Abstract:
:Treated carbon fiber electrodes were used with differential normal pulse voltammetry (DNPV) for in vivo determination of the relative participation of uric acid (UA) to peak 3 derived between 250-300 mV in the dorsal horn of the spinal cord of anesthetized rats. In vitro, treated carbon fiber electrodes respond linearly over a large range of concentrations of UA (oxidation potential around 250 mV) and 5-hydroxyindoleacetic acid (5-HIAA, oxidation potential around 280-290 mV), but are 3 to 4 times more sensitive to 5-HIAA than to UA. In vivo the question remains as to the exact nature of peak 3 because the difference between oxidation potentials of UA and 5-HIAA is not great enough to permit a separate monitoring of the two compounds. In normal rats, administration of the xanthine oxidase inhibitor allopurinol, produced a progressive decrease of the signal, which reached 64.3% of controls at 120 min (35.6% diminution) after injection, and then plateaued around this value for up to 2 h. The administration of the monoamine oxidase inhibitor (MAOI) clorgyline, produced a classical decay in the voltammograms due to a diminution of endogenous 5-HIAA; however, allopurinol injected 3 h after MAOI gave an additional decrease of peak 3 of about 28%. Finally, in rats pretreated with parachlorophenylalanine (pCPA), the residual peak (32.48% as compared to peak 3 of normal rats taken as 100%), the potential of which is shifted to near that of UA, could be decreased by allopurinol to a level of 9.6% of the peak in control animals.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Resjournal_title
Brain researchauthors
Rivot JP,Noret E,Ory-Lavollée L,Besson JMdoi
10.1016/0006-8993(87)90584-1subject
Has Abstractpub_date
1987-09-01 00:00:00pages
201-7issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(87)90584-1journal_volume
419pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Intracellular staining with recording micropipettes filled with a Procion yellow solution was attempted on 11 lateral geniculate neurons of chloralose-anesthetized cats for the purpose of correlating electrophysiologically identified cell types with morphologically identified cell types. Five neurons were successfully...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90058-6
更新日期:1978-01-06 00:00:00
abstract::The present study gives a detailed description of the functional characteristics and of the topographic distribution of responses mediated through the climbing fiber (CF) pathway in the cerebellum of adult rats which have been repeatedly irradiated from birth so that the Purkinje cells (PCs) in the adult remained inne...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91291-1
更新日期:1987-09-22 00:00:00
abstract::The localization of calcitonin gene-related peptide (CGRP)-like immunoreactive (CGRPI) structures in the cochlea was examined in the rat using immunocytochemistry. Numerous CGRPI fibers entered the organ of Corti in the intraganglionic spiral bundle and formed a dense fiber patch at the base of the inner hair cells. M...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90992-8
更新日期:1985-12-09 00:00:00
abstract::Calbindin D28k (CaBP)-containing splanchnic and cutaneous sensory neurons in the rat dorsal root ganglia (DRGs) were investigated immunocytochemically in combination with a fluorescent dye tracer (Fluoro gold). About 15% of the DRG neurons at Th9-10 levels showed CaBP-like immunoreactivity. Eighty-four % of the splanc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91673-5
更新日期:1990-10-01 00:00:00
abstract::Lysosomal storage diseases are a heterogeneous group of hereditary disorders characterized by a deficiency in lysosomal function. Although these disorders differ in their etiology and phenotype those that affect the nervous system generally manifest as a profound deterioration in neurologic function with age. Over the...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2014.05.029
更新日期:2014-07-21 00:00:00
abstract::To test the hypothesis that neurons in the hypothalamic paraventricular nucleus (PVN) may be under both direct and indirect regulation by alpha melanocyte-stimulating hormone (alpha-MSH)-synthesizing neurons of the arcuate nucleus, we determined whether the retrogradely transported marker substance, cholera toxin beta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.09.023
更新日期:2005-12-07 00:00:00
abstract::To determine possible mechanisms by which NFTs are formed in Alzheimer's disease (AD), we investigated the ability of tissue transglutaminase (TGase) to convert human recombinant tau proteins into insoluble filamentous structures. TGase derived from guinea pig liver was activated by calcium to catalyze the in vitro cr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01121-3
