Is substance P a primary afferent neurotransmitter for nociceptive input? II. Spinalization does not reduce and intrathecal morphine potentiates behavioral responses to substance P.

abstract：:The senescence-accelerated mouse prone 8 (SAMP8) is a novel aging model characterized by early onset and rapid advancement of senescence. In the present study, 6-month-old male SAMP8 mice were orally administered icariin (75, 150mg/kg) for 15weeks. Mice were submitted to passageway water maze test and step-down passiv...

journal_title：Brain research

authors： He XL,Zhou WQ,Bi MG,Du GH

更新日期：2010-06-02 00:00:00

abstract：:Amyloid deposition, a histopathological feature of Alzheimer's disease brain, may be the underlying cause of this disease. The isolation of enzymes involved in both the normal and aberrant or alternative processing of the beta-amyloid precursor protein may lead to an understanding of how beta-protein, the major compon...

journal_title：Brain research

authors： Razzaboni BL,Papastoitsis G,Koo EH,Abraham CR

更新日期：1992-09-04 00:00:00

abstract：:Corticotropin-releasing hormone (CRH) and vasopressin (AVP) participate in the endocrine, autonomic, immunological and behavioral response to stress. CRH and AVP receptors are found in hippocampus and anterior pituitary, where mineralocorticoid (MR) and glucocorticoid (GR) receptors are abundant. We investigated the p...

journal_title：Brain research

authors： Hügin-Flores ME,Steimer T,Schulz P,Vallotton MB,Aubert ML

更新日期：2003-06-27 00:00:00

abstract：:The [14C]2-deoxyglucose (2-DG) technique has been widely utilized for quantitative measurement of local cerebral metabolic for glucose (1CMRG) in animals. The technique as presently used is limited by the energy of 14C beta-particles, which can travel relatively great distances in tissue. This results in limited audio...

journal_title：Brain research

authors： Alexander GM,Schwartzman RJ,Bell RD,Yu J,Renthal A

更新日期：1981-10-26 00:00:00

abstract：:Acetylcholinesterase activity, which may be indicative of cholinergic synapses, has been ultrastructurally localized in the outer plexiform layer of the larval tiger salamander retina using the cholinesterase staining method of Karnovsky and Roots. In the presence of the butyrylcholinesterase inhibitor, ethopropazine,...

journal_title：Brain research

authors： Hutchins JB,Polans AS,Werblin FS

更新日期：1984-02-06 00:00:00

abstract：:Studies of the subcellular localization of neuroreceptors in the rat brain have shown that most of them are associated with light and low density subcellular fractions. In two human brain areas, quite different subcellular distributions were observed. After fractionation by differential centrifugation of frontal corte...

journal_title：Brain research

authors： Maloteaux JM,Luabeya MK,Vanisberg MA,Jeanjean AP,Baudhuin P,Scherman D,Laduron PM

更新日期：1995-07-31 00:00:00

abstract：:Previous studies have observed that pial artery dilation to activators of the ATP sensitive K (K(ATP)) and calcium sensitive K (K(ca)) channel was blunted following fluid percussion brain injury (FPI) in the piglet. In recent studies in the rat, protein tyrosine kinase (PTK) activation was observed to contribute to K(...

journal_title：Brain research

authors： Armstead WM

更新日期：2002-07-12 00:00:00

abstract：:The hypothesis according to which BoTx and TeTx block neuromuscular transmission by impairing Ca2+ influx was tested by recording presynaptic membrane currents at motor endplates of the mouse by means of external electrodes. The use of K-channel blockers allowed us to observe inward Ca current which was unaffected by ...

journal_title：Brain research

authors： Dreyer F,Mallart A,Brigant JL

更新日期：1983-07-04 00:00:00

abstract：:Ia synapses in laminae VI and IX of the cat's spinal cord were examined in the electron microscope following iontophoretic injection of horseradish peroxidase (HRP) into single, identified, Ia afferent fibers from gastrocnemius muscles. Ia boutons contacting motoneuron dendrites in lamina IX contained spherical synapt...

journal_title：Brain research

authors： Fyffe RE,Light AR

更新日期：1984-05-23 00:00:00

abstract：:The patch clamp technique has been used to study ion channel activity in the apical (ventricular) membrane of epithelial cells from the rat choroid plexus. Two different classes of Cl(-)-selective channel were identified. A low conductance (26 pS) channel which was the predominant feature in cell-attached and inside-o...

