Noradrenergic regulation of prolactin secretion at the level of the paraventricular nucleus of the hypothalamus: functional significance of the alpha-1b and beta-adrenergic receptor subtypes.

abstract：:Polyamines play critical roles during the development of brain neurons. In the present study we examined the effects of polyamines on neuronal apoptotic death. Rat cerebellar granule neurons were cultured in the presence of a depolarizing concentration of KCl (25 mM) in the medium. Apoptotic neuronal death was induced...

journal_title：Brain research

authors： Harada J,Sugimoto M

更新日期：1997-04-11 00:00:00

abstract：:Techniques to induce activity-dependent neuronal plasticity in vivo allow the underlying signaling pathways to be studied in their biological context. Here, we demonstrate activity-induced plasticity at neuromuscular synapses of Drosophila double mutant for comatose (an NSF mutant) and Kum (a SERCA mutant), and presen...

journal_title：Brain research

authors： Freeman A,Bowers M,Mortimer AV,Timmerman C,Roux S,Ramaswami M,Sanyal S

更新日期：2010-04-22 00:00:00

abstract：:Mouse embryonic stem (ES) cells were transplanted into the cochlea of adult guinea pigs in order to explore their survival, differentiation, and possible integration with the host tissue. With the purpose of investigating the possible effect of manipulating the local embryonic microenvironment, ES cells were transplan...

journal_title：Brain research

authors： Hu Z,Andäng M,Ni D,Ulfendahl M

更新日期：2005-07-27 00:00:00

abstract：:Experiments were carried out to determine if stimuli which augment preganglionic nerve activity to sympathetic neurons, and thereby cause trans-synaptic induction, increase the retrograde transport of nerve growth factor (NGF). It was found that nerve activity had no effect on retrograde transport of [125I]NGF. It was...

journal_title：Brain research

authors： Johnson EM Jr,Blumberg HM,Costrini NV,Bradshaw RA

更新日期：1979-12-14 00:00:00

abstract：:Inhibition of Aβ production and clearance of senile plaques have been considered as potential strategies in the treatment of Alzheimer's disease (AD). Activated protein C (APC) is an important factor in the anticoagulant system. However, whether APC can influence the condition of a chronic neurodegenerative process, s...

journal_title：Brain research

authors： Li B,Yu D,Xu Z

更新日期：2014-01-30 00:00:00

abstract：:Bilateral microinjection of kainic acid (30-117 pmol) into the substantia nigra induced convulsive seizures resembling those elicited from limbic system structures. The convulsive seizures, which consisted of facial and forelimb clonus with rearing and falling, developed after a latency of more than 30 min and were pr...

journal_title：Brain research

authors： Maggio R,Liminga U,Gale K

更新日期：1990-10-01 00:00:00

abstract：:In the present study, we observed chronological changes of antioxidant-like protein 1 (AOP-1) in the gerbil hippocampal CA1 region after 5 min of transient forebrain ischemia using immunohistochemistry and western blot. AOP-1 was significantly altered in the CA1 region after transient ischemia. In the sham-operated gr...

journal_title：Brain research

authors： Hwang IK,Hua L,Yoo KY,Kim DW,Kang TC,Choi SY,Won MH,Kim DH

更新日期：2005-11-16 00:00:00

abstract：:Multiple lines of evidence indicate that hypocretin/orexin (HCRT) participates in the regulation of arousal and arousal-related process. For example, HCRT axons and receptors are found within a variety of arousal-related systems. Moreover, when administered centrally, HCRT exerts robust wake-promoting actions. Finally...

journal_title：Brain research

authors： Berridge CW,España RA,Vittoz NM

更新日期：2010-02-16 00:00:00

abstract：:The levels of PLCgamma, a phospholipase C (PLC) isozyme, were higher in the cytosol fraction than in the membrane fraction in several control brain regions. The levels of PLCgamma were significantly elevated in the membrane, but not in the cytosolic fraction of the hippocampus of AD subjects. In the superior and middl...

journal_title：Brain research

authors： Zhang D,Dhillon H,Prasad MR,Markesbery WR

更新日期：1998-11-16 00:00:00

abstract：:Astrocytes produce and bind endothelins (ETs), suggesting that these cells have ET autoregulatory and eliminatory functions. To further investigate these functions in primary rat astrocytes, ET-1 levels in the cell culture media (RIA/HPLC) and intracellular content of ET-1 mRNA (RT PCR) were measured under basal and s...

