Abstract：
:Repeated exposure to stressful stimuli or psychostimulants increases sensitivity to the motoric effects of these drugs, i.e. behavioral sensitization. The objective of the present experiment was to determine the interaction between factors that modulate psychostimulant sensitivity, i.e. sex and circulating gonadal hormone levels, in rats with a genetically distinct locomotor response to novelty: Roman Low Avoidance rats (RLA) freeze while Roman High Avoidance rats (RHA) remain motorically active. Ninety-six male and female RHA and RLA rats were gonadectomized (GDX) just after weaning or as adults, or left gonadally intact. Each rat received a total of 9 injections of cocaine hydrochloride (10 mg/kg, IP), at 3-4 day intervals for 5 weeks. Locomotor activity was measured after each injection, and stereotypes were rated 1 x/week. Open field behavior (10 min) and plasma corticosterone were measured 2 weeks after the final injection. Overall, the RHA line was more sensitive to (1) cocaine's stereotypic effects, and (2) the influence of ovarian hormones on the cocaine's acute and sensitizing effects on locomotor activity. Therefore, genetic background not only determines cocaine sensitivity, but also the influence of gonadal hormones on locomotor activity. These interactions are relevant when considering the genetic contribution to abuse liability.
journal_name
Brain Resjournal_title
Brain researchauthors
Haney M,Castanon N,Cador M,Le Moal M,Mormède Pdoi
10.1016/0006-8993(94)91651-9subject
Has Abstractpub_date
1994-05-09 00:00:00pages
179-85issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91651-9journal_volume
645pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Freeze-fracture examination of nodes of Ranvier from adult rat optic nerve demonstrates the presence of astrocytic processes at the majority of nodes of Ranvier. Astrocytic processes often run along the entire length of the nodal gap, although they do not necessarily encircle the entire nodal circumference. The E- and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90919-3
更新日期：1984-08-06 00:00:00
abstract：:Since hypertension and/or hyperglycemia are risk factors for stroke, we examined whether the putative neuroprotectant, nicotinamide (NAm), could protect spontaneously hypertensive rats (SHR) or diabetic Fischer 344 rats against focal cerebral ischemia using a model of permanent middle cerebral artery occlusion (MCAo)....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02263-1
更新日期：2002-03-22 00:00:00
abstract：:Maternal infection during pregnancy is associated with an increased risk of neurodevelopmental injury. Our aim was to investigate whether prenatal immune challenge could alter susceptibility to seizure-induced brain injury in adulthood. Pregnant Wistar rats were injected intraperitoneally with lipopolysaccharide (LPS)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.04.047
更新日期：2013-06-26 00:00:00
abstract：:The putative neurotransmitter substance P was localized in the embryonic and neonatal mouse trigeminal nerve by indirect immunofluorescence. Central terminals in the nucleus caudalis gave a positive substance P-like immunofluorescence (SPLI) reaction of E13-E14. SPLI subsequently appeared in the peripheral mucous and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90147-x
更新日期：1982-07-01 00:00:00
abstract：:Neuronal expression of brain-derived neurotrophic factor (BDNF) has been implicated in the mechanism of infarct tolerance (resistance to stroke) (H. Yanamoto et al., Infarct tolerance accompanied enhanced BDNF-like immunoreactivity in neuronal nuclei, submitted to Brain Res.), a process that takes more than 7 days fol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)01966-1
更新日期：2000-03-24 00:00:00
abstract：:Intracellular staining with recording micropipettes filled with a Procion yellow solution was attempted on 11 lateral geniculate neurons of chloralose-anesthetized cats for the purpose of correlating electrophysiologically identified cell types with morphologically identified cell types. Five neurons were successfully...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90058-6
更新日期：1978-01-06 00:00:00
abstract：:Glucocorticoids bind with high affinity to intracellular receptors located in high density within discrete regions of the rodent and primate brain. The binding of [3H]corticosterone was compared in the brains of male vs female rats. The number and affinity of cytosol receptors in the hippocampus and hypothalamus were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91153-9
更新日期：1985-09-16 00:00:00
