Abstract：
:The present study investigated the neuroprotective potential of two novel polyamine analogues, BU43b and BU36b, when administered 30 min prior to cerebral ischaemia. Neuroprotection in a permanent and a transient focal cerebral ischaemia mouse model (induced by intraluminal middle cerebral artery occlusion (MCAO)) was investigated using a range of histological and behavioural assessments. In the permanent ischaemia model, BU43b reduced oedema and showed a trend towards reduction in %HLV (percentage hemisphere lesion volume) when administered at a dose of 30 mg/kg i.p. Following transient ischaemia, treatment with BU43b decreased the %HLV and reduced oedema when administered at 30 mg/kg. BU43b also improved the locomotor activity (LMA) in MCAO mice at both 20 mg/kg and 30 mg/kg doses. BU36b was less effective than BU43b in both the permanent and the transient models, with its most pronounced effect being a trend towards reduction in oedema in both models. These results demonstrate that BU43b administered 30 min before ischaemia provided a good level of neuroprotection in the two models of cerebral ischaemia used and may have potential as a neuroprotective treatment for stroke.
journal_name
Brain Resjournal_title
Brain researchauthors
Li J,Henman MC,Atkinson J,Fixon-Owoo S,Tatlisumak T,Shaw GG,Doyle KMdoi
10.1016/j.brainres.2005.12.097subject
Has Abstractpub_date
2006-03-03 00:00:00pages
209-15issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(05)01895-0journal_volume
1076pub_type
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