Excitotoxic hippocampal neuron loss following sustained electrical stimulation of the perforant pathway in the mouse.

Abstract:

:Prolonged electrical stimulation of the perforant pathway in the rat evokes epileptiform discharges in dentate granule cells and irreversibly damages hilar neurons. In this in vivo study, we demonstrate that similar perforant path stimulation in C57Bl/6 mice causes the same pattern of hippocampal neuron loss. Therefore, this mouse model of seizure-induced hippocampal injury can be used for a wide variety of studies in genetically altered conditions not available in rats.

journal_name

Brain Res

journal_title

Brain research

authors

Kienzler F,Jedlicka P,Vuksic M,Deller T,Schwarzacher SW

doi

10.1016/j.brainres.2006.02.055

subject

Has Abstract

pub_date

2006-04-26 00:00:00

pages

195-8

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(06)00474-4

journal_volume

1085

pub_type

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