Abstract：
:The active and passive membrane properties of developing Purkinje neurons in control cultures and cultures chronically treated with 20 or 40 mM ethanol for 1 or 2 weeks were examined using whole-cell current-clamp techniques. The membrane properties were characterized by the features of the voltage responses evoked by intracellular current injection of a series of depolarizing and hyperpolarizing current pulses. Analysis of these responses and background spontaneous activity showed several differences between the control and ethanol-treated Purkinje neurons: (1) membrane input resistance was significantly larger in the ethanol-treated neurons; (2) the percentage of neurons exhibiting immature firing patterns was significantly higher in the ethanol-treated neurons; (3) the afterhyperpolarization following a current-evoked train of action potentials was significantly larger in the ethanol-treated neurons; (4) spontaneous activity (synaptic potentials and synaptically evoked spike events) was significantly reduced in neurons treated with 40 mM ethanol for 1 week; spontaneous activity in neurons treated with 20 mM ethanol for 1 or 2 weeks was similar to that observed in the control group. These differences indicate that ethanol exposure during development directly alters the physiological properties of this CNS neuronal type. These neuronal actions of ethanol may contribute to the behavioral deficits observed in animals models of fetal alcohol syndrome. Similar target sites of ethanol action are likely to be present in the human CNS neurons and may be involved in human fetal alcohol syndrome.
journal_name
Brain Resjournal_title
Brain researchauthors
Gruol DLdoi
10.1016/0006-8993(91)90707-3subject
Has Abstractpub_date
1991-08-30 00:00:00pages
1-12issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(91)90707-3journal_volume
558pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Retrogradely labeled neurons are observed in the central nervous system of the toad after peripheral application of peroxidase to the anterior and posterior stumps of the VIIIth nerve. These efferent vestibular neurons are localized in the brainstem only ipsilaterally to the treated nerve; they are restricted within a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91183-7
更新日期：1985-09-30 00:00:00
abstract：:c-Fos protein is a nuclear protein coded by c-fos proto-oncogene subsequent to synaptic activation of the neurons. We used immunohistochemical methods to visualize the expression of c-Fos protein in myenteric neurons of the guinea pig distal colon and examined the effects of the extrinsic autonomic inputs on the enter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02943-8
更新日期：2002-09-06 00:00:00
abstract：:It has been shown that 2-deoxy-D-glucose (2-DG) inhibits glucose utilization and elicits feeding through the lateral hypothalamus. In contrast, 2,5-anhydro-D-mannitol (2,5-AM), blocking glycogenolysis and/or gluconeogenesis, elicits feeding through the ventromedial hypothalamus. The aim of the present study was to det...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00138-2
更新日期：1996-05-06 00:00:00
abstract：:Gonadal steroids have previously been shown to enhance neuritic outgrowth from mouse preoptic area explants in vitro. To examine effects within the explant proper, dendritic fields of Golgi-stained neurons of estradiol-treated and untreated cultures were compared quantitatively. Neurons of gonadal steroid-treated cult...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90085-8
更新日期：1983-03-01 00:00:00
abstract：:This paper reports studies on the biotransformation of the nonapeptide arginine-vasotocin (AVT) by both rat and chicken brain synaptic membranes. The fragments which were formed during digestion of AVT1-9, were isolated by high pressure liquid chromatography (HPLC) and chemically characterized by amino acid compositio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90419-5
更新日期：1983-09-19 00:00:00
abstract：:Axonal projections of medial brain stem areas rich in serotonin-containing neurons were identified in layers I and II of cat medullary dorsal horn using EM autoradiography. Following [3H]amino acid injections into the brain stem, labeled axonal endings were found throughout layers I and II but were most numerous in la...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90729-0
更新日期：1981-01-26 00:00:00
abstract：:The acute effects of ethanol on the gamma-aminobutyric acid (GABA)-activated current were studied with the rat dorsal root ganglion neurons in primary culture using the whole-cell patch-clamp technique. GABA produced an inward chloride current, which was composed of an initial transient and a subsequent sustained phas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90982-h
