Abstract：
:Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide. Previous MRI studies have revealed that POAG can be associated with alterations in hippocampal function. Thus, the aim of this study was to investigate a relationship between chronic high intraocular pressure (IOP) and hippocampal changes in a rat model. We used behavioural tests to assess learning and memory ability, and additionally investigated the hippocampal expression of pathological amyloid beta (Aβ), phospho-tau, and related pathway proteins. Chronic high IOP impaired learning and memory in rats and concurrently increased Aβ and phospho-tau expression in the hippocampus by altering the activation of different kinase (GSK-3β, BACE1) and phosphatase (PP2A) proteins in the hippocampus. This study provides novel evidence for the relationship between high IOP and hippocampal alterations, especially in the context of learning and memory.
journal_name
Brain Resjournal_title
Brain researchauthors
Yuan Y,Chen Z,Li L,Li X,Xia Q,Zhang H,Duan Q,Zhao Ydoi
10.1016/j.brainres.2017.09.001subject
Has Abstractpub_date
2017-11-15 00:00:00pages
78-86eissn
0006-8993issn
1872-6240pii
S0006-8993(17)30388-8journal_volume
1675pub_type
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