Abstract：
:The morphological characteristics, distribution and neurochemical phenotype of striatal neuronal subtypes expressing the GABA(A) receptor alpha3-subunit were investigated using immunocytochemical and immunofluorescent techniques with an antibody specific for this subunit. alpha3-immunopositive neurons were infrequent in the rat striatum, but two morphologically different subtypes were observed: Cholinergic neurons, and a second cellular type that may correspond to neurogliaform neurons, although it may also be a novel subtype of striatal interneuron. To identify the second cellular subtype, co-localization of the GABA(A) receptor alpha3-subunit with markers of different classes of striatal interneurons was studied using specific antibodies. It was found that there was a lack of co-localization between all interneuronal markers used in this study and the alpha3-subunit. Although the alpha3-subunit immunopositive neurons represent a small percentage of the total of striatal neuronal populations, they may play an important role in the regulation of the microcircuitry of the striatum.
journal_name
Brain Resjournal_title
Brain researchauthors
Rodríguez-Pallares J,Labandeira-García JL,Muñoz A,Caruncho HJdoi
10.1016/s0006-8993(00)02636-6subject
Has Abstractpub_date
2000-09-08 00:00:00pages
124-30issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02636-6journal_volume
876pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The present report summarizes the results obtained in previous experiments in which the responses to lateral tilt of both reticulocerebellar neurons located in the lateral reticular nucleus (NRL) and ascending spinoreticular tract axons, located in the lateral funiculi of the cervical segments C2-C3, had been recorded...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90112-2
更新日期：1975-09-23 00:00:00
abstract：:We suggested previously that increases in the extracellular [Ca2+] or [Mg2+] lengthen miniature end-plate currents (m.e.p.c.s.) because the divalent cations decrease the negative surface potential on the end-plate, and thereby increase the voltage drop within the membrane. The increased voltage drop would lengthen the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91065-4
更新日期：1982-06-10 00:00:00
abstract：:Mild acute hypertension was induced in rats pharmacologically and non-pharmacologically with metaraminol, angiotensin II or bilateral vagotomy. The extraction fraction of water (Ew) was measured in both hypertensive and normotensive animals. It was demonstrated that cerebral blood flow did not change during hypertensi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91069-2
更新日期：1984-08-13 00:00:00
abstract：BACKGROUND:Toll-like receptor 4 (TLR4) is an important mediator of the innate immune response. It significantly contributes to neuroinflammation and may be involved in ischemic tolerance. It is unknown how cerebral ischemia in the cortex and postconditioning might affect inflammatory reactions in the hippocampus or whe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.005
更新日期：2011-04-12 00:00:00
abstract：:In a single 10-s training trial, hatchling chicks were conditioned to suppress their spontaneous peck response to a small spherical target by coating it with an aversive liquid. A 24-h test trial employing a dry target demonstrated a robust memory for the training manifested in passive avoidance behavior. Leupeptin, a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90763-3
更新日期：1987-03-17 00:00:00
abstract：:Currently there are no uniform standard treatments for newborn suffering from cerebral hypoxia-ischemia (HI) and to find new and effective strategies for treating the HI injury remains a key direction for future research. Present study was designed to demonstrate that optimal dose (1 or 3%) of creatine monohydrate (Cr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.11.017
更新日期：2015-01-21 00:00:00
abstract：:This report examines the effect of decreasing serum osmolality on movement into the ventricular system of fluid and of test material injected into the brain. Trace quantities of 22NaCl and 125I-labeled cat serum albumin (CSA) were injected into cerebral white matter of cats. The rates of cerebrospinal fluid volume flo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90885-5
更新日期：1978-08-04 00:00:00
abstract：:The taste reactivity test described in the preceding paper was used to begin determining the capacity of brain stem structures to execute and regulate ingestive behavior. Both chronic thalamic and chronic decerebrate rat preparations were examined repeatedly, and their gustatory mimetic responses compared through fram...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90569-3
