Abstract：
:The locus coeruleus was stimulated in 62 cats in order to investigate the effect on cephalic blood flow and cephalic vascular resistance. Flow was measured by electromagnetic flow probes applied to the common carotid artery. Stimulation over a range of frequencies (0.2-200 s-1) produced a frequency-dependent fall in carotid vascular resistance, greater on the ipsilateral side. This response was not affected by either cervical sympathectomy or spinal cord section. The response was blocked by bilateral section of the facial nerve but was not abolished by classical cholinergic, histaminergic or adrenergic blocking agents. Stimulation of the locus coeruleus also resulted in a pressor response through spinal mechanisms in which coeruleo-hypothalamic projections were not involved. A post-stimulation constriction in the carotid vasculature followed the dilator response and was attributed to release of catecholamines from the adrenal medulla.
journal_name
Brain Resjournal_title
Brain researchauthors
Goadsby PJ,Lambert GA,Lance JWdoi
10.1016/0006-8993(83)90236-6subject
Has Abstractpub_date
1983-11-14 00:00:00pages
175-83issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(83)90236-6journal_volume
278pub_type
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