Abstract：
:Earlier studies in this laboratory have shown that partial serotonergic (5-HT) deafferentation from the hippocampus induced a homotypic sprouting. The 5-HT-denervated hippocampus was further found to be a favorable environment for the growth of grafted 5-HT, but not for norepinephrinergic neurons. In the current study, we have extracted a trophic factor in the denervated hippocampus with hypotonic solution in high-speed supernatant fraction. The trophic extract was assayed in a unique experimental paradigm--test the growth of grafted 5-HT neurons in the cerebellum, which receives the least 5-HT innervation, and where grafted 5-HT neurons have seldom survived. The diluted trophic extract (1:200) produced a dramatic increase in (a) the survival rate, (b) the 5-HT fiber-density, and (c) the 5-HT and 5-hydroxyindoleacetic acid levels of grafted 5-HT neurons in the cerebellum. In addition, Nissl-counterstaining showed that the size of the grafted raphe also apparently increased. The concentrated trophic extract (1:1) did not increase the survival rate of the grafted raphe neurons. These results indicate that (a) the supernatant in the 5-HT-denervated hippocampus contains a potent neurotrophic factor to 5-HT neurons (b) which can either directly or indirectly also support non-5-HT raphe neurons, and (c) possibly an inhibitory factor is present which is detrimental to 5-HT neurons in high concentration.
journal_name
Brain Resjournal_title
Brain researchauthors
Zhou FC,Azmitia ECdoi
10.1016/0006-8993(90)90286-ksubject
Has Abstractpub_date
1990-01-22 00:00:00pages
301-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(90)90286-Kjournal_volume
507pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:EEG power spectra exhibit site-specific and state-related differences in specific frequency bands. In the present study we investigated the effect of total sleep deprivation on sleep EEG topography. Eight healthy, young, right-handed subjects were recorded during baseline sleep and recovery sleep after sleep deprivati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02796-2
更新日期：2001-09-21 00:00:00
abstract：:Investigations of the time course of various stages of lexical processing have indicated either early or late onset of brain activation for phonological code retrieval. The basis of the differential findings is unclear, but factors related to segmental phonology appear to be part of it. The purpose of the present stud...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.01.014
更新日期：2016-03-15 00:00:00
abstract：:The jimpy gene is a sex-linked recessive mutation which produces severe hypomyelination throughout the central nervous system (CNS) in affected male mice. The female carrier also expresses the mutation, but the degree of hypomyelination varies considerably among the tracts. In the optic nerve, patches of unmyelinated ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90958-1
更新日期：1982-10-28 00:00:00
abstract：:The present study describes the biochemical changes, morphological development and the cerebrospinal fluid dynamics of the kaolin-induced hydrocephalus in the adult rat. Two, 4 and 6 weeks after microsurgical kaolin instillation into the rat cisterna magna the basal intracranial pressure and the cerebrospinal fluid ou...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03320-0
更新日期：2002-02-08 00:00:00
abstract：:Unilateral destruction of the entorhinal area in the rat results in the proliferation of a pathway from the surviving contralateral entorhinal area to the fascia dentata denervated by the lesions (the crossed temporodentate pathway). The present study analyzes the point of entry of these reinnervating fibers into the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90464-3
更新日期：1980-02-10 00:00:00
abstract：:Leptin is one of the key afferent signals that regulate food intake and energy expenditure by acting on specific receptors in the hypothalamus. Recently, leptin was reported to activate the peripheral immune system by acting directly on lymphocytes. To elucidate the brain-mediated participation of leptin in the modula...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02409-9
更新日期：2000-02-07 00:00:00
abstract：:The morphology of so-called interplexiform (IP) cells immunoreactive to tyrosine hydroxylase (TH) or somatostatin (SOM) in the rat retina was described in comparison with those in the carp retina. In frozen cross-sections of the rat retina, many processes of TH-like immunoreactive cells were found to extend toward the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91103-5
更新日期：1985-10-28 00:00:00
