Abstract:
:We have applied a technique involving multi-channel linear filtering to the problem of sorting and identifying singly unit neuronal activity in records containing several simultaneously active units. The technique is effective even when the waveforms of two or more nerve impulses are superimposed. We have applied it successfully to data involving up to 6 units, and in theory it is applicable to substantially more. Current limitations are that the waveform of the impulse from each unit must first be determined by identifying and averaging several isolated examples, and that the number of recording electrodes must approximate the number of units present.
journal_name
Brain Resjournal_title
Brain researchauthors
Roberts WM,Hartline DKdoi
10.1016/0006-8993(75)90883-5subject
Has Abstractpub_date
1975-08-22 00:00:00pages
141-9issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(75)90883-5journal_volume
94pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::After transplantation of autologous sciatic nerve segments into the retina of adult hamsters for 1-2 months, retrograde labelling with horseradish peroxidase demonstrated a population of ganglion cells situated peripheral to the graft. If an additional lesion was placed between the insertion of the graft and the optic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91203-5
更新日期:1986-07-02 00:00:00
abstract::The effects of duloxetine were examined on cloned Kv4.3 channels stably expressed in CHO cells using the whole-cell patch-clamp technique. Duloxetine decreased the peak amplitude of Kv4.3 currents with an acceleration of the decay rate of current inactivation in a concentration-dependent manner. The IC(50) values requ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.05.028
更新日期:2012-07-23 00:00:00
abstract::Many phosphorylated extracellular signal-regulated kinase (pERK)-immunoreactive (IR) cells are expressed in the trigeminal spinal subnucleus caudalis (Vc), upper cervical spinal cord (C1-C2), nucleus tractus solitarii (NTS) and paratrigeminal nucleus (Pa5) after capsaicin injection into the whisker pad (WP), masseter ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.08.032
更新日期:2011-10-12 00:00:00
abstract::Diabetic retinopathy is the leading cause of acquired blindness in working-age individuals. Recent work has revealed that neurodegeneration occurs earlier than vascular insult and that distal optic nerve damage precedes retinal degeneration and vascular insult. Since we have shown that optic nerve degeneration is redu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.07.018
更新日期:2018-12-01 00:00:00
abstract::ACTH4-10, a fragment of the adrenocorticotropic hormone (ACTH) molecule, has marked effects on the compensation process following unilateral labyrinthectomy. In Rana temporaria ACTH4-10-treatment (5-250 micrograms/kg) influences both the acquisition and the maintenance of the compensated state. The compensation proces...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)91158-1
更新日期:1982-09-23 00:00:00
abstract::We investigated the effect of Cerebrospinal Fluid (CSF) from sporadic Amyotrophic Lateral Sclerosis patients (SALS-CSF) on motor neuron-like cells to delineate the pathomechanism of SALS. Exposure of NSC-34 cells to SALS-CSF caused lower viability, reduction in differentiation and enhanced lactate dehydrogenase activi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.01.041
更新日期:2009-03-31 00:00:00
abstract::The substantia nigra pars reticulata (SNr) receives both inhibitory GABAergic and excitatory glutamatergic afferents from diverse origins. Ischemic injury to the striatum and/or the globus pallidus causes delayed transneuronal death of the SNr neurons, in the course of which neuronal disinhibition induced by loss of G...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01052-9
更新日期:1996-12-16 00:00:00
abstract::Ramified microglial cells were investigated in primary cultures of dissociated cerebral cortical tissue from rats. The identification of these cells was confirmed through immunohistochemical staining with 7 monoclonal antibodies selective for microglia. While there was significant variation in staining intensity with ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91118-k
更新日期:1991-05-10 00:00:00
abstract::The objective of this study was to determine whether the aging process influences the changes in the electrophysiological properties of motoneurons that occur as a consequence of axotomy. Accordingly, using intracellular recording and stimulating techniques, the basic electrical properties of control (unaxotomized) an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90594-y
更新日期:1992-01-20 00:00:00
abstract::Nordihydroguaiaretic acid (NDGA) is a powerful antioxidant and/or lipoxygenase (LOX) inhibitor which is isolated from Larrea tridentate. NDGA has been shown to have neuroprotective effects both in vitro and in vivo experiments. However, little is known regarding NDGA's protective mechanism in ischemia/reperfusion (I/R...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.01.031
更新日期:2012-03-22 00:00:00
abstract::EEG recordings of hippocampal theta activity and neocortical activity were correlated with direct observations and photographic recordings of the behaviour of unrestrained cats. The behaviour studied included (1) both spontaneous and induced changes in level of arousal (sleep-wakefulness), (2) different types of orien...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90110-9
更新日期:1975-09-23 00:00:00
abstract::An antagonist to amino acid evoked excitation, gamma-D-glutamylglycine (gamma-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive affe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90798-5
更新日期:1986-08-06 00:00:00
abstract::Experiments were performed in pigeons (Columba livia). Sympathetic preganglionic neurons (SPNs) in the first thoracic spinal cord segment (T1) were identified electrophysiologically using antidromic activation and collision techniques and then intracellularly labeled with horseradish peroxidase (HRP). In 6 of 10 HRP-l...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91024-u
更新日期:1991-02-15 00:00:00
abstract::A large body of evidence shows that methamphetamine (METH) causes sustained damage to the brain in animal models and human METH users. In chronic users there are indications of cognitive and motor deficits. Striatal neuropeptides are in a position to modulate the neurochemical effects of METH and consequently striatal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.03.010
更新日期:2013-05-13 00:00:00
