Protein kinase C in focal ischemic rat brain: dual autoradiographic analysis of [14C]iodoantipyrine (IAP) and [3H]phorbol-12,13-dibutyrate (PDBu).

abstract：:Injection of inositol 1,4,5-trisphosphate (InsP3) into dark-adapted Limulus ventral photoreceptors produces a series of discrete bursts of membrane depolarization. Prior injection of aequorin, a luminescent calcium indicator, reveals that the bursts of depolarization are accompanied by individual bursts of intracellul...

journal_title：Brain research

authors： Corson DW,Fein A

更新日期：1987-10-13 00:00:00

abstract：:Temporo-nasal asymmetry in visual responses has been observed in many behavioural studies. These observations have typically been attributed to the anatomical asymmetry of fibres projecting to the Superior Colliculus (SC), even though this attribution is debated. The present study investigates temporo-nasal asymmetry ...

journal_title：Brain research

authors： Bertini C,Leo F,Làdavas E

更新日期：2008-11-25 00:00:00

abstract：:The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is known to be fundamental to the neuronal processes underlying visual orientation and vibrotactile frequency and amplitude discrimination. Previous studies have demonstrated that performance on visual and vibrotactile psychophysics tasks is associated with in...

journal_title：Brain research

authors： Mikkelsen M,Harris AD,Edden RAE,Puts NAJ

更新日期：2018-12-15 00:00:00

abstract：:We examined whether mild brain hypothermia during pretreatment with sublethal 2-min ischemia affected the tolerance to subsequent lethal 5-min ischemia. The neuronal densities in the hippocampal CA1 sector of gerbils preconditioned at mild brain hypothermia (32% of normal) were significantly lower than those in gerbil...

journal_title：Brain research

authors： Wada K,Miyazawa T,Katoh H,Nomura N,Yano A,Shima K,Chigasaki H

更新日期：1997-01-23 00:00:00

abstract：:A disintegrin and metalloproteinase (ADAM) 12 represents a member of a large family of similarly structured multi-domain proteins. In the central nervous system (CNS), ADAM12 has been suggested to play a role in brain development, glioblastoma cell proliferation, and in experimental autoimmune encephalomyelitis. Furth...

journal_title：Brain research

authors： Baertling F,Kokozidou M,Pufe T,Clarner T,Windoffer R,Wruck CJ,Brandenburg LO,Beyer C,Kipp M

更新日期：2010-04-22 00:00:00

abstract：:Recently generated knockout mice with disrupted genes encoding endothelin (ET)-1 showed an elevation of arterial blood pressure (AP) and supplied an evidence for intrinsic ET-1 as one of the physiological regulators of systemic AP. Little is yet known, however, why deficiency of ET-1, which was originally found as a p...

journal_title：Brain research

authors： Ling GY,Cao WH,Onodera M,Ju KH,Kurihara H,Kurihara Y,Yazaki Y,Kumada M,Fukuda Y,Kuwaki T

更新日期：1998-10-19 00:00:00

abstract：:Hypoxia markedly depresses synaptic transmission in hippocampal slices of the rat. This depression is attributed to presynaptic inhibition of glutamate release and is largely mediated by adenosine released during hypoxia acting through presynaptic adenosine A(1) receptors. Paired pulse facilitation studies allowed us ...

journal_title：Brain research

authors： Coelho JE,de Mendonça A,Ribeiro JA

更新日期：2000-06-30 00:00:00

abstract：:The purpose of this study was to determine if motoneurons in the spinal ventral horn express the muscarinic m2 acetylcholine receptor. Motoneurons were retrogradely labelled in adult rats by intramuscular injection of Fluorogold and examined with confocal microscopy for evidence of immunoreactivity for the receptor. T...

journal_title：Brain research

authors： Welton J,Stewart W,Kerr R,Maxwell DJ

更新日期：1999-01-30 00:00:00

abstract：:The stapedius muscle activity associated with vocalization was analyzed in young and adult roosters. Our results show that remarkable differences in the behavior of vocalization-related stapedius muscle activity exist between these two ages. Unlike young roosters, electrical stimulation in the midbrain of adult cocks ...

journal_title：Brain research

authors： Grassi S,Ottaviani F,Bambagioni D

更新日期：1990-10-08 00:00:00

abstract：:Transplantation of fetal substantia nigra into the brain can alleviate some of the manifestations of animal models of Parkinson's disease. The purpose of the present experiment was to determine the optimal embryonic donor age for solid tissue substantia nigra grafts. Rats with unilateral substantia nigra lesions were ...

