Abstract：
:Development and aging are often mirror image processes and this may be equally true in the effects of estradiol, a potent endogenous steroid regulating brain development as well as a therapeutic used to relieve the negative components of perimenopause. Both the developing and perimenopausal brain are characterized by a sensitive period of hormone responsiveness, and in both cases, the neurotransmitters GABA and glutamate, as well as synaptogenesis and cell proliferation are major hormone targets. This review compares and contrasts the effects of estradiol on the developing and aging brain and highlights new avenues of exploration and therapeutic development.
journal_name
Brain Resjournal_title
Brain researchauthors
McCarthy MMdoi
10.1016/j.brainres.2010.11.094subject
Has Abstractpub_date
2011-03-16 00:00:00pages
109-18eissn
0006-8993issn
1872-6240pii
S0006-8993(10)02607-7journal_volume
1379pub_type
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