Abstract:
:Short-term potentiation of extracellular field excitatory postsynaptic potentials (EPSP's) was investigated in the stratum radiatum of CA1 of the rat hippocampal slice in vitro. A presynaptic tetanus consisting of a single train of stimuli at 250 Hz evoked short-term potentiation (STP), but not long-term potentiation (LTP) of small amplitude, just suprathreshold, EPSP's in a medium containing 2 mM Ca and 2 mM Mg. Increasing the number of stimuli in the tetanus enhanced the initial amplitude of the STP to a maximum of 40-70% with 30-40 stimuli, and enhanced the decay time constant of STP to a maximum of 60-80 s. Increasing the Ca influx by raising external Ca, lowering Mg or adding the agent 4-aminopyridine caused a large increase in the initial amplitude of STP but only a very slight increase in the decay time of STP. LTP was frequently evoked in high Ca/Mg ratios of 2.0 or 4.0, but not in 1.0 or 0.5.
journal_name
Brain Resjournal_title
Brain researchauthors
Anwyl R,Lee WL,Rowan Mdoi
10.1016/0006-8993(88)90304-6subject
Has Abstractpub_date
1988-08-30 00:00:00pages
192-5issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(88)90304-6journal_volume
459pub_type
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