Abstract:
:Prolonged electrical stimulation of the perforant pathway in the rat evokes epileptiform discharges in dentate granule cells and irreversibly damages hilar neurons. In this in vivo study, we demonstrate that similar perforant path stimulation in C57Bl/6 mice causes the same pattern of hippocampal neuron loss. Therefore, this mouse model of seizure-induced hippocampal injury can be used for a wide variety of studies in genetically altered conditions not available in rats.
journal_name
Brain Resjournal_title
Brain researchauthors
Kienzler F,Jedlicka P,Vuksic M,Deller T,Schwarzacher SWdoi
10.1016/j.brainres.2006.02.055subject
Has Abstractpub_date
2006-04-26 00:00:00pages
195-8issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)00474-4journal_volume
1085pub_type
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