journal_title：Brain research

authors： Garner C,Brown PD

更新日期：1992-09-18 00:00:00

abstract：:The aim of this study was to evaluate spatial organization of hyperactive microglial cells in trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord (C1), and to clarify the involvement in mechanisms underlying orofacial secondary hyperalgesia following infraorbital nerve injury. We found that the h...

journal_title：Brain research

authors： Shibuta K,Suzuki I,Shinoda M,Tsuboi Y,Honda K,Shimizu N,Sessle BJ,Iwata K

更新日期：2012-04-27 00:00:00

abstract：:The present study examined whether substance P (Sub P) could protect against quinolinic acid (QA)-induced lesions of the striatum, as measured by a loss of striatal D1 dopamine receptors. Sub P was extruded into Evac polymer rods for slow release. One 4 mm rod segment was implanted unilaterally into the striatum of ea...

journal_title：Brain research

authors： Sanberg PR,Emerich DF,Aebischer P,Amisetti SM,Ouellette W,Koutouzis TK,Cahill DW,Norman AB

更新日期：1993-11-19 00:00:00

abstract：:Inhibition of Aβ production and clearance of senile plaques have been considered as potential strategies in the treatment of Alzheimer's disease (AD). Activated protein C (APC) is an important factor in the anticoagulant system. However, whether APC can influence the condition of a chronic neurodegenerative process, s...

journal_title：Brain research

authors： Li B,Yu D,Xu Z

更新日期：2014-01-30 00:00:00

abstract：:Neural activity was recorded from 218 sites in the striatum (caudate-putamen and nucleus accumbens) of rats trained on a lever-release version of the conditioned avoidance response (CAR) task, in which an auditory signal elicits a short-latency, forelimb withdrawal. > 80% of these recording sites showed task-related a...

journal_title：Brain research

authors： White IM,Rebec GV

更新日期：1993-07-09 00:00:00

abstract：:Male rats were dehydrated for 22 h and then given 4 h intracerebroventricular (i.c.v.) infusions which commenced 2 h prior to the beginning of a 2-h fluid access period. I.c.v. infusion of iso-osmotic 0.27 M mannitol-CSF more than halved the amount of water normally drunk by dehydrated rats during the fluid access per...

journal_title：Brain research

authors： Osborne PG,Denton DA,Weisinger RS

更新日期：1987-05-26 00:00:00

abstract：:The depolarizing photoreceptor potential in the molluscan extraocular photoreceptor, A-P-1, results from the light-induced suppression of specific K+ currents. An application of cGMP or IBMX (inhibitor of phosphodiesterase) to A-P-1-evoked light-suppressed currents, similar to the above specific K+ currents. Thus, the...

journal_title：Brain research

authors： Nishi T,Gotow T

更新日期：1989-04-17 00:00:00

abstract：:Voltage-gated potassium (Kv) channels are essential components of neuronal excitability. The Kv3.4 channel protein is widely distributed throughout the central nervous system (CNS), where it can form heteromeric or homomeric Kv3 channels. Electrophysiological studies reported here highlight a functional role for this ...

journal_title：Brain research

authors： Dallas ML,Morris NP,Lewis DI,Deuchars SA,Deuchars J

更新日期：2008-01-16 00:00:00

abstract：:A study was made of the release of excitatory, inhibitory and other amino acids from epileptic foci induced in the sensorimotor cortex of rats by cobalt implantation. A new in vivo superfusion method was employed which gives free movement to the animals and allows study over periods of days and weeks. Most amino acids...

journal_title：Brain research

authors： Dodd PR,Bradford HF

更新日期：1976-07-30 00:00:00

abstract：:Superfusion of rat hypothalamic slices with 10(-4) M N-methyl-D-aspartic acid (NMDA) resulted in increased release of alpha-melanocyte-stimulating hormone (alpha-MSH). Peptide release was blocked by 10(-6) M NG-nitro-L-arginine methyl ester (L-NAME) a specific competitive inhibitor of nitric oxide synthase but not by ...

journal_title：Brain research

authors： Wayman CP,Pike NV,Wilson JF

更新日期：1994-12-15 00:00:00

abstract：:The expression of the neurofilament (NF) protein triplet (70, 150 and 200 k daltons (K)) was studied by immunofluorescence in two clones of murine C-1300 neuroblastoma. Clone 1 formed clumps of round cells with few processes, while in clone 2 the cells were more dispersed and extended many processes. In both clones se...