journal_title：Brain research

authors： Hasselblatt M,Kamrowski-Kruck H,Jensen N,Schilling L,Kratzin H,Sirén AL,Ehrenreich H

更新日期：1998-03-02 00:00:00

abstract：:The aim of the present study was to develop a model culture system for the study of factors controlling regeneration of axons from injured adult mammalian central nervous system. We show, for the first that retinal ganglion cells (RGC) dissociated from adult rat retina, regrow processes in vitro over long distances un...

journal_title：Brain research

authors： Wigley CB,Berry M

更新日期：1988-07-01 00:00:00

abstract：:Breakdown products (BDPs) resulting from the partial proteolysis of spectrin were examined in hippocampal slices after periods of hypoxia lasting for 5 or 10 min. The concentration of a approximately 155 kDa BDP increased nearly twofold after 5 min of hypoxia; further increases were not seen with 10 min episodes or 10...

journal_title：Brain research

authors： Arai A,Vanderklish P,Kessler M,Lee K,Lynch G

更新日期：1991-08-02 00:00:00

abstract：:The occurrence of hypoxia-ischemia (HI) during early fetal or neonatal stages of an individual leads to the damaging of immature neurons resulting in behavioral and psychological dysfunctions, such as motor or learning disabilities, cerebral palsy, epilepsy or even death. No effective treatment is currently available ...

journal_title：Brain research

authors： Calvert JW,Yin W,Patel M,Badr A,Mychaskiw G,Parent AD,Zhang JH

更新日期：2002-09-27 00:00:00

abstract：:The pyrithiamine-treated rats produced by our method histopathologically exhibited the edematous lesion not only around the third ventricle and at the tegmentum of pons, as expected, but also in the cerebral cortex. These animals were, therefore, used in a biochemical study of the cerebral cortex, in particular, gluco...

journal_title：Brain research

authors： Takahashi H,Nakazawa S,Yoshino Y,Shimura T

更新日期：1988-02-16 00:00:00

abstract：:Intracellular recordings in vivo from serotonergic dorsal raphe neurons of the rat brain reveal that these cells undergo a pronounced postspike hyperpolarization followed by a gradual interspike depolarization leading to the succeeding spike. Such repetitive cycles of interspike hyperpolarization and depolarization, w...

journal_title：Brain research

authors： Aghajanian GK,Vandermaelen CP

更新日期：1982-04-29 00:00:00

abstract：:In tasks involving the learning of verbal or non-verbal sequences, groupings are spontaneously produced. These groupings are generally marked by a lengthening of final elements and have been attributed to a domain-general perceptual chunking linked to working memory. Yet, no study has shown how this domain-general chu...

journal_title：Brain research

authors： Gilbert AC,Boucher VJ,Jemel B

更新日期：2015-04-07 00:00:00

abstract：:Geranylgeranylacetone (GGA), more commonly known as an antiulcer agent, reportedly induces the heat shock protein 70 (HSP70) family in the gastric mucosa, liver and heart of rats. However, it has not been reported whether HSPs, and other factors that contribute to neuroprotection, are inducible in the brain following ...

journal_title：Brain research

authors： Fujiki M,Kobayashi H,Abe T,Ishii K

更新日期：2003-11-21 00:00:00

abstract：:The aim of this study was to describe the normal distribution of the water content in several regions of the rat brain and furthermore to determine if global ischemia results in a variable increase in water content in these regions. Water content was determined in 40 regions; in 8 unaffected brains by gravimetry and i...

journal_title：Brain research

authors： Schwab M,Bauer R,Zwiener U

更新日期：1997-02-21 00:00:00

abstract：:Ventilation is peripherally controlled by afferent activity arising from the peripheral chemoreceptors. In the rat, chemosensory activity is conveyed to the central nervous system through axons of neurons located in the nodose-petrosal-jugular-complex. These neurons have distinct electrophysiological properties, inclu...

journal_title：Brain research

authors： Alcayaga J,Oyarce MP,Del Rio R

更新日期：2016-10-15 00:00:00

abstract：:Cardiovascular responses to electrical microstimulation of the ventrolateral medulla were investigated in both Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) under pentobarbital anesthesia. The threshold intensity required to elicit a change in blood pressure (BP) and the cardiovascular responses in...

