The characterization of alpha-bungarotoxin receptors on the surface of parasympathetic neurons in the frog heart.

Abstract:

:Receptors for alpha-bungarotoxin are found on the surface of parasympathetic neurons in the frog cardiac ganglion by light microscopic autoradiography. Competition studies suggest that these receptors are cholinergic and indicate that they are also recognized by neuronal bungarotoxin (kappa-bungarotoxin). These receptors are outnumbered by those recognized exclusively by neuronal bungarotoxin. Unlike neuronal bungarotoxin receptors, alpha-bungarotoxin receptors are not concentrated at synaptic sites. Fluorescence techniques fail to find evidence for clusters of alpha-bungarotoxin receptors anywhere on the neuronal surface. The possible function of these receptors, which apparently do not play a role in fast synaptic transmission, is discussed.

journal_name

Brain Res

journal_title

Brain research

authors

Sargent PB,Garrett EN

doi

10.1016/0006-8993(95)00250-t

subject

Has Abstract

pub_date

1995-05-22 00:00:00

pages

99-107

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(95)00250-T

journal_volume

680

pub_type

杂志文章
  • Memory impairment induced by chronic intracerebroventricular infusion of beta-amyloid (1-40) involves downregulation of protein kinase C.

    abstract::Signaling pathways underlying the cognitive deficit of the Alzheimer's disease (AD) are not completely understood. Protein kinase C (PKC), a major neuronal protein plays a critical role in cellular signal transduction and it is known to be subjected to modulation in AD. We showed previously that, chronic infusion of b...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03608-9

    authors: Olariu A,Yamada K,Mamiya T,Hefco V,Nabeshima T

    更新日期:2002-12-13 00:00:00

  • Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats.

    abstract::Recent anatomical evidence suggests that the shell of the nucleus accumbens, the bed nucleus of the stria terminalis, and the central nucleus of the amygdala, together referred to as the extended amygdala, may play a role in opiate dependence. The bed nucleus of the stria terminalis and the shell of the nucleus accumb...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02288-x

    authors: Walker JR,Ahmed SH,Gracy KN,Koob GF

    更新日期:2000-01-31 00:00:00

  • Spinal and trigeminal lamina I input to the locus coeruleus anterogradely labeled with Phaseolus vulgaris leucoagglutinin (PHA-L) in the cat and the monkey.

    abstract::Terminal fibers anterogradely labeled with Phaseolus vulgaris leucoagglutinin (PHA-L) were observed in the locus coeruleus in the brainstem of the cat and the cynomolgus monkey following injections in lamina I of the spinal or medullary dorsal horn. Thus, thermoreceptive- or nociceptive-specific lamina I cells that pr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90915-v

    authors: Craig AD

    更新日期:1992-07-03 00:00:00

  • Monoamine metabolism during bicuculline-induced epileptic seizures in the rat.

    abstract::Brain levels of tyrosine, dopamine (DA), noradrenaline (NA), tryptophan, 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) were measured after 30, 60 and 120 min of sustained seizure activity, induced in paralyzed, artificially ventilated and anaesthetized (70% N2O) rats by administration of bicucull...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(78)90031-8

    authors: Calderini G,Carlsson A,Nordström CH

    更新日期:1978-11-24 00:00:00

  • Cytochemical study on enzyme activity associated with cerebrospinal fluid secretion in the choroid plexus and ventricular ependyma.

    abstract::Normal adult albino and Sprague-Dawley rats, under intraperitoneal Nembutal anesthesia, were used to demonstrate enzymatic activity in the choroid plexus and ventricular ependyma. The brain tissues were perfused or immersed with cold 2% glutaraldehyde and 8% sucrose in 0.1 M cacodylate buffer (pH 7.2-7.4) for 30 min a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)91035-0

    authors: Masuzawa T,Saito T,Sato F

    更新日期:1981-10-19 00:00:00

  • Role of N-methyl-D-aspartate receptors in dopamine D1-, but not D2-, mediated changes in striatal and accumbens neurotensin systems.

    abstract::The role of N-methyl-D-aspartate (NMDA) receptors in specific D1 and D2 regulation of striatal and accumbens neurotensin (NT) systems was investigated. As demonstrated previously, stimulation of D1 receptors with multiple administrations of SKF 38393 significantly increased striatal and accumbens NT content to approxi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90663-t

    authors: Singh NA,Bush LG,Gibb JW,Hanson GR

    更新日期:1992-02-07 00:00:00

  • Interaction between excitatory and inhibitory amino acids in the ventromedial nucleus of the hypothalamus in inducing hyper-running.

