Abstract:
:The influence of glutamate and aspartate on the time course of decay of excitatory currents at neuromuscular junctions of locust skeletal muscle was examined. Both aspartate (up to 10 mM) and glutamate (up to 0.3 mM) had little influence on the decay time of the synaptic currents, whether measured intracellularly by voltage-clamp or extracellularly with a focal electrode. These results do not exclude a role for an active uptake system in sequestering neurally released transmitter at locust neuromuscular junctions, but they suggest that it has a negligible influence on the time course of the synaptic currents.
journal_name
Brain Resjournal_title
Brain researchauthors
Clark RB,Gration KA,Usherwood PNdoi
10.1016/0006-8993(80)91020-3subject
Has Abstractpub_date
1980-06-16 00:00:00pages
205-16issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(80)91020-3journal_volume
192pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Ultrastructural localization of a calcium-binding protein, calretinin, in the cerebellar cortex of the rat was examined with an immunoperoxidase method. The cerebellar lobule V was investigated in detail. In the molecular layer, calretinin immunoreactivity was found in parallel fibers and in their varicosities that fo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90915-a
更新日期:1993-06-11 00:00:00
abstract::Preconditioning describes a variety of treatments that induce neurons to become more resistant to a subsequent ischemic insult. How preconditioned neurons adapt to subsequent ischemic stress is not fully understood, but is likely to involve multiple protective mechanisms. We hypothesized hypoxic preconditioning induce...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.05.031
更新日期:2004-08-13 00:00:00
abstract::In the present experiment we use a rat model of traumatic brain injury to evaluate the ability of low-pressure hyperbaric oxygen therapy (HBOT) to improve behavioral and neurobiological outcomes. The study employed an adaptation of the focal cortical contusion model. 64 Male Long-Evans rats received unilateral cortica...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.06.105
更新日期:2007-10-12 00:00:00
abstract::The solitary tract nucleus (NTS) is the termination site for cranial visceral afferents-peripheral primary afferent neurons which differ by phenotype (e.g. myelinated and unmyelinated). These afferents have very uniform glutamate release properties calculated by variance mean analysis. In the present study, we optical...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.11.042
更新日期:2010-02-02 00:00:00
abstract::Activity produced by direct microelectrophoretic application of glutamate onto 19 convergent neurones in trigeminal nucleus caudalis, was strongly depressed during and after the application of heterotopic noxious conditioning stimuli: noxious heat (52 degrees C) applied to the tail, noxious pinches applied to the tail...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90695-4
更新日期:1984-10-29 00:00:00
abstract::We examined the effects of early epileptiform activity on development of visuocortical receptive fields in the rabbit. Aqueous penicillin was injected twice a day into a cannula implanted over the monocular area of one visual cortex. Drug administration was begun on postnatal day 8-9 and continued until postnatal day ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(81)90113-9
更新日期:1981-04-01 00:00:00
abstract::The morphological and physiological identification of the cells in the inner retina of Japanese dace was made by means of intracellular single cell recording and dye injection techniques. Our flat mounts and physiological classification revealed that 97 out of 102 sample cells were amacrine cells except for 3 transien...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91140-6
更新日期:1986-05-07 00:00:00
abstract::Vasoactive intestinal polypeptide (VIP)-like immunoreactivity in the anterior hypothalamic area (AHA) was studied in 15 bats which are seasonal hibernators, using the unlabeled antibody enzyme method of Sternberger. Our results showed that the density of immunoreactive fibers and terminal plexuses in the AHA was great...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91422-9
更新日期:1988-02-16 00:00:00
abstract::We have investigated the possibility that there is a correlation between female sexual receptivity and CNS serotonergic activity. In ovariectomized rats primed with a submaximal steroid regime of 2 micrograms oestradiol benzoate (OB) plus 0.2 mg progesterone (P), so that only a proportion were receptive, the 5-hydroxy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91575-6
更新日期:1985-05-06 00:00:00
abstract::Immunolabelling for synaptophysin and chromogranin A, two polypeptides associated with small clear and large dense core synaptic vesicles respectively, has been performed on tissue sections of the temporal cortex in Alzheimer's disease in combination with anti-A4 amyloid labelling. The dystrophic neurites in many seni...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90697-t
更新日期:1991-01-18 00:00:00
abstract::The present electric shock (ES) schedule followed in these experiments produced different functional changes in endogenous putative opioid agonist- and antagonist-type receptors, depending on the type of receptor: the amount of antagonist binding was increased by ES application, while the amount of agonist binding was...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91155-2
更新日期:1985-09-16 00:00:00
abstract::Prepro-vasoactive intestinal peptide (prepro-VIP) is processed to at least three biologically active peptides: VIP, peptide histidine isoleucine (PHI) and an extended PHI, peptide histidine valine (PHV). The aim of the present investigation was by chromatography combined with RIA and immunocytochemistry to determine w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91370-6
更新日期:1994-09-05 00:00:00
abstract::In a previous study, we have demonstrated that an ovalbumin-like antigen is present within approximately one-half of all neurons of chicken spinal ganglia. The current study demonstrates this antigen co-localizes absolutely with neural intermediate filament protein (Peripherin) in small to medium-sized neurons of spin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90342-k
更新日期:1993-11-12 00:00:00
abstract::We previously reported that the level of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) alpha and beta proteins increases with postnatal age. In the present study, we investigated the developmental changes in whole protein substrates of CaM kinase II as compared with those of cAMP-dependent protein kinase...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90861-3
