Antihypertensive effects of L-tryptophan are not mediated by brain serotonin.

Abstract:

:L-Tryptophan produces a significant antihypertensive effect in spontaneously hypertensive rats while D-tryptophan does not change blood pressure. Both isomers of tryptophan significantly increase brain serotonin to the same extent at a time when the antihypertensive effect of L-tryptophan is maximal. Thus, the antihypertensive effects of L-tryptophan do not appear to be mediated by brain serotonin.

journal_name

Brain Res

journal_title

Brain research

authors

Wolf WA,Kuhn DM

doi

10.1016/0006-8993(84)90985-5

subject

Has Abstract

pub_date

1984-03-19 00:00:00

pages

356-9

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(84)90985-5

journal_volume

295

pub_type

杂志文章
  • Mechanism of action of the epileptogenic drug pentylenetetrazol on a cloned neuronal potassium channel.

    abstract::The action of the epileptogenic agent pentylenetetrazol (PTZ) on a cloned potassium channel of the rat brain was studied. The Kv1.1 channel was expressed in oocytes of Xenopus laevis and potassium currents were investigated in outside-out and inside-out membrane patches. The results show that PTZ increased the multi-c...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00181-3

    authors: Madeja M,Musshoff U,Lorra C,Pongs O,Speckmann EJ

    更新日期:1996-05-25 00:00:00

  • Increased levels of carbonic anhydrase II in the developing Down syndrome brain.

    abstract::By using a proteomic approach, we found increased levels of carbonic anhydrase II (CA II) in the brain of Ts65Dn mice, a mouse model for Down syndrome (DS). Further immunoblot analyses showed that the levels of CA II are increased not only in the brain of adult Ts65Dn mice but also in the brain of infants and young ch...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.11.023

    authors: Palminiello S,Kida E,Kaur K,Walus M,Wisniewski KE,Wierzba-Bobrowicz T,Rabe A,Albertini G,Golabek AA

    更新日期:2008-01-23 00:00:00

  • Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS.

    abstract::The purpose of this study was to determine the ultrastructure of the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) in G93A SOD1 mice modeling ALS at different stages of disease. Electron microscope examination of brainstem, cervical and lumbar spinal cords was performed in ALS mice at early and late s...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.04.044

    authors: Garbuzova-Davis S,Haller E,Saporta S,Kolomey I,Nicosia SV,Sanberg PR

    更新日期:2007-07-09 00:00:00

  • Long-term brain metabolic alterations in exogenous Cushing's syndrome as monitored by proton magnetic resonance spectroscopy.

    abstract::The effects of exogenous Cushing's syndrome on the brain metabolism were investigated by proton magnetic resonance spectroscopy (MRS). Thirteen patients having been treated for 2 to 22 years with prednisone were recruited. On the average, none of the metabolites (NAA, Cr, Cho and mI) were significantly different from ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02697-x

    authors: Khiat A,Yared Z,Bard C,Lacroix A,Boulanger Y

    更新日期:2001-08-24 00:00:00

  • Identification and ultrastructural localization of a calretinin-like calcium-binding protein (protein 10) in the guinea pig and rat inner ear.

    abstract::Calretinin has been identified as a brain specific calcium-binding protein which appears as a prominent protein in the cochlear nucleus. We identified and localized calretinin in the guinea pig and rat inner ear using polyclonal antibodies. Immunoblot analyses of guinea pig and rat auditory nerve homogenates revealed ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91224-o

    authors: Dechesne CJ,Winsky L,Kim HN,Goping G,Vu TD,Wenthold RJ,Jacobowitz DM

    更新日期:1991-09-27 00:00:00

  • Co-localization of substance P and Met-enkephalin-Arg6-Gly7-Leu8 in the intraspinal neurons of the rat, with special reference to the neurons in the substantia gelatinosa.

