Effects of GRF on paraventricular neurons in slices of guinea-pig hypothalamus.

Abstract:

:Growth hormone releasing factor (GRF) applied by iontophoresis, pressure, and in the perfusate, increased (14.81%) or decreased (45.92%) the firing of paraventricular neurons extracellularly recorded from guinea-pig hypothalamic slices. Effects were similar whatever the mode of application and were elicited in the nanomolar range. They persisted in high Mg2+ medium, indicating a post-synaptic action of the peptide. Of the neurons 27.40% had a phasic activity suggestive of vasopressin neurons and were recorded in the vasopressinergic parts of the paraventricular nucleus. The effect of GRF on these phasic neurons was a reduction of firing. The present results demonstrate the action of GRF on paraventricular neurons and suggest that this action is inhibitory on vasopressin neurons.

journal_name

Brain Res

journal_title

Brain research

authors

Poulain P,Carette B

doi

10.1016/0006-8993(86)90374-4

subject

Has Abstract

pub_date

1986-04-23 00:00:00

pages

355-9

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(86)90374-4

journal_volume

371

pub_type

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