abstract：:We have previously reported that some neurons in the anterior hypothalamic area (AHA) are tonically activated by endogenous angiotensins in rats and that activities of these angiotensin II-sensitive neurons in the AHA are enhanced in spontaneously hypertensive rats (SHR). In addition, neural activations induced by bot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.11.029
更新日期：2005-02-08 00:00:00
abstract：:The effects of the dopamine transporter (DAT) inhibitors cocaine and GBR12909 on DAT and dopamine D(2) receptors were evaluated in the brains under awake and isoflurane-anesthetized monkeys using high-resolution positron emission tomography (PET) in combination with microdialysis. The striatal DAT availability and dop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02018-1
更新日期：1999-12-04 00:00:00
abstract：:The effect of lung inflation on the excitability of inspiratory neurons of the dorsal respiratory group was studied in decerebrate, paralyzed, artificially ventilated cats. Variations in the antidromic latency (AL) were used as a measure of the changes in excitability. The antidromic responses of single cells were rec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91278-3
更新日期：1986-02-26 00:00:00
abstract：:Tyrosine hydroxylase phenotype expression was investigated in the catecholaminergic population of the locus coeruleus neurons of two pure inbred mouse strains, Balb/C and C57Black/6. Therefore, we have characterized the precise organization of tyrosine hydroxylase-expressing perikarya population, in control animals an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00074-1
更新日期：1996-05-20 00:00:00
abstract：:In normal adult rats, intense immunostaining for the 75 kDa low-affinity receptor for nerve growth factor and other neurotrophins (p75NGFR) is concentrated in the middle region of the cuneate nucleus (CN), distributed in a blotchy pattern similar to that of cytochrome oxidase (CO) activity. In the adult rats, partial ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90051-5
更新日期：1994-05-16 00:00:00
abstract：:Nitric oxide (NO) is an endothelium-derived relaxing factor and its main mechanism of action is activation of soluble guanylyl cyclase. NO and NO-related compounds have been reported to affect several neuronal functions in the central nervous system. In this study, we investigated the effects of NO donors (sodium nitr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00291-6
更新日期：1997-06-20 00:00:00
abstract：:Motor behavior not seen in newborn cats can be revealed by spinal transection and is therefore normally suppressed. Motor performance of these spinal kittens after reaching adulthood surpasses that of chronic adult-operated spinal cats but the latter display a significant improvement when GABAergic inhibition is block...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90879-0
更新日期：1985-11-04 00:00:00
abstract：:The ability to recognize previous experience depends on two neurocognitive processes, familiarity, fast-acting and relatively automatic, and recollection, slower-acting and more effortful. Familiarity appears to mature relatively early in development and is maintained with aging, whereas recollection shows protracted ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.016
更新日期：2010-01-15 00:00:00
abstract：:The excitatory amino acid L-glutamate injected into the nucleus of the solitary tract (NTS) in unanesthetized rats similar to peripheral chemoreceptor activation increases mean arterial pressure (MAP) and reduces heart rate. In this study, we investigated the effects of acute (1 day) and chronic (15 days) electrolytic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.08.006
更新日期：2004-10-29 00:00:00
abstract：:There is a strong link between cognitive impairment and depression, but up to date it is not clear whether cognitive impairment is 'cause' or 'consequence' of depression. Therefore, we here examined the effect of cognitive impairment induced by permanent occlusion of common carotid arteries, a model known as two-vesse...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.056
更新日期：2015-01-30 00:00:00
abstract：:The transcription factor cAMP responsive element binding protein (CREB) is important in regulating immediate-early genes and some late-effector genes involved in neuroplasticity in response to peripheral injury and stressful insults. Partial nerve injury elicited neuropathic pain is accompanied by increased phosphoryl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03348-1
更新日期：2003-10-24 00:00:00
abstract：:Effects of alpha-adrenoceptor agents on electrophysiologically and immunohistochemically identified supraoptic nucleus (SON) vasopressin (VP) units were investigated by intracarotid infusion. Clonidine, an alpha 2-adrenoceptor agonist always excited SON units and alpha 2-adrenoceptor antagonists consistently inhibited...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91526-x