更新日期:1994-10-03 00:00:00
abstract::There is evidence that heme oxygenase plays a role in cellular defense against reactive oxygen species and thereby has neuroprotective effects. We examined the interaction of Neotrofin, a cognitive-enhancing and neuroprotective drug, with the heme oxygenase system. In adult rats, both a single administration or seven ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03670-3
更新日期:2003-02-07 00:00:00
abstract::Numerous studies have suggested that nitric oxide (NO) in the nucleus tractus solitarii (NTS) participates in modulating cardiovascular function. Nitric oxide synthase (NOS), the enzyme responsible for synthesis of NO, exists in 3 isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS). Althoug...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.057
更新日期:2007-09-26 00:00:00
abstract::To determine possible mechanisms by which NFTs are formed in Alzheimer's disease (AD), we investigated the ability of tissue transglutaminase (TGase) to convert human recombinant tau proteins into insoluble filamentous structures. TGase derived from guinea pig liver was activated by calcium to catalyze the in vitro cr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01121-3
更新日期:1997-01-16 00:00:00
abstract::Injections with [3H]leucine in the ventral parabrachial nuclei and nucleus Kölliker-Fuse of the cat revealed strong projections to the nucleus raphe magnus (NRM) and adjacent tegmentum, while similar injections in the adjacent nucleus subcoeruleus produced diffuse projections to large parts of the tegmentum, but not s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90977-8
更新日期:1988-04-26 00:00:00
abstract::The density of specific prostaglandin E2 (PGE2) binding sites was quantitatively mapped in the rat brain using in vitro autoradiography. The anterior wall of the third ventricle and the nucleus solitary tract were found to have a very high density of binding sites (greater than 15 fmol/mg tissue). Two thalamic nuclei ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90720-t
更新日期:1992-05-29 00:00:00
abstract::Selective D1 (SCH-23390) and D2 (eticlopride and sulpiride) dopamine receptor antagonists were assessed for their ability to reverse the effects of 1.0 mg/kg D-amphetamine on excitatory motor-related neurons in the striatum of freely moving rats. SCH-23390 (0.125, 0.25, 0.5 and 1.0 mg/kg) rapidly and consistently bloc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91633-4
更新日期:1993-08-13 00:00:00
abstract::The connectivity of the stellate ganglion of Octopus was investigated using cobalt and horseradish peroxidase (HRP) tracers applied to severed preganglionic and postganglionic nerves. Centripetal cells, defined as cells in the ganglion which send their axons back toward the brain, were discovered by both methods. Appl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90583-1
更新日期:1980-02-17 00:00:00
abstract::Our recent results showed that angiotensin II or III (AII, AIII) microinjected into the zona incerta (ZI) significantly increased water intake. The most effective doses of AII and AIII were also defined. The two neuropeptides had their effects differently on drinking via different receptors. AII bound to AT(1) that wa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.01.002
更新日期:2004-03-26 00:00:00
abstract::Perfusion of the forebrain with glucose at concentrations which alter neither plasma insulin nor glucose levels leads to sympathetic activation in some rats. We used the expression of Fos-like immunoreactivity (FLI) as an index of neuronal activation to examine the anatomic substrate underlying this phenomenon. Male S...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01280-2
更新日期:1997-02-14 00:00:00
abstract::A microdialysis technique for the in vivo assessment of the monoaminergic and GABAergic levels in the ventromedial (VMN) and paraventricular nuclei (PVN) of the hypothalamus was used in order to examine the activities of neurons that project to the hypothalamic regions and are implicated in the regulation of ingestive...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01796-5
更新日期:1999-09-18 00:00:00
abstract::To identify the subtype of dopamine receptors critically involved in the rewarding effect of brain stimulation, four dopamine antagonists were intracranially injected in 25 rats. The importance of dopamine D1 receptors had been demonstrated previously by using SCH 23390, a highly selective D1 antagonist. Rats were imp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00304-1
更新日期:1997-06-20 00:00:00
abstract::7-Chlorokynurenic acid (7-Cl KYNA) has been reported to attenuate N-methyl-D-aspartate (NMDA) receptor functioning by a potent and selective inhibitory action mediated at the strychnine-insensitive glycine recognition site of the NMDA complex. Here we report that 7-Cl KYNA dose-dependently inhibits [3H]MK-801 binding ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91378-4
更新日期:1989-12-18 00:00:00
abstract::The central melanocortin system plays a critical role in regulation of energy balance, including thermogenesis in brown adipose tissue (BAT). Activation of the hypothalamic melanocortin signaling stimulates sympathetically-mediated interscapular BAT (IBAT) thermogenesis. The rostral raphe pallidus (rRPa) and adjacent ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.006
更新日期:2007-11-07 00:00:00
abstract::Purkinje cell degeneration (pcd) mutant mice lose virtually all Purkinje cells. It was found that the pcd mutants did not show within-sessions habituation in terms of hole-poking responses. This type of perseverative responding has been found in rats with limbic system damage and implies a role for the cerebellum in b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91354-1
更新日期:1989-02-06 00:00:00
abstract::Unilateral visual cortex ablations in neonatal rabbits produced no detectable loss of ganglion cells in the contralateral retina following a survival period of 3, 4 or 8 months. Analysis of neuron size distributions and neuron densities from whole-mounted retinas indicate that transneuronal retrograde degeneration doe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90218-4
更新日期:1985-08-01 00:00:00
abstract::Experiments were carried out to determine if stimuli which augment preganglionic nerve activity to sympathetic neurons, and thereby cause trans-synaptic induction, increase the retrograde transport of nerve growth factor (NGF). It was found that nerve activity had no effect on retrograde transport of [125I]NGF. It was...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90701-7
更新日期:1979-12-14 00:00:00