Intracellular calcium in NCB-20 cells: elevation by depolarization and ethanol but not by glutamate.


:Intracellular Ca2+, measured in NCB-20 cells with the fluorescent indicator fura-2, was elevated by K(+)-depolarization and by ethanol, but not by the excitatory amino acids L-glutamate and N-methyl-D-aspartate. These amino acids failed to raise intracellular Ca2+ levels even in the presence of elevated extracellular Ca2+, in the absence of extracellular Mg2+ or Na+, under depolarizing conditions, or in differentiated cells, and induced neither 45Ca2+ uptake nor excitotoxic cell death. NCB-20 cells thus appear to express functional voltage-gated, but not N-methyl-D-aspartate receptor-gated, Ca2+ channels.


Brain Res


Brain research


Chan J,Greenberg DA




Has Abstract


1991-01-25 00:00:00














  • Kappa opioid receptor density is consistent along the rostrocaudal axis of the female rat spinal cord.

    abstract::Kappa opioid receptors (KORs) were immunocytochemically localized at four different levels of the spinal cord of normally-cycling female rats in estrus or diestrus. KOR labeling was primarily observed in fine processes and a few neuronal cell bodies in the superficial dorsal horn and the dorsolateral funiculus. Quanti...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Harris JA,Drake CT

    更新日期:2001-06-29 00:00:00

  • Dissociable neural systems for moral judgment of anti- and pro-social lying.

    abstract::Pro-social lying, which serves to benefit listeners, is considered more socially and morally acceptable than anti-social lying, which serves to harm listeners. However, it is still unclear whether the neural mechanisms underlying the moral judgment of pro-social lying differ from those underlying the moral judgment of...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hayashi A,Abe N,Fujii T,Ito A,Ueno A,Koseki Y,Mugikura S,Takahashi S,Mori E

    更新日期:2014-03-27 00:00:00

  • Calcium currents in acutely isolated stellate and pyramidal neurons of rat entorhinal cortex.

    abstract::Calcium currents were studied in morphologically identified pyramidal and stellate neurons acutely isolated from layer II/III of rat entorhinal cortex, using the whole-cell patch-clamp configuration. The peak amplitude of high-voltage activated current (HVA) measured at +10 mV was not different in both neuron populati...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bruehl C,Wadman WJ

    更新日期:1999-01-23 00:00:00

  • Some properties of membrane current fluctuations induced by kainate, quisqualate, and NMDA in cultured septal neurons of rat.

    abstract::Ionic currents induced by glutamate, kainate, quisqualate, and N-methyl-D-aspartate (NMDA) in cultured septal neurons were analyzed by fluctuations analysis. The power spectrum (PWS) of NMDA current fluctuations always fitted a single Lorentzian. PWSs of the other agonists fitted the sum of two Lorentzians; however, t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shingai R,Ebina Y

    更新日期:1988-05-10 00:00:00

  • From sublexical facilitation to lexical competition: ERP effects of masked neighbor priming.

    abstract::Interactive-activation models posit that visual word recognition involves co-activation of orthographic neighbors (e.g., note, node) and competition among them via lateral inhibitory connections. Behavioral evidence of this lexical competition comes from masked priming paradigms, in which target words elicit slower re...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Meade G,Grainger J,Midgley KJ,Emmorey K,Holcomb PJ

    更新日期:2018-04-15 00:00:00

  • Comparative effects of the antipsychotics sulpiride or risperidone in rats. I: bodyweight, food intake, body composition, hormones and glucose tolerance.

    abstract::Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antago...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Baptista T,Araujo de Baptista E,Ying Kin NM,Beaulieu S,Walker D,Joober R,Lalonde J,Richard D

    更新日期:2002-12-06 00:00:00

  • Increased [3H]glutamate receptor binding in aged rats.

    abstract::Na-independent [3H]glutamate binding to rat hippocampal membranes increases progressively as a function of age. The increased binding represents an increased number of binding sites without changes in their apparent affinity for glutamate. However, [3H]glutamate binding, measured with a saturating concentration of cal...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Baudry M,Arst DS,Lynch G