journal_title：Brain research

authors： Chan RK,Chan YS,Wong TM

更新日期：1990-07-02 00:00:00

abstract：:There is a strong link between cognitive impairment and depression, but up to date it is not clear whether cognitive impairment is 'cause' or 'consequence' of depression. Therefore, we here examined the effect of cognitive impairment induced by permanent occlusion of common carotid arteries, a model known as two-vesse...

journal_title：Brain research

authors： Khojasteh F,Nahavandi A,Mehrpouya S,Homberg JR,Mirzamohammadi S,Raufi S,Soleimani M,Barati M

更新日期：2015-01-30 00:00:00

abstract：:Damage to the cerebral endothelium from ischemia could exacerbate brain injury by altering vascular integrity, but little is known concerning the response of cerebral endothelial cells to hypoxia. To address this issue, cerebral capillary endothelial cells were isolated from 14-day-old rats, grown to confluence, and p...

journal_title：Brain research

authors： Gobbel GT,Chan TY,Gregory GA,Chan PH

更新日期：1994-08-08 00:00:00

abstract：:Specific binding of [3H](+-)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), a highly selective antagonist for N-methyl-D-aspartic acid (NMDA) receptors, was examined in brain synaptic membranes treated with Triton X-100 by using a filtration assay method. Elevation of incubation temperature from 2 to 30 de...

journal_title：Brain research

authors： Ogita K,Yoneda Y

更新日期：1990-05-07 00:00:00

abstract：:The developmental time course and life span of the human brain are different from those of laboratory animals. These variations may be the reflection of metabolic differences of the neurons between different species. Using immunocytochemistry, we show that pyramidal neurons accumulate advanced glycosylation end produc...

journal_title：Brain research

authors： Li JJ,Voisin D,Quiquerez AL,Bouras C

更新日期：1994-04-04 00:00:00

abstract：:The distribution of cells expressing mu-receptor mRNA and mu-receptor binding sites were compared in brain and spinal cord tissue sections using a combination of in situ hybridization and receptor autoradiographic techniques. mu-Receptor mRNA was visualized with a 35S-labeled cRNA probe directed to transmembrane III-V...

journal_title：Brain research

authors： Mansour A,Fox CA,Thompson RC,Akil H,Watson SJ

更新日期：1994-04-18 00:00:00

abstract：:Previous studies have demonstrated that postnatal (days 2-29 of life) administration of lead (200 mg/kg/day by gavage) to Long-Evans rats caused permanent increases in lithium-induced polydipsia (LIP). These lead-induced increases in LIP were apparently not of renal origin, did not occur in animals treated with lead a...

journal_title：Brain research

authors： DeHaven DL,Krigman MR,Gaynor JJ,Mailman RB

更新日期：1984-04-16 00:00:00

abstract：:Descending protocerebral neurons in the male silkworm moth brain responding to the sexual pheromone (Bombykol) were identified. The neurons responded well with a tonic type of response and the high-frequency spikes evoked continued even after the end of the stimulus. Characteristics of the dose-response curves of the ...

journal_title：Brain research

authors： Kanzaki R,Shibuya T

更新日期：1986-07-09 00:00:00

abstract：:The present in vitro study was performed to characterize neurons within dorsal regions of the nucleus tractus solitarii (NTS), principally at the level of area postrema, and known to receive inputs predominantly from cardiovascular and respiratory afferents (i.e. cardiorespiratory NTS). This report describes 4 classes...

journal_title：Brain research

authors： Paton JF,Foster WR,Schwaber JS

更新日期：1993-02-26 00:00:00

abstract：:Electrophysiological characteristics were described for neurons of the parabrachial nucleus (PBN) which receive baroreceptive and somatosensory inputs in the rat. Following focal electrical stimulation in the ipsilateral caudal nucleus of the tractus solitarii (NTS), the firing rates of these neurons were increased in...

journal_title：Brain research

authors： Han ZS,Gu GB,Sun CQ,Ju G

更新日期：1991-12-06 00:00:00

abstract：:Regulation of myelin protein gene expression in the presence and absence of myelin assembly can be assessed using crushed or permanently transected adult sciatic nerves of rats. The P0 glycoprotein and the myelin basic protein (MBP) are the major myelin-specific proteins of the peripheral nervous system. The steady-st...

journal_title：Brain research

authors： LeBlanc AC,Poduslo JF,Mezei C

更新日期：1987-04-01 00:00:00