Abstract：
:Amyloid deposition, a histopathological feature of Alzheimer's disease brain, may be the underlying cause of this disease. The isolation of enzymes involved in both the normal and aberrant or alternative processing of the beta-amyloid precursor protein may lead to an understanding of how beta-protein, the major component of amyloid deposits, is formed in the brain parenchyma and vasculature of Alzheimer's disease patients and aged humans. As the same kind of deposits is also found in aged primates, the use of primates will undoubtedly help to understand the mechanisms of amyloid deposition, both spatially and temporally. Here we report the partial purification from adult monkey brain of a calcium-activated serine protease that is immunoreactive with antibodies against cathepsin G and is potentially involved in the abnormal degradation of the beta-amyloid precursor protein. Moreover, immunoreactivity with cathepsin G antibodies was localised to astrocytes in both adult and aged monkey cortex, suggesting that our protease may be expressed in astrocytes.
journal_name
Brain Resjournal_title
Brain researchauthors
Razzaboni BL,Papastoitsis G,Koo EH,Abraham CRdoi
10.1016/0006-8993(92)91279-nsubject
Has Abstractpub_date
1992-09-04 00:00:00pages
207-16issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(92)91279-Njournal_volume
589pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90018-4
更新日期：1983-06-01 00:00:00
abstract：:Pharmacological properties of glycine (Gly)-induced Cl- current (ICl) in the dorsal cochlear nucleus (DCN) neurons acutely dissociated from C57BL/6J mouse were investigated in the whole-cell configuration of the patch-clamp technique. Gly-induced ICl increased in a sigmoidal manner with higher Gly concentrations. Stry...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90794-a
更新日期：1992-03-06 00:00:00
abstract：:Previous studies found that injection of the GABA uptake inhibitor nipecotic acid into the nucleus tractus solitarius (NTS) increases arterial pressure. This effect of nipecotic acid was not antagonized by the selective GABAA receptor blocking agent bicuculline, suggesting that the action of nipecotic acid was mediate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91227-8
更新日期：1990-09-03 00:00:00
abstract：:Recently, [125I]S(-)5-OH-PIPAT (5-hydroxy-2-(N-n-propyl-N-3'-iodo-2'-propenyl)amino-tetralin) was reported to be a selective radioiodinated ligand for dopamine D2-like receptors. This ligand displayed a high binding affinity (Kd = 0.3-0.4 nM) and an agonist binding profile to dopamine D2 and D3 receptors expressed in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01014-7
更新日期：1997-12-05 00:00:00
abstract：:We examined regional cerebral metabolic rates for glucose (rCMRglc) and brain incorporation coefficients (k*) of each of three intravenously infused fatty acid radiotracers, [9,10-(3H)]palmitate ([3H]PAM), [1-(14C)]arachidonate ([14C]AA) and [1-(14C)]docosahe-xaenoate ([14C]DHA), in awake rats fully kindled by once-da...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00854-2
更新日期：1996-12-16 00:00:00
abstract：:Venous capacitance plays an important role in the control of cardiac output. However, the central nervous system sites and neurochemical signals involved in modulating venous function remain to be fully elucidated. The hypothalamic paraventricular nucleus (PVN) is an important site modulating autonomic outflow to the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00128-5
更新日期：1997-05-09 00:00:00
abstract：:Evidence exists that repeated injections of melatonin in rather large doses inhibit sexual performance in male rats. In contrast, systemic injection of small doses of this hormone stimulates sexual activity of normal male rats. In these experiments, systemic acute administration of melatonin in small doses (10-100 mic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02715-3
更新日期：2000-09-29 00:00:00
abstract：:Long-term potentiation (LTP) is a form of synaptic plasticity that may underlie learning and memory. The experiments reported here demonstrate that cocaine blocks the induction of LTP at the excitatory synapses in the CA1 region of the hippocampus, but does not appear to do so by blocking NMDA receptors or channels. O...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91466-6
更新日期：1993-04-16 00:00:00
