Abstract:
:Growth hormone releasing factor (GRF) applied by iontophoresis, pressure, and in the perfusate, increased (14.81%) or decreased (45.92%) the firing of paraventricular neurons extracellularly recorded from guinea-pig hypothalamic slices. Effects were similar whatever the mode of application and were elicited in the nanomolar range. They persisted in high Mg2+ medium, indicating a post-synaptic action of the peptide. Of the neurons 27.40% had a phasic activity suggestive of vasopressin neurons and were recorded in the vasopressinergic parts of the paraventricular nucleus. The effect of GRF on these phasic neurons was a reduction of firing. The present results demonstrate the action of GRF on paraventricular neurons and suggest that this action is inhibitory on vasopressin neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Poulain P,Carette Bdoi
10.1016/0006-8993(86)90374-4subject
Has Abstractpub_date
1986-04-23 00:00:00pages
355-9issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(86)90374-4journal_volume
371pub_type
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