Abstract:
:In the present study, we observed chronological changes of antioxidant-like protein 1 (AOP-1) in the gerbil hippocampal CA1 region after 5 min of transient forebrain ischemia using immunohistochemistry and western blot. AOP-1 was significantly altered in the CA1 region after transient ischemia. In the sham-operated group, AOP-1 immunoreactivity was detected in pyramidal and non-pyramidal cells of the CA1 region. At 30 min after ischemic insult, AOP-1 immunoreactivity and protein level was decreased in the CA1 region. At 12 h after ischemic insult, AOP-1 immunoreactivity and protein level was highest in this region. At this time, after ischemia, AOP-1 immunoreactivity in non-pyramidal cells was high compared to the sham-operated group. Based on double immunofluorescence study, AOP-1-immunoreactive neurons were identified as GABAergic, which were stained with GAD or parvalbumin. Thereafter, AOP-1 immunoreactivity and protein levels were decreased time-dependently. From 4 days after ischemic insult, AOP 1 immunoreactivity was generally expressed in astrocytes. Five days after ischemic insult, AOP-1 immunoreactivity and protein level was increased again to 1.4 folds compared to that of the sham-operated group. In brief, AOP-1 immunoreactivity was increased in GABAergic non-pyramidal cells in the hippocampal CA1 region at early time after ischemic insult and was expressed in astrocytes at late time after ischemia. This result suggests that AOP-1 may be important role in homeostasis of GABAergic neurons because these neurons are resistant to ischemic damage.
journal_name
Brain Resjournal_title
Brain researchauthors
Hwang IK,Hua L,Yoo KY,Kim DW,Kang TC,Choi SY,Won MH,Kim DHdoi
10.1016/j.brainres.2005.09.022subject
Has Abstractpub_date
2005-11-16 00:00:00pages
111-9issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(05)01325-9journal_volume
1062pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The induction of gene expression has been correlated with long-lasting neuronal plasticity and long-term memory (LTM) formation. The fast activation of constitutive transcription factors by signaling mechanisms is thought to be the link between synaptic events and gene expression. However, only one constitutive transc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02358-6
更新日期:2000-02-14 00:00:00
abstract::We examined the in vivo synthesis of brain phosphatidylcholine (PC) by the methylation of phosphatidylethanolamine (PE). [3H-methyl]methionine was infused i.c.v., by indwelling cannula, and brain samples were taken 0.5-18 h thereafter and assayed for [3H]PC, as well as for its biosynthetic intermediates [3H]phosphatid...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90576-2
更新日期:1987-09-01 00:00:00
abstract::The pretectal olivary nucleus of the squirrel monkey was examined in both normal and autoradiographic material. In the Nissl- and fiber-stained tissue the nucleus appears as a laminated structure. The distribution of retinal terminals within the nucleus was examined by the autoradiographic tracing method. These data r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91125-2
更新日期:1981-11-09 00:00:00
abstract::We have already demonstrated that, although exogenous gamma-aminobutyric acidA (GABAA) receptor agonist is capable of inhibiting the activity of luteinizing hormone releasing hormone (LHRH) pulse generator, the reduction in the endogenous GABAA receptor activity does not have a significant effect in ovariectomized rat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90145-7
更新日期:1994-04-04 00:00:00
abstract::Alterations in local cerebral glucose utilization (LCGU) induced by electrical stimulation of the sensory relay nucleus (VPL) or parafascicular nucleus (Pf) of the thalamus in conscious rats were measured by the [14C]2-deoxyglucose method, the objective being to assess the mechanism of analgesia induced by electrical ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90357-x
更新日期:1987-04-07 00:00:00
abstract::Protein kinase C (PKC) activity was measured in rat brain with 2 h of middle cerebral artery (MCA) and common carotid artery (CCA) occlusion, using dual autoradiography of [14C]iodoantipyrine (IAP) and [3H]phorbol-12,13-dibutyrate (PDBu). In the ischemic brain, it required more than 120 min of incubation to obtain a p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01342-x
更新日期:1997-03-07 00:00:00
abstract::Neural plasticity of afferent pain pathways that is induced by prolonged or repeated noxious stimuli may contribute to activate intrinsic inhibitory mechanisms in CNS. In order to clarify the role of the monoaminergic descending inhibitory system in acute nociception and inflammatory pain, we examined if this inhibito...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01086-5
