Abstract：
:One optic nerve of mature goldfish was crushed in the orbit and allowed to regenerate. During regeneration impulse activity was eliminated by periodic intraocular injections of tetrodotoxin (TTX). At 32-104 days, the retinotopography of the retinotectal projection was measured autoradiographically by intraocular [3H]proline injections simultaneous with either small (10-20 degrees sector) or half retinal mapping lesions. TTX had no effect on the time-course and quality of the regeneration of gross topography seen with half retina mapping, but indefinitely inhibited higher order (refined) retinotopography normally seen by 2 months with retina sector mapping.
journal_name
Brain Resjournal_title
Brain researchauthors
Meyer RLdoi
10.1016/0165-3806(83)90068-8subject
Has Abstractpub_date
1983-02-01 00:00:00pages
293-8issue
3eissn
0006-8993issn
1872-6240journal_volume
282pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Systemic administration of mesenchymal stem cells (MSCs) following cerebral infarction exerts functional improvements. Previous research has suggested potential therapeutic mechanisms that promote neuroprotection and synaptogenesis. These include secretion of neurotrophic factors, remodeling of neural circuits, restor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.05.033
更新日期：2018-09-15 00:00:00
abstract：:In Alzheimer's disease (AD), there is a loss of presynaptic cholinergic markers in the cerebral cortex, but the nature of cholinergic receptor changes is unclear. In this study, [3H]acetylcholine and [3H]nicotine were used to label nicotinic cholinergic binding sites in cerebral cortical tissues obtained at autopsy fr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90819-x
更新日期：1986-04-16 00:00:00
abstract：:Ethanol and nerve growth factor (NGF) affect the survival of cholinergic neurons in the rat medial septum. To investigate whether calcium (Ca2+) homeostasis in these neurons is affected by ethanol or NGF treatment, changes in intracellular free Ca2+ concentration ([Ca2+]i) were studied in embryonic (E21) cultured medi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00955-3
更新日期：1995-12-01 00:00:00
abstract：:The pathogenic mechanisms of gene-environment interactions determining variability of human neurodevelopmental disorders remain unclear. In the two consecutive papers, we used the neonatal Borna disease virus (BDV) infection rat model of neurodevelopmental damage to evaluate brain pathology, monoamine alterations, beh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02723-3
更新日期：2002-07-19 00:00:00
abstract：:Semaphorins constitute a family of signaling molecules with functions in axon pathfinding and neuronal migration. Neuropilins 1 and 2 have been identified as the ligand-binding component of semaphorin receptors. Both ligands and receptors are expressed in embryonic and adult organs in complementary and sometimes redun...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.028
更新日期：2006-01-05 00:00:00
abstract：:Brain edema is a serious consequence of hemispheric stroke and traumatic brain injury and contributes significantly to patient mortality. In the present study, we measured water contents in hippocampal slices as an in vitro model of edema formation. Excitotoxic conditions induced by N-methyl-D-aspartate (NMDA, 300 mic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.012
更新日期：2006-11-29 00:00:00
abstract：:The neurotoxic effects of exogenous glutamate were studied in the rat cochlea. Glutamate-treated rats (4 g/kg/day i.p., postnatal days 2-9) exhibited electrophysiologically-measured elevations in high frequency thresholds usually associated with hair cell loss in the basal region of the cochlea. While surface preparat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90090-i
更新日期：1991-06-28 00:00:00
abstract：:Application of 4-aminopyridine (4-AP) has previously been reported to produce different patterns of epileptiform discharges in entorhinal cortex (EC)-hippocampal slices: recurrent short discharges (RSDs) in hippocampal area CA1, seizure-like events (SLEs) and negative-going potentials (NGPs) in the medial entorhinal c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02348-3
更新日期：2000-03-17 00:00:00
abstract：:Adenosine and its agonists exert a depressant effect on neuronal activity by interacting with the adenosine A1 receptor. There is now also evidence for electrophysiological effects mediated by adenosine receptors other than the A1 type, possibly A2 receptors. A1 and A2 receptor-induced changes in the electrical proper...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91160-3
更新日期：1991-04-12 00:00:00
abstract：:A hemodynamic mechanism has long been assumed to play an important role in watershed infarction. In recent years, however, clinical evidence has indicated that an embolic mechanism is involved. The mechanism by which emboli are trapped preferentially in watershed areas remains unclear. In the present study, we develop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.11.028
更新日期：2018-01-15 00:00:00
abstract：:The dopamine transporter from rat caudate-putamen was photolabeled with [125I]DEEP as previously described. Treatment of photolabeled membranes with neuraminidase and N-glycanase reduced the molecular weight of the [125I]DEEP photolabeled dopamine transporter complex, whereas treatment with alpha-mannosidase had no ef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91627-d
更新日期：1991-01-25 00:00:00
abstract：:The lipid, protein, acetylcholine and ATP content of cholinergic synaptic vesicles isolated from the richly innervated electric organ of Torpedo marmorata and purified to constant composition has been determined. The number of vesicles present in the preparations has been estimated by quantitative electron microscopy ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90674-7
更新日期：1979-02-09 00:00:00
abstract：:In the following study the behavioural effects of simultaneous lesion of the nucleus basalis magnocellularis (NBM) using ibotenic acid and noradrenergic depletion following a single i.p. administration of DSP4 (50 mg/kg) were examined in the rat. NBM lesion induced a deficit in acquisition of a reinforced T-maze alter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91067-o
更新日期：1992-11-13 00:00:00
abstract：:The GABA agonist muscimol, injected into the depressor area of the caudal ventrolateral medulla, increased blood pressure and increased the expression of the immediate early gene c-fos in the rostral ventral medulla (RVM) of the rat. The number of Fos-immunoreactive (Fos-IR) neurons seen in the RVM was increased 3-fol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90056-6
