Abstract:
:Receptors for alpha-bungarotoxin are found on the surface of parasympathetic neurons in the frog cardiac ganglion by light microscopic autoradiography. Competition studies suggest that these receptors are cholinergic and indicate that they are also recognized by neuronal bungarotoxin (kappa-bungarotoxin). These receptors are outnumbered by those recognized exclusively by neuronal bungarotoxin. Unlike neuronal bungarotoxin receptors, alpha-bungarotoxin receptors are not concentrated at synaptic sites. Fluorescence techniques fail to find evidence for clusters of alpha-bungarotoxin receptors anywhere on the neuronal surface. The possible function of these receptors, which apparently do not play a role in fast synaptic transmission, is discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Sargent PB,Garrett ENdoi
10.1016/0006-8993(95)00250-tsubject
Has Abstractpub_date
1995-05-22 00:00:00pages
99-107issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(95)00250-Tjournal_volume
680pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Signaling pathways underlying the cognitive deficit of the Alzheimer's disease (AD) are not completely understood. Protein kinase C (PKC), a major neuronal protein plays a critical role in cellular signal transduction and it is known to be subjected to modulation in AD. We showed previously that, chronic infusion of b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03608-9
更新日期:2002-12-13 00:00:00
abstract::Recent anatomical evidence suggests that the shell of the nucleus accumbens, the bed nucleus of the stria terminalis, and the central nucleus of the amygdala, together referred to as the extended amygdala, may play a role in opiate dependence. The bed nucleus of the stria terminalis and the shell of the nucleus accumb...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02288-x
更新日期:2000-01-31 00:00:00
abstract::Terminal fibers anterogradely labeled with Phaseolus vulgaris leucoagglutinin (PHA-L) were observed in the locus coeruleus in the brainstem of the cat and the cynomolgus monkey following injections in lamina I of the spinal or medullary dorsal horn. Thus, thermoreceptive- or nociceptive-specific lamina I cells that pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90915-v
更新日期:1992-07-03 00:00:00
abstract::Brain levels of tyrosine, dopamine (DA), noradrenaline (NA), tryptophan, 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) were measured after 30, 60 and 120 min of sustained seizure activity, induced in paralyzed, artificially ventilated and anaesthetized (70% N2O) rats by administration of bicucull...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90031-8
更新日期:1978-11-24 00:00:00
abstract::Normal adult albino and Sprague-Dawley rats, under intraperitoneal Nembutal anesthesia, were used to demonstrate enzymatic activity in the choroid plexus and ventricular ependyma. The brain tissues were perfused or immersed with cold 2% glutaraldehyde and 8% sucrose in 0.1 M cacodylate buffer (pH 7.2-7.4) for 30 min a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91035-0
更新日期:1981-10-19 00:00:00
abstract::The role of N-methyl-D-aspartate (NMDA) receptors in specific D1 and D2 regulation of striatal and accumbens neurotensin (NT) systems was investigated. As demonstrated previously, stimulation of D1 receptors with multiple administrations of SKF 38393 significantly increased striatal and accumbens NT content to approxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90663-t
更新日期:1992-02-07 00:00:00
abstract::We have previously shown that blockade of neurotransmission mediated by gamma-aminobutyric acid (GABA) in the ventromedial nucleus of the hypothalamus (VMH) by the microinjection of a GABAA receptor antagonist, bicuculline methiodide (BM), exclusively induced running activity in the rat. The purpose of the present stu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91243-l
更新日期:1993-02-19 00:00:00
abstract::From 4 or 5 postnatal days, rat pups were either reared by their mothers (MR) or artificially reared (AR) without their mothers by infusion of 'milk' through a gastric cannula. In AR, but not MR, pups the left eye was more likely to open first than the right eye (P less than 0.001). The left-biassed eye-opening of AR ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90073-8
更新日期:1986-07-01 00:00:00
abstract::The aim of this work was to study the role of the dorsal noradrenergic ascending pathway (DNAP), which originates in the locus coeruleus (LC) on the preovulatory surge of luteinizing hormone (LH) follicle-stimulating hormone (FSH) and prolactin (PRL) by producing bilateral electrolytic lesions (cathodal or anodal) in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00613-6
更新日期:1997-09-05 00:00:00
abstract::It has been demonstrated that castration alters the functioning of the olfactory bulb (OB)-norepinephrine (NE) system. In the present experiment, we examined one of the mechanisms by which castration modulates the OB-NE system by comparing NE uptake activity between intact and castrated male rats as studied using an i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01101-3
更新日期:1998-01-01 00:00:00
abstract::A quantitative freeze-fracture study of perivascular astrocytic processes in rat cerebral cortex disclosed rapid disintegration of orthogonal arrays of the intramembrane particles in acute global ischemia. The process apparently preceded the development of astrocytic swelling. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91348-9
更新日期:1984-05-21 00:00:00
abstract::Chronic peripheral inflammation or peripheral neurectomy cause changes in GABA levels and GABA immunoreactivity in the spinal cord dorsal horn. The present study aimed to investigate if such changes are accompanied by alterations in GABA receptor binding. Neurectomy of the sciatic nerve caused an ipsilateral down-regu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00262-o
更新日期:1995-05-15 00:00:00
abstract::We utilized nylon arrays to measure gene expression in mouse brains after various postmortem intervals (PMIs). Gene expression after overnight refrigeration or 4 h at room temperature then overnight refrigeration correlated highly and approximately equivalently to that in brains processed immediately. After 8-24 h at ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02644-6
更新日期:2002-06-28 00:00:00
abstract::Soman is an organophosphorus (OP) compound which irreversibly inhibits acetylcholinesterase (AChE), the primary synaptic inactivator of acetylcholine. Resultant excessive cholinergic activity elicits generalized convulsions and brain lesions. Recent evidence suggests that other neurotransmitter/neuromodulator systems ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01315-7
