Abstract：
:Evidence exists that repeated injections of melatonin in rather large doses inhibit sexual performance in male rats. In contrast, systemic injection of small doses of this hormone stimulates sexual activity of normal male rats. In these experiments, systemic acute administration of melatonin in small doses (10-100 microg/kg) induced the appearance of ejaculations in impotent Wistar male rats that were selected as showing null sexual approach or showing mounts, intromissions but no ejaculations. This effect was partially abolished by the simultaneous peripheral injection of the non-selective melatonin receptor antagonist, luzindole, or by the acute administration of serotonin or of the 5HT(2A) receptor agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), into the amygdala or the ventral hypothalamus. These results suggest that melatonin may stimulate, in a dose-dependent manner, several copulatory parameters of male sexual behavior and may restore sexual activity in impotent animals by interacting with brain receptors, i. e. melatonin and serotonin receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Drago F,Busa' Ldoi
10.1016/s0006-8993(00)02715-3subject
Has Abstractpub_date
2000-09-29 00:00:00pages
98-104issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02715-3journal_volume
878pub_type
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