journal_title：Brain research

authors： Simonds GR,Freed WJ

更新日期：1990-10-15 00:00:00

abstract：:Two myelin sheaths sharing a common outer tongue process are illustrated in a thin section electron micrograph from mouse optic nerve. Although they derive from the same outer tongue process, and therefore from the same oligodendrocyte, the two sheaths are of different thicknesses (6 and 9 turns). The example demonstr...

journal_title：Brain research

authors： Friedrich VL Jr,Mugnaini E

更新日期：1983-09-12 00:00:00

abstract：:Oxidative stress in brain tissue was measured experimentally in situ using microdialysis to sample the extracellular environment for a lipid peroxidation breakdown product and antioxidants. The extracellular concentrations of the lipid peroxidation product malonaldehyde (MDA) and the antioxidants ascorbic acid (AA) an...

journal_title：Brain research

authors： Waterfall AH,Singh G,Fry JR,Marsden CA

更新日期：1996-03-11 00:00:00

abstract：:The effect of five daily intraperitoneal (i.p.) injections of NT69L on in vitro dopamine release, uptake, and [(3)H]NT binding in rat striatal tissue was investigated. NT69L perfusion increased K(+)-evoked and electrically evoked [(3)H]DA release. NT receptor-1 antagonist SR48692 inhibited the stimulatory effect of NT...

journal_title：Brain research

authors： Wang R,Boules M,Tiner W,Richelson E

更新日期：2004-10-29 00:00:00

abstract：:While exercise is commonly recommended for PD patients to improve motor function, little is known about the disease-altering potential of exercise. Although others have demonstrated neuroprotective or neurorestorative effects of exercise in animal models of PD, the majority of these studies utilize young animals. In o...

journal_title：Brain research

authors： Hood RL,Liguore WA,Moore C,Pflibsen L,Meshul CK

更新日期：2016-09-01 00:00:00

abstract：:Long-term exposure to different antidepressant treatments induces increased motor response to central stimulants, due to a selective supersensitivity of dopamine D2 receptors in the limbic areas. Such an effect is accompanied by down-regulation of dopamine D1 receptor number, and by a decreased response of adenylyl cy...

journal_title：Brain research

authors： De Montis MG,Gambarana C,Meloni D,Taddei I,Tagliamonte A

更新日期：1993-03-19 00:00:00

abstract：:Glucose modulates substantia nigra (SN) dopamine (DA) neuronal activity and GABA axon terminal transmitter release by actions on an ATP-sensitive potassium channel (K(ATP)). Here, the effect of altering SN glucose levels on striatal DA release was assessed by placing microdialysis probes into both the SN and striatum ...

journal_title：Brain research

authors： Levin BE

更新日期：2000-08-25 00:00:00

abstract：:Several lines of evidence indicate that psychostimulant withdrawal can induce negative emotional symptoms, such as anhedonia and dysphoria, which may be due in part, to dysfunction of the serotonin (5-HT) system, including alterations in 5-HT receptors. For example, changes in 5-HT(2A) receptor function in prefrontal ...

journal_title：Brain research

authors： Horner KA,Gilbert YE,Noble ES

更新日期：2011-05-16 00:00:00

abstract：:Experiments were conducted to investigate whether or not reciprocal descending commands occur simultaneously in the brain as well as the phasic changes in the agonist facilitation and the antagonist inhibition involved in the initiation of varying forces of ankle dorsiflexion. The H-reflex and reaction time method wer...

journal_title：Brain research

authors： Kasai T,Komiyama T

更新日期：1988-05-03 00:00:00

abstract：:Highly specific antibodies to dynorphin A(1-13), infused into the lateral ventricle, elevated brain stimulation threshold for eliciting feeding behavior. Antibodies to beta-endorphin had little or no effect. Temporal analysis of the anorectic action indicated a striking similarity to the effect of systemically adminis...

journal_title：Brain research

authors： Carr KD,Bak TH,Gioannini TL,Simon EJ

更新日期：1987-10-06 00:00:00

abstract：:Approximately 40-60% of BXSB mice have ectopic cell clusters in layer 1 of neocortex. Prior studies have shown distinct behavioral differences between those with ectopias and their non-ectopic littermates. In this study, female BXSB mice were reared after weaning in either enriched environments or standard cages. Foll...

journal_title：Brain research

authors： Boehm GW,Sherman GF,Hoplight BJ 2nd,Hyde LA,Waters NS,Bradway DM,Galaburda AM,Denenberg VH