    abstract::We have previously shown that blockade of neurotransmission mediated by gamma-aminobutyric acid (GABA) in the ventromedial nucleus of the hypothalamus (VMH) by the microinjection of a GABAA receptor antagonist, bicuculline methiodide (BM), exclusively induced running activity in the rat. The purpose of the present stu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)91243-l

    authors: Narita K,Yokawa T,Nishihara M,Takahashi M

    更新日期:1993-02-19 00:00:00

  • A phenomenon: left-biassed asymmetrical eye-opening in artificially reared rat pups.

    abstract::From 4 or 5 postnatal days, rat pups were either reared by their mothers (MR) or artificially reared (AR) without their mothers by infusion of 'milk' through a gastric cannula. In AR, but not MR, pups the left eye was more likely to open first than the right eye (P less than 0.001). The left-biassed eye-opening of AR ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(86)90073-8

    authors: Smart JL,Tonkiss J,Massey RF

    更新日期:1986-07-01 00:00:00

  • Locus coeruleus lesions decrease norepinephrine input into the medial preoptic area and medial basal hypothalamus and block the LH, FSH and prolactin preovulatory surge.

    abstract::The aim of this work was to study the role of the dorsal noradrenergic ascending pathway (DNAP), which originates in the locus coeruleus (LC) on the preovulatory surge of luteinizing hormone (LH) follicle-stimulating hormone (FSH) and prolactin (PRL) by producing bilateral electrolytic lesions (cathodal or anodal) in ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00613-6

    authors: Anselmo-Franci JA,Franci CR,Krulich L,Antunes-Rodrigues J,McCann SM

    更新日期:1997-09-05 00:00:00

  • Castration reduces olfactory bulb norepinephrine transporter function as indicated by responses to noradrenergic uptake blockers.

    abstract::It has been demonstrated that castration alters the functioning of the olfactory bulb (OB)-norepinephrine (NE) system. In the present experiment, we examined one of the mechanisms by which castration modulates the OB-NE system by comparing NE uptake activity between intact and castrated male rats as studied using an i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01101-3

    authors: Shang Y,Dluzen DE

    更新日期:1998-01-01 00:00:00

  • Disintegration of orthogonal arrays in perivascular astrocytic processes as an early event in acute global ischemia.

    abstract::A quantitative freeze-fracture study of perivascular astrocytic processes in rat cerebral cortex disclosed rapid disintegration of orthogonal arrays of the intramembrane particles in acute global ischemia. The process apparently preceded the development of astrocytic swelling. ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)91348-9

    authors: Suzuki M,Iwasaki Y,Yamamoto T,Konno H,Yoshimoto T,Suzuki J

    更新日期:1984-05-21 00:00:00

  • Complex changes of GABAA and GABAB receptor binding in the spinal cord dorsal horn following peripheral inflammation or neurectomy.

    abstract::Chronic peripheral inflammation or peripheral neurectomy cause changes in GABA levels and GABA immunoreactivity in the spinal cord dorsal horn. The present study aimed to investigate if such changes are accompanied by alterations in GABA receptor binding. Neurectomy of the sciatic nerve caused an ipsilateral down-regu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00262-o

    authors: Castro-Lopes JM,Malcangio M,Pan BH,Bowery NG

    更新日期:1995-05-15 00:00:00

  • Stability of gene expression in postmortem brain revealed by cDNA gene array analysis.

    abstract::We utilized nylon arrays to measure gene expression in mouse brains after various postmortem intervals (PMIs). Gene expression after overnight refrigeration or 4 h at room temperature then overnight refrigeration correlated highly and approximately equivalently to that in brains processed immediately. After 8-24 h at ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02644-6

    authors: Trotter SA,Brill LB 2nd,Bennett JP Jr

    更新日期:2002-06-28 00:00:00

  • Thyrotropin-releasing hormone (TRH) is markedly increased in the rat brain following soman-induced convulsions.

    abstract::Soman is an organophosphorus (OP) compound which irreversibly inhibits acetylcholinesterase (AChE), the primary synaptic inactivator of acetylcholine. Resultant excessive cholinergic activity elicits generalized convulsions and brain lesions. Recent evidence suggests that other neurotransmitter/neuromodulator systems ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)01315-7

    authors: Kubek MJ,Shih TM,Meyerhoff JL

    更新日期:1997-02-07 00:00:00

  • Implication of substance P neuronal system in the amygdala as a possible mechanism for hypergravity-induced motion sickness.