更新日期:1998-12-14 00:00:00
abstract::We have examined the saturation features (Kd and Bmax) of [3H]naloxone binding in rat brain regions in cytoarchitectonically intact tissues of naive, morphine dependent and precipitated withdrawal states using quantitative film autoradiography. Sixty-one saturation experiments in 13 regions of naive rat brains yielded...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91237-5
更新日期:1985-12-23 00:00:00
abstract::Effect of chronic restraint stress on the number of dendritic spines and excrescences of hippocampal CA3 pyramidal neurons has been investigated. The results revealed a significant increase in the number of dendritic spines of apical and basal dendrites in rats subjected to restraint stress (6 h per day for 21 days). ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00822-8
更新日期:1995-10-02 00:00:00
abstract::A highly specific antibody to alpha-melanocyte stimulating hormone (alpha-MSH) was used to histochemically localize and biochemically identify and quantitate alpha-MSH immunoreactivity in nerve fibers and cell bodies of the rat brain. alpha-MSH-like immunoreactivity was contained in fibers throughout the brain. The di...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90873-4
更新日期:1979-10-26 00:00:00
abstract::Glial cell line derived neurotrophic factor (GDNF) is a potent survival factor for several types of neurons. GDNF binds with high affinity to GDNF-family receptor alpha-1 (GFR alpha-1). This receptor is expressed in different areas of the brain, including the hippocampus and dentate gyrus. By using in situ hybridizati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02682-2
更新日期:2000-09-22 00:00:00
abstract:BACKGROUND:Previous studies have shown that regulating the target region by real-time fMRI-based neurofeedback training can influence the activation of other regions and the functional connectivity between them. However, it is not clear whether the training effect of neurofeedback, especially in emotion regulation, is ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146853
更新日期:2020-08-01 00:00:00
abstract::The aim of the current study was to assess modality-specific brain oscillatory responses during cognitive processing. Brain oscillatory ERD/ERS responses of the 4- to 30-Hz EEG frequency bands were examined during lexical decision where the task is to identify whether the presented stimulus is a word or a pseudoword. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.06.100
更新日期:2006-09-19 00:00:00
abstract::The pontine respiratory neurons (PRG) in the 'pneumotaxic centre' have been hypothesized to contribute to phase-switching of neural respiratory activity, especially in terminating inspiration. To define the neural elements involved in phase-switching, we recorded respiratory neurons extra- and intracellularly in anest...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91025-1
更新日期:1994-02-14 00:00:00
abstract::Cajal-Retzius (CR) cells of the mammalian neocortex co-express the extracellular matrix protein Reelin and p73, a transcription factor involved in cell death and survival. Most neocortical CR cells derive from the cortical hem, with minor additional sources. We analyzed the distribution of Reelin and p73 immunoreactiv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.11.015
更新日期:2007-02-09 00:00:00
abstract::Butyrate treatment results in the rapid formation of processes on F98 anaplastic glioma cells. The morphological differentiation occurs more rapidly and to a greater extent than that induced by nerve growth factor (NGF). The incorporation of [3H]thymidine is virtually stopped 1 day after treatment of F98 cells with so...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90109-2
更新日期:1982-09-01 00:00:00
abstract::Male Fischer-344 rats were injected i.p. with diethyldithiocarbamate or dithizone 15 min after kainic acid (KA), s.c. Diethyldithiocarbamate and dithizone reduced both the number of wet dog shakes and the latency to onset of seizures induced by KA. Moreover, they increased the severity of seizures. These compounds may...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91273-j
更新日期:1990-01-08 00:00:00
abstract::Visually identified and electrophysiologically characterized sympathetic preganglionic neurons (SPNs) were recorded using the whole-cell voltage clamp technique in slices of neonatal rat spinal cord. Monosynaptic excitatory postsynaptic currents (EPSCs) were evoked by electrical stimulation of the nucleus intercalatus...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01549-7
更新日期:1998-04-20 00:00:00