    abstract::A double-labeling immunofluorescence technique was employed to investigate the co-localization of the functionally antagonistic neuropeptides, substance P and enkephalins, within intraspinal neurons of the rat. Anti-Met-enkephalin-Arg6-Gly7-Leu8 (Enk-8) antiserum was used as a marker of the preproenkephalin A neuron s...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90148-5

    authors: Senba E,Yanaihara C,Yanaihara N,Tohyama M

    更新日期:1988-06-21 00:00:00

  • Effects of intrastriatal injections of the cholinergic neurotoxin AF64A on spontaneous nocturnal locomotor behavior in the rat.

    abstract::Rats with bilateral striatal cholinergic lesions induced by the neurotoxin AF64A were found to have increased spontaneous nocturnal locomotor activity as measured in terms of the amount of time spent moving, the total distance traveled and the number of episodes and time of stereotypic behaviors. No significant differ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90715-7

    authors: Sandberg K,Sanberg PR,Coyle JT

    更新日期:1984-05-14 00:00:00

  • The avian somatosensory system: connections of regions of body representation in the forebrain of the pigeon.

    abstract::In order to establish the basic connectivity of physiologically identified somatosensory regions of the thalamus and telencephalon in the pigeon, injections of wheatgerm agglutinin-horseradish peroxidase were made under electrophysiological control and the projections were charted following conventional neurohistochem...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/0006-8993(87)91127-9

    authors: Wild JM

    更新日期:1987-06-02 00:00:00

  • Vagus nerve stimulation promotes cortical reorganization and reduces task-dependent calorie intake in male and female rats.

    abstract::Numerous preclinical studies demonstrate that vagus nerve stimulation (VNS) paired with motor rehabilitation improves functional recovery after neural injuries such as stroke, traumatic brain injury, and spinal cord injury, in part by driving neural plasticity within the motor cortex. To date, these studies have been ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.147099

    authors: Tseng CT,Brougher J,Gaulding SJ,Hassan BS,Thorn CA

    更新日期:2020-12-01 00:00:00

  • The rostral projection of small diameter primary afferents in Lissauer's tract.

    abstract::The rostral projection of A delta and C primary afferents in Lissauer's tract (LT) was studied by assessing how far, rostrally, axons entering at a given level could be activated by electrical stimulation. Sural A delta primary afferents in LT exhibited a rostral projection at least as far as the L3/L4 border, 4 segme...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)90617-7

    authors: Traub RJ,Sedivec MJ,Mendell LM

    更新日期:1986-12-03 00:00:00

  • High density of cholinergic muscarinic receptors accompanies high intensity acetylcholinesterase-staining in layer IV of infant rat somatosensory cortex.

    abstract::In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(83)90018-4

    authors: Kristt DA,Kasper EK

    更新日期:1983-06-01 00:00:00

  • Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats.

    abstract::The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (2...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01952-6

    authors: Belayev L,Saul I,Huh PW,Finotti N,Zhao W,Busto R,Ginsberg MD

    更新日期:1999-10-16 00:00:00

  • Characterization of tissue and functional deficits in a clinically translational pig model of acute ischemic stroke.

    abstract::The acute stroke phase is a critical time frame used to evaluate stroke severity, therapeutic options, and prognosis while also serving as a major tool for the development of diagnostics. To further understand stroke pathophysiology and to enhance the development of treatments, our group developed a translational pig ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146778

    authors: Kaiser EE,Waters ES,Fagan MM,Scheulin KM,Platt SR,Jeon JH,Fang X,Kinder HA,Shin SK,Duberstein KJ,Park HJ,West FD

    更新日期:2020-06-01 00:00:00

  • Behavior of intracellular cyclic nucleotide and calcium in pentylenetetrazole-induced bursting activity in snail neurons.

    abstract::To elucidate the intracellular mechanism of the bursting activity which is characteristic of seizure discharge, the behavior of the intracellular cyclic nucleotide and the intracellular calcium during pentylenetetrazole (PTZ)-induced bursting activity in snail neurons was investigated. Cyclic AMP was increased about 3...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90137-3

    authors: Onozuka M,Kishii K,Furuichi H,Sugaya E

    更新日期:1983-06-20 00:00:00

  • Stimulation of the parabrachial nuclei with monosodium glutamate increases arterial pressure.

