Abstract：
:Mild acute hypertension was induced in rats pharmacologically and non-pharmacologically with metaraminol, angiotensin II or bilateral vagotomy. The extraction fraction of water (Ew) was measured in both hypertensive and normotensive animals. It was demonstrated that cerebral blood flow did not change during hypertensive states. Under constant flow conditions Ew becomes a direct index of the cerebral capillary permeability to water. Ew was significantly decreased (P less than 0.001) in all brain regions examined in the hypertensive animals as compared to normotensive controls. However, the decrease Ew induced by hypertension was not observed if the animal had previously received bilateral carotid sinus denervation. This observation indicated that the capillary permeability response induced by hypertension is mediated by a neurogenic mechanism involving information transfer from the peripheral baroreceptors in the carotid sinus along afferent connections into the central nervous system.
journal_name
Brain Resjournal_title
Brain researchauthors
Ling RT,Hartman BK,Clark HBdoi
10.1016/0006-8993(84)91069-2subject
Has Abstractpub_date
1984-08-13 00:00:00pages
301-8issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(84)91069-2journal_volume
308pub_type
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