更新日期:1997-01-16 00:00:00
abstract::Reactive oxygen species (ROS) are supposed to be involved in neurodegenerative processes like Parkinson's or Alzheimer's disease. Beside this there are an increasing number of studies indicating an involvement of ROS in traumatic brain injury. We therefore studied the potential role of astrocytes against neurotoxic ef...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01029-3
更新日期:1996-12-16 00:00:00
abstract::In vitro evidence indicates that norepinephrine release in the mammalian hippocampus is modulated by glutamate receptors. With the use of microdialysis, we have now evaluated the role of ionotropic glutamate receptors in the regulation of hippocampal norepinephrine output in vivo. Stimulation of N-methyl-D-aspartate (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.02.065
更新日期:2011-04-22 00:00:00
abstract::One optic nerve of mature goldfish was crushed in the orbit and allowed to regenerate. During regeneration impulse activity was eliminated by periodic intraocular injections of tetrodotoxin (TTX). At 32-104 days, the retinotopography of the retinotectal projection was measured autoradiographically by intraocular [3H]p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90068-8
更新日期:1983-02-01 00:00:00
abstract::We report an fMRI experiment on deductive reasoning with acoustically presented problems. Twelve volunteers received problems in which an acoustic stimulus came from the left or the right of another stimulus. The participants then heard a third stimulus coming from the left or the right of one of the proceeding stimul...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.10.025
更新日期:2009-01-16 00:00:00
abstract::Choline uptake and ecto-cholinesterase activities have been measured in intact astroblast and neuroblast cultures. The data show that choline uptake is dependent upon the ionic composition of the culture medium and is sensitive to metabolic inhibitors. However, the high concentrations of the inhibitors necessary for t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90337-1
更新日期:1976-08-06 00:00:00
abstract::In this study, we aimed at investigating the effect of an enriched environment (EE) on the recovery from chronic inflammatory pain. Inflammatory pain was induced by the injection of 2 mg of carrageenan (CAR) into the right knee of male Sprague-Dawley rats (n=34). Rats were housed either singly (S-housed) or in an EE (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.04.039
更新日期:2009-06-18 00:00:00
abstract::The stress-related neurohormone, corticotropin-releasing factor (CRF), also acts as a neurotransmitter to activate the brain noradrenergic nucleus, locus coeruleus (LC). Previous electrophysiological findings demonstrating that tonic CRF secretion in the LC is increased in adrenalectomized rats suggest that activity o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00900-7
更新日期:1999-01-16 00:00:00
abstract::The present study aimed to employ an electrophysiological approach to evaluate the adaptive task-set inhibition hypothesis. According to the adaptive task-set inhibition hypothesis, task switching should depend on whether the previous trial is univalent or bivalent. This study employed a pairwise task-switching paradi...
journal_title:Brain research
pub_type: 临床试验,杂志文章
doi:10.1016/j.brainres.2008.11.103
更新日期:2009-02-19 00:00:00
abstract::In adult rodents, neuroblasts originating from the subventricular zone migrate tangentially through the rostral migratory stream (RMS) toward the olfactory bulb where they differentiate into interneurons. Neuroblasts in the RMS migrate in chains for a long distance along specifically arranged blood vessels which promo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.08.010
更新日期:2018-11-01 00:00:00
abstract::A total of 183 nucleus basalis of Meynert (NBM) neurons were recorded in a monkey performing a delayed response task. Significant changes in discharge rate were detected in 74% of the NBM cells sampled with most responses occurring in the choice (64%) or the reward (67%) epochs of the task. Neuronal responses in the c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91529-5
更新日期:1986-12-10 00:00:00
abstract::Tissue culture preparations of the myenteric plexus from the guinea pig taenia coli have been studied by electron microscopy. Three main cell types can be identified: neurons, enteric glial cells and fibroblasts. The ultrastructure of these cells resembles that of the same cells in situ. Neuronal processes form close ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90467-5
更新日期:1983-02-28 00:00:00
