Aminooxyacetic acid provides transient protection against seizures induced by hyperbaric oxygen.

Abstract:

:In an attempt to demonstrate a protective effect against convulsions induced by hyperbaric oxygen (OHP), aminooxyacetic acid (AOAA at 2.5 mg/kg) was administered subcutaneously to 60 white leghorn cockerels (aged 21-28 days) at periods of 1-72 h before exposure to OHP. A transient protection was noted 1-8 h after administration of the AOAA. This took the form of a 51-67% increase in the latent period before OHP induced convulsions began. By 12 h after injection, the protective effect had disappeared. Thereafter a phase of increased susceptibility to hyperbaric oxygen commenced. This phase lasted for at least a further 60 h.

journal_name

Brain Res

journal_title

Brain research

authors

Davison AJ

doi

10.1016/0006-8993(83)90753-9

subject

Has Abstract

pub_date

1983-10-16 00:00:00

pages

384-7

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(83)90753-9

journal_volume

276

pub_type

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