Immunoreactive interleukin-1 beta localization in the rat forebrain.

Abstract:

:To determine whether the cytokine, interleukin-1 beta, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1 beta. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1 beta is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

journal_name

Brain Res

journal_title

Brain research

authors

Lechan RM,Toni R,Clark BD,Cannon JG,Shaw AR,Dinarello CA,Reichlin S

doi

10.1016/0006-8993(90)90445-h

subject

Has Abstract

pub_date

1990-04-23 00:00:00

pages

135-40

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(90)90445-H

journal_volume

514

pub_type

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