Abstract:
:The role of N-methyl-D-aspartate (NMDA) receptors in specific D1 and D2 regulation of striatal and accumbens neurotensin (NT) systems was investigated. As demonstrated previously, stimulation of D1 receptors with multiple administrations of SKF 38393 significantly increased striatal and accumbens NT content to approximately 145% of control. These responses were completely blocked by coadministration of the non-competitive NMDA antagonist, MK 801. Previous studies have documented that D2 receptors tonically regulate striatal NT systems. Thus, multiple doses of sulpiride, a D2 antagonist, increased striatal NT content to 167% of control while quinpirole, a D2 agonist, decreased striatal NT content to 58% of control. MK 801 did not alter either striatal NT response to D2 manipulation. As previously reported, levels of accumbens NT changed only in response to D2 blockade and not to D2 stimulation. Thus, sulpiride increased accumbens NT content to 138% of control; this was not blocked by the coadministration of MK 801. NT content also significantly increased after stimulation of glutamate receptors with NMDA. To determine if D1 receptors participate in this NMDA-mediated change, the D1 antagonist SCH 23390 was coadministered. Blockade of D1 receptors did not significantly alter the response of striatal NT systems to NMDA. However, in both striatum and nucleus accumbens, the NMDA effect on NT systems appeared to be lessened. In summary, expression of D1-, but not D2-mediated changes in striatal and accumbens NT systems are markedly dependent on NMDA receptor activity. In comparison, expression of the NMDA-mediated changes in the same NT systems do not appear to be as dependent on D1 receptor activity.
journal_name
Brain Resjournal_title
Brain researchauthors
Singh NA,Bush LG,Gibb JW,Hanson GRdoi
10.1016/0006-8993(92)90663-tsubject
Has Abstractpub_date
1992-02-07 00:00:00pages
260-4issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(92)90663-Tjournal_volume
571pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::To assess the role of androgen-dependent brain vasopressinergic transmission in the modulation of social recognition, castrated male rats which are deficient in vasopressin were implanted intracerebroventricularly with an Accurel collodion mini-device containing 10 micrograms vasopressin (AVP) whereas intact male rats...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90480-w
更新日期:1992-02-14 00:00:00
abstract::The effects of clonidine (CLO) and phentolamine (PHE) on the sleep-waking cycle in the cat treated with alpha-methyl-p-tyrosine (AMPT) were investigated with continuous 16--24 h polygraphic recordings. For the evaluation of possible cholinergic interactions in the paradoxical sleep (PS) increasing effect of AMPT, an a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90949-x
更新日期:1980-07-07 00:00:00
abstract::Data from several laboratories indicate that cerebral endothelial cells possess cell surface receptors for numerous vasoactive agents including angiotensin II (AII) and atrial natriuretic factor (ANF). The intracellular messengers of these receptors as well as possible receptor interactions were explored. ANF increase...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91191-3
更新日期:1991-10-18 00:00:00
abstract::The effects of infusing N-methyl-d-aspartate (NMDA) into the raphe nuclei on release of 5-HT in this brain region and also the frontal cortex of the same animal were studied using in vivo microdialysis in freely moving rats. Infusion of 25 microM NMDA into the raphe led to a substantial decrease in dialysate 5-HT in t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01333-4
更新日期:1998-02-09 00:00:00
abstract::gamma-Aminobutyric acid (GABA), pentobarbital and ethanol were applied by bath superfusion to rat locus coeruleus (LC) neurons in a brain slice preparation. The GABA-induced current and conductance increase was measured with single-electrode voltage clamp. Pentobarbital potentiated the GABA-induced current and conduct...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91044-h
更新日期:1990-05-28 00:00:00
abstract::Acetylcholinesterase (AChE) histochemical staining occurred in neurons of the dentate gyrus at the day of birth and steadily increased in intensity and distribution during the first 3 postnatal weeks until the adult pattern was reached. Granule cells failed to display AChE staining; however, the somata of most non-pri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90072-1
更新日期:1987-11-01 00:00:00
abstract::The anatomical structure of the basal ganglia indicates that the input from the cerebral cortex is funnelled through the striatum to the globus pallidus and substantia nigra. This structure implies integration of the information as it is transferred through the basal ganglia. In order to investigate this integration, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90363-4
