First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist.

Abstract:

:An antagonist to amino acid evoked excitation, gamma-D-glutamylglycine (gamma-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesic drugs.

journal_name

Brain Res

journal_title

Brain research

authors

Schouenborg J,Sjölund BH

doi

10.1016/0006-8993(86)90798-5

subject

Has Abstract

pub_date

1986-08-06 00:00:00

pages

394-8

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(86)90798-5

journal_volume

379

pub_type

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