更新日期：1978-03-24 00:00:00
abstract：:Human truncated tau protein is an active constituent of the neurofibrillary degeneration in sporadic Alzheimer's disease. We have shown that modified tau protein, when expressed as a transgene in rats, induced AD characteristic tau cascade consisting of tau hyperphosphorylation, formation of argyrophilic tangles and s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.085
更新日期：2007-01-26 00:00:00
abstract：:MicroRNAs (miRNAs) are short, non-coding RNAs that negatively regulate target gene expression, and play an important role in cerebral ischemic injury. MiR-146a has been reported to be highly related to cell invasion, metastasis, immunity, inflammation and apoptosis. Previous studies have indicated that miR-146a can ei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.034
更新日期：2016-10-01 00:00:00
abstract：:In the adult rabbit, the somatostatin-immunoreactive neurons are seen in all visual cortical layers, with the majority of them being found in layers II-III, V and VI. During postnatal development, we can see labeled cells in layer VI at birth and in layers V and VI on the 3rd day. The labeled cells are seen in layers ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91456-8
更新日期：1985-12-16 00:00:00
abstract：:Motor-related regions of parietal and prefrontal cortices have been shown to selectively activate when observers passively view objects that afford manual grasping. Yet, it remains unknown whether these cortical responses depend on prior motor-related experience with the object being observed. To address this question...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.059
更新日期：2006-06-30 00:00:00
abstract：:Dopamine neurons are overstimulated by drugs of abuse and suffer molecular alterations that lead to addiction behavior. Nurr1 is a transcription factor crucial for dopamine neurons survival and dopamine production, activating the transcription of key genes like tyrosine hydroxylase (TH). Interestingly, nuclear factor-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.09.031
更新日期：2016-12-01 00:00:00
abstract：:Rats treated neonatally with pargyline and 5,7-dihydroxytryptamine (5,7-DHT) have an elevated paCO2 and reduced minute ventilation when given 0.7% halothane in oxygen as adults. Serotonin content in the spinal cord of 5,7-DHT treated rats was undetectable and TRH content was reduced by 35%. The 5,7-DHT treated rats we...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91440-9
更新日期：1984-04-30 00:00:00
abstract：:Rapid eye movement (REM) sleep is hypothesized to result from the activity of REM sleep-generating and REM sleep-inhibiting neurons. The serotoninergic (5-HT) neurons of the dorsal raphe nucleus (DRN) represents one such population of REM-sleep inhibiting neurons since they are silent during REM sleep. Consistent with...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03209-7
更新日期：2001-12-27 00:00:00
abstract：:In humans and many other mammalian species, the behavioural consequences of a cortical lesion tend to be milder when it occurs early in life, and there is evidence that an important factor contributing to the behavioural sparing in the young is the formation of new thalamo-cortical connections by thalamic neurons init...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.063
更新日期：2007-09-05 00:00:00
abstract：:Using the passive avoidance learning task in rats, the role of brain somatostatin in cognitive function was investigated with special reference to that of the brain cholinergic system. In addition, the involvement of both the brain somatostatinergic and cholinergic systems in the anti-amnesic action of a newly introdu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90900-8
更新日期：1994-04-11 00:00:00
abstract：:To provide evidence to support the calcium hypothesis of cerebral ischemia, we examined the effects of extracellular calcium and calcium antagonists (verapamil, flunarizine, nicardipine) on in vitro 'ischemia' using guinea pig hippocampal slices. As a model of in vivo ischemia we used a state of both glucose and oxyge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90242-4
更新日期：1990-08-27 00:00:00
abstract：:In 16-week-old Sprague-Dawley rats lightly anesthetized with pentobarbital, 5-HT (3-96 micrograms/kg, i.v.; n = 6) produced distinct pseudaffective responses and a dose-dependent (slope = 17.2 +/- 6.8 s/log10 dose) inhibition of the tail-flick (TF) reflex (ED50 = 32.6 +/- 9.2 micrograms/kg). In the same rats, a 1:1 co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90749-l