更新日期：1990-06-04 00:00:00
abstract：:Our previous studies demonstrated that Austrolebias charrua annual fish is an excellent model to study adult brain cell proliferation and neurogenesis due to the presence of active and fast neurogenesis in several regions during its short lifespan. Our main goal was to identify and localize the cells that compose the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.08.003
更新日期：2017-10-15 00:00:00
abstract：:Growth hormone releasing factor (GRF) applied by iontophoresis, pressure, and in the perfusate, increased (14.81%) or decreased (45.92%) the firing of paraventricular neurons extracellularly recorded from guinea-pig hypothalamic slices. Effects were similar whatever the mode of application and were elicited in the nan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90374-4
更新日期：1986-04-23 00:00:00
abstract：:Immunohistochemistry for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase and calbindin D-28k was performed on the glossopharyngeal and vagal ganglia in mCOUP-TFI knockout mice to know the effect of its deficiency on different types of primary sensory neurons. In wild type and heterozygous mice, the glosso...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.04.024
更新日期：2004-07-16 00:00:00
abstract：:Early environmental factors can modulate the development of the hypothalamic-pituitary-adrenal (HPA) axis response to stress, together with subsequent brain functions and emotional behaviors. Two rat strains, Sprague-Dawley (SD) and Fischer 344 (F344), are known to exhibit differences in HPA axis reactivity and anxiet...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.070
更新日期：2010-02-26 00:00:00
abstract：:Neurotensin (NT) is an endogenous peptide which has been hypothesized to function in the central nervous systems as a neurotransmitter. Injection of NT into the cerebral ventricular system of rodents produces antinociception in a variety of analgesia tests. In the hot plate test, direct microinjection of NT into the c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90251-7
更新日期：1982-07-15 00:00:00
abstract：:Experimental and genetic hypertension in male rate is accompanied by a lower specific [3H]naloxone binding in the dorsal horn of the spinal cord, and in the hippocampus as compared to controls. Rats which are genetically resistant to hypertensive stimuli have a higher specific [3H]naloxone binding in the nucleus tract...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91265-8
更新日期：1981-05-25 00:00:00
abstract：:We have investigated sensitivity to the conditioned fear procedure of mice is influenced by the genetic deletion of alpha2A adrenoceptors (ARs). We observed a heightened freezing response in the discrete cue memory test in alpha2A AR knockout (alpha2A AR KO) mice and in D79N mice, a transgenic mouse strain with functi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03248-7
更新日期：2003-10-03 00:00:00
abstract：:Soman is an organophosphorus (OP) compound which irreversibly inhibits acetylcholinesterase (AChE), the primary synaptic inactivator of acetylcholine. Resultant excessive cholinergic activity elicits generalized convulsions and brain lesions. Recent evidence suggests that other neurotransmitter/neuromodulator systems ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01315-7
更新日期：1997-02-07 00:00:00
abstract：:Rats received a unilateral lesion of the nucleus basalis magnocellularis (NBM) by infusion of ibotenic acid. Starting 2 weeks after the lesion, the animals were treated with nerve growth factor (NGF) or brain-derived neurotrophic factor (BDNF) by intraparenchymal infusion of 3 micrograms per day for 4 weeks. Lesioned ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91775-2
更新日期：1994-03-07 00:00:00
abstract：:The purpose of this study was to determine the effects of specific proinflammatory cytokines interleukin-6 (Il-6), interleukin-1beta (Il-1beta), interferon-gamma (IFN), and tumor necrosis factor-alpha (TNFalpha), on content and distribution of alpha-synuclein (alpha-synuclein), tau and ubiquitin in human derived cultu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.03.081
更新日期：2008-06-27 00:00:00
abstract：:Kernicterus is a bilirubin-induced encephalopathy in newborn. Its spectrum ranges from subtle extrapyramidal to acute encephalopathy and chronic posticteric sequelae. Current treatment of this serious problem is far from optimal. Taurine has been documented to have protective effects on neuronal cells against ischemia...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.036
更新日期：2010-03-12 00:00:00
