Polycyclic neuromodulation of the feeding rhythm of the pond snail Lymnaea stagnalis by the intrinsic octopaminergic interneuron, OC.

Abstract:

:We have examined the role of the octopamine-containing buccal OC interneuron in the fictive feeding rhythm generated by depolarizing a modulatory interneuron, SO, in the isolated central nervous system (CNS) of Lymnaea stagnalis. Before stimulating the SO, the initial fictive feeding rate was 2.0+/-0.37 bites/min (mean+/-S.E.). When the SO was stimulated, the fictive feeding rate more than doubled, increasing by 5.4+/-2.6 bites/min. Prestimulation of OC facilitates the ability of the modulatory neuron SO to drive fictive feeding 4 s later. Following OC stimulation, the increase in SO-driven feeding rate was 10.8+/-1.6 bites/min, significantly more than when only the SO was stimulated (P<0.02, paired t-test on five preparations). OC activity is not required during the SO stimulation for this enhancement. The maximum of the SO driven rhythm occurs between 6 and 12 s after the end of the OC stimulation at 20 bites/min. This is the maximum feeding rate of intact Lymnaea in sucrose. Facilitation is mimicked by bath applied octopamine at 5 microM. Facilitation is specific to OC interneurons, as the same prestimulation of the electrically coupled neuron N3P (central pattern generator) interneurons does not affect the feeding rhythm. The OC interneuron acts as a long term, polycyclic modulator, which peaks several feeding cycles after the OC activity.

journal_name

Brain Res

journal_title

Brain research

authors

Elliott CJ,Vehovszky A

doi

10.1016/s0006-8993(00)02968-1

subject

Has Abstract

pub_date

2000-12-22 00:00:00

pages

63-9

issue

1

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(00)02968-1

journal_volume

887

pub_type

杂志文章
  • Neural substrates of sarcasm: a functional magnetic-resonance imaging study.

    abstract::The understanding of sarcasm reflects a complex process, which involves recognizing the beliefs of the speaker. There is a clear association between deficits in mentalizing, which is the ability to understand other people's behavior in terms of their mental state, and the understanding of sarcasm in individuals with a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.09.088

    authors: Uchiyama H,Seki A,Kageyama H,Saito DN,Koeda T,Ohno K,Sadato N

    更新日期:2006-12-08 00:00:00

  • Retrograde optogenetic characterization of the pontospinal module of the locus coeruleus with a canine adenoviral vector.

    abstract::Noradrenergic neurons of the brainstem extend projections throughout the neuraxis to modulate a wide range of processes including attention, arousal, autonomic control and sensory processing. A spinal projection from the locus coeruleus (LC) is thought to regulate nociceptive processing. To characterize and selectivel...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2016.02.023

    authors: Li Y,Hickey L,Perrins R,Werlen E,Patel AA,Hirschberg S,Jones MW,Salinas S,Kremer EJ,Pickering AE

    更新日期:2016-06-15 00:00:00

  • Identification of the opioid receptors involved in passive-avoidance learning in the day-old chick during the second wave of neuronal activity.

    abstract::Long-term memory formation for passive-avoidance learning in the day-old chick is known to have two distinct time windows of protein synthesis (F.M. Freeman, S.P.R. Rose, A.B. Scholey, 1995. Two time windows of anisomycin-induced amnesia for passive-avoidance training in the day-old chick. Neurobiol. Learn. Mem. 63, 2...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02181-8

    authors: Freeman FM,Young IG

    更新日期:2000-05-12 00:00:00

  • A brief period of hypoxia causes proteolysis of cytoskeletal proteins in hippocampal slices.

    abstract::Breakdown products (BDPs) resulting from the partial proteolysis of spectrin were examined in hippocampal slices after periods of hypoxia lasting for 5 or 10 min. The concentration of a approximately 155 kDa BDP increased nearly twofold after 5 min of hypoxia; further increases were not seen with 10 min episodes or 10...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90352-v

    authors: Arai A,Vanderklish P,Kessler M,Lee K,Lynch G

    更新日期:1991-08-02 00:00:00

  • Effects of light and temperature on the response gradient of retinal rod outer segments.

    abstract::Photoreceptor outer segments are continually renewed from base to tip and consequently the membrane at the tip is older than at the base. In parallel with this, there are differences in light responsiveness, and it has been proposed that these may be due to the aforementioned differences in age. We have tested this pr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)01357-1

    authors: Leibovic KN,Bandarchi J

    更新日期:1997-03-07 00:00:00

  • Discharge of neurons in the parabrachial pons related to the cardiac cycle: changes during different sleep-waking states.

