Abstract：
:Cerebral autoregulation was tested here in 3- and 18-month-old spontaneously hypertensive rats (SHR) and Wistar Kyoto controls (WKY). Cerebral blood flow (CBF) was measured in each rat using radioactive micropheres under unanesthetized control conditions and after hypotension induced by ganglionic blockade. Under control conditions there was no significant difference in CBF between SHR and WKY. During drug induced hypotension CBF decreased significantly in all except 3 month WKY. CBF was decreased significantly more in 18 month SHR after ganglionic blockade compared to other test groups. These results indicate an influence of both age and hypertension in altering the ability of the cerebrovasculature to autoregulate.
journal_name
Brain Resjournal_title
Brain researchauthors
Hoffman WE,Albrecht RF,Miletich DJdoi
10.1016/0006-8993(81)90454-6subject
Has Abstractpub_date
1981-06-09 00:00:00pages
196-9issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(81)90454-6journal_volume
214pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The Fragile X mental retardation syndrome is the largest source of inherited mental retardation. The syndrome usually results from the transcriptional silencing of the fragile X mental retardation gene (FMR1). To date the most prominent reported neuronal abnormalities for the fragile X mental retardation syndrome incl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02363-1
更新日期：2003-05-02 00:00:00
abstract：:To determine the effect of thyroid hormones (TH) on cerebral tissue malondialdehyde (MDA) content and accumulation of MDA-bound proteins, hyperthyroid rats and hypothyroid rats were compared to euthyroid controls. Hyperthyroidism was induced by daily injection of l-3,5, 3'-triiodothyronine (15 ug (100 g)-1) intraperit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01368-2
更新日期：1999-05-22 00:00:00
abstract：:The axonal transport of radiolabeled slow phase proteins and fast phase glycoproteins was studied in rabbit hypoglossal nerve one week after axotomy. The nerves were ligated and cut to prevent axonal regeneration into the distal stump. In this situation of obstructed axonal outgrowth, the axonal transport of these com...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90953-2
更新日期：1982-10-28 00:00:00
abstract：:Electrical stimulation of the retina evokes at the optic tract level rhythmic bursts of activity whose temporal structure is predictable from the polarity of the stimulation and the receptive field type. The reaction of lateral geniculate units to this input was studied in fast and slow relay cells as well as in inter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90135-x
更新日期：1978-08-18 00:00:00
abstract：:The immediate-early gene egr-1 has been shown to have an increased expression during long-term potentiation (LTP). High frequency electrical stimulation induces an increase in such expression in the dorsal horn of the spinal cord. However, evidence demonstrating the activation of this gene in the spinal cord and its r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.041
更新日期：2010-07-23 00:00:00
abstract：:The understanding of sarcasm reflects a complex process, which involves recognizing the beliefs of the speaker. There is a clear association between deficits in mentalizing, which is the ability to understand other people's behavior in terms of their mental state, and the understanding of sarcasm in individuals with a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.088
更新日期：2006-12-08 00:00:00
abstract：:The effect of lead as a neurotoxic agent has been associated with alterations in calcium metabolism. On this line, the present study shows that lead alters the characteristics of [3H]nitrendipine ([ 3H]NDP) binding to rat striatal membranes. In vitro, lead shares the action of calcium in enhancing [3H]NDP binding alth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91202-2
更新日期：1984-11-19 00:00:00
abstract：:The binding of the adenosine receptor agonists, [3H]N-ethylcarboxamidoadenosine (NECA) and [3H]cyclohexyladenosine (CHA) to membrane preparations and to cryostat sections of the rat brain was examined. The xanthine derivative, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) was ca. 500-fold more effective at A1 than at A2 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90589-5
更新日期：1986-03-19 00:00:00
abstract：:Extracellular signal-regulated kinase 1/2 (ERK1/2) plays diverse roles in the central nervous system. Activation of ERK1/2 has been observed in various types of neuronal excitation, including seizure activity in vivo and in vitro. However, studies examining ERK1/2 activity and its substrate phosphorylation in parallel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.08.023
更新日期：2015-11-02 00:00:00
abstract：:[125I]CGP 42112, first developed to identify angiotensin II receptor subtype 2 (AT2), was recently shown to bind to a novel non-angiotensin binding site in injured rat brain tissue. We addressed the question whether non-angiotensin [125I]CGP 42112 binding appears after kainic acid induced hippocampal neurodegeneration...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01035-3
更新日期：1995-12-08 00:00:00
abstract：:Discharges of neurons in the midpontine dorsal tegmental field (DTF neurons) were recorded and analyzed during locomotion and were compared with those of reticulospinal neurons (RS neurons) located lateral to the DTF area. The conduction velocity of the descending axon of the DTF neurons was significantly smaller than...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91078-9
更新日期：1985-08-26 00:00:00
abstract：:Hyperactivity of the dopaminergic pathway is thought to contribute to clinical symptoms in the early stages of Huntington's disease (HD). It is suggested to be result of a reduced dopaminergic inhibition by degeneration of medium spiny neurons in the striatum. Previously, we have shown that the number of dopaminergic ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.01.041
更新日期：2019-06-01 00:00:00
abstract：:Rd mutant mice are visually blind but they maintain the ability of synchronising their circadian rhythms to the external light-dark cycles. We used immunocytochemical procedures to detect light-induced Fos expression in the rd mice retina. We found that Fos is expressed in the rd retina in an unattenuated pattern thro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01604-2
更新日期：1999-07-10 00:00:00
abstract：:(1) The possibility that water intake elicited by the administration of angiotensin-II to the preoptic region (POA), subfornical organ and anterior third ventricle is mediated by separate neural systems was investigated in 58 male Wistar rats using electrolytic lesion techniques. (2) Lesions of the midlateral hypothal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90189-x
