What can development teach us about menopause?

Abstract:

:Development and aging are often mirror image processes and this may be equally true in the effects of estradiol, a potent endogenous steroid regulating brain development as well as a therapeutic used to relieve the negative components of perimenopause. Both the developing and perimenopausal brain are characterized by a sensitive period of hormone responsiveness, and in both cases, the neurotransmitters GABA and glutamate, as well as synaptogenesis and cell proliferation are major hormone targets. This review compares and contrasts the effects of estradiol on the developing and aging brain and highlights new avenues of exploration and therapeutic development.

journal_name

Brain Res

journal_title

Brain research

authors

McCarthy MM

doi

10.1016/j.brainres.2010.11.094

subject

Has Abstract

pub_date

2011-03-16 00:00:00

pages

109-18

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(10)02607-7

journal_volume

1379

pub_type

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