Up-regulation of calretinin in the supraoptic nucleus of the rat after chronic salt loading.

abstract：:Calcium accumulation and neuronal injury of rat cortical cell cultures in vitro were examined following oxygen deprivation under conditions of normal and low glucose. 45Ca2+ uptake and lactate dehydrogenase (LDH) release, measured at 12 and 24 h after oxygen deprivation, were significantly elevated in cultures exposed...

journal_title：Brain research

authors： Birrell GJ,Marcoux FW

更新日期：1993-04-02 00:00:00

abstract：:Amphetamine releases dopamine through a transporter-mediated mechanism. The purpose of this report was to further our understanding of the intracellular pool from which amphetamine releases dopamine: the cytoplasmic pool, the vesicular pool, or both. Rats were treated with D-amphetamine (AMPH) (1.0 or 10.0 mg/kg) or a...

journal_title：Brain research

authors： Sabol KE,Seiden LS

更新日期：1998-09-21 00:00:00

abstract：:L-3, 4-Dihydroxyphenylalanine (L-dopa) has been widely used for the treatment of Parkinson's disease (PD), but its pharmacokinetics in the striatum have hardly been investigated, especially in primates. In this study, we examined the concentration of L-dopa in plasma and in the extracellular fluid (ECF) of the striatu...

journal_title：Brain research

authors： Zhang J,Qu FR,Nakatsuka A,Nomura T,Nagai M,Nomoto M

更新日期：2003-12-12 00:00:00

abstract：:Dopamine-containing amacrine cells of rhesus monkey were found everywhere outside of the foveola in whole, flat retinas by the formaldehyde-glutaraldehyde fluorescent method. There were about 7500 such cells in a single retina and their density, determined by cell counts and measured by a nearest neighbor method, was ...

journal_title：Brain research

authors： Mariani AP,Kolb H,Nelson R

更新日期：1984-11-19 00:00:00

abstract：:Tacrolimus (FK506), a potent immunosuppressive drug, is effective in attenuating brain infarction after cerebral ischemia. However, there has been no report characterizing the neuroprotective action and therapeutic time window of tacrolimus systematically using different types of stroke models and extended observation...

journal_title：Brain research

authors： Furuichi Y,Katsuta K,Maeda M,Ueyama N,Moriguchi A,Matsuoka N,Goto T,Yanagihara T

更新日期：2003-03-07 00:00:00

abstract：:In this report, using a push-pull perfusion technique, we examined in vivo the effects of exogenous dopamine (DA) on the output of neurochemical substances from the caudate nucleus (CN) of freely behaving rats. Exogenous DA, at concentrations of 10(-5) M, 5 x 10(-5) M and 10(-4) M, in modified Krebs-Ringer phosphate m...

journal_title：Brain research

authors： Chang GD,Ramirez VD

更新日期：1989-03-06 00:00:00

abstract：:NO (nitric oxide) produced in limbic brain regions has important roles in the regulation of autonomic nervous system and HPA axis activity, anxiety, fear learning, long-term memory formation, and depression. NO is synthesized from l-arginine in a reaction catalyzed by nitric oxide synthase (NOS). Neuronal nitric oxide...

journal_title：Brain research

authors： Keser A,Balkan B,Gozen O,Kanit L,Pogun S

更新日期：2011-01-12 00:00:00

abstract：:Heterotopic transplantations of brain vesicles of a quail embryo into a chick embryo were carried out in order to elucidate if CNS anlagen have plasticity in differentiation at the 7-10 somite stage. Quail cells are distinguished from chick cells due to the difference in nuclear morphology. The prosencephalon did not ...

journal_title：Brain research

authors： Nakamura H

更新日期：1990-03-12 00:00:00

abstract：:Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and e...

journal_title：Brain research

authors： Read SJ,Parsons AA

更新日期：2000-07-07 00:00:00

abstract：:Preconditioning-induced cellular adaptation is a new therapeutic strategy for ischemic stroke. This research aims to examine the role of peroxisome proliferator activated receptor (PPAR)-γ co-activator 1-α (PGC-1α) and hypoxia induced factor-1α (HIF-1α) in hypoxic preconditioning-induced protection. In this study, rat...

