Abstract：
:The pathogenic mechanisms of gene-environment interactions determining variability of human neurodevelopmental disorders remain unclear. In the two consecutive papers, we used the neonatal Borna disease virus (BDV) infection rat model of neurodevelopmental damage to evaluate brain pathology, monoamine alterations, behavioral deficits, and responses to pharmacological treatments in two inbred rat strains, Lewis and Fisher344. The first paper reports that despite comparable virus replication and distribution in the brain of both rat strains, neonatal BDV infection produced significantly greater thinning of the neocortex in BDV-infected Fisher344 rats compared to BDV-infected Lewis rats, while no strain-related differences were found in BDV-induced granule cell loss in the dentate gyrus of the hippocampus and cerebellar hypoplasia. Unlike BDV-infected Lewis rats, more severe BDV-induced brain pathology in Fisher344 rats was associated with (1) greater locomotor activity to novelty and (2) impairment of habituation and prepulse inhibition of the acoustic startle response. The present data demonstrate that the same environmental insult can produce differential neuroanatomical and behavioral abnormalities in genetically different inbred rat strains.
journal_name
Brain Resjournal_title
Brain researchauthors
Pletnikov MV,Rubin SA,Vogel MW,Moran TH,Carbone KMdoi
10.1016/s0006-8993(02)02723-3subject
Has Abstractpub_date
2002-07-19 00:00:00pages
97-107issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899302027233journal_volume
944pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:To determine whether oculomotor internuclear neurons (INOs) establish unilateral or bilateral connections with the abducens nucleus (nVI), horseradish peroxidase (HRP) and either DAPI or Nuclear Yellow (NY) were injected into nVI and the oculomotor complex (nIII) examined for retrogradely labeled cells. Such injection...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90464-x
更新日期：1983-02-28 00:00:00
abstract：:Recent evidence suggest that the blockade of cannabinoid CB1 receptors might be beneficial to alleviate motor inhibition typical of Parkinson's disease (PD). In the present study, we have explored the motor effects of rimonabant, a selective antagonist of CB1 receptors, in a rat model of PD generated by an intracerebr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.014
更新日期：2006-02-16 00:00:00
abstract：:The adult rat retina was evaluated following surgical lesion and after transplantation of embryonic day 15 (E15) retinal tissue. While a surgical incision caused degeneration and ganglion cell death peripheral to lesion site, the addition of an embryonic retinal implant to the lesion site resulted in a reduction of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90300-4
更新日期：1989-10-23 00:00:00
abstract：:Visual acuity was measured by determining the highest spatial acuity at which chickens aged 1-25 days jumped consistently to a physically supported grating instead of to an unsupported homogeneous field. In contrast to the gradual visual development found for kittens, monkeys, and humans, the chicken exhibits asymptot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90967-7
更新日期：1981-05-04 00:00:00
abstract：:The mammalian circadian clock in the suprachiasmatic nuclei (SCN) can be phase-shifted in vitro by the serotonin agonist quipazine. Here we show that quipazine resets the SCN clock in the presence of tetrodotoxin or 10 mM Mg2+, treatments that block Na+ action potentials and Ca2+ channels, respectively. These results ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90784-7
更新日期：1992-02-28 00:00:00
abstract：:Intraventricular injections of kainic acid were used to destroy the hippocampal CA3-CA4 cells, thus denervating the inner third of the molecular layer of the fascia dentata and stratum radiatum and stratum oriens of area CA1. The responses of intact afferents to such lesions were then examined histologically. The hipp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90825-2
更新日期：1980-01-20 00:00:00
abstract：:Death receptors are associated with the homeostatic and pathologic induction of cell death. TR3 is a recently characterised member of the death receptor family that is expressed in the adult brain. In order to establish the role of TR3 in acute CNS disease and chronic neurodegeneration, we analysed brain regions from ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02417-8
更新日期：2000-02-28 00:00:00