更新日期:1985-11-25 00:00:00
abstract::The potential evoked at the surface of the cerebral cortex of a guinea pig, by stimulation of the contralateral forepaw, usually consists of an initial double positive wave whose waveform remains unchanged during rapid stimulation. In a guinea pig with experimental allergic encephalomyelitis (EAE) the response is atte...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90350-9
更新日期:1975-08-08 00:00:00
abstract::In the present study we evaluated the role of NMDA receptors on the pressor and bradycardic responses to L-glutamate (L-Glu) microinjected into the nucleus tractus solitarius (NTS) of unanesthetized rats. L-Glu (1 nmol/100 nl) was microinjected into the NTS before and 10 min after microinjection of phosponovaleric aci...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/S0006-8993(96)01169-9
更新日期:1997-02-28 00:00:00
abstract::To elucidate the intracellular mechanism of the bursting activity which is characteristic of seizure discharge, the behavior of the intracellular cyclic nucleotide and the intracellular calcium during pentylenetetrazole (PTZ)-induced bursting activity in snail neurons was investigated. Cyclic AMP was increased about 3...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90137-3
更新日期:1983-06-20 00:00:00
abstract::Neurokinin A and B (NKA and NKB) and neuropeptide K (NPK) were recently isolated from porcine spinal cord and brain, and together with substance P (SP) considerably extend the list of tachykinin-like peptides present in the mammalian nervous system. In order to investigate the distribution of tachykinins in the centra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91514-3
更新日期:1986-12-10 00:00:00
abstract::Nestin is an embryonic intermediate filament that transiently expressed in the neural stem/progenitor cells in the developing central nervous system (CNS). Growing evidence has shown that abundant expression of nestin also occurs in both pathological glial-derived tumor cells and reactive astrocytes in various CNS inj...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.11.026
更新日期:2008-02-27 00:00:00
abstract::Neurons and glial cells can be stained by Lucifer Yellow CH in vitro to produce a Golgi-like fluorescent or electron-dense stain. This technique has been applied successfully in the retinas of several species, rat brain slices and embryonic chick spinal cord. The relative proportion of stained neurons residing in diff...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90027-2
更新日期:1986-09-24 00:00:00
abstract::We hypothesized that abnormal activity and adrenergic sensitivity in injured dorsal root ganglion (DRG) neurons are due to an intrinsic alteration of the cell body membrane. We investigated the effects of adrenergic stimulus on the activities of Ca2+ and K+ channels of DRG neurons in a rat chronic constriction injury ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01499-7
更新日期:1999-06-19 00:00:00
abstract::Hereditary Cystatin C Amyloid Angiopathy (HCCAA) is a rare genetic disease in Icelandic families caused by a mutation in the cystatin C gene, CST3. HCCAA is classified as a cerebral amyloid angiopathy and mutant cystatin C forms amyloid deposits in cerebral arteries resulting in fatal haemorrhagic strokes in young adu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.08.029
更新日期:2013-10-16 00:00:00
abstract::Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1. This study investigated the distribution and expression of the CB1 re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.03.031
更新日期:2010-06-04 00:00:00
abstract::Deacetylation is a rapid clearance mechanism for ocular melatonin. We have studied the distribution of retinal melatonin deacetylase activity among vertebrate classes. Exogenous radiolabeled melatonin is metabolized by ocular tissue prepared from the amphibian Xenopus laevis, the reptile Anolis carolinensis, the teleo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90286-5
更新日期:1991-09-13 00:00:00
abstract::The medial septal area has been implicated in the control of the magnocellular neurosecretory cells of the hypothalamus, and in particular, in the regulation of neurons secreting oxytocin. The present study investigated the hypothesis that this medial septal pathway originates in the subfornical organ. Brief electrica...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01278-p
更新日期:1995-02-20 00:00:00
abstract::Fast axonal transport and neuronal protein synthesis was studied in the isolated nervous system of Aplysia californica. The abdominal ganglion with attached pleural-abdominal connectives (PAC) was removed and the ganglion pulse-labelled with [35S]methionine for 30 min in vitro. The axon containing connectives were lig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90388-9