    abstract::Neuronal activity in the nucleus parabrachialis medialis (NPBM) was examined in unanesthetized, unrestrained cats during each sleep-waking state. Discharge related to the cardiac cycle was assessed by calculating cross-correlation functions between neuronal and cardiac events (using the peak of the EKG 'R' wave as a r...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)90696-4

    authors: Sieck GC,Harper RM

    更新日期:1980-10-20 00:00:00

  • Visual stimulation reduces EEG activity in man.

    abstract::Data are presented which show that background electric activity of the human brain is reduced by visual stimulation. Occipital EEG amplitude decreases 5-15% for all frequencies analyzed (0.2-40 Hz) upon pattern stimulation. The reduction is stimulus-specific, i.e. is the strongest for stimuli that activate a large num...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90403-i

    authors: Vijn PC,van Dijk BW,Spekreijse H

    更新日期:1991-05-31 00:00:00

  • Hippocampal mediation of raphe lesion- and PCPA-induced hyperactivity in the rat.

    abstract::These experiments provide a direct test of the hypothesis that median raphe lesion- or PCPA-induced hyperactivity in the rat is mediated specifically by the hippocampus. Previous studies had shown that a marked depletion of hippocampal serotonin accompanied median lesion-induced hyperactivity. In the present studies, ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(75)90060-8

    authors: Jacobs BL,Trimbach C,Eubanks EE,Trulson M

    更新日期:1975-08-29 00:00:00

  • Effects of internal calcium and sodium on photocurrent kinetics in toad rod photoreceptors.

    abstract::Reducing external calcium from 1.0 to 0.1 mM increased the flash sensitivity and the time-to-peak (tp) of linear responses of rod photoreceptors. The quantitative relation between flash sensitivity and tp was the same as during light adaptation. However, the calcium ionophore A23187 reduced sensitivity without affecti...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90405-6

    authors: Matthews GG

    更新日期:1985-04-15 00:00:00

  • Cholinergic innervation of the lateralis medialis-suprageniculate nuclear complex (LM-Sg) of the cat's thalamus: a double labeling immunohistochemical study.

    abstract::The purpose of this study was to investigate morphological characteristics of the synaptic relations of choline acetyltransferase (ChAT)-positive terminals that are made with a variety of post-synaptic profiles in the lateralis medialis-suprageniculate nuclear complex (LM-Sg) using ChAT, gamma-aminobutyric acid (GABA)...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(96)01208-5

    authors: Hoshino K,Hicks TP,Meguro R,Hirano S,Kase M,Norita M

    更新日期:1997-01-30 00:00:00

  • Enriched environment delays the onset of hippocampal damage after global cerebral ischemia in rats.

    abstract::An enriched environment has been shown to improve cognitive, behavioral and histopathological outcome after focal cerebral ischemia and head trauma. The purpose of this study was to determine the effect of an enriched environment on histopathology following global cerebral ischemia. Wistar rats (21 weeks of age) were ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)04089-1

    authors: Belayev A,Saul I,Liu Y,Zhao W,Ginsberg MD,Valdes MA,Busto R,Belayev L

    更新日期:2003-02-21 00:00:00

  • Neurodegeneration induced by MoMuLV-ts1 and increased expression of Fas and TNF-alpha in the central nervous system.

    abstract::Infection of neonatal mice with ts1, the neuropathogenic mutant of the Moloney murine leukemia virus, results in motor neuronal death in the brainstem and the spinal cord, with gliosis and demyelination, but no inflammatory cell infiltration into the CNS. To evaluate the possible mechanism(s) of ts1-induced neuropatho...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00929-3

    authors: Choe W,Stoica G,Lynn W,Wong PK

    更新日期:1998-01-01 00:00:00

  • The distribution and central termination of single cutaneous and muscle unmyelinated fibres in rat spinal cord.

    abstract::An electrophysiological approach has been used to trace the central course of individual C fibres from a cutaneous (sural) and muscle (gastrocnemius) nerve in anaesthetized rats. Single C fibres were recorded from the central part of cut peripheral nerves and a glass micropipette used to map the spinal cord with low t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91410-6

    authors: McMahon SB,Wall PD

    更新日期:1985-12-16 00:00:00

  • Localization of GAD- and GABA-like immunoreactivity in ground squirrel retina: retrograde labeling demonstrates GAD-positive ganglion cells.

