Abstract：
:Zinc and other cations were iontophoretically applied to neurones in the frontoparietal cortex of urethane-anaesthetised rats and their effect on the activity of these cells was examined. Slow and often prolonged increases in firing rate occurred in 45.2% of neurones after zinc application and 72.7% after barium. Calcium caused short duration decreases in firing rate in 89.3% of neurones as did manganese (78.6%) cerium (21.9%) and magnesium (33.3%). When applied simultaneously zinc blocked the depressant effect of calcium (in 79.3% of neurones) but not that of manganese or GABA; other ions were ineffective. These results suggest that zinc, which is known to be present in nerve terminals, may modulate neuronal activity.
journal_name
Brain Resjournal_title
Brain researchauthors
Wright DMdoi
10.1016/0006-8993(84)90097-0subject
Has Abstractpub_date
1984-10-08 00:00:00pages
343-7issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(84)90097-0journal_volume
311pub_type
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