Abstract：
:We previously reported that the level of Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) alpha and beta proteins increases with postnatal age. In the present study, we investigated the developmental changes in whole protein substrates of CaM kinase II as compared with those of cAMP-dependent protein kinase (A-kinase) in the rat forebrain. Protein substrates were phosphorylated with [gamma-33P]ATP, and analysed by two-dimensional gel electrophoresis. More than 50 substrates for CaM kinase II were found in the soluble and particulate fractions. The phosphorylation level of more than 15 substrates increased in the particulate fraction during development. Similarly, that of more than 3 substrates increased in the soluble fraction. Some substrates for A-kinase also increased during development, although some decreased. These findings suggest that the expression of some substrates is regulated during development and that the phosphorylation reaction involves the regulation of neuronal development.
journal_name
Brain Resjournal_title
Brain researchauthors
Sugiura H,Yamauchi Tdoi
10.1016/0006-8993(94)90861-3subject
Has Abstractpub_date
1994-10-03 00:00:00pages
42-54issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(94)90861-3journal_volume
659pub_type
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