Abstract：
:In order to establish possible stimulatory effects of increasing plasma concentrations of substance P (SP) on the arginine vasopressin (AVP) and/or oxytocin (OT) secretion, successively increasing doses of SP(0.5, 1 and 1.5 pmol/kg-1/min-1; each dose for 20 min) were infused in 7 normal men. Plasma AVP and OT levels were measured before infusion and every 20 min, just before increasing the infusion dose of SP. During tests, SP infusion did not produce untoward side effects or changes in blood osmolality and/or pressure. Plasma OT levels did not change during SP infusion. Plasma AVP concentrations were not modified by the infusion of the lowest dose of SP, whereas they were significantly increased in a dose response fashion when higher amounts of SP were given. These findings demonstrate for the first time in humans that the systemic administration of SP exerts stimulatory effects on AVP, but not on OT secretion.
journal_name
Brain Resjournal_title
Brain researchauthors
Chiodera P,Coiro Vdoi
10.1016/0006-8993(92)90387-osubject
Has Abstractpub_date
1992-01-08 00:00:00pages
173-6issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(92)90387-Ojournal_volume
569pub_type
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