Abstract：
:Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with known CAA on magnetic resonance imaging (MRI) and 14 age-matched controls were examined with transcranial Doppler. Dynamic CA was assessed in the middle (MCA) and posterior cerebral artery (PCA) via transfer function phase and gain during respiratory-induced 0.1 Hz oscillations of arterial pressure. Within the patient group, 4 patients showed additional microbleeds in the basal ganglia on the MRI performed within the study (pure CAA vs mixed microbleeds). PCA phase was significantly lower in patients compared with controls (p = 0.018), particularly in patients with pure CAA (p = 0.0034). MCA values showed a similar but non-significant trend towards lower phase in patients with pure CAA. Poorer phase was associated with a higher number of microbleeds on MRI (MCA r = -0.57, p = 0.027; PCA r = -0.52, p = 0.098) and superficial cortical siderosis (PCA: p = 0.0025). In conclusion, dynamic cerebral autoregulation is impaired in patients with CAA. The degree of impairment is associated with the extent of cerebral microbleeds.
journal_name
Brain Resjournal_title
Brain researchauthors
Reinhard M,Lorenz L,Sommerlade L,Allignol A,Urbach H,Weiller C,Egger Kdoi
10.1016/j.brainres.2019.04.014subject
Has Abstractpub_date
2019-08-15 00:00:00pages
60-65eissn
0006-8993issn
1872-6240pii
S0006-8993(19)30207-0journal_volume
1717pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:A potential mechanism for valproate (VPA)-induced increases in glial cell-substratum adhesivity has been demonstrated. Metabolically labelled glioma (C6) and primary astrocytes showed a statistically significant accumulation of protein when cultured in the presence of therapeutic concentrations of VPA (1 mM). This was...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90292-2
更新日期：1988-08-30 00:00:00
abstract：:Most experimental spinal cord injury studies described to date have relied on a limited number of injury gradations, and have tacitly assumed that outcome (functional, histological, and/or neurophysiological) is a monotonically graded function of injury severity. In contrast, the present study provides evidence that f...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-08-05 00:00:00
abstract：:The depolarizing photoreceptor potential in the molluscan extraocular photoreceptor, A-P-1, results from the light-induced suppression of specific K+ currents. An application of cGMP or IBMX (inhibitor of phosphodiesterase) to A-P-1-evoked light-suppressed currents, similar to the above specific K+ currents. Thus, the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90682-3
更新日期：1989-04-17 00:00:00
abstract：:The healthy maturation of the brain is one of the intriguing topics that need to be investigated to understand human brain and child development. The present study aimed to investigate the development of memory processes both for auditory and visual memory using electroencephalography (EEG)-Brain Dynamics methodologie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147042
更新日期：2020-11-15 00:00:00
abstract：:Phosphorylation of cyclic AMP response element binding protein (CREB) is one of the most important mechanisms controlling various gene transcriptions. In the present study, the phosphorylation of CREB was examined immunohistochemically at 24 h of recirculation following 1.5 h of middle cerebral artery occlusion (MCAO)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01263-3
更新日期：1999-02-13 00:00:00
abstract：:Prolonged electrical stimulation of the perforant pathway in the rat evokes epileptiform discharges in dentate granule cells and irreversibly damages hilar neurons. In this in vivo study, we demonstrate that similar perforant path stimulation in C57Bl/6 mice causes the same pattern of hippocampal neuron loss. Therefor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.055
更新日期：2006-04-26 00:00:00
abstract：:Little is known about the movement of 5-aminolevulinic acid (delta-aminolevulinic acid; ALA) between blood and brain. This is despite the fact that increases in brain ALA may be involved in generating the neuropsychiatric symptoms in porphyrias and that systemic administration of ALA is currently being used to delinea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03749-6
更新日期：2003-01-10 00:00:00
abstract：:The present study was designed to investigate the existence of two key enzymes involved in the metabolism of gamma-aminobutyric acid, glutamic acid decarboxylase (GAD) and glutamine synthetase (GS), in the area postrema (AP) of the cat. The results showed that punctuate structures of variable size corresponding to axo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90320-9