abstract：:Neurons containing immunoreactivity to the endogenous lactose-binding lectin, RL-29, were examined in the L4 segment of the spinal cord of rats with an experimental neuropathy. The cells appeared by 5 days and were also present at 14 and 28 days postoperatively. All neurons were found in the dorsal horn ipsilateral to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90271-n
更新日期：1993-08-20 00:00:00
abstract：:The effect of repetitive stimulation of the locus coeruleus (LC) on the discharge rate of spontaneously active neurons of the visual, rostral and cingulate cortex was investigated in untreated and catecholamine-depleted rats under chloral hydrate anesthesia. In untreated animals, the inhibitory transsynaptic effects p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90251-6
更新日期：1980-03-17 00:00:00
abstract：:The present study has examined the involvement of sensory neurotransmitters in activating neurones in the trigeminal nucleus caudalis following stimulation of the trigeminovascular system in anaesthetised guinea-pigs. Electrical stimulation of the right trigeminal ganglion produced a unilateral expression of Fos-like ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00930-x
更新日期：1997-11-14 00:00:00
abstract：:The developmental and age-related changes of the dopamine transporter (DAT), and the dopamine D1 and D2 receptor (D1R and D2R) subtypes were investigated in basal ganglia (BG) of human brain. DAT immunostaining was mainly observed in the neuropil, neurons, and glia of the striatum. The DAT-positive neuropil was detect...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01933-2
更新日期：1999-10-02 00:00:00
abstract：:The present study examined the ability of antioxidant effects of angiotensin-converting enzyme (ACE) inhibitor, imidaprilat, on the synergistic effect of bisphenol A and 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical (*OH) formation and dopamine (DA) efflux in extracellular fluid of rat striatum. Bi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.11.100
更新日期：2006-02-03 00:00:00
abstract：:The effect of high concentrations of L-ascorbic acid on the in vivo and in vitro growth of human neuroblastoma has been investigated. Directly implemented into cell culture it decreased the DNA, RNA and protein synthesis, and mitosis of neuroblastoma cells, without affecting normal neuronal cells. In vivo treatment of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91139-4
更新日期：1985-09-09 00:00:00
abstract：:Oxidative stress in brain tissue was measured experimentally in situ using microdialysis to sample the extracellular environment for a lipid peroxidation breakdown product and antioxidants. The extracellular concentrations of the lipid peroxidation product malonaldehyde (MDA) and the antioxidants ascorbic acid (AA) an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01540-x
更新日期：1996-03-11 00:00:00
abstract：:Motor-related regions of parietal and prefrontal cortices have been shown to selectively activate when observers passively view objects that afford manual grasping. Yet, it remains unknown whether these cortical responses depend on prior motor-related experience with the object being observed. To address this question...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.059
更新日期：2006-06-30 00:00:00
abstract：:Terminal fibers anterogradely labeled with Phaseolus vulgaris leucoagglutinin (PHA-L) were observed in the locus coeruleus in the brainstem of the cat and the cynomolgus monkey following injections in lamina I of the spinal or medullary dorsal horn. Thus, thermoreceptive- or nociceptive-specific lamina I cells that pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90915-v
更新日期：1992-07-03 00:00:00
abstract：:The cholinergic agonist pilocarpine injected intraperitoneally (ip) increases mean arterial pressure (MAP) and superior mesenteric (SM) vascular resistance and reduces submandibular/sublingual gland (SSG) vascular resistance. In the present study, we investigated the effects of electrolytic lesions of the anteroventra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.06.071
更新日期：2005-09-07 00:00:00
abstract：:We have used the post-embedding immunogold labelling method using antibodies to gamma-aminobutyric acid (GABA) to obtain quantitative data on the distribution, frequency, postsynaptic targets and ultrastructural characteristics of GABA-immunoreactive (GABA-IR) boutons in the trigeminal motor nucleus of rats. We have a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90757-m
更新日期：1991-10-04 00:00:00