abstract：:Excitatory actions of acromelic acid were investigated in the isolated newborn rat spinal cord. Test compounds were added to the perfusing fluid and the responses were recorded from the ventral root extracellularly. Acromelic acid caused a depolarizing response in a dose-dependent manner and the depolarizing activity ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90456-8
更新日期：1988-12-06 00:00:00
abstract：:Branches of the facial nerve were transected in newborn mice, resulting in paralysis of whisking of the mystacial vibrissae. After maturation, the brains were examined in Nissl preparations for alterations in the barrel field of the primary somatosensory cortex. There were no evident changes as a result of this interv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90141-0
更新日期：1984-11-26 00:00:00
abstract：:Males show suppressed cell proliferation in the hippocampus in response to acute stress but no studies to date have examined cell proliferation in response to acute stress in females. In the current study, we examined the effects of acute exposure to a predator odor stressor [trimethyl thiazoline (TMT); the main compo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02542-3
更新日期：2003-06-13 00:00:00
abstract：:Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain studies and in vivo imaging studies report a variety of age and sex effects on brain 5-HT(1A) binding. Behavioral data from 5-HT(1A) specific pharmacological challen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03243-2
更新日期：2002-11-08 00:00:00
abstract：:Neurons in the ventromedial tegmental area that project to the rostral part of the dorsal cap of the ipsilateral inferior olive were labeled by the technique of retrograde transport of horseradish peroxidase (HRP). Following iontophoresis of HRP into the rostral part of the dorsal cap a cluster of labeled cells are fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90574-2
更新日期：1979-08-31 00:00:00
abstract：:Qualitative and computer-assisted analyses were performed on Golgi-impregnated neurons which were serially reconstructed in 3 dimensions. Analysis of the temporal pattern of growth indicated that the initial outgrowth, formation of the adult number of dendrites and virtually all dendritic branching occurred in the pre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90192-6
更新日期：1986-01-01 00:00:00
abstract：:Circadian and neural mechanisms important for the organization of reproductive behavior in the male golden hamster were examined. The sexual behavior of male hamsters exhibits diel variations; males are quicker to initiate copulation and to ejaculate in the dark phase than in the light phase of a daily light-dark cycl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91460-4
更新日期：1984-02-13 00:00:00
abstract：:Physical activity has been proposed as a behavior intervention that promotes mental health and some of the benefits induced by exercise have been related to the glutamatergic system. Indeed, glutamate is the most abundant excitatory neurotransmitter in brain. Thus, we evaluated if voluntary exercise in mice could modu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.038
更新日期：2005-12-14 00:00:00
abstract：:Abnormal increase in native long-chain ceramides (lcCer) in AD implicates roles in neuronal atrophy and cognitive dysfunction especially in view of divergent roles this second messenger plays in cell function. Since clearance is mediated by glucosylceramide synthase (GCS, EC 2.4.1.80) levels of the enzyme were compare...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.066
更新日期：2008-01-29 00:00:00
abstract：:Diazoxide (DZ), a highly selective opener of the mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel, has neuroprotective effects. However, the mechanism of DZ protecting hippocampal neurons against cell death in pilocarpine-induced seizures is unknown. In this study, we investigated DZ attenuating neuronal los...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.037
更新日期：2011-04-06 00:00:00
abstract：:Extracellular signal-regulated kinase 1/2 (ERK1/2) plays diverse roles in the central nervous system. Activation of ERK1/2 has been observed in various types of neuronal excitation, including seizure activity in vivo and in vitro. However, studies examining ERK1/2 activity and its substrate phosphorylation in parallel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.08.023
更新日期：2015-11-02 00:00:00
abstract：:Mesencephalic dopamine neurons form synapses with acetylcholine (ACh)-containing interneurons in the nucleus accumbens (NAcc). Although their involvement in drug reward has not been systematically investigated, these large aspiny interneurons may serve an important integrative function. We previously found that repeat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.029