abstract::gamma-Aminobutyric acid (GABA), pentobarbital and ethanol were applied by bath superfusion to rat locus coeruleus (LC) neurons in a brain slice preparation. The GABA-induced current and conductance increase was measured with single-electrode voltage clamp. Pentobarbital potentiated the GABA-induced current and conduct...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91044-h
更新日期:1990-05-28 00:00:00
abstract::Heterotopic transplantations of brain vesicles of a quail embryo into a chick embryo were carried out in order to elucidate if CNS anlagen have plasticity in differentiation at the 7-10 somite stage. Quail cells are distinguished from chick cells due to the difference in nuclear morphology. The prosencephalon did not ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90231-y
更新日期:1990-03-12 00:00:00
abstract::Caspases, a family of cysteine proteases, are widely activated in neurons and glia in the injured brain, a response thought to induce apoptosis. However, caspase activation in astrocytes following injury is not strongly associated with apoptosis. The present study investigates the potential role of caspase activation ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.02.056
更新日期:2012-04-23 00:00:00
abstract::How does attention interact with learning? Kruschke [Kruschke, J.K. (2001). Toward a unified Model of Attention in Associative Learning. J. Math. Psychol. 45, 812-863.] proposed a model (EXIT) that captures Mackintosh's [Mackintosh, N.J. (1975). A theory of attention: Variations in the associability of stimuli with re...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2007.06.097
更新日期:2008-04-02 00:00:00
abstract::The present study investigated the neuroprotective potential of two novel polyamine analogues, BU43b and BU36b, when administered 30 min prior to cerebral ischaemia. Neuroprotection in a permanent and a transient focal cerebral ischaemia mouse model (induced by intraluminal middle cerebral artery occlusion (MCAO)) was...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.12.097
更新日期:2006-03-03 00:00:00
abstract::The morphological characteristics, distribution and neurochemical phenotype of striatal neuronal subtypes expressing the GABA(A) receptor alpha3-subunit were investigated using immunocytochemical and immunofluorescent techniques with an antibody specific for this subunit. alpha3-immunopositive neurons were infrequent ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02636-6
更新日期:2000-09-08 00:00:00
abstract::The synaptic connections between frog retinal ganglion cells and tectal neurons were examined by whole-cell recordings in vivo combined with nystatin perforated patch-clamp technique and pulse-triggered averaging analysis. In five tectal neurons, monosynaptic EPSPs from seven R3 retinal ganglion cells were observed. O...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91355-2
更新日期:1994-12-05 00:00:00
abstract::It is known that the execution of the motor response in a simple reaction time (RT) task can be delayed by transcranial magnetic stimulation (TMS). This paper is aimed at determining the site of action where the delay in RT occurs. A delay in RT was obtained only at those TMS sites over the motor cortex contralateral ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01062-1
更新日期:1997-01-02 00:00:00
abstract::The present study sought to determine if axonal connectivity is established between 6-month-old neostriatal transplants and the host substantia nigra. Cell suspensions of fetal neostriatum were transplanted into the adult rat neostriatum lesioned previously by kainic acid. Horseradish peroxidase injections into the ip...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91256-0
更新日期:1989-01-09 00:00:00
abstract::In larval lamprey 4 weeks after a spinal transection locomotor patterns were usually complete along the body in whole animals. In in vitro preparations locomotor activity was restricted to a few millimeters below the transection. Retrograde labeling indicated that descending axons from a few brainstem neurons had grow...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90252-i
更新日期:1993-01-29 00:00:00
abstract::Unilateral visual cortex ablations in neonatal rabbits produced no detectable loss of ganglion cells in the contralateral retina following a survival period of 3, 4 or 8 months. Analysis of neuron size distributions and neuron densities from whole-mounted retinas indicate that transneuronal retrograde degeneration doe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90218-4
更新日期:1985-08-01 00:00:00
abstract::The intermediate, medial part of the hyperstriatum ventrale (IMHV) is an area of the avian forebrain which is essential for two forms of early learning in the domestic chick. We have developed an in vitro slice preparation which contains part of the IMHV and have found that the electrophysiological properties of the a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00361-7
更新日期:1996-07-15 00:00:00