journal_title：Brain research

authors： Dahl D,Rustigian R,Bignami A

更新日期：1984-05-14 00:00:00

abstract：:The purpose of this study was to investigate morphological characteristics of the synaptic relations of choline acetyltransferase (ChAT)-positive terminals that are made with a variety of post-synaptic profiles in the lateralis medialis-suprageniculate nuclear complex (LM-Sg) using ChAT, gamma-aminobutyric acid (GABA)...

journal_title：Brain research

authors： Hoshino K,Hicks TP,Meguro R,Hirano S,Kase M,Norita M

更新日期：1997-01-30 00:00:00

abstract：:Axonal projections of medial brain stem areas rich in serotonin-containing neurons were identified in layers I and II of cat medullary dorsal horn using EM autoradiography. Following [3H]amino acid injections into the brain stem, labeled axonal endings were found throughout layers I and II but were most numerous in la...

journal_title：Brain research

authors： Ruda MA,Allen B,Gobel S

更新日期：1981-01-26 00:00:00

abstract：:The central nervous system of the mollusc Helix pomatia was stimulated with NO donors sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP) or hydroxylamine, in the presence of a phosphodiesterase inhibitor 1-methyl-3-isobutylxanthine (IBMX). Radioimmunoassay revealed that all of the three NO donors signi...

journal_title：Brain research

authors： Huang S,Kerschbaum HH,Hermann A

更新日期：1998-01-12 00:00:00

abstract：:We have previously demonstrated that NMDA receptor-mediated extracellular adenosine accumulation in neuronal cultures is receptor-mediated and requires calcium influx. Because protein kinase C (PKC) is a calcium-dependent enzyme, we hypothesized that activation of PKC might be involved in NMDA-mediated adenosine accum...

journal_title：Brain research

authors： Lu Y,Rosenberg PA

更新日期：2007-06-25 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) is a 38-amino-acid polypeptide, first isolated from hypothalamus, which directly stimulates in vitro the production of cAMP as well as the release of several pituitary hormones, such as growth hormone and luteinizing hormone. In vivo, PACAP has been shown to stimu...

journal_title：Brain research

authors： Grinevich V,Fournier A,Pelletier G

更新日期：1997-10-31 00:00:00

abstract：:Rats were subjected to transient global ischemia (four vessel occlusion) and time-related changes in the selectively vulnerable hippocampal field CA1 were characterized. The assessment included ex vivo field responses to afferent stimulation, silver staining, calpain-induced spectrin breakdown, chromatolysis, and cell...

journal_title：Brain research

authors： Bartus RT,Dean RL,Mennerick S,Eveleth D,Lynch G

更新日期：1998-04-20 00:00:00

abstract：:The present study using near-infrared spectroscopy (NIRS) examined prefrontal activation associated with maze-solving performance in adult humans. The participants were required to solve a plus-shaped maze, comparable to the one used for pigeons and human children to behaviorally assess planning processes, by moving a...

journal_title：Brain research

authors： Miyata H,Watanabe S,Minagawa-Kawai Y

更新日期：2011-02-16 00:00:00

abstract：:The characteristics of synaptic transmission in whole embryonic avian sympathetic ganglia have been examined by intracellular recording. Neurons in lumbar paravertebral ganglia of chick embryos exhibit both fast nicotinic excitatory postsynaptic potentials (EPSPs) and non-cholinergic slow EPSPs. Fast nicotinic transmi...

journal_title：Brain research

authors： Dryer SE,Chiappinelli VA

更新日期：1985-09-01 00:00:00

abstract：:Subcutaneous administration of rotenone has recently attracted attention because of its convenience, simplicity and efficacy in replicating features of Parkinson's disease (PD) in animal models. However, the wide range of doses reported in the literature makes it difficult to evaluate the effectiveness of this techniq...

journal_title：Brain research

authors： Zhang ZN,Zhang JS,Xiang J,Yu ZH,Zhang W,Cai M,Li XT,Wu T,Li WW,Cai DF

更新日期：2017-01-15 00:00:00

abstract：:Recent studies have confirmed the presence of insulin receptors in the rat brain although their function has still not been well defined. The present study explores the possibility that insulin receptors in the brain can alter or contribute to central neurotransmission. Insulin caused a dose-dependent inhibition of hi...

journal_title：Brain research

authors： Palovcik RA,Phillips MI,Kappy MS,Raizada MK

更新日期：1984-08-20 00:00:00