Abstract：
:Radioligand-binding studies were performed to ascertain the actions of noribogaine, a suspected metabolite of ibogaine, on opioid receptors. Consistent with previous results, ibogaine showed highest affinity for kappa opioid receptors (Ki = 3.77 +/- 0.81 microM), less affinity for mu receptors (Ki = 11.04 +/- 0.66 microM) and no affinity for delta receptors (Ki > 100 microM). Noribogaine showed a higher affinity than ibogaine for all of the opioid receptors: kappa Ki = 0.96 +/- 0.08 microM, mu Ki = 2.66 +/- 0.62 microM and delta Ki = 24.72 +/- 2.26 microM. These data suggest that noribogaine is active in vivo and that it may contribute to ibogaine's pharmacological effects.
journal_name
Brain Resjournal_title
Brain researchauthors
Pearl SM,Herrick-Davis K,Teitler M,Glick SDdoi
10.1016/0006-8993(95)00123-8subject
Has Abstractpub_date
1995-03-27 00:00:00pages
342-4issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(95)00123-8journal_volume
675pub_type
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