms of transport fr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Korobkin RK,Cutler RW

    更新日期:1977-01-01 00:00:00

  • Extracellular guanosine and guanosine-5'-triphosphate increase: NGF synthesis and release from cultured mouse neopallial astrocytes.

    abstract::Cultures of neonatal mouse cortical astrocytes synthesized NGF mRNA and released immunoreactive NGF (ir-NGF) into the culture medium. Addition of 10 microM guanosine or GTP to the cultures increased ir-NGF release by 6 and 2 fold, respectively, after 24 h, and increased NGF mRNA 6 fold after 4 h and 2-3 fold after 24 ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Middlemiss PJ,Gysbers JW,Rathbone MP

    更新日期:1995-04-17 00:00:00

  • Centrifugal innervation of the lamprey retina. Light- and electron microscopic and electrophysiological investigations.

    abstract::Centrifugal fibers and their synaptic connections were studied in retinas of the lamprey Lampetra fluviatilis. The morphological analysis of retinofugal and retinopetal elements was performed after their horseradish peroxidase (HRP) filling through either the cut optic nerve in isolated retina preparations or after in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vesselkin NP,Repérant J,Kenigfest NB,Rio JP,Miceli D,Shupliakov OV

    更新日期:1989-07-24 00:00:00