Abstract:
:NO (nitric oxide) produced in limbic brain regions has important roles in the regulation of autonomic nervous system and HPA axis activity, anxiety, fear learning, long-term memory formation, and depression. NO is synthesized from l-arginine in a reaction catalyzed by nitric oxide synthase (NOS). Neuronal nitric oxide synthase (nNOS), one of the three isoforms of NOS, is synthesized constitutively in nerve cells. Increasing evidence indicates that nNOS expression in the nervous system may be regulated by stress and nicotinic receptors. Furthermore, data obtained from several studies suggest that signaling pathways induced by stress and nicotinic receptors may converge on various signal transduction molecules to regulate nNOS expression in brain. In the present study, we used Western Blot analysis to test the effect of forced swim stress, chronic nicotine administration, and the combined effect of both procedures on nNOS expression in the hippocampus, amygdala and frontal cortex of the male and female rat brain. Basal nNOS levels of the three brain regions examined did not show sex differences. However, forced swim stress and chronic nicotine administration increased nNOS expression in the hippocampus of female rats. When stress and nicotine were applied together, no additional increment was observed. Stress and nicotine did not regulate nNOS expression in the amygdala and the frontal cortex of either sex. Data obtained from the present study indicate that the regulation of stress and nicotine induced-nNOS expression in rat hippocampus shows sexual dimorphism and nNOS expression in the female rat hippocampus increases by nicotine and stress.
journal_name
Brain Resjournal_title
Brain researchauthors
Keser A,Balkan B,Gozen O,Kanit L,Pogun Sdoi
10.1016/j.brainres.2010.10.090subject
Has Abstractpub_date
2011-01-12 00:00:00pages
134-42eissn
0006-8993issn
1872-6240pii
S0006-8993(10)02433-9journal_volume
1368pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The present experiments were designed to assess whether brain hypothermia can reduce the behavioral and histopathological deficits associated with global forebrain ischemia. Animals were subjected to 12.5 min of four vessel occlusion (4VO) with moderate hypotension, and brain temperature maintained at either 37 degree...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90945-6
更新日期:1992-05-15 00:00:00
abstract::Previous studies employing systemic administration of the dopamine agonist apomorphine have shown that the dose response curves for apomorphine's effects on penile reflexes and seminal emission differ, suggesting that experimentally separable populations of dopamine receptors regulate these two responses. The present ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90328-4
更新日期:1989-10-23 00:00:00
abstract::Previous studies have reported that high concentrations of homocysteine and lower concentrations of vitamins B6, B12, and folate increase the risk for cognitive decline and pathology in aging populations. In this cross-sectional study, high resolution magnetic resonance imaging (MRI) scans and a 3-day food diary were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.030
更新日期:2008-03-14 00:00:00
abstract::Three groups of rats, one with amygdala lesions, one with hippocampal lesions and a control group were trained on a brightness discrimination task under one of three different conditions, enhancement of the negative cue, enhancement of the positive cue or a non-enhanced condition. Animals with amygdala lesions showed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90621-7
更新日期:1977-04-15 00:00:00
abstract::Female rats were subjected to unilateral left or right, bilateral, or sham ablation of the cerebral cortex. Eight weeks after surgery, the rats were sacrificed by decapitation and spleen cells were grown in culture for 96 h in the presence or absence of the T-cell mitogen concanavalin A or the B-cell mitogen lipopolys...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90042-5
更新日期:1989-03-27 00:00:00
abstract::Our previous study [32] indicated that blockade of kappa-opioid receptors with nor-binaltorphimine (nor-BNI) in the medial preoptic area (MPOA) produced two different LH responses during midpregnancy in the rat: an increase in basal pulsatile LH secretion, followed in many cases by a larger and/or sustained increase i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00874-p
更新日期:1995-11-06 00:00:00
abstract::Putative serotonergic dorsal raphe (DRN) neurons display a dramatic state-related change in behaviour, discharging regularly at a high rate during waking and at progressively slower rates during slow-wave sleep (SWS) and ceasing firing during paradoxical sleep (PS). Using the antidromic latency technique and extracell...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02210-7