abstract：:Tissue accumulation of ornithine (Orn), homocitrulline (Hcit), ammonia and orotic acid (Oro) is the biochemical hallmark of patients affected by hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, a disorder clinically characterized by neurological symptoms, whose pathophysiology is practically unknown....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.021
更新日期：2009-09-29 00:00:00
abstract：:Postsynaptic potentials evoked in motoneurons innervating m. posterior biceps and semitendinosus (PBSt) and m. triceps surae (GS) by low threshold afferents from various tail muscles located at the level of the second-third caudal vertebrae were investigated in the non-anesthetized and spinalized cat. Afferent inputs ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00039-0
更新日期：1998-03-30 00:00:00
abstract：:FRAT1 was originally characterized as a protein frequently rearranged in advanced T cell lymphoma, which inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. FRAT1 has been identified as a proto-oncogene involved in tumorigenesis. Previous studies have shown that ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.037
更新日期：2010-03-12 00:00:00
abstract：:The purpose of this investigation was to test the hypothesis that the discriminative stimulus properties of pentazocine are mediated through an interaction with dopamine receptors. Rats were trained to discriminate s.c. injections of pentazocine (3.0 mg/kg) from vehicle in a two-choice discrete trial avoidance paradig...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91092-5
更新日期：1989-09-04 00:00:00
abstract：:The frequency-dependent effect of various anticonvulsant drugs on the conduction in central axons was studied in the corpus callosum of rat and guinea pig brain slices from the parietal region. Extracellularly recorded compound action potentials (CAPs) were evoked by either single stimulus or high frequency stimulatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91636-s
更新日期：1992-07-24 00:00:00
abstract：:The putative neurotransmitter substance P was localized in the embryonic and neonatal mouse trigeminal nerve by indirect immunofluorescence. Central terminals in the nucleus caudalis gave a positive substance P-like immunofluorescence (SPLI) reaction of E13-E14. SPLI subsequently appeared in the peripheral mucous and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90147-x
更新日期：1982-07-01 00:00:00
abstract：:Microinjection of the neuronal inhibitor muscimol into the midbrain lateral/dorsolateral periaqueductal gray (l/dlPAG) suppresses increases in heart rate (HR) and mean arterial pressure (MAP) evoked by microinjection of the GABA(A) receptor antagonist bicuculline methiodide (BMI) into the dorsomedial hypothalamus (DMH...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.080
更新日期：2006-05-30 00:00:00
abstract：:During aerobic incubation at 37 degrees C, active uptake of labeled non-metabolizable alpha-aminoisobutyric acid (AIB) into isolated nodose ganglia (NG) excised from adult rats was accelerated to nearly twice that of the control, by the addition of glia maturation factor (GMF, 5 micrograms/ml) in a dose-dependent mann...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90350-1
更新日期：1986-05-14 00:00:00
abstract：:An intracerebral microdialysis technique was applied to study the effect of metabotropic glutamate receptor (mGluR) agonist on dopamine release in the striatum of methamphetamine (MAP)-sensitized rats. Rats were treated with MAP (1 mg/kg, i.p.) once daily for 6 consecutive days, followed by a 6-day withdrawal. Perfusi...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-08-12 00:00:00
abstract：:A procedure is described which allows for the selective and non-injectional staining of the three-dimensional microvasculatory bed (MVB) in thick sections (60-140 microm) of formalin-fixed brain tissue of white rats Rattus norvegicus. This histochemical method detects ATPase activity and takes place between pH 10.5 an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.11.059
更新日期：2006-01-27 00:00:00
abstract：:The biochemical changes associated with conduction block following exogenous application of purified phospholipase A2 to bullfrog sciatic nerves were investigated. Nerves were treated with concentrations of phospholipase A2 needed to produce at least a 50% decrease in the compound action potential after a 2-2 1/2 h in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90354-9
更新日期：1986-05-14 00:00:00
abstract：:Microtubule-stabilizing drugs are useful in cancer therapy and show promise for treatment of neurodegenerative diseases. An overlapping binding site between tau and taxoid site drugs has led to a number of research papers investigating the competitive interaction between these drugs and the microtubule. This has impli...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.022
更新日期：2012-12-13 00:00:00