journal_title：Brain research

authors： Zhao J,Li L,Pei Z,Li C,Wei H,Zhang B,Peng Y,Wang Y,Tao Y,Huang R

更新日期：2012-04-04 00:00:00

abstract：:Maternal cigarette use during pregnancy is associated with increased incidence of neural impairments in offspring, but nicotine's unique contribution to any neuropathology remains unclear, and nicotine's neurodevelopmental effects assessed in animal models vary with concentration. During ontogenesis, the chick oculomo...

journal_title：Brain research

authors： Wielgus JJ,Corbin Downey L,Ewald KW,Hatley ME,Wilson KC,Yeilding RH

更新日期：2004-03-12 00:00:00

abstract：:Locations of cells responsive to microiontophoretically applied angiotensin II (AII) were compared to distributions of AII receptor binding sites identified by autoradiography in the lumbar enlargement region of the rat spinal cord. Angiotensin II receptor binding sites were densely concentrated in the superficial lay...

journal_title：Brain research

authors： White SR,Penner JD,Speth RC,Chan JY

更新日期：1988-02-16 00:00:00

abstract：:The cell-mediated inflammatory component of experimental autoimmune encephalomyelitis (EAE) in mice is measured by the radioisotopic technique. Mice are challenged with autologous spinal cord homogenate in Freund's complete adjuvant and at various time intervals after such immunization given [125I]5-iodo-2'-deoxyuridi...

journal_title：Brain research

authors： Linthicum DS,Horvath L,Carnegie PR

更新日期：1979-10-05 00:00:00

abstract：:Blockade of gamma-aminobutyric acid (GABA) function in the posterior hypothalamus of rats elicits a pattern of physiological and behavioral arousal consisting of increases in heart rate, respiration and blood pressure as well as intense locomotor stimulation and a selective enhancement of avoidance responding. The pre...

journal_title：Brain research

authors： Shekhar A,Hingtgen JN,DiMicco JA

更新日期：1990-03-26 00:00:00

abstract：:A carbohydrate epitope on adhesion proteins of the developing nervous system, and on myelin-associated glycoprotein, is recognized by the monoclonal antibody HNK-1. The HNK-1 epitope bearing proteins and the monoclonal antibody alter, in a dose-dependent manner, the interaction between neurons and neurite-promoting su...

journal_title：Brain research

authors： Riopelle RJ,McGarry RC,Roder JC

更新日期：1986-03-05 00:00:00

abstract：:Chronic administration of guanethidine to adult rats induces a selective autoimmune adrenergic neuropathy. Physiological and biochemical features of this disorder in the peripheral nervous system were explored in young adult Sprague-Dawley rats given daily intraperitoneal guanethidine monosulfate for 5 weeks. Control ...

journal_title：Brain research

authors： Zochodne DW,Ward KK,Low PA

更新日期：1988-09-27 00:00:00

abstract：:We have used magnetic resonance imaging (MRI) of the living rat brain to longitudinally analyze the ontogenesis of an ibotenic acid lesion targeted at the piriform cortex. The MRI data were systematically compared with data obtained from a battery of histopathological techniques, including Nissl stain, hematoxylin sta...

journal_title：Brain research

authors： Ben-Horin N,Hazvi S,Bendel P,Schul R

更新日期：1996-04-29 00:00:00

abstract：:Common marmosets were given a subcutaneous injection of MPTP (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. The parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine a...

journal_title：Brain research

authors： Pérez-Otaño I,Herrero MT,Oset C,De Ceballos ML,Luquin MR,Obeso JA,Del Río J

更新日期：1991-12-13 00:00:00

abstract：:Arachidonic acid metabolism in primary cultures of astroglial cells prepared from cerebra of rat embryos was examined. Arachidonic acid was mainly metabolized through the lipoxygenase pathway and the major metabolites formed were 12-hydroxyeicosatetraenoic acid (12-HETE), 11-HETE and 15-HETE. By contrast, in C6 cells,...

journal_title：Brain research

authors： Ishizaki Y,Morita I,Murota S

更新日期：1989-08-07 00:00:00

abstract：:Human seizure disorders represent a heterogeneous collection of neuropathies, many of which are poorly understood. To investigate the etiology of seizure disorders, we have used a group of Drosophila mutants known as the bang-sensitive (BS) paralytics. The BS mutants exhibit seizure-like activity (SLA) following a wid...