    abstract::In the urethane-anesthetized rat both electrical stimulation (20 microA, 0.2 ms, 30 s) through micropipettes and glutamate injections (0.1 M, 100 nl) within an area including the dorsal lateral parabrachial nucleus, the adjacent central lateral parabrachial nucleus, the external lateral parabrachial nucleus, the Kölli...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90570-7

    authors: Ward DG

    更新日期:1988-10-18 00:00:00

  • N-alpha-p-tosyl-L-lysine chloromethyl ketone (TLCK) suppresses neuritic degeneration caused by different experimental paradigms including in vitro Wallerian degeneration.

    abstract::Accumulating evidence indicates that neurite degeneration occurs via a distinct mechanism from somal death programs. We have previously shown that neuritic ATP level in sympathetic neurons decreases, whereas somal ATP level remains unaltered during degeneration caused by the microtubule-disrupting agent, vinblastine. ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.09.050

    authors: Ikegami K,Kato S,Koike T

    更新日期:2004-12-24 00:00:00

  • Calretinin distribution in the octopus brain: an immunohistochemical and in situ hybridization histochemical analysis.

    abstract::The distribution of calretinin containing neurons examined by in situ hybridization mapping was compared with that obtained by immunocytochemistry in the brain of octopus. Results revealed a close correspondence between the two types of investigations. Western blot analysis disclosed a 29 kDa protein immunostained wit...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.11.056

    authors: Altobelli GG,Cimini V

    更新日期:2007-02-09 00:00:00

  • Differing distributions of receptors for morphine and Met5-enkephalinamide in the dorsal horn of the cat.

    abstract::In the dorsal horn of barbiturate-anaesthetized cats evidence was obtained for a different distribution of enkephalin-preferring and morphine-preferring receptors. When ejected electrophoretically from micropipettes, morphine reduced the nociceptive responses of neurones of laminae IV and V when administered in the su...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)91002-7

    authors: Duggan AW,Johnson SM,Morton CR

    更新日期:1981-12-21 00:00:00

  • Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress.

    abstract::Early adverse events have been shown to increase the incidence of interstitial cystitis/painful bladder syndrome in adulthood. Despite high clinical relevance and reports of stress-related symptom exacerbation, animal models investigating the contribution of early life stress to female urological pain are lacking. We ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.02.039

    authors: Pierce AN,Di Silvestro ER,Eller OC,Wang R,Ryals JM,Christianson JA

    更新日期:2016-05-15 00:00:00

  • Genetically-targeted and conditionally-regulated ablation of astroglial cells in the central, enteric and peripheral nervous systems in adult transgenic mice.

    abstract::Ablation of tissue regions, specific genes, or specific cell types represent important means of studying function in the nervous system. Here we summarize recent experience using a strategy for the genetically-targeted and conditionally regulated ablation of astroglial cells in different parts of the nervous system. T...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0006-8993(99)01639-x

    authors: Sofroniew MV,Bush TG,Blumauer N,Lawrence Kruger,Mucke L,Johnson MH

    更新日期:1999-07-17 00:00:00

  • Estrogen-dependent changes in estrogen receptor-β mRNA expression in middle-aged female rat brain.

    abstract::During aging, estrogen production and circulating levels of estrogen are markedly decreased in females. Although several differences exist in the process of reproductive aging between women and female rats, the results of many studies suggest that the female rat, especially the middle-aged or aged ovariectomized femal...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.11.010

    authors: Yamaguchi N,Yuri K

    更新日期:2014-01-16 00:00:00

  • Maternal and genetic factors in stress-resilient and -vulnerable rats: a cross-fostering study.

    abstract::Early environmental factors can modulate the development of the hypothalamic-pituitary-adrenal (HPA) axis response to stress, together with subsequent brain functions and emotional behaviors. Two rat strains, Sprague-Dawley (SD) and Fischer 344 (F344), are known to exhibit differences in HPA axis reactivity and anxiet...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.11.070

    authors: Uchida S,Hara K,Kobayashi A,Otsuki K,Hobara T,Yamagata H,Watanabe Y

    更新日期:2010-02-26 00:00:00

  • Specific bindings of prostaglandin D2, E2 and F2 alpha in postmortem human brain.

