Abstract：
:The release of amino acids in the locus coeruleus (LC) of conscious, freely moving rats was studied in time periods of 3 min by use of push-pull superfusion under basal conditions and during application of various experimental stimuli known to influence the activity of the LC-noradrenergic system. Tail pinch for 3 min led immediately to a pronounced tetrodotoxin-sensitive increase in the release rates of the excitatory amino acids (EAA) glutamate (Glu) and aspartate (Asp) and to moderate increases in GABA and taurine (Tau) outflow. Immobilization stress for 9 min elevated the release of the EAA Glu and Asp, as well as that of the inhibitory amino acid GABA to a similar extent. A fall of blood pressure (BP) by nitroprusside or haemorrhage slightly enhanced the release rates of Glu and Asp. Noradrenaline-induced rise in BP, as well as hypervolaemia increased the release rate of GABA, but did not influence the release rates of Glu, Asp, Tau and arginine (Arg). The results provide direct evidence that the amino acid release pattern in the LC of conscious rats differs in response to various stimuli, according to the modality of the stimulus. A functional significance of excitatory and inhibitory amino acids in the regulation of LC activity during stress and haemodynamic changes is suggested.
journal_name
Brain Resjournal_title
Brain researchauthors
Singewald N,Zhou GY,Schneider Cdoi
10.1016/0006-8993(95)01102-1subject
Has Abstractpub_date
1995-12-15 00:00:00pages
42-50issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(95)01102-1journal_volume
704pub_type
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