更新日期:1997-02-07 00:00:00
abstract::We previously reported that motion sickness was prevented in rats with amygdala lesion and that provocative motion stimuli increased the number of Fos-positive neurons in the amygdala, suggesting that the amygdala is one of the neural substrates involved in the development of motion sickness. NK-1 receptors in the bra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.11.047
更新日期:2012-01-30 00:00:00
abstract::Endogenous opioid systems (i.e. opioids and opioid receptors) play a role in regulating neural development. Using the cerebellar cortex of 6-day-old rats, the most potent opioid peptides involved with cell proliferation were assessed. In both the external germinal (granule) layer (EGL), a germinative matrix giving ris...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91585-o
更新日期:1991-03-01 00:00:00
abstract::The purpose of this study was to examine whether endothelium-mediated dilation is responsible for the cortical hyperemia that occurs during cortical spreading depression (CSD) in rats using three different approaches. The first approach taken was the acute pharmacological inhibition of the predominant endothelium-cent...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03352-2
更新日期:2002-02-22 00:00:00
abstract::The effects of dexmedetomidine, a highly selective alpha(2)-adrenoceptor agonist, on extracellular dopamine (DA) concentrations in the nucleus accumbens of awake rats were collected via in vivo cerebral microdialysis and measured using HPLC with electrochemical detection. The administration of dexmedetomidine (DEX) at...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03012-8
更新日期:2001-11-16 00:00:00
abstract::Rat cerebral cortex slices were incubated in small volumes of medium in order to study the bidirectional movements of gamma-aminobutyric acid (GABA) between tissue and medium, and to measure the extent of release of endogenous amino acids of interest as potential neurotransmitters. The apparent uptake, real uptake, an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90558-4
更新日期:1979-04-13 00:00:00
abstract::Diurnal changes in the intranuclear release of vasopressin (VP) and oxytocin (OT) in the suprachiasmatic (SCN), paraventricular (PVN) and supraoptic nuclei (SON) of the rat were studied by means of brain microdialysis. A significant diurnal variation in VP release in the SCN was detected, with the highest levels occur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00324-j
更新日期:1995-06-05 00:00:00
abstract::Recent radioligand binding studies demonstrated an increase in the density of dopamine D2 receptors in the nucleus accumbens ipsilateral to the stimulating electrode in amygdala- or hippocampal-kindled rats. In the present study we examined the anticonvulsant effect of dopamine agonists by unilateral microinjections i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90822-d
更新日期:1991-07-12 00:00:00
abstract::Perinatal exposure to cannabinoids has been shown to elicit central nervous system impairment in rodents. This includes changes in monoaminergic and neuropeptidergic activities. We have examined the effect of perinatal exposure to delta 9-tetrahydrocannabinol (delta 9-THC) on sensitivity to radiant heat in both male a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00255-o
更新日期:1995-05-22 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) is a well neurotrophic factor with neuroprotective potentials for various diseases in the central nervous system. However several previous studies demonstrated that BDNF might deteriorate symptoms for epilepsy model of animals by progression of abnormal neurogenesis. We hypothe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.10.054
更新日期:2011-01-12 00:00:00
abstract::Previous studies have shown that chronic morphine increases levels of the G-protein subunits Gia and Goa, adenylate cyclase, cyclic AMP-dependent protein kinase, and certain phosphoproteins in the rat locus coeruleus, but not in several other brain regions studied, and that chronic morphine decreases levels of Gia and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91111-d
更新日期:1991-05-10 00:00:00
abstract::The relationship between placental antigen X-P2 (PAX)-immunoreactive glomeruli and intensely acetylcholinesterase-reactive (IAE) patchy regions was evaluated by comparison of neighboring cryostat sections of the rat olfactory bulb. Both groups of distribution show similar necklace patterns. Each IAE region consists of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90440-x
更新日期:1993-07-30 00:00:00
abstract::Wayfinding is a complex cognitive function involving different types of information, such as knowledge about landmarks and direction information. This variety of processes suggest that multiple neural mechanisms are involved, e.g., the hippocampal system, the posterior parietal and temporal cortical areas. Although pa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.10.048
更新日期:2006-01-05 00:00:00
abstract::Novel environments induce a conflicting emotional approach-withdrawal state that triggers stress-related reactions. Social support through the presence of a highly familiar conspecific buffers the individual against such challenges. Although aversive events seem to be predominantly processed by the right hemisphere, t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147198
更新日期:2021-01-15 00:00:00
abstract::The exposure of cultured rat striatal neurons to L-DOPA caused marked cell death. The L-DOPA cytotoxicity was inhibited by the addition of Mg2+ to and by the removal of Ca2+ from the culture medium, and also by the application of tetrodotoxin. Moreover, prolonged application of L-DOPA increased the glutamate content i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00908-6
更新日期:1997-10-10 00:00:00
abstract::Intracellular and extracellular recordings from CA3 hippocampal neurons in vitro were used to study the ability of several NMDA (N-methyl-D-aspartate) receptor antagonists to suppress epileptiform bursts induced by NMDA and convulsants not thought to act at NMDA receptors. The antagonists, APV (D-2-amino-5-phosphonova...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90642-7
更新日期:1988-09-06 00:00:00
abstract::Noradrenergic and dopaminergic regulation of thyrotropin (TSH) secretion was investigated in adult male Wistar rats. TSH secretion displayed a circadian variation with peak serum TSH levels at 10.00 h. The alpha 2-adrenoceptor agonist, clonidine (250 micrograms/kg, i.p.), was found to cause an enhancement of serum TSH...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91378-3
更新日期:1987-02-24 00:00:00