    abstract::Binding activities specific for each of [3H]prostaglandin (PG) D2, E2 and F2 alpha were detected in the P2 fraction of the human brain homogenates. The bindings were time-dependent, saturable and of high affinity; Kd values were 30 nM for all the PG bindings. Regional distribution of these binding activities was deter...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91358-7

    authors: Watanabe Y,Tokumoto H,Yamashita A,Narumiya S,Mizuno N,Hayaishi O

    更新日期:1985-09-02 00:00:00

  • Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence-accelerated mouse prone 8 (SAMP8) mice.

    abstract::The senescence-accelerated mouse prone 8 (SAMP8) is a novel aging model characterized by early onset and rapid advancement of senescence. In the present study, 6-month-old male SAMP8 mice were orally administered icariin (75, 150mg/kg) for 15weeks. Mice were submitted to passageway water maze test and step-down passiv...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.03.084

    authors: He XL,Zhou WQ,Bi MG,Du GH

    更新日期:2010-06-02 00:00:00

  • Environmental enrichment restores cognitive deficits induced by prenatal maternal seizure.

    abstract::Maternal seizure has adverse effects on brain histology as well as on learning and memory ability in progeny. An enriched environment (EE) is known to promote structural changes in the brain and improve cognitive and motor deficits following a variety of brain injuries. Whether EE treatment in early postnatal periods ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.06.034

    authors: Xie T,Wang WP,Jia LJ,Mao ZF,Qu ZZ,Luan SQ,Kan MC

    更新日期:2012-08-27 00:00:00

  • Anatomical evidence for a strong ventral parabrachial projection to nucleus raphe magnus and adjacent tegmental field.

    abstract::Injections with [3H]leucine in the ventral parabrachial nuclei and nucleus Kölliker-Fuse of the cat revealed strong projections to the nucleus raphe magnus (NRM) and adjacent tegmentum, while similar injections in the adjacent nucleus subcoeruleus produced diffuse projections to large parts of the tegmentum, but not s...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90977-8

    authors: Holstege G

    更新日期:1988-04-26 00:00:00

  • Quantitative studies of mitoses in fetal rat brain: orientations of the spindles.

    abstract::In continuation of our quantitative studies on 15-day fetal rat brain development, evidence was obtained of ventricular mitoses whose spindles are perpendicular to the surface of the ventricle. In most locations the proportion (ratio) between cells with perpendicular mitoses and predominant cells with mitoses parallel...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(87)90094-0

    authors: Zamenhof S

    更新日期:1987-01-01 00:00:00

  • Variations in the retinal synapses of the cat superior colliculus revealed using quantitative electron microscope autoradiography.

    abstract::This study has examined the retinal synapses of the cat superior colliculus using electron microscope autoradiography and morphometric techniques. The depth of each retinal synapse was measured using a computer-based EM plotter. The area, perimeter, and synapse contact density of selected synapses were calculated usin...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90130-0

    authors: Mize RR

    更新日期:1983-06-20 00:00:00

  • Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats.

    abstract::Lithium is known to potentiate the ability of pilocarpine to induce status epilepticus in rats. The goal of this study was to determine whether lithium could potentiate pilocarpine-induced seizures in developing animals. Behavioral, electroencephalographic (EEG), and histopathological changes induced by systemic admin...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(10)80015-0

    authors: Hirsch E,Baram TZ,Snead OC 3rd

    更新日期:1992-06-26 00:00:00

  • Gender-specific apposition between vasoactive intestinal peptide-containing axons and gonadotrophin-releasing hormone-producing neurons in the rat.

    abstract::Light microscopic double labeling immunocytochemistry for vasoactive intestinal peptide (VIP) and gonadotrophin-releasing hormone (GnRH) was carried out on the hypothalami of male and female rats. It was found that the number of VIP boutons that terminate on GnRH neurons and the percentage of GnRH neurons contacted by...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00208-x

    authors: Horvath TL,Cela V,van der Beek EM

    更新日期:1998-06-08 00:00:00