Abstract：
:Motor-related regions of parietal and prefrontal cortices have been shown to selectively activate when observers passively view objects that afford manual grasping. Yet, it remains unknown whether these cortical responses depend on prior motor-related experience with the object being observed. To address this question, we asked participants to undergo fMRI scanning while viewing exemplars of two different categories of graspable objects: one associated with extensive motor experience (door knobs) and one associated with no self-reported motor experience (artificial rock climbing holds). Despite participants' lack of experience grasping climbing holds, these objects were found to generate a systematic response in several visuomotor-related regions of cortex-including left PMv and left AIP. Interestingly, however, the response to door knobs did not include activity in any motor-related regions, being limited instead to a comparatively small bilateral area of lateral occipital cortex, relative to the more spatially extensive response in occipital and temporal cortex that was observed for climbing holds. This result suggested that object-specific responses in both visual- and motor-related cortex may in fact negatively correlate with object-specific motor experience. To test this possibility, we repeated the experiment using participants having extensive self-reported experience grasping climbing holds (i.e., veteran indoor rock climbers). Consistent with our hypothesis, both climbing holds and door knobs generated activity limited to lateral occipital cortex. Taken together, these data support the proposal that repeated real-world motor experience with an object category may lead to reduced implicit analysis in both motor- and visual-related regions of cortex.
journal_name
Brain Resjournal_title
Brain researchauthors
Handy TC,Tipper CM,Schaich Borg J,Grafton ST,Gazzaniga MSdoi
10.1016/j.brainres.2006.04.059subject
Has Abstractpub_date
2006-06-30 00:00:00pages
156-66issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)01097-3journal_volume
1097pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The developmental control of neuroblast proliferation is absolutely required for the assembly and function of the central nervous system. A lethal mutation in trol results in the failure of quiescent neuroblasts to begin division at the appropriate time. I have established a culture system in which quiescent neuroblas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01292-x
更新日期：1999-02-06 00:00:00
abstract：:The effects of dexmedetomidine, a highly selective alpha(2)-adrenoceptor agonist, on extracellular dopamine (DA) concentrations in the nucleus accumbens of awake rats were collected via in vivo cerebral microdialysis and measured using HPLC with electrochemical detection. The administration of dexmedetomidine (DEX) at...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03012-8
更新日期：2001-11-16 00:00:00
abstract：:The effects of unilateral naris closure on the olfactory bulbs of adult mice were assessed quantitatively by measuring four parameters. Naris closures were performed when animals were at least 5 months of age and lasted for 4-8 months. The first parameter measured was mitral cell number, which revealed that there was ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91402-m
更新日期：1991-12-24 00:00:00
abstract：:Medium conditioned by NG108-15 neuroblastoma x glioma hybrid cells contains a factor which increases the number of acetylcholine receptor (AChR) aggregates on cultured myotubes. Protease digestion indicates that the AChR aggregation factor is a protein, and the molecular weight is from 150,000 to 250,000 daltons as es...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90161-x
更新日期：1981-03-30 00:00:00
abstract：:The non-toxic neuronal binding domain of tetanus toxin (tetanus toxin fragment C, TTC) has been used as a vector to enhance delivery of potentially therapeutic proteins to motor neurons from the periphery following an intramuscular injection. The unique binding and transport properties of this 50-kDa polypeptide sugge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.007
更新日期：2004-06-11 00:00:00
abstract：:The radioprotective thiophosphate S-2(3 amino-propyl-amino) phosphorothioic acid (WR 2721) induced an early reduction of striatal acetylcholinesterase activity followed by an increase, when intraperitoneally injected to rats, although it does not cross the blood-brain barrier. These results were obtained using an orig...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90788-o
更新日期：1993-04-09 00:00:00
abstract：:The effect of the non-phenothiazine calmodulin-inhibitor R 24571 on transmitter release at the frog neuromuscular junction has been investigated. MEPP frequency was reduced by 25-40% at low concentrations of the drug (2-5 X 10(-7) M) but increased at higher concentrations. These effects were independent of [Ca2+]o. EP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90379-8
