Abstract:
:The effects of 3 different non-noxious stressors on body temperature (Tb) were investigated in the rat: (1) loose restraint in cylinders, (2) removal of the rats from cylinders, exposure to a novel environment and replacement in cylinders, a stressor called here 'novelty', and (3) gentle holding of the rats by the nape of the neck. Loose restraint and 'novelty' produced hyperthermia. On the contrary, holding induced hypothermia. Hypophysectomy (HX) reduced basal Tb, abolished restraint hyperthermia and reduced both 'novelty' hyperthermia and holding hypothermia. Dexamethasone ( DEXA ) had no effect upon either restraint or novelty hyperthermia but reduced the hypothermia. Naloxone (Nx) produced a slight fall in basal Tb accounting for its reduction of restraint and 'novelty' hyperthermias ; it did not affect holding hypothermia. The inhibitory effects of HX suggest a participation of the pituitary in the hyperthermias ; the neurointermediate lobe would be involved as the hyperthermias were not affected by DEXA , which is known to block the stress-induced release of pituitary secretions from the anterior lobe but not from the neurointermediate lobe. In contrast, substances from the anterior lobe might participate in hypothermia due to holding since it is reduced by HX and DEXA . As to the effects of Nx, endogenous opioids would not be significantly involved in the thermic effects of the stressors used in this study; they might play, if any, only a minor role in the regulation of basal Tb. These results are compared with those previously obtained on nociception using the same non-noxious stressors. It emerges that, depending on the stressor, different types of association between thermoregulation and nociception may occur, i.e. hyperthermia with analgesia, hyperthermia with hyperalgesia and hypothermia with hyperalgesia.
journal_name
Brain Resjournal_title
Brain researchauthors
Vidal C,Suaudeau C,Jacob Jdoi
10.1016/0006-8993(84)90537-7subject
Has Abstractpub_date
1984-04-09 00:00:00pages
1-10issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)90537-7journal_volume
297pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Considerable disagreement exists concerning the degree to which sparing and/or recovery of function occurs following CNS damage at birth rather than in adulthood. To study this question, the spinal cord was hemisected in neonatal and adult cats and the motor behavior of the two groups was compared when the neonatal op...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90046-9
更新日期:1983-08-01 00:00:00
abstract::In order to establish possible stimulatory effects of increasing plasma concentrations of substance P (SP) on the arginine vasopressin (AVP) and/or oxytocin (OT) secretion, successively increasing doses of SP(0.5, 1 and 1.5 pmol/kg-1/min-1; each dose for 20 min) were infused in 7 normal men. Plasma AVP and OT levels w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90387-o
更新日期:1992-01-08 00:00:00
abstract::Oxidative stress has been implicated as a pathogenic mediator of neuronal perikarya cell death. Axons and oligodendrocytes, components of white matter, could also be vulnerable to oxidative damage. An experimental model of oxidative stress was induced by systemic injection of 3-nitropropionic acid (3-NPA). Animals rec...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)03266-2
更新日期:2001-02-23 00:00:00
abstract::Cerebral autoregulation was tested here in 3- and 18-month-old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKY). Cerebral blood flow (CBF) was measured in each rat using radioactive micropheres under unanesthetized control conditions and after hypotension induced by ganglionic blockade. Under cont...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90454-6
更新日期:1981-06-09 00:00:00
abstract::On average, cells in areas 17, 18 or 19 of normal and stroboscopically reared cats respond with equal maximum firing rates to a narrow bar of light whether moving at the optimal velocity in the preferred direction of movement of flashed at the optimal position within the receptive field. Firing rates in the non-prefer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90223-7
更新日期:1981-09-07 00:00:00
abstract::10-fold higher doses in SW mice. Furthermore, cotreatment of 129/SvEv mice with morphine plus a low dose of naltrexone (ca. 0.1 microgram/kg) that markedly enhances and prolongs morphine's antinociceptive effects in SW mice did not enhance, and often attenuated6 h. The marked GM1-induced attenuation of morphine's anti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02446-4
更新日期:2000-02-21 00:00:00
abstract::From 4 or 5 postnatal days, rat pups were either reared by their mothers (MR) or artificially reared (AR) without their mothers by infusion of 'milk' through a gastric cannula. In AR, but not MR, pups the left eye was more likely to open first than the right eye (P less than 0.001). The left-biassed eye-opening of AR ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90073-8