abstract：:A search for vasomotor depressor sites in the lateral medullary brainstem of anesthetized cat using microinjections of AMPA has delineated a longitudinal column of sympathoinhibitory neurons consisting of the rostral depressor area, the caudal ventrolateral medulla, and a new intermediate depressor area. Systematic bl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91257-s
更新日期：1993-02-19 00:00:00
abstract：:We have recently demonstrated that the formation of myelin sheaths in the optic nerve of young postnatal mice deficient in the myelin-associated glycoprotein (MAG) is retarded when compared to age-matched wild-type mice. In the present study, we analyzed whether impaired myelination of retinal ganglion cell axons is d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00484-8
更新日期：1997-07-11 00:00:00
abstract：:Two rat lines bred for kindling susceptibility were previously observed to engage in different behavioral strategies in tests of emotionality. In order to extend past research on defensive behaviors in these strains which largely used males, Fast- and Slow-kindling females were assessed for anxiety-like behaviors in a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.08.090
更新日期：2008-11-13 00:00:00
abstract：:Neural correlates of conscious awareness can be comfortably studied when awareness of the target stimuli is a varying dependent variable in the experimental conditions where the key independent variables are kept invariant. We presented vernier targets backward masked by an invariant grating with invariant SOA. EEG da...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.085
更新日期：2009-05-19 00:00:00
abstract：:The binding of the adenosine receptor agonists, [3H]N-ethylcarboxamidoadenosine (NECA) and [3H]cyclohexyladenosine (CHA) to membrane preparations and to cryostat sections of the rat brain was examined. The xanthine derivative, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) was ca. 500-fold more effective at A1 than at A2 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90589-5
更新日期：1986-03-19 00:00:00
abstract：:Bromodeoxyuridine (BrUdR) injected into Xenopus embryos at stages before, during or after the last period of DNA synthesis in Mauthner's neurons had no serious effect on differentiation of Mauthner's neurons. However, the BrUdR caused widespread cell degeneration in the central nervous system. The action of BrUdR on r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90819-3
更新日期：1978-07-21 00:00:00
abstract：:Female B6C3F1 mice were rendered tolerant-dependent on morphine by a combination of injections and pellet implantation. Mice were injected with morphine sulfate (20 mg/kg, s.c.) twice a day on day 1. On day 2, they were implanted s.c. with a 75 mg morphine pellet for 3 days. On day 5, the pellets were either left inta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90899-0
更新日期：1994-04-11 00:00:00
abstract：:Discharges of neurons in the midpontine dorsal tegmental field (DTF neurons) were recorded and analyzed during locomotion and were compared with those of reticulospinal neurons (RS neurons) located lateral to the DTF area. The conduction velocity of the descending axon of the DTF neurons was significantly smaller than...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91078-9
更新日期：1985-08-26 00:00:00
abstract：:Considerable evidence indicates an enhanced sympathetic innervation of muscular resistance arteries in the spontaneously hypertensive rat (SHR) compared with its normotensive Wistar-Kyoto (WKY) control. Since nerve growth factor (NGF) is known to affect the growth of sympathetic nerves, we have utilized a sensitive tw...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91012-h
更新日期：1993-06-18 00:00:00
abstract：:The melanocortins (MC) can affect interscapular brown adipose tissue (IBAT) thermogenesis via its sympathetic nervous system (SNS) innervation. We chose a site of high MC4-receptor (MC4-R) mRNA co-localization with SNS outflow neurons to IBAT, the subzona incerta (subZI) to test whether IBAT thermogenesis could be inc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.003
更新日期：2011-09-09 00:00:00
abstract：:The responses of single alpha motoneurons to various "natural' stimuli were recorded from dissected ventral root filaments in lightly anesthetized control and recently decerebellate cats. The identity of the motoneurons was established by recording the unitary responses to orthodromic stimulation of nerves innervating...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90208-5
更新日期：1975-09-12 00:00:00
abstract：:The visual system in the pigeon is composed of the tectofugal, thalamofugal and accessory optic pathways. Though their anatomy and physiology have been extensively studied, the functional interactions between these pathways are largely unknown. The present study shows by using multiple electrophysiological techniques ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.11.063