更新日期：1986-12-10 00:00:00
abstract：:The effects of 3 different non-noxious stressors on body temperature (Tb) were investigated in the rat: (1) loose restraint in cylinders, (2) removal of the rats from cylinders, exposure to a novel environment and replacement in cylinders, a stressor called here 'novelty', and (3) gentle holding of the rats by the nap...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90537-7
更新日期：1984-04-09 00:00:00
abstract：:Using the teased fiber recording method, we have compared pathophysiological properties of afferent axons injured in the infraorbital nerve (ION) vs the sciatic nerve in rats. Both myelinated and unmyelinated axons ending in ION neuromas produced much less ongoing discharge than those ending in sciatic nerve neuromas....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90753-v
更新日期：1992-05-01 00:00:00
abstract：:The effects of chronic administration of naloxone, morphine and met-enkephalin on benzodiazepine (BDZ) receptor binding in rat brain were determined 2 and 50 days after treatments were accomplished. Two days after naloxone treatment (75 micrograms/h s.c. for 14 days), enhanced BDZ receptor binding was observed in cing...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91668-i
更新日期：1993-05-28 00:00:00
abstract：:Monoclonal antibody N210 (mabN210) recognizes the 210 kdalton neurofilament protein in mammals and gives characteristic immunocytochemical staining of neurofilament-rich processes. For example, in the cerebellum it recognizes myelinated axons and the calyx formed by basket cell axon collaterals. The distribution of ma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90937-6
更新日期：1986-07-23 00:00:00
abstract：:We used triple-labeling immunohistochemistry in rat midbrain sections to identify dopaminergic neurons that contain either one or both of the calcium-binding proteins, calretinin (CR) and calbindin-D28k (CB). Midbrain dopaminergic neurons were immunohistochemically labeled for tyrosine hydroxylase (TH), CR, and CB. In...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01950-2
更新日期：1999-10-30 00:00:00
abstract：:In this microdialysis study we measured the extracellular neuropeptide Y (NPY) levels in the dorsal hippocampus of conscious rats. During potassium-induced depolarisations, a 93% increase in extracellular levels of NPY was observed. NPY has been demonstrated to reduce kainic acid-induced convulsions in rats, but it is...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01374-7
更新日期：1998-01-19 00:00:00
abstract：:The effects of pentylenetetrazol (PTZ) following induction of long-term potentiation (LTP) on population spikes in CA1 of hippocampal slices were investigated. Population spikes were evoked by activation of Schaffer collaterals with a range of stimulation intensities. LTP was induced using θ-pattern primed burst...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02672-x
更新日期：2000-09-22 00:00:00
abstract：:Genetic variability in the behavioral responses of experimental subjects to psychostimulants such as amphetamine and cocaine have been reported. However, genetic differences in the locomotor responses of rat strains to methylphenidate (MPD), a commonly used psychostimulant in the treatment of attention deficit/hyperac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04240-3
更新日期：2003-05-09 00:00:00
abstract：:The distribution of carbonic anhydrase (CA) activity was determined histochemically using Hansson's cobalt phosphate method in cross-sections of peripheral nerves from rats. As the studied nerves contain either efferent, proprioceptive or exteroceptive myelinated fibres, our survey particularly focused on the question...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90895-0
更新日期：1989-07-17 00:00:00
abstract：:The effects of ventromedial hypothalamic (VMH) stimulation on various metabolic parameters in freely moving animals were measured using a specific indirect calorimetric chamber associated with a quantitative measurement of locomotor activity, which allows the separate measurement of locomotor energy expenditure from t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01922-8
更新日期：1999-10-30 00:00:00
abstract：:The density of binding sites for excitatory amino acids in the hippocampus of SDAT (senile dementia of the Alzheimer type) patients has been investigated. This was compared to that found in younger and old non-dement cases. In the SDAT hippocampi there was a significant decrease in the glutamate and kainate binding. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90706-8
更新日期：1988-08-09 00:00:00