更新日期：1994-05-16 00:00:00
abstract：:Using a double-labeling method that combines retrograde tracing and immunocytochemistry, we demonstrated the presence of a hippocampofugal gamma-aminobutyric acid (GABA)-like immunoreactive (GABA-LI) neuron system in the rat. As a preliminary experiment, knife-cut of the dorsal fornix was made and it resulted in a rem...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90757-8
更新日期：1987-04-14 00:00:00
abstract：:In the present study we evaluated the role of NMDA receptors on the pressor and bradycardic responses to L-glutamate (L-Glu) microinjected into the nucleus tractus solitarius (NTS) of unanesthetized rats. L-Glu (1 nmol/100 nl) was microinjected into the NTS before and 10 min after microinjection of phosponovaleric aci...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/S0006-8993(96)01169-9
更新日期：1997-02-28 00:00:00
abstract：:Cerebellar Purkinje neurons (PNs) are selectively vulnerable to AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepriopionic acid)-induced delayed neurotoxicity known as dark cell degeneration (DCD) that is expressed as cytoplasmic and nuclear condensation, neuron shrinkage, and failure of physiology. The present study ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.048
更新日期：2003-12-24 00:00:00
abstract：:We examined the effect of nitric oxide (NO) on the expression of phosphorylated cAMP response element binding (pCREB) protein and on the polysialylated form of the neural cell adhesion molecule (PSA-NCAM), in the hippocampus of the adult rat, by administering 7-nitroindazole (7-NI) for 5 days, to block neuronal nitric...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.055
更新日期：2004-05-15 00:00:00
abstract：:The present study gives a detailed description of the functional characteristics and of the topographic distribution of responses mediated through the climbing fiber (CF) pathway in the cerebellum of adult rats which have been repeatedly irradiated from birth so that the Purkinje cells (PCs) in the adult remained inne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91291-1
更新日期：1987-09-22 00:00:00
abstract：:Cross-sectional areas of the forebrain ventricles were measured from coronal sections in spontaneously hypertensive rats (SHRs) 4, 8, 12, 16, 21 and 56 weeks of age and in age-matched Wistar--Kyoto (WKY) and Sprague--Dawley (SD) normotensive rats. Progressive ventricular dilation and associated attrition of brain tiss...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90488-9
更新日期：1986-04-09 00:00:00
abstract：:The myosin S-1 subfragment was used to label actin filaments in the developing rat brain. The results show actin filaments present throughout the dendritic region with highest concentrations within growth cones and regions of spine development. Between 6 and 25 days postnatal, spines became more complex and actin fila...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90253-1
更新日期：1986-06-01 00:00:00
abstract：:We have previously reported that lead (Pb(2+)) exposure results in both presynaptic and postsynaptic changes in developing neurons as a result of inhibition of the N-methyl-d-aspartate receptor (NMDAR). NMDAR inhibition by Pb(2+) during synaptogenesis disrupts downstream trans-synaptic signaling of brain-derived neuro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.12.037
更新日期：2012-02-23 00:00:00
abstract：:Clozapine therapy has been associated with a high degree of urinary disturbances. The purpose of this study is to examine the effect of clozapine on urodynamic parameters and on the activity of the external urethral sphincter in anesthetized rats. Single cystometrograms (CMG) were performed on urethane-anesthetized fe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02352-6
更新日期：2001-05-18 00:00:00
abstract：:The rubrointerposital projection was studied in cats where wheat germ agglutinin-horseradish peroxidase (WGA-HRP) was implanted in various parts of the interposed nuclei. No retrogradely labelled rubral cells were observed following implantations in the posterior interposed nucleus, and only very few such cells were i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91370-3
更新日期：1986-11-05 00:00:00
abstract：:The primary objective of this study was to test the hypothesis that intravenous administration of autologous bone marrow cells could improve functional recovery after middle cerebral artery occlusion (MCAO) for 45 min in the rat and to determine specific time windows for efficacy. Mononuclear cells from autologous bon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.084
更新日期：2004-05-08 00:00:00
abstract：:We examined whether there are the neurotransmitter candidate amino acid L-proline containing neurons localized in the rat brain. Antibodies against L-proline conjugated with rabbit serum albumin were raised in a rabbit and purified with affinity chromatography. Strong L-proline-like immunoreactivity was confined to se...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.064
更新日期：2006-02-16 00:00:00
abstract：:Zinc and other cations were iontophoretically applied to neurones in the frontoparietal cortex of urethane-anaesthetised rats and their effect on the activity of these cells was examined. Slow and often prolonged increases in firing rate occurred in 45.2% of neurones after zinc application and 72.7% after barium. Calc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90097-0
更新日期：1984-10-08 00:00:00
abstract：:Catecholamine-containing fibers have been examined in the cerebella of normal and hypocerebellar mutant mice using Falck-Hillarp and glyoxylic acid histofluorescence techniques. The amounts of norepinephrine and dopamine were also determined chemically in the same mutants. Green fluorescent fibers in cerebella of norm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90349-2
更新日期：1975-08-08 00:00:00
abstract：:Visual acuity was measured by determining the highest spatial acuity at which chickens aged 1-25 days jumped consistently to a physically supported grating instead of to an unsupported homogeneous field. In contrast to the gradual visual development found for kittens, monkeys, and humans, the chicken exhibits asymptot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90967-7
更新日期：1981-05-04 00:00:00
abstract：:Cytosolic phospholipase A2 (cPLA2) catalyzes the selective release of arachidonic acid from the sn-2 position of membrane phospholipids and has been suggested as an effector in the receptor-mediated release of arachidonic acid in signal transduction. The potential role of cPLA2 as an effector in muscarinic acetylcholi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00806-3
更新日期：1998-10-26 00:00:00