更新日期:1986-07-01 00:00:00
abstract::A study was undertaken of the possible relationship of the binding affinity of a series of anticholinergic psychotomimetic drugs to their psychopharmacological and anticholinergic effects. Binding was measured to brain homogenates and nerve endings using [3H]quinuclidinyl benzilate (QB), a highly potent psychotomimeti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90889-7
更新日期:1977-03-25 00:00:00
abstract::Endogenous acetylcholine (ACh) release from rat striatal slices was measured by a chemiluminescent method. Several opiate agents were tested for their ability to modulate ACh release evoked by potassium ions (K+) or glutamic acid (GLU). Morphine, [D-Ala2,Gly(0l)5]-enkephalin (DAGO), [D-Ala2,D-Leu5]-enkephalin (DADLE) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91633-r
更新日期:1990-07-16 00:00:00
abstract::Gastrin-releasing peptide (GRP) mediated signals in the central nervous system (CNS) influence many functions associated with energy metabolism. The purpose of the present study was to investigate the central effect of GRP on glucose metabolism in the male rat. Intracerebroventricular (icv) administration of GRP cause...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.08.040
更新日期:2015-11-02 00:00:00
abstract::Autism is marked by overgrowth of the brain at the earliest ages but not at older ages when decreases in structural volumes and neuron numbers are observed instead. This has led to the theory of age-specific anatomic abnormalities in autism. Here we report age-related changes in brain size in autistic and typical subj...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.09.101
更新日期:2011-03-22 00:00:00
abstract::In tasks involving the learning of verbal or non-verbal sequences, groupings are spontaneously produced. These groupings are generally marked by a lengthening of final elements and have been attributed to a domain-general perceptual chunking linked to working memory. Yet, no study has shown how this domain-general chu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.01.032
更新日期:2015-04-07 00:00:00
abstract::The purpose of the current study is to investigate the functional connections between the central histaminergic and cholinergic systems at NTS level in hypotensive condition. Experiments were carried out in male Wistar Albino rats. The hypotension was achieved by withdrawing a total volume of 1.5ml blood/100g bodyweig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.06.047
更新日期:2016-10-15 00:00:00
abstract::This manuscript describes the use of staining of Fos-related antigens (FRAs) as markers for changes in neuronal activity. The model system consisted of the tuberoinfundibular dopamine (TIDA) neurons located in the arcuate nucleus of the hypothalamus. Under normal conditions, these neurons are devoid of c-Fos staining ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90481-2
更新日期:1994-08-22 00:00:00
abstract::These experiments examined the effects, on retention, of posttraining intra-amygdala administration of norepinephrine (NE), and propranolol. Rats were trained on a one-trial step-through inhibitory avoidance task and tested for retention 24 h later. Injections were administered bilaterally (1.0 microliter/injection) t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91049-8
更新日期:1986-03-12 00:00:00
abstract::While adult mice receiving picrotoxin (PTX) alone responded with clonic and tonic-clonic seizures, this response was greatly suppressed for mice simultaneously injected with 2,3-butanedione monoxime (BDM). For example, 60% and 10% of the mice convulsed when injected (i.p.) with 3.0 mg/kg PTX alone or PTX plus 205 mg/k...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00175-p
更新日期:1995-04-24 00:00:00
abstract::Delta-9-tetrahydrocannabinol (Delta(9)-THC), the main psychoactive component of marijuana, is known to dysregulate various immune responses. Cannabinoid (CB)-1 and -2 receptors are expressed mainly on cells of the central nervous system (CNS) and the immune system. The CNS is the primary target of cannabinoids and ast...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.062
更新日期:2008-01-29 00:00:00
abstract::Data reported up to now on neuron-glia relationships, show that neuron cell bodies and glial cells are separated by a narrow intercellular cleft which is considered as the microenvironment of the nervous system, and where neuron-glia exchange occurs. We present here evidence that neuron perikarya and ensheathing glial...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91394-0
更新日期:1985-02-04 00:00:00