    更新日期:1981-10-26 00:00:00

  • Volume regulation and metabolism of suspended C6 glioma cells: an in vitro model to study cytotoxic brain edema.

    abstract::The in vitro model presented provides an approach to study the nature of cell volume control as well as of swelling mechanisms under pathophysiological conditions. Pertinent parameters of cell volume control can be analyzed in isolation due to a virtually infinite extracellular environment precluding secondary effects...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kempski O,Chaussy L,Gross U,Zimmer M,Baethmann A

    更新日期:1983-11-21 00:00:00

  • Plasma epinephrine modulates the cerebrovasodilation evoked by electrical stimulation of dorsal medulla.

    abstract::We examined whether plasma epinephrine contributes to the increase in regional cerebral blood flow (rCBF) evoked by electrical stimulation of the dorsal medullary reticular formation (DMRF). Rats were anesthetized (alpha-chloralose, 30 mg/kg, s.c.), paralyzed and artificially ventilated. The DMRF was electrically stim...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lacombe PM,Iadecola C,Underwood MD,Sved AF,Reis DJ

    更新日期:1990-01-01 00:00:00

  • Chronic exposure to estrogen and tamoxifen regulates synaptophysin and phosphorylated cAMP response element-binding (CREB) protein expression in CA1 of ovariectomized rat hippocampus.

    abstract::We report here the in vivo effects of estrogen (E2) on modulation of synaptic plasticity and the agonistic (estrogen-like) role of selective estrogen receptor modulator (SERM), tamoxifen (TAM) in the CA1 of the rat hippocampus. Effects on synaptophysin (SYP), a presynaptic vesicular protein, and phosphorylated cyclic ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sharma K,Mehra RD,Dhar P,Vij U

    更新日期:2007-02-09 00:00:00

  • Antibodies to ependymin block the sharpening of the regenerating retinotectal projection in goldfish.

    abstract::The regenerating optic nerve of goldfish first reestablishes a rough retinotopic map on the tectum, then goes through an activity dependent refinement that appears to involve the elimination of inappropriate branches from early regenerated arbors. Retinotopically appropriate branches and synapses may be stabilized bec...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schmidt JT,Shashoua VE

    更新日期:1988-04-19 00:00:00

  • Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1.

    abstract::Abeta amyloidosis and tauopathy are characteristic changes in the brain of Alzheimer's disease. Although much evidence suggests that Abeta deposit is a critical initiation factor, the pathological pathway between Abeta amyloidosis and tau accumulation remains unclear. Tau accumulation was examined in the doubly transg...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Samura E,Shoji M,Kawarabayashi T,Sasaki A,Matsubara E,Murakami T,Wuhua X,Tamura S,Ikeda M,Ishiguro K,Saido TC,Westaway D,St George Hyslop P,Harigaya Y,Abe K

    更新日期:2006-06-13 00:00:00

  • Anticipatory changes of long-latency stretch responses during preparation for directional hand movements.

    abstract::We have investigated, in 9 normal subjects, the time course of amplitude changes in the automatic long latency stretch reflex of wrist flexors during the preparatory period as a function of the precued direction of hand movement. Subjects maintained right hand position against a weak force and learned to compensate pr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bonnet M

    更新日期:1983-11-28 00:00:00

  • Gender differences in hyperthermia and regional 5-HT and 5-HIAA depletion in the brain following MDMA administration in rats.

    abstract::In the present research the role of gender in MDMA-induced hyperthermia and serotonin depletion is studied by injecting male and female male rats with MDMA or saline 3 times (i.p.) with 3h interval at dosages of 0.3, 1, 3 or 9 mg/kg at an ambient temperature of 25°C. The acute hyperthermia following the higher dosages...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wallinga AE,Grahlmann C,Granneman RA,Koolhaas JM,Buwalda B

    更新日期:2011-06-29 00:00:00

  • An HRP study of afferent connections of the supracommissural ventral telencephalon and the medial preoptic area in himé salmon (landlocked red salmon, Oncorhynchus nerka).

