Abstract：
:The effects of unilateral naris closure on the olfactory bulbs of adult mice were assessed quantitatively by measuring four parameters. Naris closures were performed when animals were at least 5 months of age and lasted for 4-8 months. The first parameter measured was mitral cell number, which revealed that there was no significant effect of closure on numbers of these cells. The next parameter measured was the area of the external plexiform layer (EPL). The area of the EPL was 41% smaller in the closed-side olfactory bulbs than in the open-side olfactory bulbs (P less than 0.01). Comparisons of the areas of the granule cell layers (GCL) showed that the closed-side GCL was 25% smaller than the open-side GCL (P less than 0.01). Finally, the number of cells in the open- and closed-side GCLs were compared. The number of cells in the closed-side GCL was 30% lower than the number of cells in the open-side GCL (P less than 0.01). These data show that the shrinkage of closed-side olfactory bulb after naris closure in adult mice is due, at least in part, to the loss of granule cells and not to the loss of the main output neurons, the mitral cells.
journal_name
Brain Resjournal_title
Brain researchauthors
Henegar JR,Maruniak JAdoi
10.1016/0006-8993(91)91402-msubject
Has Abstractpub_date
1991-12-24 00:00:00pages
230-4issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91402-Mjournal_volume
568pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The link between the state of energy balance and reproductive function is well known. Thus, signals denoting negative energy balance and the accompanying hyperphagic drive are likely to be factors in the suppression of gonadotropin releasing hormone (GnRH) activity. We have previously found that appetite-regulating sy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.11.066
更新日期：2005-04-18 00:00:00
abstract：:Na-independent [3H]glutamate binding to rat hippocampal membranes increases progressively as a function of age. The increased binding represents an increased number of binding sites without changes in their apparent affinity for glutamate. However, [3H]glutamate binding, measured with a saturating concentration of cal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90823-4
更新日期：1981-10-26 00:00:00
abstract：:This report deals with a comparison of total and regional cerebral blood flow with red cell velocity in the microcirculation of the ecto- and suprasylvian areas of the cerebral cortex of the cat and their response to changes in systemic blood pressure. Total and regional blood flows were measured during a steady-state...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90912-0
更新日期：1984-08-06 00:00:00
abstract：:Prepro-vasoactive intestinal peptide (prepro-VIP) is processed to at least three biologically active peptides: VIP, peptide histidine isoleucine (PHI) and an extended PHI, peptide histidine valine (PHV). The aim of the present investigation was by chromatography combined with RIA and immunocytochemistry to determine w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91370-6
更新日期：1994-09-05 00:00:00
abstract：:We have applied a technique involving multi-channel linear filtering to the problem of sorting and identifying singly unit neuronal activity in records containing several simultaneously active units. The technique is effective even when the waveforms of two or more nerve impulses are superimposed. We have applied it s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90883-5
更新日期：1975-08-22 00:00:00
abstract：:4-hydroxybenzyl alcohol (4-HBA), one of the major active phenolic constituents of Gastrodia elata Blume, a very important traditional Chinese medicinal herb, has been shown to be an effective agent against the central and peripheral nervous disorders. In this study, we attempted to explore the possible mechanisms unde...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.037
更新日期：2010-01-13 00:00:00
abstract：:We examined whether mild brain hypothermia during pretreatment with sublethal 2-min ischemia affected the tolerance to subsequent lethal 5-min ischemia. The neuronal densities in the hippocampal CA1 sector of gerbils preconditioned at mild brain hypothermia (32% of normal) were significantly lower than those in gerbil...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01139-0
更新日期：1997-01-23 00:00:00
abstract：:Presumptive neurons, immature neurons and degenerating structures were found in the intermediate and deep layers of the superior colliculus of normal cats over the age range 7-45 days postnatal. Electron microscopical analysis revealed these structures to be unexpectedly frequent in the early postnatal period. There w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90013-0
更新日期：1984-05-01 00:00:00
abstract：:Ethanol withdrawal (ETX) after induction of ethanol dependence results in a syndrome that includes enhanced seizure susceptibility. During ETX in rodents, generalized audiogenic seizures (AGS) can be triggered by intense acoustic stimulation. Previous studies have implicated specific brainstem nuclei in the neuronal n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.017
更新日期：2007-04-13 00:00:00
abstract：:Amyloid deposition, a histopathological feature of Alzheimer's disease brain, may be the underlying cause of this disease. The isolation of enzymes involved in both the normal and aberrant or alternative processing of the beta-amyloid precursor protein may lead to an understanding of how beta-protein, the major compon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91279-n
更新日期：1992-09-04 00:00:00
abstract：:Previous studies have clearly shown that the progressive decrease of growth hormone (GH) secretion occurring during ageing is coupled with a reduced responsiveness of pituitary GHRH receptors both in terms of GH secretion and activation of the adenylyl cyclase (AC), in the presence of increased basal values of the enz...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90340-9
更新日期：1994-04-25 00:00:00
abstract：:Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts aimed at understanding the molecular mechanisms governing myelination have primarily focused on rodent models; however, with the advent...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2015.10.011
更新日期：2016-06-15 00:00:00
abstract：:Recent evidence suggest that the blockade of cannabinoid CB1 receptors might be beneficial to alleviate motor inhibition typical of Parkinson's disease (PD). In the present study, we have explored the motor effects of rimonabant, a selective antagonist of CB1 receptors, in a rat model of PD generated by an intracerebr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.014
更新日期：2006-02-16 00:00:00