abstract::In recent years microvillar cells (MVC) have been identified in the olfactory epithelium of numerous species, including rodents, canines, and primates. However, there is no consensus on the morphologic or histochemical features of this cell, nor is the function of these cells currently known. Previous studies have exa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01144-7
更新日期:1995-01-09 00:00:00
abstract::Peripheral nerve injury in animals can cause neuropathic pain often expressed in the form of hyperalgesia and allodynia. Spinal nerve ligation, in which the fifth and sixth lumbar (L5 and L6) or only the L5 spinal nerve is ligated and cut, is a model commonly used to produce neuropathic pain. The purpose of the presen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.02.089
更新日期:2008-05-07 00:00:00
abstract::Oxidative stress and massive production of nitric oxide (NO) have been implicated in the neuropathogenesis following peripheral nerve injury. This study was aimed to ascertain whether melatonin would exert its neuroprotective effect on the lesioned hypoglossal neurons after peripheral axotomy, since it is known to red...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02489-6
更新日期:2000-08-11 00:00:00
abstract::The effect of central and peripheral administrations of angiotensin II (AII) on cerebrospinal fluid (CSF) formation was investigated in rabbits anesthetized with intravenous alpha-chloralose and urethane. CSF production was measured by the ventriculo-cisternal perfusion method with Blue dextran 2000 used as an indicat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91027-c
更新日期:1992-10-23 00:00:00
abstract::Cocaine increases dopamine concentration in the nucleus accumbens through competitive binding to the dopamine transporter (DAT). However, it also increases the frequency of dopamine release events, a finding that cannot be explained by action at the DAT alone. Rather, this effect may be mediated by cocaine-induced mod...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.10.022
更新日期:2017-01-15 00:00:00
abstract::The role of bulbospinal neuropeptide Y (NPY)-containing neurons of the rostral ventrolateral medulla in the rabbit in mediating the increase in blood pressure that occurs during inhibition of cells in the caudal ventrolateral medulla was investigated in urethane-anaesthetized rabbits. In the present experiments bilate...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91261-3
更新日期:1987-09-15 00:00:00
abstract::Repeating a stimulus generally leads to a decreased response in neural activity compared to that for novel items. This neural attenuation provides a marker for stimulus-specific perceptual encoding and memory that can be detected using functional magnetic resonance imaging (fMRI). Although previously assumed to occur ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.01.090
更新日期:2006-03-29 00:00:00
abstract::The distribution of antidiabetic sulfonylurea [( 3H]glibenclamide) binding sites is heterogeneous in rat brain. Pyramidal and extrapyramidal motor system contain the highest densities of sites, particularly in the substantia nigra and in the globus pallidus. Only low levels are present in the hypothalamic nuclei and t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91288-2
更新日期:1989-05-01 00:00:00
abstract::The postnatal development of soma size and cytochrome oxidase activity was examined in the perigeniculate nucleus (PGN) and reticular nucleus of the thalamus (RNT). Neurons in the PGN and RNT exhibited a rapid increase in soma size between 2 and 4 weeks of age. During this period of cell growth there is an increase in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90047-2
更新日期:1987-10-01 00:00:00
abstract::Until recently, the bulk of research on the human reward system was focused on studying the dopaminergic and opioid neurotransmitter systems. However, extending the initial data from animal studies on reward, recent pharmacological brain imaging studies on human participants bring a new line of evidence on the key rol...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2014.02.003
更新日期:2014-03-27 00:00:00
abstract::Extracellular ATP can influence cells via activation of P2X purinoceptors, the distribution of which can be altered in the central and peripheral nervous systems following injury or tissue damage. Here we have investigated the effect of a unilateral section of the cervical vagus nerve on the distribution of P2X(1), P2...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02797-5
更新日期:2003-07-04 00:00:00
abstract::Data are presented which show that background electric activity of the human brain is reduced by visual stimulation. Occipital EEG amplitude decreases 5-15% for all frequencies analyzed (0.2-40 Hz) upon pattern stimulation. The reduction is stimulus-specific, i.e. is the strongest for stimuli that activate a large num...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90403-i
更新日期:1991-05-31 00:00:00
abstract::The effect of 4-aminopyridine (4-AP) on the release of labeled transmitters in mouse brain synaptosomes was studied in a superfusion system. 4-AP at microM concentrations notably stimulated the spontaneous release of labeled GABA and glutamate, and of acetylcholine (ACh) derived from tritiated choline. No effects on t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90423-1
更新日期:1982-11-04 00:00:00
abstract::Immunolabelling for synaptophysin and chromogranin A, two polypeptides associated with small clear and large dense core synaptic vesicles respectively, has been performed on tissue sections of the temporal cortex in Alzheimer's disease in combination with anti-A4 amyloid labelling. The dystrophic neurites in many seni...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90697-t
更新日期:1991-01-18 00:00:00
abstract::Quantitative morphological changes in the superior colliculus (SC) and the parabigeminal nucleus (PB) were studied in hereditary bilaterally microphthalmic rat, which lacks the optic nerve completely. Volumes of the retinorecipient superficial collicular layers of SC (SCS) to the central gray matter were decreased by ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90012-4
更新日期:1985-11-01 00:00:00
abstract::The substance P and Met-enkephalin content were measured in the rat lumbar spinal cord after monolateral section of the sciatic nerve. The proximal stump of the lesioned nerve was either ligated, limiting the formation of neuroma, or sutured intraperitoneally, allowing the formation of a very large neuroma. Both types...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91147-3
更新日期:1985-09-09 00:00:00