Abstract：
:The purpose of this study was to examine whether endothelium-mediated dilation is responsible for the cortical hyperemia that occurs during cortical spreading depression (CSD) in rats using three different approaches. The first approach taken was the acute pharmacological inhibition of the predominant endothelium-centered dilator systems, using indomethacin, a cyclooxygenase inhibitor, Nomega-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase (NOS) inhibitor, and miconazole, a cytochrome P-450 epoxygenase inhibitor. The second approach used was the acute general pharmacological impairment of endothelial function by the intravascular administration of phorbol 12, 13-dibutyrate (PDBu). The third approach taken was the chronic impairment of endothelium-dependent dilator responses by diet in insulin resistant (IR) rats. Cerebral blood flow (CBF) was measured using laser Doppler flowmetry. CSD was elicited by the topical application of potassium chloride. Pharmacological inhibition of endothelium-dependent dilator factors did not affect CSD. For example, with 20 mg/kg L-NAME, CBF peak of the first series of CSDs was 377 +/- 67% of baseline CBF. After drug administration, CBF peaks of the second and the third series of CSDs were 451 +/- 67% and 390 +/- 69% (n=5, P=n.s.), respectively. Control and IR animals and those treated with indomethacin, miconazole and PDBu showed similar results. We also calculated the area under the CBF curve to fully represent the extent of hyperemia during CSD. However, there were no significant differences in the CBF area with any treatment compared to control animals. Thus, our results provide strong evidence that endothelium-mediated mechanisms have minimal effects on the CSD-associated hyperemia.
journal_name
Brain Resjournal_title
Brain researchauthors
Shimizu K,Miller AW,Erdös B,Bari F,Busija DWdoi
10.1016/s0006-8993(01)03352-2subject
Has Abstractpub_date
2002-02-22 00:00:00pages
40-9issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899301033522journal_volume
928pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Low concentrations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) enhanced neuronal and glial survival and/or differentiation in dissociated cultures of 14-day mouse embryo brain. Posttrial intracisternal injection into the brains of mice undergoing active avoidance training alleviated amn...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90807-9
更新日期：1987-03-17 00:00:00
abstract：:From measured effects of amino acids on synaptosomal tyrosine uptake and from published data on human CNS levels of amino acids hypothetical calculations were made to compare CNS tyrosine availability for catecholamine synthesis in the hyperphenylalaninemic and non-hyperphenylalaninemic condition. These calculations i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90380-3
更新日期：1983-08-01 00:00:00
abstract：:Emotional events are preferentially retained in episodic memory. This effect is commonly attributed to enhanced consolidation and has been linked specifically to rapid eye movement (REM) sleep physiology. While several studies have demonstrated an enhancing effect of REM sleep on emotional item memory, it has not been...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.06.020
更新日期：2018-11-01 00:00:00
abstract：:Patches excised from fields CA1 and CA3 of the hippocampus were used to study AMPA receptor responses to repetitive application of brief pulses of agonist. AMPA receptors in field CA1 exhibited a larger degree of paired-pulse depression and a slower recovery rate from desensitization than those from CA3 patches. Respo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00030-3
更新日期：1996-04-15 00:00:00
abstract：:The possible involvement of the nitric oxide (NO)-cyclic GMP (cGMP)-protein kinase G (PKG) pathway on bovine lactoferrin (BLF)-induced spinal antihyperalgesic activity was elucidated in sciatic nerve injured rats. Intrathecal BLF reduced thermal hyperalgesia in a dose-dependent manner. Pretreatment with NG-L-nitro-arg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.03.004
更新日期：2008-05-13 00:00:00
abstract：:Sensory fibers trapped in nerve-end neuromas become abnormally excitable, and produce an ectopic discharge which is believed to contribute to paresthesias and pain associated with chronic nerve injury in man. Here we report that stimulation of injured nerves can alter this discharge, directly by antidromic invasion of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90275-7
更新日期：1987-07-07 00:00:00
abstract：:Intracellular recordings were obtained from 212 neurons of the coronal pericruciate cortex of 7 awake, untrained cats. Glass microelectrodes, filled with K+ citrate alone or K+ citrate with either cyclic GMP or 5'-GMP were used for recording and for injecting steady depolarizing and hyperpolarizing currents intracellu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90680-7