    abstract::We previously reported that motion sickness was prevented in rats with amygdala lesion and that provocative motion stimuli increased the number of Fos-positive neurons in the amygdala, suggesting that the amygdala is one of the neural substrates involved in the development of motion sickness. NK-1 receptors in the bra...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.11.047

    authors: Horii A,Nakagawa A,Uno A,Kitahara T,Imai T,Nishiike S,Takeda N,Inohara H

    更新日期:2012-01-30 00:00:00

  • Identification of opioid peptides regulating proliferation of neurons and glia in the developing nervous system.

    abstract::Endogenous opioid systems (i.e. opioids and opioid receptors) play a role in regulating neural development. Using the cerebellar cortex of 6-day-old rats, the most potent opioid peptides involved with cell proliferation were assessed. In both the external germinal (granule) layer (EGL), a germinative matrix giving ris...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91585-o

    authors: Zagon IS,McLaughlin PJ

    更新日期:1991-03-01 00:00:00

  • Role of endothelium in hyperemia during cortical spreading depression (CSD) in the rat.

    abstract::The purpose of this study was to examine whether endothelium-mediated dilation is responsible for the cortical hyperemia that occurs during cortical spreading depression (CSD) in rats using three different approaches. The first approach taken was the acute pharmacological inhibition of the predominant endothelium-cent...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)03352-2

    authors: Shimizu K,Miller AW,Erdös B,Bari F,Busija DW

    更新日期:2002-02-22 00:00:00

  • Dexmedetomidine decreases extracellular dopamine concentrations in the rat nucleus accumbens.

    abstract::The effects of dexmedetomidine, a highly selective alpha(2)-adrenoceptor agonist, on extracellular dopamine (DA) concentrations in the nucleus accumbens of awake rats were collected via in vivo cerebral microdialysis and measured using HPLC with electrochemical detection. The administration of dexmedetomidine (DEX) at...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)03012-8

    authors: Whittington RA,Virag L,Morishima HO,Vulliemoz Y

    更新日期:2001-11-16 00:00:00

  • Bidirectional movement of gamma-aminobutyric acid in cerebral cortex slices incubated in small volumes of medium.

    abstract::Rat cerebral cortex slices were incubated in small volumes of medium in order to study the bidirectional movements of gamma-aminobutyric acid (GABA) between tissue and medium, and to measure the extent of release of endogenous amino acids of interest as potential neurotransmitters. The apparent uptake, real uptake, an...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)90558-4

    authors: Cutler RW,Young J

    更新日期:1979-04-13 00:00:00

  • In vivo measurement of a diurnal variation in vasopressin release in the rat suprachiasmatic nucleus.

    abstract::Diurnal changes in the intranuclear release of vasopressin (VP) and oxytocin (OT) in the suprachiasmatic (SCN), paraventricular (PVN) and supraoptic nuclei (SON) of the rat were studied by means of brain microdialysis. A significant diurnal variation in VP release in the SCN was detected, with the highest levels occur...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00324-j

    authors: Kalsbeek A,Buijs RM,Engelmann M,Wotjak CT,Landgraf R

    更新日期:1995-06-05 00:00:00

  • Anticonvulsant effects of ipsilateral but not contralateral microinjections of the dopamine D2 agonist LY 171555 into the nucleus accumbens of amygdala-kindled rats.

    abstract::Recent radioligand binding studies demonstrated an increase in the density of dopamine D2 receptors in the nucleus accumbens ipsilateral to the stimulating electrode in amygdala- or hippocampal-kindled rats. In the present study we examined the anticonvulsant effect of dopamine agonists by unilateral microinjections i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90822-d

    authors: Wahnschaffe U,Löscher W

    更新日期:1991-07-12 00:00:00

  • Perinatal exposure to delta 9-tetrahydrocannabinol (delta 9-THC) leads to changes in opioid-related behavioral patterns in rats.

    abstract::Perinatal exposure to cannabinoids has been shown to elicit central nervous system impairment in rodents. This includes changes in monoaminergic and neuropeptidergic activities. We have examined the effect of perinatal exposure to delta 9-tetrahydrocannabinol (delta 9-THC) on sensitivity to radiant heat in both male a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00255-o

    authors: Vela G,Fuentes JA,Bonnin A,Fernández-Ruiz J,Ruiz-Gayo M

    更新日期:1995-05-22 00:00:00

  • BDNF-secreting capsule exerts neuroprotective effects on epilepsy model of rats.