更新日期:2001-04-20 00:00:00
abstract::Cytosolic enzymes AMP deaminase and adenosine deaminase (ADA) catalyze AMP and adenosine deamination, constitute rate-limiting steps of adenine nucleotide catabolism and play important roles in cellular energy metabolism. In this study, AMP deaminase and ADA activities of rat liver, neocortex, cerebellum, striatum and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.10.073
更新日期:2010-01-22 00:00:00
abstract::Vanadate (VO-3), an essential trace element with insulin-mimetic actions, produces systemic hyperglycemia following central administration in mice. The hyperglycemic effect is due to specific action of vanadate or its reduced form, vanadyl (VO2+); other ions of similar atomic weight (Cr, Mn) or structure (phosphate) h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90615-9
更新日期:1987-09-01 00:00:00
abstract::Fluoxetine is widely used for the treatment of depression. We examined the action of fluoxetine on cloned Kv4.3 stably expressed in CHO cells using the whole-cell patch-clamp technique. Fluoxetine did not significantly produce a reduction in the peak amplitude of Kv4.3, but increased the rate of current inactivation i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.01.028
更新日期:2013-03-15 00:00:00
abstract::Peripheral nerve injury induces changes in gene expressions of a variety of neuroactive substances in cell somata, which may have roles in the adaptive response to the injury, neuronal survival, growth and regeneration. In this study, we designed a rat model of ischemic peripheral facial paralysis with a selective emb...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03319-9
更新日期:2001-03-02 00:00:00
abstract::We employed a highly sensitive combination method of retrograde tracing and immunohistochemistry to identify calcitonin gene-related peptide (CGRP)-containing fiber pathways in the rat from the ventrolateral part of the ventrolateral thalamic nucleus (vl-vl) and the caudal continuation to the insular cortex. Biotin-wh...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91211-9
更新日期:1985-09-30 00:00:00
abstract::Emotional events are preferentially retained in episodic memory. This effect is commonly attributed to enhanced consolidation and has been linked specifically to rapid eye movement (REM) sleep physiology. While several studies have demonstrated an enhancing effect of REM sleep on emotional item memory, it has not been...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.06.020
更新日期:2018-11-01 00:00:00
abstract::Adenylate cyclase activity accumulated proximal to a constriction placed around the frog sciatic nerve. The rate of accumulation was linear between 8 and 24 h following placement of the constriction; accumulation rate declined substantially after 24 h. Accumulation of activity distal to the constriction in normal nerv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90284-0
更新日期:1982-01-28 00:00:00
abstract::Whole-cell patch recordings of neurons in the rostral (gustatory) nucleus tractus solitarius (rNTS) were performed in a brain slice preparation from rat medulla. Neural responses to brief applications (10-45 s) of substance P (SP), via a constant superfusion apparatus, were recorded. SP transiently depolarized 80 of 1...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91603-p
更新日期:1993-08-13 00:00:00
abstract::Recently, this laboratory provided evidence that interleukin-1beta (IL-1beta), an immune and brain-derived cytokine, microinjected into the medial hypothalamus, potentiates defensive rage behavior in the cat elicited from the midbrain periaqueductal gray (PAG), and that such effects are blocked by a 5-HT2 receptor ant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.04.086
更新日期:2005-06-28 00:00:00
abstract::The anatomical distribution of L-[3H]glutamate binding sites was determined in the presence of various glutamate analogues using quantitative autoradiography. The binding of L-[3H]glutamate is accounted for by the presence of 3 distinct binding sites when measured in the absence of Ca2+, Cl- and Na+ ions. The anatomic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90936-9
更新日期:1985-08-12 00:00:00
abstract::Radioligand-binding studies were performed to ascertain the actions of noribogaine, a suspected metabolite of ibogaine, on opioid receptors. Consistent with previous results, ibogaine showed highest affinity for kappa opioid receptors (Ki = 3.77 +/- 0.81 microM), less affinity for mu receptors (Ki = 11.04 +/- 0.66 mic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00123-8
更新日期:1995-03-27 00:00:00