    abstract::Glutamic acid decarboxylase (GAD)- and gamma-aminobutyric acid (GABA)-like immunoreactivity was examined in the retina of the 13-lined ground squirrel (Spermophilus tridecemlineatus). Labeling was observed in the inner nuclear layer (INL), inner plexiform layer (IPL) and ganglion cell layer (GCL). The immunoreactive c...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91346-3

    authors: Lugo-García N,Blanco RE

    更新日期:1991-11-08 00:00:00

  • Glucagon and the paraventricular hypothalamus: modulation of energy balance.

    abstract::The effects of glucagon injections (25, 100 and 200 ng) into the paraventricular nucleus of the hypothalamus (PVN) were investigated in an open-circuit calorimeter. Wistar rats were tested, with no food available during the tests. High doses of glucagon (100 and 200 ng) produced small and short-lasting increases in en...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90663-8

    authors: Atrens DM,Menéndez JA

    更新日期:1993-12-10 00:00:00

  • Differential interaction of the Pafah1b alpha subunits with the Reelin transducer Dab1.

    abstract::The Reelin signaling pathway controls radial neuronal migration and maturation in the developing brain. The platelet activating factor (PAF) acetyl hydrolase 1b (Pafah1b) complex is also involved in multiple aspects of brain development. We previously showed that the Reelin pathway and the Pafah1b complex interact gen...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.02.059

    authors: Zhang G,Assadi AH,Roceri M,Clark GD,D'Arcangelo G

    更新日期:2009-04-24 00:00:00

  • Autoreceptor-mediated changes in dopaminergic terminal excitability: effects of striatal drug infusions.

    abstract::The neurophysiological correlates of autoinhibition at the terminals of nigrostriatal dopaminergic neurons were studied by measuring the changes in antidromic excitability of nigrostriatal neurons following local infusions of various catecholamine agonists and antagonists into the neostriatum. Infusions of apomorphine...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:

    authors: Tepper JM,Nakamura S,Young SJ,Groves PM

    更新日期:1984-09-10 00:00:00

  • Effects of behaviorally rewarding hypothalamic electrical stimulation on intracellularly recorded neuronal activity in the motor cortex of awake monkeys.

    abstract::Effects of hypothalamic stimulation (HS) were studied in intracellular recordings obtained from 125 neurons of the motor cortex (MC). HS that was effective in reinforcing bar-press behavior, i.e. satisfactory for intracranial self-stimulation (ICSS), evoked short-latency (less than 3 ms) activation of these cortical n...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91458-8

    authors: Aou S,Oomura Y,Woody CD,Nishino H

    更新日期:1988-01-26 00:00:00

  • Effects of SFO lesion or captopril on drinking induced by intragastric hypertonic saline.

    abstract::This study examined the hypothesis that the subfornical organ (SFO), a circumventricular organ with both osmosensitive elements and dipsogenic receptors for circulating angiotensin (ANG) II, is important for the water drinking response that follows an intragastric (ig) load of hypertonic NaCl. A 2-ml saline load was a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00249-2

    authors: Starbuck EM,Fitts DA

    更新日期:1998-06-08 00:00:00

  • Atrophy of medium spiny I striatal dendrites in advanced Parkinson's disease.

    abstract::Loss of dopaminergic neurons from the pars compacta of the substantia nigra is the pathological hallmark of Parkinson's disease (PD) and results in a partial deafferentation to the striatum. Since deafferentation is known to induce transynaptic atrophy of postsynaptic cells, we examined by Golgi impregnation the morph...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90124-2

    authors: McNeill TH,Brown SA,Rafols JA,Shoulson I

    更新日期:1988-07-05 00:00:00

  • 5-Hydroxytryptamine stimulates corticosteroid-sensitive CRF release from cultured foetal hypothalamic cells. Role of protein kinases.

    abstract::5-Hydroxytryptamine (5-HT) has been shown to activate the hypothalamo-pituitary-adrenal axis, possibly by a direct action on hypothalamic CRF synthesis and release. In order to study the mechanisms involved in this effect, foetal hypothalamic cells were cultured and corticotropin-releasing factor-41 (CRF) release was ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90826-u

    authors: Hu SB,Lightman SL,Tannahill LA

    更新日期:1992-03-06 00:00:00

  • Neonatal exposure to MK-801, an N-methyl-D-aspartate receptor antagonist, enhances methamphetamine-induced locomotion and disrupts sensorimotor gating in pre- and postpubertal rats.

