Abstract：
:Appetite suppressants lose efficacy when given chronically; the mechanisms are unknown. We gave male rats once-daily dl-fenfluramine (dl-FEN, 5 mg/kg, i.p.) injections for 15 days and measured mRNA expression of corticotropin releasing factor (CRF), neuropeptide Y (NPY) and proopiomelanocortin (POMC) in hypothalamic neurons on days 1, 2 and 15. dl-FEN decreased food intake on days 1-2 but not on day 15. The drug increased CRF mRNA and decreased NPY mRNA on days 1-2; on day 15, NPY mRNA was normal, but CRF mRNA remained elevated. No changes occurred in POMC mRNA. Thus, only the NPY mRNA response to dl-FEN correlated with changes in food intake over time in a manner consistent with the known effects of NPY on food intake.
journal_name
Brain Resjournal_title
Brain researchauthors
Choi S,Blake V,Cole S,Fernstrom JDdoi
10.1016/j.brainres.2006.02.129subject
Has Abstractpub_date
2006-05-04 00:00:00pages
83-6issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(06)00718-9journal_volume
1087pub_type
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