    abstract::Brain-derived neurotrophic factor (BDNF) is a well neurotrophic factor with neuroprotective potentials for various diseases in the central nervous system. However several previous studies demonstrated that BDNF might deteriorate symptoms for epilepsy model of animals by progression of abnormal neurogenesis. We hypothe...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.10.054

    authors: Kuramoto S,Yasuhara T,Agari T,Kondo A,Jing M,Kikuchi Y,Shinko A,Wakamori T,Kameda M,Wang F,Kin K,Edahiro S,Miyoshi Y,Date I

    更新日期:2011-01-12 00:00:00

  • A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function.

    abstract::Previous studies have shown that chronic morphine increases levels of the G-protein subunits Gia and Goa, adenylate cyclase, cyclic AMP-dependent protein kinase, and certain phosphoproteins in the rat locus coeruleus, but not in several other brain regions studied, and that chronic morphine decreases levels of Gia and...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91111-d

    authors: Terwilliger RZ,Beitner-Johnson D,Sevarino KA,Crain SM,Nestler EJ

    更新日期:1991-05-10 00:00:00

  • A possible functional necklace formed by placental antigen X-P2-immunoreactive and intensely acetylcholinesterase-reactive (PAX/IAE) glomerular complexes in the rat olfactory bulb.

    abstract::The relationship between placental antigen X-P2 (PAX)-immunoreactive glomeruli and intensely acetylcholinesterase-reactive (IAE) patchy regions was evaluated by comparison of neighboring cryostat sections of the rat olfactory bulb. Both groups of distribution show similar necklace patterns. Each IAE region consists of...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90440-x

    authors: Shinoda K,Ohtsuki T,Nagano M,Okumura T

    更新日期:1993-07-30 00:00:00

  • Neural correlates of human wayfinding in stroke patients.

    abstract::Wayfinding is a complex cognitive function involving different types of information, such as knowledge about landmarks and direction information. This variety of processes suggest that multiple neural mechanisms are involved, e.g., the hippocampal system, the posterior parietal and temporal cortical areas. Although pa...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.10.048

    authors: van Asselen M,Kessels RP,Kappelle LJ,Neggers SF,Frijns CJ,Postma A

    更新日期:2006-01-05 00:00:00

  • Social buffering of cortisol release and tympanic temperature asymmetries during novelty and isolation stress in marmoset monkeys.

    abstract::Novel environments induce a conflicting emotional approach-withdrawal state that triggers stress-related reactions. Social support through the presence of a highly familiar conspecific buffers the individual against such challenges. Although aversive events seem to be predominantly processed by the right hemisphere, t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147198

    authors: Pereira LC,Barros M

    更新日期:2021-01-15 00:00:00

  • L-DOPA neurotoxicity is mediated by glutamate release in cultured rat striatal neurons.

    abstract::The exposure of cultured rat striatal neurons to L-DOPA caused marked cell death. The L-DOPA cytotoxicity was inhibited by the addition of Mg2+ to and by the removal of Ca2+ from the culture medium, and also by the application of tetrodotoxin. Moreover, prolonged application of L-DOPA increased the glutamate content i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00908-6

    authors: Maeda T,Cheng N,Kume T,Kaneko S,Kouchiyama H,Akaike A,Ueda M,Satoh M,Goshima Y,Misu Y

    更新日期:1997-10-10 00:00:00

  • Epileptiform bursts elicited in CA3 hippocampal neurons by a variety of convulsants are not blocked by N-methyl-D-aspartate antagonists.

    abstract::Intracellular and extracellular recordings from CA3 hippocampal neurons in vitro were used to study the ability of several NMDA (N-methyl-D-aspartate) receptor antagonists to suppress epileptiform bursts induced by NMDA and convulsants not thought to act at NMDA receptors. The antagonists, APV (D-2-amino-5-phosphonova...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90642-7

    authors: Neuman R,Cherubini E,Ben-Ari Y

    更新日期:1988-09-06 00:00:00

  • Noradrenergic and dopaminergic modulation of thyrotropin secretion in the rat.

    abstract::Noradrenergic and dopaminergic regulation of thyrotropin (TSH) secretion was investigated in adult male Wistar rats. TSH secretion displayed a circadian variation with peak serum TSH levels at 10.00 h. The alpha 2-adrenoceptor agonist, clonidine (250 micrograms/kg, i.p.), was found to cause an enhancement of serum TSH...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91378-3

    authors: Jaffer A,Russell VA,Taljaard JJ

    更新日期:1987-02-24 00:00:00