journal_title：Brain research

authors： Whelan J,Burke B,Rice A,Tong M,Kuebler D

更新日期：2010-02-26 00:00:00

abstract：:In the present study fast axonal transport was examined in streptozotocin rats with 4 weeks duration in diabetes. Tritiated leucine and 14C-labelled glucosamine were injected into the fifth lumbar ganglion and TCA-soluble as well as insoluble activity were measured in segments of the sciatic nerve at various time inte...

journal_title：Brain research

authors： Sidenius P,Jakobsen J

更新日期：1979-09-14 00:00:00

abstract：:The nictitating membrane response to periocular electrostimulation was investigated in anesthetized and paralyzed rabbits. Recordings from the abducens nerve, which carries the fibers innervating retractor bulbi muscles that are primarily involved in this reflex, showed two distinct volleys to effective stimulation: a...

journal_title：Brain research

authors： Berthier NE,Moore JW

更新日期：1983-01-10 00:00:00

abstract：:These studies examined whether posttraining activation of alpha1-noradrenergic receptors in the nucleus tractus solitarius (NTS) influences neural processes that are involved in encoding information into memory. Different groups of male Sprague-Dawley rats were trained in two separate learning tasks. In experiment 1, ...

journal_title：Brain research

authors： Miyashita T,Williams CL

更新日期：2003-10-17 00:00:00

abstract：:Using the passive avoidance learning task in rats, the role of brain somatostatin in cognitive function was investigated with special reference to that of the brain cholinergic system. In addition, the involvement of both the brain somatostatinergic and cholinergic systems in the anti-amnesic action of a newly introdu...

journal_title：Brain research

authors： Matsuoka N,Maeda N,Yamaguchi I,Satoh M

更新日期：1994-04-11 00:00:00

abstract：:Serum-free aggregating cell cultures of fetal rat telencephalon grown in the presence of 3 ng/ml (5 X 10(-10) M) epidermal growth factor (EGF) until day 12 showed 2- to 3-fold increased activities in the two glial enzymes, glutamine synthetase (GLU-S) and 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase). This effe...

journal_title：Brain research

authors： Honegger P,Guentert-Lauber B

更新日期：1983-12-01 00:00:00

abstract：:Release of Ca(2+) from intracellular Ca(2+) stores (ICS) is involved in age-related changes in the induction of long-term potentiation. However, the role of this Ca(2+) source for the increased susceptibility to long-term depression (LTD) with advanced age is unknown. Extracellular excitatory postsynaptic field potent...

journal_title：Brain research

authors： Kumar A,Foster TC

更新日期：2005-01-07 00:00:00

abstract：:Chronic neuropathic pain has demonstrated that coexisting psychiatric disorders are associated with disability and poorer treatment outcomes. Hyperpolarization-activated cyclic nucleotide-gated (HCN, Ih) channels play a major role in pain via hyperexcitability and facilitation of ectopic firing in neurons. Neuronal hy...

journal_title：Brain research

authors： Yang L,Liu X,Yao K,Sun Y,Jiang F,Yan H,Mao P,Fan S,Wei X,Liu Y,Yuan W,Zhang S

更新日期：2019-08-15 00:00:00

abstract：:A water soluble benzodiazepine, clorazepate, has been used to establish the point of benzodiazepine proliferative arrest in the rat C6 glioma. Clorazepate inhibited C6 proliferation in a dose-dependent manner with an IC50 value of 280 microM, as judged by a nuclei counting procedure. Release of cells from a 48 h expos...

journal_title：Brain research

authors： Maguire C,O'Connell C,Regan CM

更新日期：1992-09-11 00:00:00

abstract：:Intracellular recordings from locus coeruleus neurons grown in explant cultures reveal age-related differences in the responses to iontophoretically applied noradrenaline. Cells grown in culture for more than 26 days exhibit a simple hyperpolarizing response while cells cultured for less than 26 days often have biphas...

journal_title：Brain research

authors： Finlayson PG,Marshall KC

更新日期：1986-03-01 00:00:00

abstract：:The compound m-chlorophenylpiperazine (m-CPP) is used clinically to manipulate serotonergic function, though its precise mechanisms of actions are not well understood. m-CPP alters synaptic transmission and neuronal function in vertebrates by non-selective agonistic actions on 5-HT(1) and 5-HT(2) receptors. In this st...

journal_title：Brain research

authors： Sparks GM,Brailoiu E,Brailoiu GC,Dun NJ,Tabor J,Cooper RL

更新日期：2003-04-18 00:00:00