    abstract::The supracommissural ventral telencephalon and the medial preoptic area have been shown to play important roles in the sexual behavior of himé salmon (landlocked red salmon, Oncorhynchus nerka). In the present study, the sites of neurons projecting to these regions were examined by means of the retrograde horseradish ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shiga T,Oka Y,Satou M,Okumoto N,Ueda K

    更新日期:1985-12-30 00:00:00

  • Localization of cholecystokinin receptors on neuronal elements in rat caudate nucleus.

    abstract::Various chemical and physical lesions were employed to elucidate the cellular localization of cholecystokinin (CCK) receptors in the rat caudate nucleus. A wide knife cut severing all caudal afferents reduced caudate CCK receptors by approximately 25%, indicating that some receptors lie on axons and (or) terminals of ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hays SE,Meyer DK,Paul SM

    更新日期:1981-08-24 00:00:00

  • Mononuclear cell proliferation and hyperplasia during Wallerian degeneration in the visual system of the goldfish in the presence or absence of regenerating optic axons.

    abstract::Patterns of proliferation and changes in non-neuronal cell number in the visual system of the goldfish have been quantitatively examined during optic axon regeneration after an optic nerve crush (ONC). In addition, in order to examine the effect of the regenerating axons on cellular responses in the visual pathways, w...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ghali RP,Herx LM,Maa A,Levine RL

    更新日期:2000-01-31 00:00:00

  • Microglial responsiveness as a sensitive marker for trimethyltin (TMT) neurotoxicity.

    abstract::Activation of microglia is a well-documented phenomenon associated with diverse pathological conditions of the central nervous system. In order to investigate the involvement of microglial cells in the neurotoxic action of the heavy metal compound trimethyltin, three-dimensional brain cell cultures were treated during...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Monnet-Tschudi F,Zurich MG,Pithon E,van Melle G,Honegger P

    更新日期:1995-08-28 00:00:00

  • Two distinct serotonin receptors: regional variations in receptor binding in mammalian brain.

    abstract::Two distinct serotonin receptors in mammalian brain are labeled respectively with [3H]serotonin (5-HT1) and [3H]spiperone (5-HT2). In general agonists display highest affinities for 5-HT1 while antagonists prefer 5-HT2 sites. To conduct regional studies of 5-HT receptors, we estimated 5-HT2 sites with [3H]spiperone, u...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Peroutka SJ,Snyder SH

    更新日期:1981-03-16 00:00:00

  • Effects of phencyclidine administration on behavior and brain neurotensin-like immunoreactivity in rats.

    abstract::The effects of acute and chronic phencyclidine (PCP) administration on neurotensin-like immunoreactivity (NTLI) were investigated in discrete regions of rat brain. Both acute and chronic administration of PCP induced high locomotor activity, stereotypy and ataxia. On PCP administration, NTLI decreased significantly in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wachi M,Okuda M,Togashi S,Fuwano S,Miyashita O

    更新日期:1985-05-06 00:00:00

  • Location of angiotensin II binding sites on neuronal and glial cells of cultured mouse spinal cord: an autoradiographic study.

    abstract::Cultures of mouse spinal cord were used to visualize binding sites for [125I]angiotensin II (AII) by autoradiography. Visualization by light microscopy shows that neurones, but also glial cells possess angiotensin II binding sites which are located both on soma and processes. These findings open a new field of investi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Simonnet G,Legendre P,Laribi C,Allard M,Vincent JD

    更新日期:1988-03-08 00:00:00

  • Substance P containing polymer implants protect against striatal excitotoxicity.

    abstract::The present study examined whether substance P (Sub P) could protect against quinolinic acid (QA)-induced lesions of the striatum, as measured by a loss of striatal D1 dopamine receptors. Sub P was extruded into Evac polymer rods for slow release. One 4 mm rod segment was implanted unilaterally into the striatum of ea...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sanberg PR,Emerich DF,Aebischer P,Amisetti SM,Ouellette W,Koutouzis TK,Cahill DW,Norman AB