更新日期：1976-05-28 00:00:00
abstract：:Treatment of castrated quail with testosterone (T) reliably activates male copulatory behavior and, at the same time, increases the aromatase activity (AA), the number of aromatase-immunoreactive (ARO-ir) cells and the concentration of aromatase mRNA as measured by RT-PCR in the brain. All these effects can be mimicke...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01008-0
更新日期：1995-12-01 00:00:00
abstract：:A reduction in adenosine deaminase acting on RNA 2 (ADAR2) activity causes the death of spinal motor neurons specifically via the GluA2 Q/R site-RNA editing failure in sporadic amyotrophic lateral sclerosis (ALS). We studied, over time, the spinal cords of ADAR2-knockout mice, which are the mechanistic model mice for ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.01.006
更新日期：2014-03-06 00:00:00
abstract：:Circadian and neural mechanisms important for the organization of reproductive behavior in the male golden hamster were examined. The sexual behavior of male hamsters exhibits diel variations; males are quicker to initiate copulation and to ejaculate in the dark phase than in the light phase of a daily light-dark cycl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91460-4
更新日期：1984-02-13 00:00:00
abstract：:We have investigated the receptor subtype(s) mediating the noradrenergic inhibition of cerebellar Purkinje cell spontaneous firing rate using local application of specific agonists and antagonists, in situ, via pressure microejection. Extracellular action potentials were recorded from Purkinje neurons in anesthetized ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90552-5
更新日期：1988-10-18 00:00:00
abstract：:The purpose of the present study is to characterize the striatum of the lamprey by immunohistochemical and tracing techniques. Cells immunoreactive for GABA and substance P (SP), and positive for acetylcholinesterase, are present in the lamprey striatum. Immunoreactive (ir) fibers were detected by antisera raised agai...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00701-4
更新日期：1997-08-22 00:00:00
abstract：:Hypoxia-inducible transcription factors (HIFs) are crucially involved in brain development and cellular adaptation to hypoxia and ischemia. Degradation of HIF is regulated under normoxia by oxygen-dependent hydroxylation of specific prolyl residues on the labile alpha-subunit by HIF prolyl hydroxylases (PHD). Prolyl-4...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.023
更新日期：2009-07-14 00:00:00
abstract：:Brainstem noradrenergic neurons located in the A5, A6, and A7 catecholamine cell groups provide the entire noradrenergic innervation of the spinal cord. We have previously demonstrated that noradrenergic neurons in the A6 and A7 cell groups innervate the ventral and dorsal horns, respectively. Since the specific spina...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90210-e
更新日期：1993-07-09 00:00:00
abstract：:Status epilepticus is a life-threatening form of seizure activity that represents a major medical emergency associated with significant morbidity and mortality. Protein Kinase A is an important regulator of synaptic strength that may play an important role in the development of status epilepticus-induced neuronal path...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.066
更新日期：2009-08-04 00:00:00
abstract：:Glutamate is a major neurotransmitter in the CNS. Its release activates NMDA and non-NMDA receptors on the postsynaptic membrane. NMDA receptor activation is shown to be important in physiological and pathological events. The modulatory sites on the NMDA receptor-channel ionophore complex are important in the regulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01461-3
更新日期：1998-03-09 00:00:00
abstract：:Autism is marked by overgrowth of the brain at the earliest ages but not at older ages when decreases in structural volumes and neuron numbers are observed instead. This has led to the theory of age-specific anatomic abnormalities in autism. Here we report age-related changes in brain size in autistic and typical subj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.101
更新日期：2011-03-22 00:00:00
abstract：:Samples of 14 brains of autopsied patients suffering from dementia of the Alzheimer type were examined. In Congo red-hemalum stained 14-microns-thick sections of the hippocampus 15 tangle-bearing and 25-30 unaffected nerve cells of area CA1 per case were measured for cell size and nucleolar size utilizing an interacti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90843-3
更新日期：1989-05-22 00:00:00
abstract：:Cerebral ischemia initiates an inflammatory response in the brain that is associated with the induction of a variety of cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1alpha/beta (IL-1alpha/beta) that contributes to stroke injury. Transient middle cerebral artery occlusion (tMCAO) in spon...
journal_title：Brain research
pub_type： 杂志文章,收录出版
doi：10.1016/j.brainres.2006.11.080
更新日期：2007-02-23 00:00:00
abstract：:Ultrastructural examination of the region near the olfactory epithelial surface of leopard frogs revealed the presence of nerve terminals just proximal to the zonula adherens between adjacent sustentacular cells, and between sustentacular cells and olfactory receptor neurons. Terminal varicosities, located about 20 nm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90920-7
更新日期：1989-07-17 00:00:00
abstract：:The participation of amygdaloid and striatal structures in the various signs of morphine withdrawal syndrome (MWS) has been investigated using two complementary approaches: intracerebral application of naloxone in various nuclei of dependent rats and effects of various lesions and transections on systemically induced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90915-6
更新日期：1979-11-09 00:00:00
abstract：:The tax-4 and tax-2 genes of Caenorhabditis elegans are essential for normal olfaction, gustation, and thermosensation, suggesting that they have a role in sensory transduction. The predicted products of these genes are similar to the cyclic nucleotide-gated (CNG) channel subunits used in vertebrate vision and olfacti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01111-7
更新日期：1999-03-06 00:00:00
abstract：:Transport of the hexapeptide dalargin across the blood-brain barrier was accomplished using a nanoparticle formulation. The formulation consisted of dalargin bound to poly(butyl cyanoacrylate) nanoparticles by sorption, coated with polysorbate 80. Intravenous injection of this formulation to mice resulted in an analge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00023-j
更新日期：1995-03-13 00:00:00