更新日期：1991-10-04 00:00:00
abstract：:The subthalamic nucleus receives serotonergic projections from the dorsal raphe nucleus. However, the role of serotonergic innervation in the activity of subthalamic neurons in vivo is unknown. The aim of the present work is to study the changes in the firing of subthalamic neurons in rats with 5,7-dihydroxytryptamine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.02.052
更新日期：2007-05-29 00:00:00
abstract：:Systemic administration of nicotinic receptor (nAChR) agonists is antinociceptive in models of acute pain whereas their intrathecal (i. t.) administration has been reported to be antinociceptive, nociceptive or without effect. It has been hypothesized that the action induced is dependent upon the subtype and location ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02472-0
更新日期：2000-07-28 00:00:00
abstract：:Microinfusions of the benzodiazepine anxiolytic midazolam into the central or basolateral amygdaloid nuclei produced different anxiolytic effects in two tests of rat 'anxiety'. Infusions into the basolateral nucleus impaired open-arm avoidance in the elevated plus-maze test, but did not impair shock-probe avoidance in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01318-c
更新日期：1995-02-13 00:00:00
abstract：:Anesthetized Sprague-Dawley rats fitted with intracerebroventricular (i.c.v.) cannulas were infused with one of the aminopeptidase inhibitors, amastatin or bestatin, over a 5-min period. After infusion, 1-2 X 10(6) cpm of [125I]angiotensin II ([125I]AII) or [125I]angiotensin III ([125I]AIII) was injected through the s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91279-6
更新日期：1988-05-17 00:00:00
abstract：:The nigrostriatal projection was studied with a retrograde tracing method (Evans blue, EB) combined with a technique for dopamine histofluorescence. The study, realized in control rats and in animals with 6-hydroxydopamine-induced lesions of the dopaminergic pathway, yielded the following results. (1) In 3 control rat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90235-3
更新日期：1981-06-01 00:00:00
abstract：:Oligodendrocytes (OLs), the predominant cell type found in cerebral white matter, are essential for structural integrity and proper neural signaling. Very little is known concerning stroke-induced OL dysfunction. Our laboratory has shown that infusion of human umbilical cord blood (HUCB) cells protects striatal white ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.078
更新日期：2010-12-17 00:00:00
abstract：:A comparative study using membrane homogenate binding, autoradiography, and Western blot assays was carried out to determine the age-related changes in N-methyl-D-aspartate (NMDA) receptors in 4-, 12- and 24-month-old male Wistar rats, treated or not with vitamin E. Vitamin E treatment was 20 mg/kg i.p. daily for 15 d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.008
更新日期：2004-12-03 00:00:00
abstract：:The substance P and Met-enkephalin content were measured in the rat lumbar spinal cord after monolateral section of the sciatic nerve. The proximal stump of the lesioned nerve was either ligated, limiting the formation of neuroma, or sutured intraperitoneally, allowing the formation of a very large neuroma. Both types...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91147-3
更新日期：1985-09-09 00:00:00
abstract：:The nicotine and muscarinic responses of differentiated mouse neuroblastoma cells from the clonal line N1E 115 to applied cholinergic agents were recorded using single channel and whole cell patch clamp techniques. An inward macroscopic current induced by acetylcholine (ACh) at the resting potential was blocked by cur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91252-7
更新日期：1986-11-19 00:00:00
abstract：:Melanotropinergic neurons in the brain may mediate the known modulatory effects of alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropic hormone (ACTH) on brain functions including thermoregulation, pituitary regulation, learning and behavior. To determine the distribution of brain melanotropin rece...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90016-5
更新日期：1990-12-17 00:00:00
abstract：:Although Rolling mouse Nagoya (RMN) has been considered to demonstrate cerebellar dysfunction, our previous metabolic and electrophysiological studies also revealed a dysfunction of the basal ganglia, with the presumable primary site of dysfunction being the striatum. In the present study, we investigated the neuroche...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01577-9
更新日期：1996-04-01 00:00:00