abstract::The immunohistochemical distributions of tyrosine hydroxylase (TH), calmodulin (CaM) and calcium/CaM-dependent protein kinase II (CaMKII) in the rat forebrain were compared quantitatively to confirm our previous finding that TH activity and dopamine synthesis in the brain are regulated by a calcium/CaM-dependent syste...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02271-0
更新日期:2002-04-12 00:00:00
abstract::Preferential uptake of dopamine occurred in mesocortical vs striatal synaptosomes obtained from acutely fighting isolated male ICR mice. Specifically, both Km and Vmax were significantly increased in the prefrontal cortex but not the caudate-putamen. The findings are similar to selective changes in mesocortical activi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90954-9
更新日期:1981-10-05 00:00:00
abstract::The extensive outgrowth from explanted goldfish retina in vitro stimulated by the axotomy of the optic nerve several days prior to the explantation, enables a more direct examination of the events which accompany optic nerve regeneration. Thus far neuritic outgrowth has been obtained in serum-containing medium. In the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90073-6
更新日期:1982-01-01 00:00:00
abstract::Horeradish peroxidase was injected at multiple sites in the mandibular and sublingual salivary glands in order to label the preganglionic salivatory neurons in the brain stem. The same injections resulted in retrograde labeling of the sympathetic and sensory neurons that project to these glands. Labeled fusiform and m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90092-x
更新日期:1980-05-12 00:00:00
abstract::Gaze processing was investigated using event-related potentials in two different tasks in which front-view and 3/4-view faces were presented, with eyes gazing straight ahead or averted. Task alternated between an explicit gaze direction judgment and a judgment on head orientation where gaze was irrelevant. Accuracy an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.094
更新日期:2007-10-26 00:00:00
abstract::The hallucinogen d-lysergic acid diethylamide (d-LSD) evokes dramatic somatic and psychological effects. In order to analyze the neural activation induced by this unique psychoactive drug, we tested the hypothesis that expression of the immediate-early gene product c-Fos is induced in specific regions of the rat foreb...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03548-5
更新日期:2002-12-27 00:00:00
abstract::Cytotoxic effects of L-glutamate and related compounds were investigated on rat glioma C6 cells in vitro. Within 12-24 h, addition of glutamate to the culture medium, resulted in degeneration of the C6 cells. The ED50 for glutamate-induced damage was about 4 mM. Seventeen structural analogues of glutamate, including a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91222-8
更新日期:1984-06-15 00:00:00
abstract::The frequency-dependent effect of various anticonvulsant drugs on the conduction in central axons was studied in the corpus callosum of rat and guinea pig brain slices from the parietal region. Extracellularly recorded compound action potentials (CAPs) were evoked by either single stimulus or high frequency stimulatio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91636-s
更新日期:1992-07-24 00:00:00
abstract::It has been reported that L-glutamate (L-glu) microinjection into the hypothalamic paraventricular nucleus (PVN) evokes pressor and tachycardiac responses in unanesthetized rats. In the present study the hypothesis was tested that a local nitric oxide (NO)-guanylate cyclase interaction mediates cardiovascular effects ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.05.023
更新日期:2010-07-16 00:00:00
abstract::Tacrolimus (FK506), a potent immunosuppressive drug, is effective in attenuating brain infarction after cerebral ischemia. However, there has been no report characterizing the neuroprotective action and therapeutic time window of tacrolimus systematically using different types of stroke models and extended observation...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04151-3
更新日期:2003-03-07 00:00:00
abstract::As previously demonstrated, spontaneously firing bulbar inspiratory neurones are periodically inhibited either at the beginning of, or throughout expiration, while bulbar expiratory neurones are inhibited during inspiration. The aim of the present study was to test the hypothesis that amino acids act as transmitters o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90447-4
更新日期:1982-04-15 00:00:00
abstract::Three different estrogen receptors (ERs) have been characterized in teleost fish, i.e. Esr1, Esr2a and Esr2b. In this study we carried out in situ hybridizations in the brain and pituitary of the sea bass (Dicentrarchus labrax) to study the putative involvement of Esr2 subtypes in the control of gonadotropin secretion...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.02.053
更新日期:2008-05-19 00:00:00