更新日期：2006-01-19 00:00:00
abstract：:To determine whether postmitotic neurons can be immortalized by oncogenic transduction, we used two approaches involving conditional expression of a temperature-sensitive SV40 large T antigen (Tts). Initially, Tts was introduced into E17 rat embryonal hippocampal cells that were then cultured at the non-permissive tem...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91484-2
更新日期：1994-09-12 00:00:00
abstract：:After an intraventricular administration of colchicine, the arcuate nucleus of rat hypothalamus was examined light and electron microscopically by pre-embedding immunohistochemistry for somatostatin. The arcuate nucleus exhibited numerous immunoreactive cell bodies and dense networks of immunoreactive fibers. The fibe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90312-8
更新日期：1983-03-21 00:00:00
abstract：:Even though animal and human studies show alterations in dopamine transporter (DAT) sites after alcohol withdrawal, the role of DAT in influencing either alcoholic or depressive behavior has not been examined extensively. Given that the Wistar-Kyoto (WKY) rat is a putative animal model of depressive behavior, the pres...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.009
更新日期：2006-02-16 00:00:00
abstract：:The properties of junctions formed de novo in ectopic regions of muscle were studied and compared to those of endplates reinnervated after nerve crush and to normals. The nerve to the frog cutaneous pectoris muscle was transposed and implanted onto an endplate-free (ectopic) region of that muscle, while the endplate-c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90673-4
更新日期：1982-12-16 00:00:00
abstract：:Responses elicited by stimulating the pre-versus postganglionic nerves were compared in cat bladder parasympathetic neurons. We observed that synaptic potentials recorded on stimulating the postganglionic nerve trunk were different from those elicited with preganglionic nerve stimulation. These findings suggest that l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91634-9
更新日期：1987-12-01 00:00:00
abstract：:Experiments were conducted to examine sex differences in striatal dopamine function using in vivo microdialysis in freely moving rats. We report here a sex difference in basal extracellular striatal dopamine determined by quantitative microdialysis (the no net flux method) when castrated and ovariectomized rats were c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91225-h
更新日期：1993-04-30 00:00:00
abstract：:A normobar hypoxia (9% oxygen) of 8 h reduces the neurotoxicity of a subcutaneous injection of 10 mg/kg kainic acid given one week later. Both seizures and degenerative changes, including cell death of hippocampal and cortical neurons are markedly decreased by hypoxia. It is also shown that hypoxia also markedly reduc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91693-4
更新日期：1994-05-02 00:00:00
abstract：:The study investigated the effect of aminoguanidine (AG) on inducible nitric oxide synthase (iNOS), aquaporin-4 (AQP4), malondialdehyde (MDA) and glutathione (GSH) levels in surgical brain injury (SBI) in rats. AG (75, 150 and 300 mg/kg, i.p.) was administered immediately following surgical resection. Using an SBI mod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.041
更新日期：2009-07-28 00:00:00
abstract：:The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is implicated in the temporal organization of circadian rhythms in a variety of physiological, endocrine and behavioral processes. There is a great deal of evidence indicating that aging is characterized by a progressive deterioration of circadian timekeep...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90689-0
更新日期：1994-07-18 00:00:00
abstract：:A sample of 302 neurons in rat hindlimb granular cortex was studied between 2 and 3 weeks after transection and ligation of the sciatic nerve. These neurons were compared to a control sample obtained from normal rats under similar experimental conditions. After sciatic nerve transection the proportion of neurons drive...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91019-0
更新日期：1988-05-24 00:00:00
abstract：:Traumatic brain injury (TBI) is one of the largest health problems in the United States and affects both cognitive and motor function. Although weakness is common in TBI patients, few studies have demonstrated a reduction in strength in models of brain injury. We have developed a behavioral method to measure volitiona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.07.039
更新日期：2014-09-25 00:00:00