    更新日期:1993-11-19 00:00:00

  • A LANT6-like substance that is distinct from neuromedin N is present in pallidal and striatal neurons in monkeys.

    abstract::The basal ganglia of rhesus and squirrel monkeys were examined using immunohistochemical techniques with antibodies against the neurotensin-related hexapeptides Lys8-Asn9-Neurotensin(8-13) (LANT6) and Neuromedin N. A high percentage of neurons in both segments of globus pallidus and many large neurons of the striatum ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Reiner A

    更新日期:1987-09-29 00:00:00

  • Excitation of lateral horn neurons of the neonatal rat spinal cord by 5-hydroxytryptamine.

    abstract::The effects of 5-hydroxytryptamine (5-HT) on lateral horn cells contained in thin in vitro slices of neonatal rat spinal cord were investigated by means of intracellular recording techniques. Superfusion of 5-HT (1-100 microM) to lateral horn cells caused a concentration-dependent membrane depolarization leading to, i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ma RC,Dun NJ

    更新日期:1986-01-01 00:00:00

  • A radiohistochemical measure of [3H]TCP binding to the activated NMDA-receptor-gated ion channel in rat brain.

    abstract::The N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor is linked to an ion channel that is blocked by the phencyclidine analog N-(1-[thienyl]cyclohexyl)piperidine (TCP). Previous studies have shown that NMDA and glycine act together to increase the access of [3H]TCP to its binding site, presumably b...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hosford DA,Bonhaus DW,McNamara JO

    更新日期:1990-05-21 00:00:00

  • Slow age-dependent decline of doublecortin expression and BrdU labeling in the forebrain from lesser hedgehog tenrecs.

    abstract::In addition to synaptic remodeling, formation of new neurons is increasingly acknowledged as an important cue for plastic changes in the central nervous system. Whereas all vertebrates retain a moderate neuroproliferative capacity, phylogenetically younger mammals become dramatically impaired in this potential during ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Alpár A,Künzle H,Gärtner U,Popkova Y,Bauer U,Grosche J,Reichenbach A,Härtig W

    更新日期:2010-05-12 00:00:00

  • Habenular and other midbrain raphe afferents demonstrated by a modified retrograde tracing technique.

    abstract::Afferents to th midbrain dorsal and median raphe nuclei in the rat were studied by means of the horseradish peroxidase (HRP) retrograde transport method. The HRP was given by means of a modified iontophoretic delivery technique. This technique permitted an efficient and localized deposition of a high concentration of ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Aghajanian GK,Wang RY

    更新日期:1977-02-18 00:00:00

  • Rat brain hypothalamic and hippocampal monoamine and hippocampal beta-adrenergic receptor changes during pregnancy.

    abstract::The concentration of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites was measured in hypothalamic and hippocampal brain tissue obtained from non-pregnant, 15- or 20-day pregnant and 4-day postpartum rats. At 20 days of pregnancy, hypothalamic NA and DA concentrations were significantly decre...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Glaser J,Russell VA,Taljaard JJ

    更新日期:1992-04-17 00:00:00

  • Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis.

    abstract::Cerebral venous thrombosis (CVT) is a rare form of cerebral stroke that causes a variety of symptoms, ranging from mild headache to severe morbidity or death in the more severe forms. The use of anti-coagulant or thrombolytic agents is the classical treatment for CVT. However, the development of new therapies for the ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rashad S,Niizuma K,Sato-Maeda M,Fujimura M,Mansour A,Endo H,Ikawa S,Tominaga T

    更新日期:2018-11-15 00:00:00

  • Preferential occupation of mineralocorticoid receptors by corticosterone enhances glutamate-induced burst firing in rat midbrain dopaminergic neurons.

    abstract::Sensitisation to the behavioural effects of amphetamine, a phenomenon which appears to involve the potentiation of excitatory amino acid (EAA)-mediated transmission at the level of dopaminergic (DA) neurons in the ventral tegmental area (the A10 cell group), is known to be affected by corticosteroid manipulations. Sin...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Overton PG,Tong ZY,Brain PF,Clark D

    更新日期:1996-10-21 00:00:00