abstract::The responses of single alpha motoneurons to various "natural' stimuli were recorded from dissected ventral root filaments in lightly anesthetized control and recently decerebellate cats. The identity of the motoneurons was established by recording the unitary responses to orthodromic stimulation of nerves innervating...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90208-5
更新日期:1975-09-12 00:00:00
abstract::In neonates, ventilatory responses to hypoxia are 'biphasic,' with an augmentation followed by a decline. The hypoxia-induced augmentations in ventilation are attenuated and the depressions are accentuated following denervation of the peripheral chemoreceptors. Piglets that were decerebrated at a rostral mesencephalic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01310-9
更新日期:1999-02-20 00:00:00
abstract::Immunohistochemical studies in rats have demonstrated dopaminergic input onto medium spiny neurons of the striatum. Medium spiny neurons, however, are known to consist of two major neuropeptide-specific types, those containing substance P (SP) and those containing enkephalin. Although both of these types have been sho...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90490-z
更新日期:1992-02-14 00:00:00
abstract::We studied seizures which were induced by a microinjection of kainic acid (KA) into the unilateral olfactory bulb (OB) in the rats. The first epileptiform discharge appeared in the OB, was then propagated to the amygdala and the hippocampus unilaterally, and finally propagated to the unilateral sensori-motor cortex. C...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00626-2
更新日期:1995-09-25 00:00:00
abstract::With the use of [3H]p-aminoclonidine (PAC), alpha 2-adrenergic binding sites were mapped in the brain of the Japanese quail (Coturnix coturnix japonica). The sites were labeled with the use of in vitro quantitative autoradiography. Special attention was given to areas implicated in the control of sexually dimorphic re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90088-7
更新日期:1989-07-03 00:00:00
abstract::The cisternal spinal fluid (CF), plasma, and brain stem concentrations of 6 amino acids were measured in suckling rats between birth and one months of age. Each of the amino acids studied had its distinctive maturational pattern of CF concentration. Presumably these amino acids have separate mechanisms of transport fr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90098-1
更新日期:1977-01-01 00:00:00
abstract::Effects of lateral vestibular nucleus (LVN) stimulation on neuronal activity in the rat lateral hypothalamic area (LHA), including specific glucose-sensitive neurons, were investigated by extracellular and intracellular recordings in vivo. Stimulation of the contralateral LVN evoked 3 types of response in 46% (111/240...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90653-6
更新日期:1987-01-01 00:00:00
abstract::In the present study, we report the localization of the Rev-ErbA alpha and beta nuclear orphan receptors, two closely related members of the nuclear hormone receptor superfamily, in the brain. Both Rev-ErbA variant mRNAs were highly expressed in the olfactory bulb, the hippocampus, and in the granular cells of the cer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00507-0
更新日期:1996-12-16 00:00:00
abstract::Total RNA was extracted from 15-day-old whole rat brains. Microinjection of the RNA into Xenopus laevis oocytes induced electrophysiological responsiveness to cholecystokinin-8 (CCK) and bombesin (BBS) but not to corticotropin-releasing factor (CRF) or somatostatin. The responses to CCK and BBS were similar in shape, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(88)90021-6
更新日期:1988-08-01 00:00:00
abstract::The response of two populations of neurones in the substantia nigra (nigro-striatal compacta neurones and reticulata neurones) to microelectrophoretically administered putative neurotransmitters and stimulation of the ipsilateral striatum has been investigated in anaesthetized rats. There were marked differences betwe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90467-4
更新日期:1981-05-18 00:00:00
abstract::Blockade of gamma-aminobutyric acid (GABA) function in the posterior hypothalamus of rats elicits a pattern of physiological and behavioral arousal consisting of increases in heart rate, respiration and blood pressure as well as intense locomotor stimulation and a selective enhancement of avoidance responding. The pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91173-e
更新日期:1990-03-26 00:00:00
abstract::The discriminative stimulus properties of ethanol are functionally regulated by ionotropic GABA(A) and NMDA receptors in specific limbic brain regions including the nucleus accumbens, amygdala, and hippocampus, as determined by microinjection studies. The purpose of the present work was to further investigate potentia...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.07.061
更新日期:2008-09-26 00:00:00