更新日期：1985-11-25 00:00:00
abstract：:Cervical spinal cord hemisection leads to a disruption of bulbospinal innervation of phrenic motoneurons resulting in paralysis of the ipsilateral hemidiaphragm. We have previously demonstrated separate therapeutic roles for theophylline, and more recently serotonin (5-HT) as modulators to phrenic nerve motor recovery...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03097-4
更新日期：2002-11-22 00:00:00
abstract：:Adenosine and its agonists exert a depressant effect on neuronal activity by interacting with the adenosine A1 receptor. There is now also evidence for electrophysiological effects mediated by adenosine receptors other than the A1 type, possibly A2 receptors. A1 and A2 receptor-induced changes in the electrical proper...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91160-3
更新日期：1991-04-12 00:00:00
abstract：:The density of binding sites for excitatory amino acids in the hippocampus of SDAT (senile dementia of the Alzheimer type) patients has been investigated. This was compared to that found in younger and old non-dement cases. In the SDAT hippocampi there was a significant decrease in the glutamate and kainate binding. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90706-8
更新日期：1988-08-09 00:00:00
abstract：:Ischemic stroke brings a huge family and social burden. Although the reperfusion of ischemic cerebral tissue is the most important way to rescue ischemic stroke, ischemia-reperfusion (I/R) injury further results in brain damage and even lead to death. Recent studies demonstrated that Tongxinluo (TXL) helps to protect ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.01.036
更新日期：2018-04-15 00:00:00
abstract：:It has been hypothesized that a disruption of gamma-aminobutyric acid (GABA) receptor-mediated processes may be involved in the pathophysiology of focal epilepsy. This disinhibition hypothesis has been postulated from the results of in vitro experiments of the interictal activity of focal epilepsy. Less is known, howe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02209-5
更新日期：2000-05-26 00:00:00
abstract：:Immobilization of frogs for 1 h induces analgesia which is blocked but not reversed by low doses of naloxone. After 9 days of daily immobilization for 1 h, the treatment fails to cause analgesia thus indicating that tolerance has developed. Animals tolerant to immobilization-induced analgesia do not show cross-toleran...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90073-8
更新日期：1984-04-02 00:00:00
abstract：:Although the role of cAMP-response-element-binding protein (CREB) binding protein (CBP) in the neuroprotective mechanisms has been the focus of many studies, very little is known about the expression or function of CBP in aged brains. We have therefore examined age-related changes in CBP expression in the cerebral cor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03562-x
更新日期：2002-11-29 00:00:00
abstract：:Neurotensin (NT) is a neuropeptide neurotransmitter in the central nervous system. It has been implicated in the therapeutic and in the adverse effects of neuroleptics. Activity of NT in brain can only be shown by direct injection of the peptide into that organ. However, we have developed a novel analog of NT(8-13), N...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02363-x
更新日期：2000-02-21 00:00:00
abstract：:High salt intake is able to evoke neuroendocrine and autonomic responses that include vasopressin release and sympathoexcitation resulting in increasing in the arterial blood pressure (BP). The C1 neurons are a specific population of catecholaminergic neurons located in the RVLM region and they control BP under homeos...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147107
更新日期：2020-12-01 00:00:00
abstract：:We have previously reported that lead (Pb(2+)) exposure results in both presynaptic and postsynaptic changes in developing neurons as a result of inhibition of the N-methyl-d-aspartate receptor (NMDAR). NMDAR inhibition by Pb(2+) during synaptogenesis disrupts downstream trans-synaptic signaling of brain-derived neuro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.12.037
更新日期：2012-02-23 00:00:00
abstract：:SC1 is an extracellular matrix glycoprotein that is related to the multifunctional protein SPARC. These matricellular members play regulatory roles in modulating cellular interactions. SC1 expression is enriched in the central nervous system during embryonic and postnatal development as well as in the adult brain. In ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02270-9
更新日期：2002-03-29 00:00:00
