What can development teach us about menopause?

abstract：:Activation of neuronal nicotinic acetylcholine receptors (nAChRs) modulates the induction of long-term potentiation (LTP), a possible cellular mechanism for learning. This study was undertaken to determine the effects of activation of nAChRs by nicotine on long-term plasticity in the songbird zebra finch, which is a v...

journal_title：Brain research

authors： Salgado-Commissariat D,Rosenfield DB,Helekar SA

更新日期：2004-08-20 00:00:00

abstract：:In the present study fast axonal transport was examined in streptozotocin rats with 4 weeks duration in diabetes. Tritiated leucine and 14C-labelled glucosamine were injected into the fifth lumbar ganglion and TCA-soluble as well as insoluble activity were measured in segments of the sciatic nerve at various time inte...

journal_title：Brain research

authors： Sidenius P,Jakobsen J

更新日期：1979-09-14 00:00:00

abstract：:Long-term potentiation (LTP) is a form of synaptic plasticity that may underlie learning and memory. The experiments reported here demonstrate that cocaine blocks the induction of LTP at the excitatory synapses in the CA1 region of the hippocampus, but does not appear to do so by blocking NMDA receptors or channels. O...

journal_title：Brain research

authors： Smith DA,Browning M,Dunwiddie TV

更新日期：1993-04-16 00:00:00

abstract：:Ligation of CD27, a member of the tumor necrosis factor (TNF) receptor family, by its ligand CD70 is thought to be important in T cell activation, expansion and survival, B cell activation, and NK cell activation. We examined the role of CD70 in Theiler's murine encephalomyelitis virus-induced demyelinating disease (T...

journal_title：Brain research

authors： Yanagisawa S,Takeichi N,Kaneyama T,Yagita H,Taniguchi S,Kim BS,Koh CS

更新日期：2010-03-04 00:00:00

abstract：:Neurotrophins play a crucial role in the regulation of survival and the maintenance of specific functions for various populations of neurons. Neurotrophin-4 (NT-4) is most abundant in skeletal muscle, and is thought to promote sciatic nerve sprouting, inhibit agrin-induced acetylcholine receptor (AChR) clustering, evo...

journal_title：Brain research

authors： Sakuma K,Watanabe K,Sano M,Uramoto I,Nakano H,Li YJ,Kaneda S,Sorimachi Y,Yoshimoto K,Yasuhara M,Totsuka T

更新日期：2001-07-13 00:00:00

abstract：:Because the occurrence of rapid eye movement (REM) sleep is critically dependent upon an animal's thermal balance, acute pharmacological treatments may effect REM sleep through effects on thermoregulation. We describe how manipulating ambient temperature (T(a)) alters the REM sleep-suppressing effects of systemically-...

journal_title：Brain research

authors： Szymusiak R,Danowski J,McGinty D

更新日期：1994-02-04 00:00:00

abstract：:Intracellular recordings in vivo from serotonergic dorsal raphe neurons of the rat brain reveal that these cells undergo a pronounced postspike hyperpolarization followed by a gradual interspike depolarization leading to the succeeding spike. Such repetitive cycles of interspike hyperpolarization and depolarization, w...

journal_title：Brain research

authors： Aghajanian GK,Vandermaelen CP

更新日期：1982-04-29 00:00:00

abstract：:Neurotrophins regulate many aspects of neuronal function and activity. Specifically, the binding of Brain-derived neurotrophic factor (BDNF) to Tyrosine receptor kinase-B (TrkB) or its truncated version, TrkB-T1, can cause growth and differentiation or dominant inhibition of receptor signaling, respectively. There is ...

journal_title：Brain research

authors： Brague JC,Swann JM

更新日期：2017-08-15 00:00:00

abstract：:The effects of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), on the fast tetrodotoxin-sensitive (TTX-S) and the slow tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion neurons were investigated using the whole-cell patch-clamp method. Diclofenac suppressed both sodium currents in a...

journal_title：Brain research

authors： Lee HM,Kim HI,Shin YK,Lee CS,Park M,Song JH

更新日期：2003-11-28 00:00:00

abstract：:The present study demonstrates changes in rat brain glial metabolism during the acute phase of epilepsy. Status epilepticus (SE) was induced using the lithium-pilocarpine model. Glial metabolism was measured with (14)C-acetate. Local cerebral blood flow and glucose metabolism were also measured using (14)C-N-isopropyl...