更新日期：1987-05-05 00:00:00
abstract：:Two distinct patterns of terminal labeling were seen after injections of [3H]amino acids into the second somatosensory area (S2) and the retroinsular area (Ri). The first pattern, seen both in S2 after an injection in Ri and in the granular or dysgranular insular fields after an injection in S2, is characterized by he...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91103-4
更新日期：1983-08-22 00:00:00
abstract：:The glial cell line-derived neurotrophic factor (GDNF) exerts trophic actions on a number of cell types, including mesencephalic dopaminergic (mDA) neurons. Using rat mesencephalic primary cultures enriched in mDA neurons, we show that protracted GDNF stimulation increases their survival and neurite outgrowth. It modu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.071
更新日期：2007-07-23 00:00:00
abstract：:Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide. Previous MRI studies have revealed that POAG can be associated with alterations in hippocampal function. Thus, the aim of this study was to investigate a relationship between chronic high intraocular pressure (IOP) and hippocamp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.09.001
更新日期：2017-11-15 00:00:00
abstract：:Chronically epileptic male adult rats in the pilocarpine model of temporal lobe epilepsy (TLE), exhibited gross expansion of abdominal fat mass and significant weight gain several months after induction of status epilepticus (SE) when compared to control rats. We hypothesized that epileptogenesis can induce molecular ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.10.006
更新日期：2011-12-02 00:00:00
abstract：:A procedure is described which allows for the selective and non-injectional staining of the three-dimensional microvasculatory bed (MVB) in thick sections (60-140 microm) of formalin-fixed brain tissue of white rats Rattus norvegicus. This histochemical method detects ATPase activity and takes place between pH 10.5 an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.11.059
更新日期：2006-01-27 00:00:00
abstract：:Safe, long-term gene expression is a primary criteria for effective gene therapy in the brain, so studies were initiated to evaluate adeno-associated virus (AAV) vector transfer of a reporter gene into specific sites of the rat brain. In the 4 day old rat, site infusions of AAV-CMV-lacZ (1 microliter; 5 x 10(4) partic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01488-8
更新日期：1996-03-25 00:00:00
abstract：:The morphological characteristics, distribution and neurochemical phenotype of striatal neuronal subtypes expressing the GABA(A) receptor alpha3-subunit were investigated using immunocytochemical and immunofluorescent techniques with an antibody specific for this subunit. alpha3-immunopositive neurons were infrequent ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02636-6
更新日期：2000-09-08 00:00:00
abstract：:Subcommissural organ (SCO) is a highly specialized ependymal gland located in the roof of the third ventricle. The secretory products of the SCO, which condense to form Reissner's fiber (RF), were recently found to cross-react with the anti-calcitonin antibody. To understand the mechanisms regulating the formation of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02144-7
更新日期：2000-01-10 00:00:00
abstract：:The Snell dwarf mouse (dw/dw) shows significantly decreased somatostatin levels in the hypothalamus whereas more or less increased somatostatin concentrations are observed in any central extrahypothalamic sites studied. These opposite results in hypothalamus and extrahypothalamic areas may be linked to the apparently ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91337-x
更新日期：1985-02-25 00:00:00
abstract：:Kindling is an experimental model for epilepsy in which repeated stimuli induce longer electrographic seizures and eventually cause behavioral convulsions. Although kindling has some features that are similar to chronic human epilepsy, it is not known whether this process plays a role in the development of chronic sei...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91071-y
更新日期：1993-10-22 00:00:00
abstract：:The effects of various nucleotides on the fast tetrodotoxin-sensitive (f-TTX-S) and the slow tetrodotoxin-resistant (s-TTX-R) sodium currents in rat dorsal root ganglion (DRG) neurons were investigated using the patch-clamp technique. Nucleoside triphosphates (NTPs; ATP, GTP, UTP and CTP) and nucleoside diphosphates (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.061