abstract：:Determining the mechanism by which fluorescent retrograde neuronal tracers are taken up requires knowledge of their composition. It has been claimed that Fluoro-Gold, a retrogradely transported fluorescent neuronal tracer, is 2-hydroxy-4,4'-diamidinostilbene (hydroxystilbamidine), an amidine antibiotic. However, this ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90241-m
更新日期：1991-07-05 00:00:00
abstract：:Bilateral quisqualic acid-induced lesions of the nucleus basalis magnocellularis (nbm) in rats disrupted the expression of latent inhibition, a phenomenon thought to be dependent upon selective attention processes. Since grafts of adrenal chromaffin cells to the cerebral cortex of nbm-lesioned rats have been shown to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01364-n
更新日期：1995-02-13 00:00:00
abstract：:During aging, estrogen production and circulating levels of estrogen are markedly decreased in females. Although several differences exist in the process of reproductive aging between women and female rats, the results of many studies suggest that the female rat, especially the middle-aged or aged ovariectomized femal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.11.010
更新日期：2014-01-16 00:00:00
abstract：:In pentobarbitone-anesthetized cats, the spike sequences of dorsal horn neurons were recorded in response to random stimulation of branches of the suralis nerve. Combined frequency- and time-domain analysis was performed on the stimulus and spike trains. Coherence function estimates computed by spectral analysis were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90598-7
更新日期：1988-10-11 00:00:00
abstract：UNLABELLED:This study examines the effects of progesterone on blood-brain barrier (BBB) integrity following thrombin administration. Thrombin is expressed in many diseases which affect neural tissue and is associated with breakdown of the BBB. Progesterone has shown protective effects on the BBB in stroke and traumatic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.04.002
更新日期：2015-07-10 00:00:00
abstract：:Antibodies were raised in rabbits against the neuropeptide N-acetyl-L-aspartyl-L-glutamate (NAAG) coupled to bovine serum albumin via a carbodiimide linkage. One of these rabbit antisera, which preferentially recognizes coupled NAAG-like immunoreactivity (LIR), has been previously used to immunocytochemically localize...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(88)90045-9
更新日期：1988-06-01 00:00:00
abstract：:The prognosis of patients with malignant glioma remains extremely poor despite surgery and improvements in radio- and chemo-therapies. We recently showed that marrow-isolated adult mutilineage inducible (MIAMI) cells, a subpopulation of human mesenchymal stromal cells (MSCs), can serve as cellular carriers of drug-loa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.07.030
更新日期：2012-09-14 00:00:00
abstract：:Acetylcholinesterase (AchE) is an important peripheral membrane-bound enzyme, crucial for cholinergic neurotransmission. Changes in AchE activity, kinetic and thermotropic properties were studied in hepatic encephalopathy (HE) associated with acute liver failure induced experimentally by the administration of the hepa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.02.095
更新日期：2007-06-11 00:00:00
abstract：:Erythropoietin (EPO), a hematopoietic hormonal cytokine induced in response to hypoxia, has neuroprotective effects. EPO receptor (EPOR) is expressed in microglia, resident immune cells in the brain. However, the effect of EPO on microglial activation is not clear. In the present study, we demonstrated that the EPOR i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.02.023
更新日期：2017-05-01 00:00:00
abstract：:The possibility has been mentioned that a change in the structure is responsible for the deviant behavioral activity of gamma-endorphin in extracts of postmortem brain and pituitary gland samples of schizophrenic patients. This paper describes the investigation of this possibility by means of: amino acid composition a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90896-6
更新日期：1986-06-18 00:00:00
abstract：:The organophosphate, diisopropyl fluorophosphate, and the aminoglycoside antibiotic, neomycin, both independently block neuromuscular transmission. At the neuromuscular junction, neomycin reduces the presynaptic release of acetylcholine, whereas diisopropyl fluorophosphate irreversibly inhibits acetylcholinesterase, t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90098-3
更新日期：1986-09-03 00:00:00
abstract：:Our previous studies demonstrated that Austrolebias charrua annual fish is an excellent model to study adult brain cell proliferation and neurogenesis due to the presence of active and fast neurogenesis in several regions during its short lifespan. Our main goal was to identify and localize the cells that compose the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.08.003
更新日期：2017-10-15 00:00:00