更新日期：1978-12-15 00:00:00
abstract：:Weaver mutant mice alternated above chance levels but less often than normal mice in a 2-trial spontaneous alternation test. When the inter-trial (or retention) interval was manipulated, the weaver mutants alternated above chance levels only at the shortest (15 s) but not at the longest (4 or 5 min) intervals, contrar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91265-5
更新日期：1986-11-19 00:00:00
abstract：:Cortical projection areas and distribution and response characteristics of masseteric nerve-driven neurons (MDN) were studied by recording surface-evoked potentials and single neuronal activities elicited by stimulation of the contralateral masseteric nerve in cats. Neuronal activities of MDNs could be recorded in two...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91371-x
更新日期：1985-09-02 00:00:00
abstract：:Seventy-two hybridoma lines that produce monoclonal antibodies to molecules of a rat synaptosomal plasma membrane fraction (SPM) were generated. The topographical distribution of the antigens in the cerebellum and other areas of the brain was studied by light microscopy immunocytochemistry. Some of the antibodies reco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90118-5
更新日期：1984-11-26 00:00:00
abstract：:Aging leads to a decrease in the number of neurons expressing vasopressin (VP) and vasoactive intestinal polypeptide (VIP) in the suprachiasmatic nucleus (SCN) of the rat. Similar results were observed following prolonged alcohol consumption and withdrawal. In the latter circumstances, the administration of nerve grow...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.04.066
更新日期：2005-06-28 00:00:00
abstract：:Neurotensin-producing perikarya and fibers have been identified in the ventral tegmental area of the rat, and recent microinjection studies indicate that neurotensin may function in the ventral tegmental area to regulate body temperature. In this study, the hypothermic response produced by intraventral tegmental injec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90031-9
更新日期：1985-02-11 00:00:00
abstract：:We investigated the protective effect of subchronic treatment of the A2A receptor antagonist, SCH 58261 (0.01 mg/kg, i.p.), administered 5 min, 6 h and 15 h after permanent right middle cerebral artery occlusion (MCAo). Twenty-four hours after ischemia, an extensive pallid area, evaluated by cresyl violet staining, is...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.010
更新日期：2006-02-16 00:00:00
abstract：:Congenitally anophthalmic mice (ZRDCT-AN) have circadian rhythms which 'free-run' and are not light modulated. Their rhythms differ from those of controls in: duration of circadian period, length of active phase, and pattern/intensity of activity. Three different populations have been described based upon wheel-runnin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03272-9
更新日期：2002-10-25 00:00:00
abstract：:The acquisition and retention of tolerance to the antinociceptive effect of supraspinal morphine on the tail withdrawal reflex was assessed in rats implanted with unilateral cannulae in the periaqueductal gray (PAG). Development of tolerance to daily microinjections of morphine was indicated by the return of the tail ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91476-4
更新日期：1987-10-27 00:00:00
abstract：:There is a population of neurons in the cortex in the middle and anterior part of the superior temporal sulcus (STS) of the monkey with responses which are selective for faces. If, consistent with the effects of damage to the temporal lobe, these neurons are involved in face recognition or in making appropriate social...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91356-3
更新日期：1985-09-02 00:00:00
abstract：:The neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) is synthesized by discrete populations of hypothalamic neurons which project in different brain regions including the cerebral cortex, hippocampus and amygdala nuclei. The purpose of the present study was to identify the alpha-MSH-immunoreactive species...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90471-m
更新日期：1990-04-16 00:00:00
abstract：:The aim of this work was to study the role of the dorsal noradrenergic ascending pathway (DNAP), which originates in the locus coeruleus (LC) on the preovulatory surge of luteinizing hormone (LH) follicle-stimulating hormone (FSH) and prolactin (PRL) by producing bilateral electrolytic lesions (cathodal or anodal) in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00613-6
更新日期：1997-09-05 00:00:00