    abstract::Administration of non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists (e.g. phencyclidine, MK-801) has been shown to elicit behavioral abnormalities related to symptoms of schizophrenia, such as spontaneous locomotor activity and impaired sensorimotor gating, as represented by deficits of prepulse inhibit...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.07.013

    authors: Uehara T,Sumiyoshi T,Seo T,Matsuoka T,Itoh H,Suzuki M,Kurachi M

    更新日期:2010-09-17 00:00:00

  • Immunocytochemical localization of cholecystokinin and glutamic acid decarboxylase during normal development in the prepyriform cortex of rats.

    abstract::Immunocytochemical localization of specific neurotransmitters in the brain is becoming increasingly important in studies of maturation. We have used the trilaminar prepyriform cortex (PC) of rats to study the distribution, patterns and relative number of cells, fibers and terminals during postnatal development using a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(87)90208-2

    authors: Westenbroek RE,Westrum LE,Hendrickson AE,Wu JY

    更新日期:1987-08-01 00:00:00

  • Expression of the functional D-glucose transport system in Xenopus oocytes injected with mRNA of rat small intestine.

    abstract::mRNA prepared from rat small intestine was injected into Xenopus oocytes. The injected oocytes showed a clear electrical response to D-glucose (Glu) in the form of membrane depolarization and conductance increase, while none was shown to D-fructose. The membrane electrical response of the injected oocytes evoked by Gl...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0169-328x(87)90033-7

    authors: Aoshima H,Ishii H,Anan M

    更新日期:1987-09-01 00:00:00

  • Changes in the visual system of monocularly sutured or enucleated cats demonstrable with cytochrome oxidase histochemistry.

    abstract::Endogenous cytochrome oxidase activity within the mitochondria of neurons and neuropil was demonstrated histochemically under normal and experimental conditions. Since enzymatic changes were noted with chronic neuronal inactivity in the auditory system (Wong-Riley et al), the present study sought to examine functional...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)90728-5

    authors: Wong-Riley M

    更新日期:1979-07-27 00:00:00

  • Effects of ramelteon and triazolam in a mouse genetic model of early morning awakenings.

    abstract::The onset of the daily wheel running bout precedes dark onset by several hours in the early runner genetic variant of mice. Here, we test the hypothesis that timed daily administration of a melatonin agonist, ramelteon, or a benzodiazepine, triazolam, normalizes the timing of daily wheel-running rhythms in early runne...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.07.103

    authors: Wisor JP,Jiang P,Striz M,O'Hara BF

    更新日期:2009-11-03 00:00:00

  • Lateral geniculate cell responses to electrical stimulation of the retina.

    abstract::Electrical stimulation of the retina evokes at the optic tract level rhythmic bursts of activity whose temporal structure is predictable from the polarity of the stimulation and the receptive field type. The reaction of lateral geniculate units to this input was studied in fast and slow relay cells as well as in inter...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(78)90135-x

    authors: Molotchnikoff S,Lachapelle P

    更新日期:1978-08-18 00:00:00

  • Afferent projections related to attack sites in the pontine tegmentum.

    abstract::Attack by a cat on a rat was elicited by electrical stimulation of the ventral parabrachial nucleus or the paralemniscal pontine reticular formation. The attack was quiet and it differed from similar behavior elicited at other sites in that the cat not only bit the rat but struck it with its paw. Horseradish peroxidas...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)90009-x

    authors: Smith DA,Flynn JP

    更新日期:1979-03-23 00:00:00

  • Cisplatin-evoked induction of c-fos protein in the brainstem of the ferret: the effect of cervical vagotomy and the anti-emetic 5-HT3 receptor antagonist granisetron (BRL 43694).

    abstract::We have monitored the expression of c-fos protein in the medulla oblongata of the ferret, using immunocytochemistry, to identify the brainstem pathways involved in the mediation of nausea and vomiting caused by the antineoplastic drug cisplatin. Cisplatin administration resulted in c-fos-like immunoreactivity (FLI) in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91654-j

    authors: Reynolds DJ,Barber NA,Grahame-Smith DG,Leslie RA

    更新日期:1991-11-29 00:00:00

  • Effects of hypothalamic lesions upon the sexual and social behaviour of the male common marmoset (Callithrix jacchus).

    abstract::The sexual and associated behaviour of 10 adult male marmosets was recorded during pair tests with ovariectomized females, before and after bilateral thermal lesions of the hypothalamus. Four sham-lesioned males served as controls. Lesions varied in volume from 1.49 to 3.28 mm3 and extended from the ventromedial hypot...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90405-2

    authors: Lloyd SA,Dixson AF

    更新日期:1988-11-01 00:00:00