更新日期：2004-05-01 00:00:00
abstract：:While schizophrenia has a genetic component, its pathogenesis is unknown. Abnormal concentrations of two cell recognition molecules (CRMs), neural-cell adhesion molecule (N-CAM) and L1 antigen have been described in the cerebrospinal fluid (CSF) of patients with schizophrenia. Studies of monozygotic twins discordant f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00023-1
更新日期：1997-03-14 00:00:00
abstract：:Patients undergoing dental treatment employ different attentional strategies. In order to investigate associated neuronal correlates, we exposed 20 women suffering from dental phobia and 20 non-anxious women to disorder-related and unrelated pictures. They were asked to either direct their attention to a foreground st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.04.017
更新日期：2014-05-30 00:00:00
abstract：:Lysosomal storage diseases are a heterogeneous group of hereditary disorders characterized by a deficiency in lysosomal function. Although these disorders differ in their etiology and phenotype those that affect the nervous system generally manifest as a profound deterioration in neurologic function with age. Over the...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2014.05.029
更新日期：2014-07-21 00:00:00
abstract：:The feedback effect of activity of area 21a on orientation maps of areas 17 and 18 was investigated in cats using intrinsic signal optical imaging. A spatial frequency-dependent decrease in response amplitude of orientation maps to grating stimuli was observed in areas 17 and 18 when area 21a was inactivated by local ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.024
更新日期：2004-02-20 00:00:00
abstract：BACKGROUND:Cerebral ischemia is a major leading cause of death and at the first place cause of disability all over the world. There are a lot of drugs that are in experimental stage for treatment of stroke. Among them are calcium channel blockers (CCBs) that have, in animal models, different effectiveness in healing of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.038
更新日期：2007-10-24 00:00:00
abstract：:Spinal nociceptive neural circuits undergo considerable changes during the postnatal period. This study showed that neonatal rats exhibited earlier upregulation and faster recovery of spinal preprodynorphin (PPD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation. These da...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.039
更新日期：2005-03-21 00:00:00
abstract：:The endocrine disruptor Bisphenol-A (BPA) has been shown to modulate estrogenic, androgenic, and anti-androgenic effects. The effects of BPA exposure during early organizational periods of development have been well documented. The current study focuses on the effects of short term, low-dose BPA exposure on anxiety, s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.07.018
更新日期：2013-09-05 00:00:00
abstract：:GABA-A receptors mediate both phasic synaptic inhibition and more recently appreciated tonic currents in the vertebrate central nervous system. We addressed discrepancies in the literature regarding the pharmacology of tonic currents by examining tonic currents in a controlled environment of dissociated, solitary glut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.033
更新日期：2006-11-06 00:00:00
abstract：:Thyrotropin-releasing hormone (TRH; Protirelin) is an endogenous neuropeptide known to have anticonvulsant effects in several seizure models and in intractable epileptic patients. Like most neuropeptides, its duration of action may be limited by a lack of sustained site-specific bioavailability. To attempt to provide ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00860-9
更新日期：1998-11-02 00:00:00
abstract：:The occurrence of unmyelinated axons was examined ultrastructurally in rat molar and incisor root pulps of normal rats, of neonatally capsaicin-treated rats, of rats subjected to neonatal capsaicin treatment followed by resection of the superior cervical ganglion and of sympathectomized but otherwise normal rats. Foll...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90533-1
更新日期：1988-10-25 00:00:00
abstract：:We examined the effect of the peripheral application of glutamate and capsaicin to the temporomandibular joint (TMJ) in influencing the activation and central sensitization of TMJ-responsive nociceptive neurons in the trigeminal subnucleus caudalis/upper cervical cord (Vc/UCC). The activity of single neurons activated...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.11.056
更新日期：2009-02-09 00:00:00
