Intracellular calcium in NCB-20 cells: elevation by depolarization and ethanol but not by glutamate.

Abstract:

:Intracellular Ca2+, measured in NCB-20 cells with the fluorescent indicator fura-2, was elevated by K(+)-depolarization and by ethanol, but not by the excitatory amino acids L-glutamate and N-methyl-D-aspartate. These amino acids failed to raise intracellular Ca2+ levels even in the presence of elevated extracellular Ca2+, in the absence of extracellular Mg2+ or Na+, under depolarizing conditions, or in differentiated cells, and induced neither 45Ca2+ uptake nor excitotoxic cell death. NCB-20 cells thus appear to express functional voltage-gated, but not N-methyl-D-aspartate receptor-gated, Ca2+ channels.

journal_name

Brain Res

journal_title

Brain research

authors

Chan J,Greenberg DA

doi

10.1016/0006-8993(91)91639-i

subject

Has Abstract

pub_date

1991-01-25 00:00:00

pages

328-31

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(91)91639-I

journal_volume

539

pub_type

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