Abstract：
:The neurotoxic effects of exogenous glutamate were studied in the rat cochlea. Glutamate-treated rats (4 g/kg/day i.p., postnatal days 2-9) exhibited electrophysiologically-measured elevations in high frequency thresholds usually associated with hair cell loss in the basal region of the cochlea. While surface preparations of the organ of Corti revealed no loss of hair cells, there was a dramatic and selective reduction of neurons in the basal, high frequency-related portion of the spiral ganglion. This sensitivity of developing spiral ganglion cells to the neurotoxicity of glutamate is consistent with the hypothesis that glutamate or a structurally related substance is a neurotransmitter at afferent synapses of cochlear hair cells.
journal_name
Brain Resjournal_title
Brain researchauthors
Janssen R,Schweitzer L,Jensen KFdoi
10.1016/0006-8993(91)90090-isubject
Has Abstractpub_date
1991-06-28 00:00:00pages
255-64issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(91)90090-Ijournal_volume
552pub_type
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