abstract::Previous examination of binge cocaine self-administration and 2 week withdrawal from cocaine self-administration on ionotropic glutamate receptor subunit (iGluRs) protein levels revealed significant alterations in iGluR protein levels that differed between the mesocorticolimbic and nigrostriatal pathways. The present ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.09.051
更新日期:2005-12-07 00:00:00
abstract::Previous electrophysiological experiments have shown that brain noradrenaline neurons in the locus ceruleus are activated by thermal cutaneous stimuli. In the present study a putative involvement of excitatory amino acids (EAA) in cutaneous LC activation was analyzed. Intraventricular administration of kynurenic acid ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91560-4
更新日期:1990-06-25 00:00:00
abstract::Ethanol and nerve growth factor (NGF) affect the survival of cholinergic neurons in the rat medial septum. To investigate whether calcium (Ca2+) homeostasis in these neurons is affected by ethanol or NGF treatment, changes in intracellular free Ca2+ concentration ([Ca2+]i) were studied in embryonic (E21) cultured medi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00955-3
更新日期:1995-12-01 00:00:00
abstract::The dorsal lateral geniculate nucleus of tree shrews is very susceptible to the neurotoxic effects of kainic acid. In addition to neuronal loss, there is a profound loss of retinal terminals that is manifested through a disruption of anterograde transport of WGA/HRP from the retina to the kainic acid-lesioned area of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91516-2
更新日期:1987-07-21 00:00:00
abstract::The ability of embryonic tissue to survive cross-transplantation between histologically incompatible rat strains was examined by transplanting septal neurons from Sprague Dawley fetuses to adult Wistar rats (Ag-B6 to Ag-B2 histocompatibility haplotype). Transplants were found to survive without rejection over a period...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91028-4
更新日期:1983-03-07 00:00:00
abstract::To see if activation of central alpha 1-adrenergic receptors can cause facilitation of lordosis in rats, the behavioral effects of centrally administered alpha 1-agonists, methoxamine (MA) and phenylephrine (PhE), and related agents were studied. In ovariectomized rats treated with estrogen, infusion of MA, PhE, or a ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91581-x
更新日期:1992-08-21 00:00:00
abstract::Electrical stimulation of the brain, particularly in the periventricular grey areas, caused long-lasting increases in behavioural escape thresholds to heating and mechanical stimuli applied to the facial region of the rat. The brain stimulation selectively suppressed responses to noxious stimuli. Responses to non-noxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00927-i
更新日期:1995-11-27 00:00:00
abstract::Previous work has suggested that the rewarding effect of hippocampal stimulation develops only as a consequence of neuroplastic change resulting from repeated stimulation experience: naive rats will not initiate self-stimulation for several days, but a prior program of hippocampal kindling greatly facilitates acquisit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91706-m
更新日期:1990-06-18 00:00:00
abstract::Lesions of the anterior hypothalamus-medial preoptic area (AH-MPOA) impair courtship and copulatory behavior in male Cnemidophorus inornatus, a sexually reproducing species of whiptail lizard, and male-like pseudosexual behaviors in C. uniparens, an all-female species. These results suggest that, since C. inornatus is...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90046-9
更新日期:1994-04-18 00:00:00
abstract::This study addressed the issue of multiple parallel auditory processing systems and their relationship to the skull-recorded auditory evoked potentials (AEPs) in the unanesthetized, unrestrained rat. In the preceding paper (Brain Res., 602 (1993) 240-250) it has been shown that auditory cortex activity does not contri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90690-o
更新日期:1993-02-05 00:00:00
abstract::The purpose of this study was to compare the relative effects of mannitol and hypertonic saline (HTS) on calpain activity, apoptosis and neuroinflammatory response induced by experimental cortical contusion. Four groups of 5 Sprague-Dawley male rats were submitted to focal brain injury produced by exposing the parieta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.045
更新日期:2006-07-26 00:00:00
abstract::These studies examined the microsomal brain metabolism of phencyclidine (PCP) in male and female Sprague-Dawley rats. Several monohydroxylated metabolites of PCP were detected including cis- and trans-1-(1-phenyl-4-hydroxycyclohexyl)piperidine (c-PPC and t-PPC) and 1-(1-phenylcyclohexyl)-4-hydroxypiperidine (PCHP). Th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00203-5
更新日期:1997-05-09 00:00:00