abstract：:In barbiturate-anaesthetized spinal cats, antibody microprobes were used to examine immunoreactive substance P (irSP) release at sites within the spinal cord following cutaneous stimuli. A basal level of irSP release was detected in the region of the substantia gelatinosa of the lumbar spinal cord. No increase in this...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90771-8
更新日期：1988-06-07 00:00:00
abstract：:Increasing evidences show that hippocampal synaptic plasticity plays a crucial role in the pathogenesis of depression. The objective of this study was to determine whether electroacupuncture (EA) in the Wistar Kyoto (WKY) rat model of depression would exert antidepressant effects and whether this effect would be assoc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.10.033
更新日期：2015-12-10 00:00:00
abstract：:Tumor necrosis factor-alpha (TNFalpha) affects several CNS functions such as regulation of sleep, body temperature, and feeding during pathology. There is also evidence for TNFalpha involvement in physiological sleep regulation, e.g., TNFalpha induces sleep and brain levels of TNFalpha increase during prolonged wakefu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.06.044
更新日期：2005-08-16 00:00:00
abstract：:The first phase of this study involves injecting a different fluorescent retrograde axonal tracer into the subthalamic nucleus, the substantia nigra, and the mesopontine tegmentum. Multiple labeled cells are found within the caudal third of the globus pallidus. The entopeduncular nucleus and adjacent basal forebrain s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90948-7
更新日期：1989-05-15 00:00:00
abstract：:Adult Sprague-Dawley rats were exposed to a single session of 100 inescapable tail shocks (IS). Bromodeoxyuridine (BrdU) was administered 1 h, 2 days or 7 days later and hippocampal cell proliferation (CP) was assessed after a 2-h survival period. Measures of plasma corticosterone (CORT) levels were also obtained. Des...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.081
更新日期：2007-01-26 00:00:00
abstract：:Repeated exposure to stressful stimuli or psychostimulants increases sensitivity to the motoric effects of these drugs, i.e. behavioral sensitization. The objective of the present experiment was to determine the interaction between factors that modulate psychostimulant sensitivity, i.e. sex and circulating gonadal hor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91651-9
更新日期：1994-05-09 00:00:00
abstract：:In the present study, we used an innovative music-rest interleaved fMRI paradigm to investigate the neural correlates of tinnitus distress. Tinnitus is a poorly-understood hearing disorder where individuals perceive sounds, in the absence of an external source. Although the great majority of individuals habituate to c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2021.147277
更新日期：2021-01-07 00:00:00
abstract：:Total RNA was extracted from 15-day-old whole rat brains. Microinjection of the RNA into Xenopus laevis oocytes induced electrophysiological responsiveness to cholecystokinin-8 (CCK) and bombesin (BBS) but not to corticotropin-releasing factor (CRF) or somatostatin. The responses to CCK and BBS were similar in shape, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(88)90021-6
更新日期：1988-08-01 00:00:00
abstract：:Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, is an essential component of membrane phosphatides and has been implicated in cognitive functions. Low levels of circulating or brain DHA are associated with various neurocognitive disorders including Alzheimer's disease (AD), while laboratory animals,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.08.089
更新日期：2007-11-28 00:00:00
abstract：:Lycium barbarum is an oriental medicinal herb that has long been used for its anti-aging and cell-protective properties. Previous studies have shown that aqueous extracts from L. barbarum exhibit neuroprotection via inhibiting pro-apoptotic signaling pathways. Other active components can also be accomplished by novel ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.075
更新日期：2007-07-16 00:00:00
abstract：:The depolarizing photoreceptor potential in the molluscan extraocular photoreceptor, A-P-1, results from the light-induced suppression of specific K+ currents. An application of cGMP or IBMX (inhibitor of phosphodiesterase) to A-P-1-evoked light-suppressed currents, similar to the above specific K+ currents. Thus, the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90682-3
更新日期：1989-04-17 00:00:00
