Abstract：
:The potential evoked in the pyriform cortex by single-pulse stimulation of the olfactory bulb was examined before and after single and repeated elicitation of an epileptiform afterdischarge produced by stimulation of the olfactory bulb. A single afterdischarge (AD) produced a rapid (i.e. within 5 min) increase in the amplitude of an early surface-negative wave and duration of a later surface-positive wave. These effects persisted at least 48-72 h. Repeated elicitation of ADs resulted in kindling. A large increase in the amplitude of a later surface-negative wave (approximately 25 ms latency) occurred during kindling. This wave remained significantly elevated for at least 72 h after the last AD. Long-term potentiation of the early surface-negative wave was produced by kindling or two focal ADs. A short-term effect which was consistently observed following a focal or generalized AD was a prolongation of a late surface-positive wave. These effects are discussed in relation to long-term potentiation, postseizure inhibition, and kindling development.
journal_name
Brain Resjournal_title
Brain researchauthors
Russell RD,Stripling JSdoi
10.1016/0006-8993(85)91275-2subject
Has Abstractpub_date
1985-12-30 00:00:00pages
61-9issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(85)91275-2journal_volume
361pub_type
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