abstract：:The cataleptic activity of morphine and methadone was markedly potentiated in frontally decorticated rats with no apparent changes in the onset or duration of action. Enhancement of the opioid cataleptic response was not due to changes in the availability of the drugs in the brain. The potentiation of methadone-induce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91028-1
更新日期：1988-05-24 00:00:00
abstract：:We previously reported that brain angiotensin II type 2 (AT2) receptors contribute to the hyperthermia induced by intrahypothalamic (intrapreoptic (i.p.o.)) administration of prostaglandin E2 (PGE2) in rats. The present study was carried out to investigate the role of angiotensin II (ANG II) receptors in the cardiovas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02218-0
更新日期：2000-01-03 00:00:00
abstract：:Physical exercise can induce brain plasticity and reduce the cognitive decline observed in type 1 diabetes mellitus (T1DM). We investigated the effects of physical exercise to prevent or reverse spatial memory deficits produced by diabetes and some biochemical and immunohistochemical changes in hippocampal astrocytes ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.10.024
更新日期：2017-01-15 00:00:00
abstract：:Individual vulnerability to the reinforcing effects of drugs appear to be a crucial factor in the development of addiction in humans. In the rat, individuals at risk for psychostimulant self-administration (SA) may be identified from their locomotor reactivity to a stress situation such as exposure to a novel environm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91452-7
更新日期：1991-12-13 00:00:00
abstract：:To investigate the role of the estrogen receptor (ER) in mediating neuroprotection, the neuroprotective profiles of selective ER agonists for ERalpha and ERbeta, propylpyrazole triol (PPT) and 2,3-bis(4-hydroxyphenyl) proprionitrile (DPN), respectively, were compared to that of 17beta-estradiol and 17alpha-estradiol i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.03.032
更新日期：2005-05-31 00:00:00
abstract：:Following a single intravitreal injection of 200 nmol of kainic acid (KA) to newly hatched chickens, there are acute and long-term effects on retinal ganglion cells in the chicken retina. Thirty min after injection, most ganglion cells showed cytoplasmic vacuolization. However, 14 days later, most ganglion cell soma a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91596-4
更新日期：1987-12-01 00:00:00
abstract：:Previous research has demonstrated that in the Siberian hamster, both photoperiod and estrous cyclicity alter the profile of noradrenergic activity with the paraventricular nucleus of the hypothalamus (PVN), and that noradrenergic activity is correlated with changes in circulating levels of prolactin. Work from our la...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.05.009
更新日期：2004-08-06 00:00:00
abstract：:Earlier studies showed that pretreatment (3 and 6 h) of rats with the glucocorticoid hormone, dexamethasone, potentiated the drinking response to either central or peripheral administration of angiotensin II (AII). In the present study the specificity and mechanisms of this potentiation were examined. Intraperitoneal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90093-b
更新日期：1991-06-28 00:00:00
abstract：:Growth cones integrate a remarkably complex concert of chemical cues to guide axons to their appropriate destinations. Recent work suggests that integrins contribute to axon guidance by interacting with a wide range of extracellular molecules including axon guidance molecules, by mechanisms that are not fully understo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.08.045
更新日期：2013-11-06 00:00:00
abstract：:alpha-Bungarotoxin (alpha-BuTX) binds in a saturable and practically irreversible fashion to membrane-associated receptors in the ciliary ganglion of the adult chick. The binding of toxin to receptors is competitively inhibited by nicotinic cholinergic ligands, and for these properties the receptors are regarded as ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)91130-7
更新日期：1978-09-15 00:00:00
abstract：:Ascending and descending projections of the nucleus reticularis gigantocellularis (NRGc) were studied in the cat by the anterograde tracer, Phaseolus vulgaris leucoagglutinin. Ascending fibers from the left or the right NRGc coursed through the bilateral medial reticular formation and some of them reached the dienceph...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91212-7
更新日期：1988-09-13 00:00:00
abstract：:The hypothesis that early social isolation results in long-term alterations in dopamine receptor sensitivity was tested using older adult rhesus monkeys. Isolated and control monkeys were challenged with apomorphine (0.1 and 0.3 mg/kg), and the drug effects on spontaneous blink rate, stereotyped behavior, and self-inj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91089-y
更新日期：1990-04-09 00:00:00