abstract：:Treated carbon fiber electrodes were used with differential normal pulse voltammetry (DNPV) for in vivo determination of the relative participation of uric acid (UA) to peak 3 derived between 250-300 mV in the dorsal horn of the spinal cord of anesthetized rats. In vitro, treated carbon fiber electrodes respond linear...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90584-1
更新日期：1987-09-01 00:00:00
abstract：:Steps of torque were applied to the human forearm during intentional flexion movements with peak velocities of 40-500 degrees/sec and during ballistically initiated flexion movements. The question asked was whether or not the motor ouput to both agonist and antagonist muscles is independent of sensory input data or is...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90656-x
更新日期：1978-07-07 00:00:00
abstract：:Neovascularization within syngeneic rat fetal neocortical grafts transplanted into a previously prepared cavity in the cerebral cortex was studied 1 to 3 months after transplantation, utilizing scanning electron microscopy of vascular corrosion casts. The grafts were easily identified and the outer surface of the graf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00304-9
更新日期：1995-05-29 00:00:00
abstract：:Combined amylin+leptin (AMN+LEP) can reduce diet induced obesity and is very effective in combating LEP resistance. The purpose of this study was to evaluate the effect of AMN+LEP on central histaminergic signaling in lean and obese rats. Male rats were administered LEP (300 μg/kg/d), AMN (100 μg/kg/d), AMN+LEP or veh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.12.022
更新日期：2012-03-09 00:00:00
abstract：:Sardinian alcohol non-preferring (sNP) rats, selected for their low ethanol preference and consumption, carry a point mutation (R100Q) in the gene coding for GABA(A) receptor alpha(6) subunit, which becomes more sensitive to diazepam-evoked GABA currents. We performed binding studies in the cerebellum of normal (RR) a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04230-0
更新日期：2003-03-28 00:00:00
abstract：:An isoindolin-1-one derivate, JM-1232(-), was recently developed as a sedative and hypnotic agent with a strong affinity for the central benzodiazepine binding site of gamma-aminobutyric acid(A) (GABA(A)) receptors. The purpose of this study was to examine the effects of JM-1232(-) on the cardiovascular and sympatheti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.092
更新日期：2009-12-01 00:00:00
abstract：:The behavioural response following infusion of a novel, stable substance P (SP) analogue, DiMe-C7, into the ventral tegmental area (VTA) of rats was characterized and contrasted with the response to an equal dose of the parent compound SP. DiMe-C7 produced a longer-lasting behavioural stimulation than SP as evidenced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90777-6
更新日期：1982-04-22 00:00:00
abstract：:Pro-social lying, which serves to benefit listeners, is considered more socially and morally acceptable than anti-social lying, which serves to harm listeners. However, it is still unclear whether the neural mechanisms underlying the moral judgment of pro-social lying differ from those underlying the moral judgment of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.02.011
更新日期：2014-03-27 00:00:00
abstract：:A new compound, 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), has been evaluated as an excitatory amino acid receptor antagonist using electrophysiological assays and radioligand binding. In autoradiographic preparations, CPP reduces L-[3H]glutamate binding in regions of the hippocampus rich in N-m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90128-9
更新日期：1986-09-10 00:00:00
abstract：:In anaesthetized, spontaneously breathing cats and dogs, extracellular recordings were made of the spontaneous activities of 28 single neurones with cardiac rhythm. It was confirmed by histological examination that the neurones were situated in the mediodorsal portion of the nucleus of the solitary tract. Different di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90049-x
更新日期：1977-09-09 00:00:00
abstract：:It has been suggested that the mechanism underlying the pain that occurs in patients with diabetic neuropathy may be similar to that mediating sympathetically maintained pain (SMP), such as occurs in patients with reflex sympathetic dystrophy. To evaluate this suggestion we have examined a model of diabetes mellitus, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90206-3
更新日期：1993-07-09 00:00:00
abstract：:In the present immunohistochemical study the distribution of nitric oxide synthase (NOS) was studied in various autonomic ganglia and in related peripheral tissues of the rat. For comparison some other neuronal markers including acetylcholinesterase and tyrosine hydroxylase as well as several neuropeptides were analys...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91483-4
更新日期：1994-09-12 00:00:00
abstract：:In the brain, the neuropeptide cholecystokinin (CCK) appears to be involved in the mediation of stress responses. Here we provide new evidence that mild stress induces long-term changes in CCK-like immunoreactivity (CCK-LI) in the prefrontal cortex (PFC). The changes in CCK-LI show a biphasic pattern, with a decrease ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02648-8
更新日期：2001-07-27 00:00:00
abstract：:The central nervous system of the mollusc Helix pomatia was stimulated with NO donors sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP) or hydroxylamine, in the presence of a phosphodiesterase inhibitor 1-methyl-3-isobutylxanthine (IBMX). Radioimmunoassay revealed that all of the three NO donors signi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01147-5
更新日期：1998-01-12 00:00:00
abstract：:Entopeduncular nucleus (EPN) cells which project to thalamic and non-thalamic sites were identified by antidromic discharge. Each population of cells, projecting to the ventral anterior nucleus of the thalamus (VA), centrum medianum (CM), the lateral habenula (LHB), and the pedunculopontine nucleus (PP), was distribut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90993-9
更新日期：1978-11-17 00:00:00
abstract：:Neonatal hypoxia-ischemia (HI) has been extensively studied in a rat model characterized by unilateral brain damage (Rice-Vannucci Model). However, as well as in humans, each rat brain hemisphere is distinctly involved in cognitive functions, as for example retrieval of emotionally based memory, and neurochemical asym...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02436-3
更新日期：2003-05-30 00:00:00
abstract：:Bismuth (Bi) can produce neurotoxic effects in both humans and animals under certain dosing conditions, but little else is known about the effects of Bi in the brain. In the present study we determined the distribution of Bi in the brains of adult female Swiss-Webster mice 4, 7, 14, 21 and 28 days after a single 2500 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00146-1
更新日期：1996-07-01 00:00:00