journal_title：Brain research

authors： Hosoi R,Kitano D,Momosaki S,Kuse K,Gee A,Inoue O

更新日期：2010-01-22 00:00:00

abstract：:In an attempt to demonstrate a protective effect against convulsions induced by hyperbaric oxygen (OHP), aminooxyacetic acid (AOAA at 2.5 mg/kg) was administered subcutaneously to 60 white leghorn cockerels (aged 21-28 days) at periods of 1-72 h before exposure to OHP. A transient protection was noted 1-8 h after admi...

journal_title：Brain research

authors： Davison AJ

更新日期：1983-10-16 00:00:00

abstract：:Little is known about the movement of 5-aminolevulinic acid (delta-aminolevulinic acid; ALA) between blood and brain. This is despite the fact that increases in brain ALA may be involved in generating the neuropsychiatric symptoms in porphyrias and that systemic administration of ALA is currently being used to delinea...

journal_title：Brain research

authors： Ennis SR,Novotny A,Xiang J,Shakui P,Masada T,Stummer W,Smith DE,Keep RF

更新日期：2003-01-10 00:00:00

abstract：:Spreading depression (SD) is characterized by a transient breakdown of neuronal function concomitant with a massive failure of ion homeostasis. It is a phenomenon that can be induced in neocortical tissue by raising excitability, e.g. injection of K(+), application of glutamatergic agonists, or blocking Na(+)/K(+) ATP...

journal_title：Brain research

authors： Köhling R,Koch UR,Hagemann G,Redecker C,Straub H,Speckmann EJ

更新日期：2003-06-13 00:00:00

abstract：:Activation of immune cells by pathogens induces the release of a variety of proinflammatory cytokines, including IL-1 beta and TNF-alpha. Previous studies using IL-1 beta have demonstrated that this cytokine can alter brain function, resulting in a variety of 'illness responses' including increased sleep, decreased fo...

journal_title：Brain research

authors： Watkins LR,Goehler LE,Relton J,Brewer MT,Maier SF

更新日期：1995-09-18 00:00:00

abstract：:Cannabinoids have neuroprotective effects that are exerted primarily through cannabinoid CB1 receptors in the brain. This study characterized CB1 receptor distribution in the double transgenic (dtg) APP(swe)/PS1(ΔE9) mouse model for Alzheimer's disease. Immunohistochemical labeling of CB1 protein in non-transgenic mic...

journal_title：Brain research

authors： Kalifa S,Polston EK,Allard JS,Manaye KF

更新日期：2011-02-28 00:00:00

abstract：:The present study is designed to investigate the effects of preconditioning with different doses of hydrogen peroxide (H2O2) on oxidative stress-induced apoptosis and the changes in mitochondrial membrane potential (MMP), intracellular reactive oxygen species (ROS) level, and expression of Bcl-2 during H2O2 preconditi...

journal_title：Brain research

authors： Tang XQ,Feng JQ,Chen J,Chen PX,Zhi JL,Cui Y,Guo RX,Yu HM

更新日期：2005-09-28 00:00:00

abstract：:Neuropeptides, including substance P (SP), calcitonin gene-related peptide (CGRP) and somatostatin (SS) in dorsal root ganglia (DRG) may play a role in neurogenic inflammation and pain transmission. Adrenal corticosteroids regulate neuropeptide synthesis in some areas of the CNS and may modulate neurogenic inflammatio...

journal_title：Brain research

authors： Smith GD,Seckl JR,Sheward WJ,Bennie JG,Carroll SM,Dick H,Harmar AJ

更新日期：1991-11-08 00:00:00

abstract：:While exercise is commonly recommended for PD patients to improve motor function, little is known about the disease-altering potential of exercise. Although others have demonstrated neuroprotective or neurorestorative effects of exercise in animal models of PD, the majority of these studies utilize young animals. In o...

journal_title：Brain research

authors： Hood RL,Liguore WA,Moore C,Pflibsen L,Meshul CK

更新日期：2016-09-01 00:00:00

abstract：:α4βδ GABA(A) receptors (GABARs) have low CNS expression, but their expression is increased by 48h exposure to the neurosteroid THP (3α-OH-5α[β]-pregnan-20-one). THP also increases the efficacy of δ-containing GABARs acutely, where GABA is a partial agonist. Thus, we examined effects of THP (100 nM) and full GABA agoni...

journal_title：Brain research

authors： Kuver A,Shen H,Smith SS

更新日期：2012-06-29 00:00:00

abstract：:Ontogeny of somatostatin (SRIF) neuron system of the rat cerebellum was investigated by means of the indirect immunofluorescent method. In addition, several operations were performed to provide the evidence of understanding the cerebellar SRIF innervation. SRIF-positive structures appeared in the primordium of the cer...