更新日期：1996-07-08 00:00:00

abstract：:The startle reflex is an unconditioned, quantifiable behavior used to study sensory modalities. We examined whether the acoustic startle reflex (ASR) was sensitive to lesions induced by focal cerebral ischemia. Sprague-Dawley rats were pre-screened for startle reflex responses 3-6 days prior to surgery and there were ...

journal_title：Brain research

authors： Maynard KI,Sukoff SJ,Ji Z,Wettstein JG,Black MD

更新日期：2005-01-25 00:00:00

abstract：:Cerebellar granule neuronal cultures have been used to study the molecular mechanisms underlying neuronal functions, including neuronal morphogenesis. However, a limitation of this system is the difficulty to analyze isolated neurons because these are required to be maintained at a high density. Therefore, in the pres...

journal_title：Brain research

authors： Kubota K,Seno T,Konishi Y

更新日期：2013-11-20 00:00:00

abstract：:Cortical superfusion with 6-aminomethyl-3-methyl, 1-4H-1,2,6-benzothiadiazine-1,1-diazide hydrocholoride (TAG) at a concentration which selectively blocks taurine (Tau) action fails to modify electroencephalographic (EEG) activity, cortical neuronal firing and caudate-induced inhibition of cortical neuronal activity. ...

journal_title：Brain research

authors： Fariello RG,Golden GT,Ente P

更新日期：1986-08-13 00:00:00

abstract：:The mesencephalic reticular formation (MRF) of cats anesthetized with N2O was stimulated electrically, and the effects of this stimulation on activity in the striate cortex were studied. The variations of intra- and extracellularly recorded unit activity and the changes in the extracellular potassium concentration wer...

journal_title：Brain research

authors： Singer W,Tretter F,Cynader M

更新日期：1976-01-30 00:00:00

abstract：:Secretion and progressive cerebral accumulation of beta-amyloid peptides (Abeta) derived by endoproteolytic ("amyloidogenic") processing of beta-amyloid precursor protein (APP) represent collectively an early and necessary event in the pathogenesis of Alzheimer's disease. We previously demonstrated that secretion of t...

journal_title：Brain research

authors： Sodhi CP,Perez RG,Gottardi-Littell NR

更新日期：2008-03-10 00:00:00

abstract：:Bromodeoxyuridine (BrUdR) injected into Xenopus embryos at stages before, during or after the last period of DNA synthesis in Mauthner's neurons had no serious effect on differentiation of Mauthner's neurons. However, the BrUdR caused widespread cell degeneration in the central nervous system. The action of BrUdR on r...

journal_title：Brain research

authors： Dribin LB,Jacobson M

更新日期：1978-07-21 00:00:00

abstract：:Sleep-suppressive activity of prostaglandin synthesis inhibitors, diclofenac sodium (DF) and indomethacin (IM), was examined in unrestrained male rats. An intraperitoneal injection of 5 mg/kg IM, or an oral administration of 5 mg/kg DF and 10 mg/kg IM at an early phase of the light period transiently decreased slow wa...

journal_title：Brain research

authors： Naito K,Osama H,Ueno R,Hayaishi O,Honda K,Inoué S

更新日期：1988-06-21 00:00:00

abstract：:The normal patterns of the occurrence of tryptophan, 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and monoamine oxidase (MAO) activity in chick brain during development were investigated. Tryptophan level in the brain on the 7th day of embryonic development was rather high and decreased gradually un...

journal_title：Brain research

authors： Suzuki O,Nagase F,Yagi

更新日期：1975-08-15 00:00:00

abstract：:Noxious stimulation of the leg increases hind limb blood flow (HBF) to the ipsilateral side and decreases to the contralateral in rat. Whether or not this asymmetrical response is due to direct control by sympathetic terminals or mediated by other factors such as local metabolism and hormones remains unclear. The aim ...

journal_title：Brain research

authors： Korim WS,McMullan S,Cravo SL,Pilowsky PM

更新日期：2011-05-19 00:00:00

abstract：:The effects of dopamine on glutamate-induced cytotoxicity were examined using the primary cultures of rat striatal neurons. Cell viability was significantly reduced by exposure of cultures to glutamate or kainate for 24 h. In contrast, similar application of N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methy...

journal_title：Brain research

authors： Amano T,Ujihara H,Matsubayashi H,Sasa M,Yokota T,Tamura Y,Akaike A

更新日期：1994-08-29 00:00:00