更新日期:1985-04-15 00:00:00
abstract::This study examined the effects of stria terminalis (ST) lesions on glucocorticoid-induced modulation of memory formation for inhibitory avoidance training and spatial learning in a water maze. Systemic (s.c.) posttraining injections of the glucocorticoid receptor agonist dexamethasone (0.3 or 1.0 mg/kg) enhanced memo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01305-9
更新日期:1996-02-19 00:00:00
abstract::We examined the role of the phosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII) and cyclic AMP-response element binding protein (CREB) in N-methyl-d-aspartate (NMDA)-induced neurotoxicity in the rat retina. Western blot analysis showed early elevation of phosphorylated CaMKII (p-CaMKII) protein ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.09.055
更新日期:2007-12-12 00:00:00
abstract::The effects of 3 different non-noxious stressors on body temperature (Tb) were investigated in the rat: (1) loose restraint in cylinders, (2) removal of the rats from cylinders, exposure to a novel environment and replacement in cylinders, a stressor called here 'novelty', and (3) gentle holding of the rats by the nap...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90537-7
更新日期:1984-04-09 00:00:00
abstract::The behavioral effects of lesions of the nucleus basalis magnocellularis (NBM) on two spatial discrimination tasks (place navigation and cross maze) were examined in the rat. These tasks were designed to test reference memory. Lesions by bilateral injection of ibotenic acid into the NBM led to a severe and permanent i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90079-0
更新日期:1988-07-12 00:00:00
abstract::Intracellular recordings were made from rabbit nodose ganglion cells in vitro. Morphine (up to 100 micro M), normorphine (up to 10 micro M) and D-Ala2, Leu5-enkephalin (DADLE) (up to 5 micro M) each had no detectable effect on the electrical properties of the cell membrane, except for local anesthetic-like actions at ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91066-0
更新日期:1981-09-21 00:00:00
abstract::Considerable evidence indicates an enhanced sympathetic innervation of muscular resistance arteries in the spontaneously hypertensive rat (SHR) compared with its normotensive Wistar-Kyoto (WKY) control. Since nerve growth factor (NGF) is known to affect the growth of sympathetic nerves, we have utilized a sensitive tw...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91012-h
更新日期:1993-06-18 00:00:00
abstract::The effects of induced L9 activity on gill motor neuron L7's ability to elicit a gill withdrawal response were studied. It was found that L9 was a modulator of L7's effectiveness to elicit gill movements. Following L9 activity, L7's ability to elicit a gill withdrawal response was significantly potentiated by up to 24...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90350-0
更新日期:1979-03-16 00:00:00
abstract::Classical conditioning the rabbit nictitating membrane involves changes in synaptic and intrinsic membrane properties of cerebellar Purkinje cell dendrites, and a 4-aminopyridine (4-AP)-sensitive potassium channel underlies these membrane properties. We characterized I(A) currents in adult, rabbit Purkinje cells to de...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.04.048
更新日期:2006-06-22 00:00:00
abstract::Mechanisms underlying hypoxia-induced neuronal adaptation have not been fully elucidated. In the present study we investigated glucose metabolism and the activities of glycolytic and TCA cycle enzymes in cerebro-cortical neurons exposed to hypoxia (3 days in 1% of O2) or normoxia (room air). Hypoxia led to increased a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.06.074
更新日期:2008-09-10 00:00:00
abstract::We sought to further elucidate signal transduction pathways for the I(1)-imidazoline receptor in PC12 cells and their interaction with the well-characterized signaling events triggered by nerve growth factor (NGF) in these cells. Stimulation of the I(1)-imidazoline receptor with moxonidine, a centrally acting antihype...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02893-2
更新日期:2003-08-01 00:00:00
abstract::We have used the post-embedding immunogold labelling method using antibodies to gamma-aminobutyric acid (GABA) to obtain quantitative data on the distribution, frequency, postsynaptic targets and ultrastructural characteristics of GABA-immunoreactive (GABA-IR) boutons in the trigeminal motor nucleus of rats. We have a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90757-m
更新日期:1991-10-04 00:00:00