更新日期：2006-12-06 00:00:00
abstract：:Treated carbon fiber electrodes were used with differential normal pulse voltammetry (DNPV) for in vivo determination of the relative participation of uric acid (UA) to peak 3 derived between 250-300 mV in the dorsal horn of the spinal cord of anesthetized rats. In vitro, treated carbon fiber electrodes respond linear...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90584-1
更新日期：1987-09-01 00:00:00
abstract：:Patches of transnueronal degeneration were produced in the lateral geniculate nucleus (LGN) by retinal laser burns and a tarsorrhaphy was performed in the contralateral eye of Macaca mulatta during infancy. The adverse effect of unilateral visual deprivation on geniculate cell growth was absent in those portions of de...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90772-1
更新日期：1976-07-30 00:00:00
abstract：:The effect of excitatory amino acid antagonists on antagonist on neuropeptide Y (NPY) and cholinergic neurons in the striatum of the rat was studied by means of NPY immunocytochemistry, DFP histochemistry for acetylcholinesterase (AChE), and biochemical determinations of choline acetyltransferase (ChAT). Intrastriatal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90026-1
更新日期：1988-06-14 00:00:00
abstract：:The projections of putative dopamine containing cells within the dorsal raphe nucleus (DR) were studied using a combination of tyrosine hydroxylase (TH) immunocytochemistry and fluorescent retrograde tracing. Substantial numbers of TH-immunoreactive cells in the DR were found to project to the nucleus accumbens. Progr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90239-8
更新日期：1990-03-12 00:00:00
abstract：:Glutamate is an excitatory neurotransmitter implicated in the pathogenesis of psychiatric disorders. Glutamate results in the activation of an enzyme called glycogen synthase kinase-3 (GSK-3) acting through N-methyl-d-aspartate (NMDA) receptors. Impaired expression of GSK-3 affects behavior and neurochemicals level in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.10.002
更新日期：2019-02-01 00:00:00
abstract：:Effects of lateral vestibular nucleus (LVN) stimulation on neuronal activity in the rat lateral hypothalamic area (LHA), including specific glucose-sensitive neurons, were investigated by extracellular and intracellular recordings in vivo. Stimulation of the contralateral LVN evoked 3 types of response in 46% (111/240...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90653-6
更新日期：1987-01-01 00:00:00
abstract：:The central nervous system (CNS) in adult mammals loses the ability to regenerate after injury. Although electrical stimulation (ES) has been shown to promote neural regeneration, the underlying mechanisms by which ES enhances CNS regeneration remain elusive. The aim of the present study was to investigate the effect ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.08.041
更新日期：2012-10-22 00:00:00
abstract：:(1) Spreading depression (SD) could be elicited in isolated carp retina by KCI application, the concomitants of which were similar to those described in other vertebrates. (2) The threshold for generating SD was greatly reduced by brief immersion of the retina in low ci-ringer's solutions. The properties of SD waves w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90498-x
更新日期：1977-01-14 00:00:00
abstract：:Stimulation frequency thresholds for lateral hypothalamic self-stimulation were monitored for 3 weeks following the induction of diabetes with streptozotocin (STZ). In each of the 3 weeks following STZ treatment, thresholds of diabetic rats were significantly lower than their pre-STZ baseline while thresholds of contr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91973-9
更新日期：1994-11-21 00:00:00
abstract：:A novel putative receptor for (3-8)angiotensin (AngIV) has recently been found in various tissues, including the brain. However, the localization of AngIV binding sites to specific types of brain cells has yet to be established. In this study tissue culture was used to determine the presence and characteristics of Ang...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00278-x
更新日期：1995-05-29 00:00:00
abstract：:Neurons immunoreactive for the calcium-binding protein calretinin (CR) were visualized in the substantia nigra (SN) pars compacta (SNc), reticulata (SNr) and lateralis (SNl), the ventral tegmental area (VTA) and the subthalamic nucleus (STN) of squirrel monkeys. The density of CR perikarya was high in VTA, moderate in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01374-1
更新日期：1996-02-05 00:00:00