journal_title：Brain research

authors： Inagaki S,Shiosaka S,Takatsuki K,Iida H,Sakanaka M,Senba E,Hara Y,Matsuzaki T,Kawai Y,Tohyama M

更新日期：1982-04-01 00:00:00

abstract：:A differential role has been suggested for two important areas in the neural circuitry of stress, central nucleus of the amygdala (CeA) and bed nucleus of stria terminalis (BNST) in the extended amygdala, in regulating fear versus anxiety. Since chronic stress enhances anxiety and consolidation of aversive memories, w...

journal_title：Brain research

authors： Vyas A,Bernal S,Chattarji S

更新日期：2003-03-07 00:00:00

abstract：:The effect of dopamine (DA) on the calcium-activated potassium conductance underlying the slow afterhyperpolarization (AHP) which follows a train of action potentials in hippocampal pyramidal cells was studied utilizing the in vitro hippocampal slice preparation. Bath-applied DA (1-100 microM) significantly reduced th...

journal_title：Brain research

authors： Malenka RC,Nicoll RA

更新日期：1986-08-06 00:00:00

abstract：:Dopamine-releasing protein (DARP) is a novel factor involved in the function and development of catecholaminergic systems. To test whether a peptide synthesized from the N-terminus of DARP (DARP-36aa) ameliorates deficits in nigrostriatal dopamine, rats were unilaterally lesioned with MPP+, 1 day before administration...

journal_title：Brain research

authors： Phelps SM,Ramirez VD

更新日期：1994-12-12 00:00:00

abstract：:The zebrafish, Danio rerio, has become an important model species for examining olfactory system structure and function, yet little is known about developmental changes in olfactory bulb morphology from embryo to adult. The present study examined both normal growth and the effects of deafferentation on the bulb from h...

journal_title：Brain research

authors： Poling KR,Brunjes PC

更新日期：2000-02-21 00:00:00

abstract：:An autoradiographic analysis of the time and sites of origin, and the migration and settling patterns of neurons was made in the spinal cord of the mouse. The neurons originated on days 10--14 of gestation with temporal gradients along the ventrodorsal and rostrocaudal axes. The motor neurons originated on days 10 and...

journal_title：Brain research

authors： Nornes HO,Carry M

更新日期：1978-12-22 00:00:00

abstract：:In recent decades, an increasing number of neuroimaging studies utilizing magnetic resonance imaging (MRI) have explored the differential effects of postherpetic neuralgia (PHN) on brain structure and function. We systematically reviewed and integrated the findings from relevant neuroimaging studies in PHN patients. A...

journal_title：Brain research

authors： Tang Y,Wang M,Zheng T,Xiao Y,Wang S,Han F,Chen G

更新日期：2021-02-01 00:00:00

abstract：:The neuroprotective effect of cilostazol, an antiplatelet drug, was examined after 24 h permanent middle cerebral artery (MCA) occlusion in mice, and explored the possible underlying mechanism by examining metallothionein (MT)-1 and -2 induction in vivo. Cilostazol (30 mg/kg) was intraperitoneally administered at 12 h...

journal_title：Brain research

authors： Wakida K,Morimoto N,Shimazawa M,Hozumi I,Nagase H,Inuzuka T,Hara H

更新日期：2006-10-20 00:00:00

abstract：:The effect of intracerebroventricular administration of dizocilpine on feeding behaviour and adrenal corticrotropic hormone (ACTH)-induced anorexia in elevated plus maze was examined. Dizocilpine (10, 20 and 40 nmol/rat, i.c.v.) showed a dose-dependent increase in food intake in 16 h food deprived rats. Dopamine recep...

journal_title：Brain research

authors： Ninan I,Kulkarni SK

更新日期：1998-11-23 00:00:00

abstract：:We investigated the protective effect of subchronic treatment of the A2A receptor antagonist, SCH 58261 (0.01 mg/kg, i.p.), administered 5 min, 6 h and 15 h after permanent right middle cerebral artery occlusion (MCAo). Twenty-four hours after ischemia, an extensive pallid area, evaluated by cresyl violet staining, is...

journal_title：Brain research

authors： Melani A,Gianfriddo M,Vannucchi MG,Cipriani S,Baraldi PG,Giovannini MG,Pedata F

更新日期：2006-02-16 00:00:00

abstract：:Neurturin (NTN) is a recently discovered neurotrophic factor related to glial cell line-derived neurotrophic factor (GDNF) and has a wide spectrum of biological roles in different types of neurons in the central and peripheral nervous systems. However, information on its expression in peripheral tissues has been limit...

journal_title：Brain research

authors： Xian CJ,Huang BR,Zhou XF

更新日期：1999-07-24 00:00:00